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New York Stem Cell Foundation

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The New York Stem Cell Foundation
Formation2005
FounderSusan L. Solomon, Mary Elizabeth Bunzel
TypeNon-profit Research Institute
HeadquartersNew York City
CEO
Derrick J. Rossi, PhD
Websitehttps://nyscf.org/

The New York Stem Cell Foundation, or NYSCF, is an American non-profit research institute focused on stem cell research, technology development, and funding researchers.[1] Headquartered on the far west side of Manhattan, New York, NYSCF employs 114 scientists, technicians, engineers, and administrative and other staff,[2] in addition to funding early career investigators and postdoctoral fellows. Since its inception, NYSCF has raised and invested more than $400 million for stem cell research.[2]

Organization

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History

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NYSCF was founded in New York City by Susan L. Solomon, a lawyer and entrepreneur, and Mary Elizabeth Bunzel, a former journalist, in 2005 to accelerate stem cell-based approaches to researching and treating type 1 diabetes[3] and in response to the refusal of the administration of President George W. Bush to make a major investment in stem cell research.[1] In 2006, NYSCF opened the NYSCF Research Institute – a 500 square foot, one-room independent laboratory located adjacent to Columbia University[4][5] – as a safe-haven to conduct somatic cell nuclear transfer research through a collaboration with Columbia University and Harvard University.[6]

In 2015, NYSCF signed a 20-year lease to move its headquarters and NYSCF Research Institute laboratories to a renovated 42,000 square foot space at 619 West 54th Street[7] in the former Warner Brothers 'Movie Lab' building,[8][9] rebranded as the Hudson Research Center by commercial real estate developer and building owner Taconic.[10] Opened in 2017, the new headquarters includes space for a Good Manufacturing Practice facility to manufacture cells for clinical trials.[11] In 2021, New York City announced it would grant NYSCF $6.5M as one of four applied research and development (R&D) facilities to equip an expansion of its Research Institute.[12]

Corporate leadership

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The NYSCF is currently led by Jennifer J. Raab, former President of Hunter College. Raab was appinted as President & Chief Executive Officer in January 2024.[13]

The board of directors includes Roy Geronemus, Stephen M. Ross, Stephen Scherr, Kay Unger, Paul Goldberger, and Siddhartha Mukherjee.[14]

Research

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High-throughput technologies

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In 2015, NYSCF described the development of the NYSCF Global Stem Cell Array, a fully-automated system for high-throughput creation, differentiation, and quality control of stem cell lines.[15][16] The system saves five to six times the cost of reagents as compared to manual stem cell derivation.[15][16] The Global Stem Cell Array has been used to conduct research on several patient groups including children with rare diseases,[17] veterans with post-traumatic stress disorder,[18][19] and Parkinson’s patients.[20][21]

Stem cell-based research

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NYSCF research resulting in the first human stem cell lines from the cells of patients with amyotrophic lateral sclerosis (ALS), commonly known as Lou Gehrig’s disease, was named as Time magazine's top medical breakthrough of 2008 and the number one breakthrough of the year by Science magazine.[22][23] In 2018, a phase 2 clinical trial for Ezogabine, an epilepsy treatment identified as a possible ALS therapy based on this human stem cell model, was shown to reduce motor neuron excitability in ALS patients.[24][25]

In 2013, NYSCF researchers created the first patient-specific bone from stem cells and successfully transplanted the grafts into mice.[26][27]

NYSCF researchers created stem cells and derived neurons from a pair of identical twins, one with Parkinson’s disease and one without, finding their neurons differed in how they produce the neurotransmitter dopamine and the enzyme beta-glucocerebrosidase in addition to differing in a molecular signaling pathway.[28][29]

NYSCF researchers, in collaboration with researchers at New York University, created astrocytes from human stem cells and showed that in disease-like environments these cells can turn into neuron killers.[30][31]

