This gene is a member of the receptor tyrosine phosphatase family and encodes a single-pass type I membrane protein with two cytoplasmic tyrosine-protein phosphatase domains, an alpha-carbonic anhydrase domain and a fibronectin type III domain. Alternative splice variants that encode different protein isoforms have been described but their full-length nature has not been determined.[7]
Expression of this gene is induced in gastric cancer cells, in the remyelinating oligodendrocytes of multiple sclerosis lesions, and in human embryonic kidney cells under hypoxic conditions. Both the protein and transcript are overexpressed in glioblastoma cells, promoting their haptotactic migration.[7]
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^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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Morton SM, Veile RA, Helms C, Lee M, Kuo WL, Gray J, Donis-Keller H (1998). "Subregional localization of 21 chromosome 7-specific expressed sequence tags (ESTs) by FISH using newly identified YACs and P1s". Genomics. 46 (3): 491–4. doi:10.1006/geno.1997.5051. PMID9441757.
Thomaidou D, Coquillat D, Meintanis S, Noda M, Rougon G, Matsas R (2001). "Soluble forms of NCAM and F3 neuronal cell adhesion molecules promote Schwann cell migration: identification of protein tyrosine phosphatases zeta/beta as the putative F3 receptors on Schwann cells". J. Neurochem. 78 (4): 767–78. doi:10.1046/j.1471-4159.2001.00454.x. PMID11520897. S2CID24682985.
Harroch S, Furtado GC, Brueck W, Rosenbluth J, Lafaille J, Chao M, Buxbaum JD, Schlessinger J (2002). "A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions". Nat. Genet. 32 (3): 411–4. doi:10.1038/ng1004. PMID12355066. S2CID19800079.
Bonora E, Lamb JA, Barnby G, Sykes N, Moberly T, Beyer KS, Klauck SM, Poustka F, Bacchelli E, Blasi F, Maestrini E, Battaglia A, Haracopos D, Pedersen L, Isager T, Eriksen G, Viskum B, Sorensen EU, Brondum-Nielsen K, Cotterill R, van Engeland H, de Jonge M, Kemner C, Steggehuis K, Scherpenisse M, Rutter M, Bolton PF, Parr JR, Poustka A, Bailey AJ, Monaco AP (2005). "Mutation screening and association analysis of six candidate genes for autism on chromosome 7q". Eur. J. Hum. Genet. 13 (2): 198–207. doi:10.1038/sj.ejhg.5201315. PMID15523497.
Wang V, Davis DA, Haque M, Huang LE, Yarchoan R (2005). "Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells". Cancer Res. 65 (8): 3299–306. doi:10.1158/0008-5472.CAN-04-4130. PMID15833863.