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Talazoparib

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Talazoparib
Clinical data
Trade namesTalzenna
Other namesBMN-673
AHFS/Drugs.comMonograph
MedlinePlusa618070
License data
Pregnancy
category
Routes of
administration		By mouth
Drug classPARP inhibitor
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding74%
MetabolismMinimal metabolisation (<30%)
Elimination half-life90 (±58) hrs
Excretion69% in urine, 20% in feces
Identifiers
  • (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one
CAS Number
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.249.319 Edit this at Wikidata
Chemical and physical data
FormulaC19H14F2N6O
Molar mass380.359 g·mol−1
3D model (JSmol)
  • Cn1c(ncn1)[C@H]2c3c4c(cc(cc4N[C@@H]2c5ccc(cc5)F)F)c(=O)[nH]n3
  • InChI=1S/C19H14F2N6O/c1-27-18(22-8-23-27)15-16(9-2-4-10(20)5-3-9)24-13-7-11(21)6-12-14(13)17(15)25-26-19(12)28/h2-8,15-16,24H,1H3,(H,26,28)/t15-,16-/m1/s1
  • Key:HWGQMRYQVZSGDQ-HZPDHXFCSA-N

Talazoparib, sold under the brand name Talzenna, is an anti-cancer medication used for the treatment of breast cancer and prostate cancer.[5] It is an orally available poly ADP ribose polymerase PARP inhibitor marketed by Pfizer for the treatment of advanced breast cancer with germline BRCA mutations.[8] Talazoparib is similar to the first in class PARP inhibitor, olaparib.[9][10]

The most common adverse reactions of any grade were fatigue, anemia, nausea, neutropenia, headache, thrombocytopenia, vomiting, alopecia, diarrhea, decreased appetite.[11]

It was approved in October 2018, in the United States and June 2019, in the European Union for germline BRCA-mutated, HER2-negative locally advanced or metastatic breast cancer.[9][12][13][7] In January 2024, the European Commission approved talazoparib in combination with enzalutamide for the treatment of metastatic castration-resistant prostate cancer (mCRPC) in adults.[14]

Medical uses

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Talazoparib is indicated for the treatment of breast cancer and prostate cancer.[5][7] It is indicated for the treatment of people with deleterious or suspected deleterious germline BRCA-mutated (gBRCAm), HER2‑negative locally advanced or metastatic breast cancer;[11] and, in combination with enzalutamide, for homologous recombination repair (HRR) gene-mutated metastatic castration-resistant prostate cancer (mCRPC).[15]

Side effects

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The most serious side effects in studies were related to the blood forming system and included anaemia (low red blood cell count), neutropenia (low neutrophil blood cell count) and thrombocytopenia (low platelet count). Serious forms of these conditions (grade 3 to 4) occurred in 39%, 21% and 15% of patients, respectively. Other adverse effects such as headache, nausea, hair loss and fatigue were mostly mild.[5]

The FDA label includes warnings and precautions for myelodysplastic syndrome/acute myeloid leukemia, myelosuppression, and embryo-fetal toxicity.[11]

Interactions

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Combination with drugs that inhibit P-glycoprotein or BCRP may increase talazoparib concentrations in the body.[5]

Mechanism of action

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Talazoparib acts as an inhibitor of poly ADP ribose polymerase (PARP) which aids in single strand DNA repair. Cells that have BRCA1/2 mutations are susceptible to the cytotoxic effects of PARP inhibitors because of an accumulation of DNA damage.[8] Talazoparib is theorized to have a higher potency than olaparib due to the additional mechanism of action called PARP trapping. PARP trapping is the mechanism of action where the PARP molecule is trapped on the DNA, which interferes with the cells ability to replicate. Talazoparib is found to be ~100 fold more efficient in PARP trapping than olaparib.[16] However, this increased potency may not translate directly to clinical effectiveness as many other factors must be considered.[10][16]

History

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The approval by the US Food and Drug Administration (FDA) for treating breast cancer was based on EMBRACA (NCT01945775), an open‑label trial randomizing 431 participants (2:1) with gBRCAm HER2‑negative locally advanced or metastatic breast cancer to receive talazoparib (1 mg) or physician's choice of chemotherapy (capecitabine, eribulin, gemcitabine, or vinorelbine).[11] All participants were required to have a known deleterious or suspected deleterious gBRCA mutation and must have received no more than three prior cytotoxic chemotherapy regimens for locally advanced or metastatic disease.[11] Participants were required to have received treatment with an anthracycline and/or a taxane (unless contraindicated) in the neoadjuvant, adjuvant, and/or metastatic treatment setting.[11] The trial was conducted at 145 sites in the US, Europe, Brazil, South Korea, Taiwan, Israel, and Australia.[17]