Mitochondrial replacement therapy

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NYSCF researchers developed mitochondrial replacement therapy in 2012, or MRT, a technique to prevent the mother-to-child transmission of mitochondrial diseases[32][33][3][34] which is now approved for clinical use in the United Kingdom.[35]

Artificial intelligence

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With Google Research, NYSCF scientists used the NYSCF Array and artificial intelligence algorithms to identify new cellular features of Parkinson’s disease by analyzing over six million images of skin cells, sampled and expanded from a group of 91 Parkinson’s patients and healthy controls.[20][36]

Partnerships

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Organizations NYSCF has or is currently partnering with include: Google;[36] the Icahn School of Medicine at Mount Sinai, the James J. Peters Veterans Affairs Medical Center, and Yale University School of Medicine;[19] Rush University Medical Center, Harvard Medical School, and Brigham and Women’s Hospital;[37] Johns Hopkins School of Medicine and Bloomberg Philanthropies;[38][39] and Columbia University Medical Center and the National Eye Institute.[40]

Activism

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NYSCF started a working group "Initiative on Women in Science and Engineering" (IWISE) to address gender equality in science and STEM fields.[41] The IWISE working group published seven actionable strategies for institutions to promote gender equity in a 2015 Cell Stem Cell paper.[41][42] One of these steps is an Institutional Report Card for Gender Equality, which NYSCF created and requires every NYSCF grant applicant to fill out. The results of a 5-year analysis of these report card submissions were published in a 2019 Cell Stem Cell paper defining the extent of gender parity issues in the academic pipeline and opportunities for improvement.[43]

Funding

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NYSCF was founded with private philanthropy from individuals and foundations. Notable early funders include former New York City mayor Michael R. Bloomberg; the investor Stanley Druckenmiller and his wife, Fiona; and a foundation founded by the late hedge-fund manager Julian Robertson.[1]

NYSCF hosts an annual fundraising Gala and Science Fair. Past honorees include Janet and Jerry Zucker, Sanjay Gupta, MD; Siddhartha Mukherjee, MD, DPhil; Irving Weissman, MD; Susan and Stephen Scherr; Victor Garber; Derrick Rossi, PhD; Kizzmekia Corbett, PhD; Barney Graham, MD, PhD; Katalin Karikó, PhD; Drew Weissman, MD, PhD; Brooke Ellison; Frank Gehry; and David Rockwell. [44][45][46][47][48] In 2021 and 2020, NYSCF held virtual Galas both directed by Scott Ellis and hosted by Sanjay Gupta, MD.[45]

In addition to philanthropy, NYSCF also receives funding from grants, partnerships, and collaborations.[citation needed]

Awards

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Several awards are administered by the NYSCF. The Robertson Early Career Investigator Awards are given to scientists who have recently launched their own laboratories and provides unrestricted funding over a five-year period to scientists around the world, funded by the Robertson Foundation since 2010.[49][50] The Druckenmiller Postdoctoral Fellows Awards provide three years of unrestricted funding to postdoctoral stem cell researchers in the tri-state area of New York, New Jersey and Connecticut, and are funded by Stanley and Fiona Druckenmiller.[51][52]

Notable recipients of NYSCF awards include Feng Zhang, Edward Boyden, Jayaraj Rajagopal, Paola Arlotta, Valentina Greco Lydia W. S. Finley, Shruti Naik, Lauren Orefice, Lauren O’Connell, Elaine Hsiao, Carolyn (Lindy) McBride, Paul J. Tesar, Vanessa Ruta, Edward Chang, Lisa Giocomo, Kay Tye, Dragana Rogulja, Maria Lehtinen, Claire Wyart, Sergiu P. Pașca, Ilana B. Witten, Franziska Michor, and Amy Wagers.[citation needed]

