The Portrait of the Marchioness of Santa Cruz or Portrait of the Marquise of Santa Cruz is an 1805 portrait by the Spanish artist Francisco José de Goya y Lucientes, a family friend of the subject. It has been owned by the Museo del Prado since 1986, when it bought it from its previous owner for over US$6 million.
It shows Joaquina Téllez-Girón, Marquise of Santa Cruz clad in a very light white dress, lying sideways on a red divan. Her head is decorated with yellow flowers; her left hand is balancing a lyre-guitar. Her gaze does not directly fix on the viewer but seems to look distant. Her body does not seem to sit in a natural position, but seemingly floats on the red divan and the pillows.