The efficacy of talazoparib used to treat prostate cancer was evaluated in TALAPRO-2 (NCT03395197), a randomized, double-blind, placebo-controlled, multi-cohort trial enrolling 399 participants with HRR gene-mutated mCRPC.[15] Participants were randomized (1:1) to receive enzalutamide 160 mg daily plus either talazoparib 0.5 mg or placebo daily.[15] Participants were required to have a prior orchiectomy and, if not performed, received gonadotropin-releasing hormone (GnRH) analogs.[15] Participants with prior systemic therapy for mCRPC were excluded; however, prior CYP17 inhibitors or docetaxel for metastatic castration-sensitive prostate cancer (mCSPC) was permitted.[15] Randomization was stratified by previous treatment with a CYP17 inhibitor or docetaxel.[15] HRR genes (ATM, ATR, BRCA1, BRCA2, CDK12, CHEK2, FANCA, MLH1, MRE11A, NBN, PALB2, or RAD51C) were assessed prospectively using tumor tissue and/or circulating tumor DNA (ctDNA)-based next generation sequencing assays.[15]

Society and culture

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Economics

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Talazoparib was developed by BioMarin Pharmaceutical Inc. and Medivation Inc. acquired all worldwide rights to talazoparib in August 2015.[18] Medivation acquired talazoparib for $410 million with additional payments of up to $160 million in royalties and milestones.[19] Pfizer acquired Medivation in 2016.

References

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  1. ^ a b "Talzenna APMDS". Therapeutic Goods Administration (TGA). 26 May 2022. Retrieved 10 March 2024.
  2. ^ "Talzenna Product information". Health Canada. 25 April 2012. Archived from the original on 30 May 2022. Retrieved 29 May 2022.
  3. ^ "Summary Basis of Decision (SBD) for Talzenna". Health Canada. 23 October 2014. Archived from the original on 31 May 2022. Retrieved 29 May 2022.
  4. ^ "Talzenna 0.25 mg hard capsules - Summary of Product Characteristics (SmPC)". (emc). 1 June 2021. Archived from the original on 9 July 2021. Retrieved 9 July 2021.
  5. ^ a b c d e "Talzenna- talazoparib capsule". DailyMed. 4 September 2023. Archived from the original on 30 July 2023. Retrieved 13 November 2023.
  6. ^ "Talzenna- talazoparib capsule". DailyMed. 4 September 2023. Archived from the original on 29 May 2023. Retrieved 13 November 2023.
  7. ^ a b c "Talzenna EPAR". European Medicines Agency (EMA). 8 July 2019. Archived from the original on 19 May 2020. Retrieved 10 March 2020.
  8. ^ a b Medivation Inc. "Talazoparib". Archived from the original on 8 June 2017. Retrieved 21 November 2016.
  9. ^ a b "FDA approves Lynparza to treat advanced ovarian cancer". U.S. Food and Drug Administration (FDA) (Press release). 19 December 2014. Archived from the original on 19 December 2014. Retrieved 16 December 2019.
  10. ^ a b Brown JS, Kaye SB, Yap TA (March 2016). "PARP inhibitors: the race is on". British Journal of Cancer. 114 (7): 713–5. doi:10.1038/bjc.2016.67. PMC 4984871. PMID 27022824.
  11. ^ a b c d e f "FDA approves talazoparib for gBRCAm HER2-negative locally advanced or". U.S. Food and Drug Administration. 16 October 2018. Retrieved 8 March 2024. Public Domain This article incorporates text from this source, which is in the public domain.
  12. ^ "European Commission Approves Talzenna (talazoparib) for Patients with Inherited (Germline) BRCA-Mutated Locally Advanced or Metastatic Breast Cancer" (Press release). Pfizer Inc. Archived from the original on 22 September 2020. Retrieved 23 June 2019.
  13. ^ "Drug Approval Package: Talzenna (talazoparib)". U.S. Food and Drug Administration (FDA). 29 October 2018. Archived from the original on 30 October 2020. Retrieved 10 March 2020.
  14. ^ "Pfizer's Talzenna combination receives EC approval for metastatic prostate cancer". PMLive. 10 January 2024. Retrieved 11 January 2024.
  15. ^ a b c d e f g "FDA approves talazoparib with enzalutamide for HRR gene-mutated metast". U.S. Food and Drug Administration. 20 June 2023. Retrieved 8 March 2024. Public Domain This article incorporates text from this source, which is in the public domain.
  16. ^ a b Shen Y, Aoyagi-Scharber M, Wang B (June 2015). "Trapping Poly(ADP-Ribose) Polymerase". The Journal of Pharmacology and Experimental Therapeutics. 353 (3): 446–57. doi:10.1124/jpet.114.222448. PMID 25758918. S2CID 9810541.
  17. ^ "Drug Trial Snapshot: Talzenna". U.S. Food and Drug Administration (FDA). 16 October 2018. Retrieved 9 March 2024. Public Domain This article incorporates text from this source, which is in the public domain.
  18. ^ Biomarin (24 August 2015). "Medivation to Expand Global Oncology Franchise With the Acquisition of All Worldwide Rights to Talazoparib (BMN 673), a Potent PARP Inhibitor, From BioMarin" (Press release). Archived from the original on 5 February 2017. Retrieved 21 November 2016.
  19. ^ Inman S (25 August 2015). "Medivation Acquires BioMarin's PARP Inhibitor Talazoparib". Archived from the original on 21 November 2016. Retrieved 21 November 2016.
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