References

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  3. ^ a b Wolfe, Alexandra (2016-02-05). "Susan L. Solomon's Stem-Cell Research Quest". WSJ. Retrieved 2023-04-25.
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  27. ^ de Peppo, Giuseppe Maria; Marcos-Campos, Iván; Kahler, David John; Alsalman, Dana; Shang, Linshan; Vunjak-Novakovic, Gordana; Marolt, Darja (2013-05-21). "Engineering bone tissue substitutes from human induced pluripotent stem cells". Proceedings of the National Academy of Sciences. 110 (21): 8680–8685. Bibcode:2013PNAS..110.8680D. doi:10.1073/pnas.1301190110. ISSN 0027-8424. PMC 3666730. PMID 23653480.
  28. ^ Henig, Robin Marantz (2015-02-23). "Did Grief Give Him Parkinson's?". Nautilus. Retrieved 2023-04-25.
  29. ^ Woodard, Chris M.; Campos, Brian A.; Kuo, Sheng-Han; Nirenberg, Melissa J.; Nestor, Michael W.; Zimmer, Matthew; Mosharov, Eugene V.; Sulzer, David; Zhou, Hongyan; Paull, Daniel; Clark, Lorraine; Schadt, Eric E.; Sardi, Sergio Pablo; Rubin, Lee; Eggan, Kevin (2014-11-20). "iPSC-Derived Dopamine Neurons Reveal Differences between Monozygotic Twins Discordant for Parkinson's Disease". Cell Reports. 9 (4): 1173–1182. doi:10.1016/j.celrep.2014.10.023. ISSN 2211-1247. PMC 4255586. PMID 25456120.
  30. ^ Jackson, Christina (2020-06-02). "Stem Cell Model Exposes Astrocytes as Potential Mechanism behind Neurodegeneration". GEN - Genetic Engineering and Biotechnology News. Retrieved 2023-04-25.
  31. ^ Barbar, Lilianne; Jain, Tanya; Zimmer, Matthew; Kruglikov, Ilya; Sadick, Jessica S.; Wang, Minghui; Kalpana, Kriti; Rose, Indigo V.L.; Burstein, Suzanne R.; Rusielewicz, Tomasz; Nijsure, Madhura; Guttenplan, Kevin A.; di Domenico, Angelique; Croft, Gist; Zhang, Bin (2020-08-05). "CD49f Is a Novel Marker of Functional and Reactive Human iPSC-Derived Astrocytes". Neuron. 107 (3): 436–453.e12. doi:10.1016/j.neuron.2020.05.014. ISSN 0896-6273. PMC 8274549. PMID 32485136.
  32. ^ Farrell, John (2012-12-19). "Nuclear Transfer Breakthrough Offers A Way To Prevent Mitochondrial Disorders". Forbes. Retrieved 2023-04-25.
  33. ^ Tingley, Kim (2014-06-27). "The Brave New World of Three-Parent I.V.F." The New York Times. ISSN 0362-4331. Retrieved 2023-04-25.
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  35. ^ Guilford, Gwynn (2015-02-03). "Make way for three-parent babies". Quartz. Retrieved 2023-04-25.
  36. ^ a b Schiff, Lauren; Migliori, Bianca; Chen, Ye; Carter, Deidre; Bonilla, Caitlyn; Hall, Jenna; Fan, Minjie; Tam, Edmund; Ahadi, Sara; Fischbacher, Brodie; Geraschenko, Anton; Hunter, Christopher J.; Venugopalan, Subhashini; DesMarteau, Sean; Narayanaswamy, Arunachalam (2022-03-25). "Integrating deep learning and unbiased automated high-content screening to identify complex disease signatures in human fibroblasts". Nature Communications. 13 (1): 1590. Bibcode:2022NatCo..13.1590S. doi:10.1038/s41467-022-28423-4. ISSN 2041-1723. PMC 8956598. PMID 35338121.
