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Protein-coding gene in the species Homo sapiens
Mannose-6-phosphate receptor binding protein 1 (M6PRBP1 ) is a protein which in humans is encoded by the M6PRBP1 gene .[5] TIP47 .
Mannose 6-phosphate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A ), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo.[6]
The mannose-6-phosphate receptor-binding properties of TIP47 are disputed,[7] lipid droplets .[8]
TIP47 belongs to the peripilin protein family and shares significant homology with the other genes of this family, including perilipin and adipophilin .[9]
M6PRBP1 has been shown to interact with both Mannose 6-phosphate receptors .[10] [11]
^ a b c GRCh38: Ensembl release 89: ENSG00000105355 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024197 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: M6PRBP1 mannose-6-phosphate receptor binding protein 1" .^ Carroll KS, Hanna J, Simon I, Krise J, Barbero P, Pfeffer SR (May 2001). "Role of Rab9 GTPase in facilitating receptor recruitment by TIP47". Science . 292 (5520): 1373–6. Bibcode :2001Sci...292.1373C . doi :10.1126/science.1056791 . PMID 11359012 . S2CID 31343936 . ^ Bulankina AV, Deggerich A, Wenzel D, Mutenda K, Wittmann JG, Rudolph MG, Burger KN, Höning S (May 2009). "TIP47 functions in the biogenesis of lipid droplets" (PDF) . J. Cell Biol . 185 (4): 641–55. doi :10.1083/jcb.200812042 . PMC 2711566 PMID 19451273 . ^ Ducharme NA, Bickel PE (March 2008). "Lipid droplets in lipogenesis and lipolysis" . Endocrinology . 149 (3): 942–9. doi :10.1210/en.2007-1713 PMID 18202123 . ^ Brasaemle DL (December 2007). "Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis" (PDF) . J. Lipid Res . 48 (12): 2547–59. doi :10.1194/jlr.R700014-JLR200 PMID 17878492 . S2CID 38744670 . ^ Díaz E, Pfeffer S R (May 1998). "TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking" . Cell . 93 (3). UNITED STATES: 433–43. doi :10.1016/S0092-8674(00)81171-X ISSN 0092-8674 . PMID 9590177 . S2CID 17161071 . ^ Orsel JG, Sincock P M, Krise J P, Pfeffer S R (August 2000). "Recognition of the 300-kDa mannose 6-phosphate receptor cytoplasmic domain by 47-kDa tail-interacting protein" . Proc. Natl. Acad. Sci. U.S.A. 97 (16). UNITED STATES: 9047–51. Bibcode :2000PNAS...97.9047O . doi :10.1073/pnas.160251397 ISSN 0027-8424 . PMC 16819 PMID 10908666 .
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