  37. ^ Lagomarsino, Valentina N.; Pearse, Richard V.; Liu, Lei; Hsieh, Yi-Chen; Fernandez, Marty A.; Vinton, Elizabeth A.; Paull, Daniel; Felsky, Daniel; Tasaki, Shinya; Gaiteri, Chris; Vardarajan, Badri; Lee, Hyo; Muratore, Christina R.; Benoit, Courtney R.; Chou, Vicky (2021-11-03). "Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors". Neuron. 109 (21): 3402–3420.e9. doi:10.1016/j.neuron.2021.08.003. ISSN 0896-6273. PMC 8571042. PMID 34473944.
  38. ^ "Johns Hopkins School of Medicine announces new partnership to advance precision medicine". The Hub. 2019-10-22. Retrieved 2023-04-25.
  39. ^ "Bloomberg Philanthropies, Johns Hopkins University School of Medicine, and The New York Stem Cell Foundation Research Institute Announce an Unprecedented Effort to Advance Precision Medicine". Bloomberg Philanthropies. Retrieved 2023-04-25.
  40. ^ "AMD Integrative Biology Initiative | National Eye Institute". www.nei.nih.gov. Retrieved 2023-04-25.
  41. ^ a b Smith, Kristin A.; Arlotta, Paola; Watt, Fiona M.; Solomon, Susan L.; Bargmann, Cori; Berg, David; Briggs, LaTese; Chao, Moses V.; Dulac, Catherine; Eggan, Kevin; Escobar-Alvarez, Sindy; Fossati, Valentina; Fuchs, Elaine; Glimcher, Laurie H. (2015-03-05). "Seven Actionable Strategies for Advancing Women in Science, Engineering, and Medicine". Cell Stem Cell. 16 (3): 221–224. doi:10.1016/j.stem.2015.02.012. ISSN 1934-5909. PMC 4476252. PMID 25748929.
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  43. ^ Beeler, Whitney H.; Smith-Doody, Kristin A.; Ha, Richard; Aiyar, Raeka S.; Schwarzbach, Elizabeth; Solomon, Susan L.; Jagsi, Reshma (2019-09-05). "Institutional Report Cards for Gender Equality: Lessons Learned from Benchmarking Efforts for Women in STEM". Cell Stem Cell. 25 (3): 306–310. doi:10.1016/j.stem.2019.08.010. ISSN 1934-5909. PMID 31491394. S2CID 201869532.
  44. ^ "Honorees – NYSCF Gala & Science Fair". Retrieved 2023-04-25.
  45. ^ a b "Past Galas – NYSCF Gala & Science Fair". Retrieved 2023-04-25.
  46. ^ Cristi, A. A. "Tony-Winner David Rockwell to Be Honored By NYSCF As Part Of First Ever Virtual Gala". BroadwayWorld.com. Retrieved 2023-04-25.
  47. ^ Rabinowitz, Chloe. "Victor Garber to be Honored at SHOW UP FOR SCIENCE Event, Featuring Jane Krakowski, Tony Shalhoub, Jesse Williams & More". BroadwayWorld.com. Retrieved 2023-04-25.
  48. ^ Rosky, Nicole. "Photos: Caissie Levy, Annaleigh Ashford & More Come Out to Support the New York Stem Cell Foundation". BroadwayWorld.com. Retrieved 2023-11-03.
  49. ^ "Hedge-Fund Founder Julian Robertson Donates $27M to Fund Stem-Cell Research". WSJ. Retrieved 2023-04-25.
  50. ^ "NYSCF – Robertson Stem Cell Investigator Awards". New York Stem Cell Foundation. Retrieved 2023-04-25.
  51. ^ "NYSCF – Druckenmiller Fellowship Awards". New York Stem Cell Foundation. Retrieved 2023-04-25.
  52. ^ Di Mento, Maria (2010-01-04). "Druckenmiller Foundation Announces $705 Million in Gifts From Founders". Philanthropy News Digest. Retrieved 2023-05-01.
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Official website

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