Hemoglobin subunit zeta

HBZ
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JEB, 3W4U
Identifiers
Aliases	HBZ, HBZ-T1, HBZ1, hemoglobin subunit zeta, HBAZ
External IDs	OMIM: 142310; MGI: 96019; HomoloGene: 110705; GeneCards: HBZ; OMA:HBZ - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16p13.3 Start 142,728 bp End 154,503 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 A4|11 18.86 cM Start 32,226,400 bp End 32,228,116 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle left testis right testis blood ganglionic eminence bone marrow subcutaneous adipose tissue anterior cingulate cortex amygdala ectocervix Top expressed in yolk sac tail of embryo genital tubercle abdominal wall maxillary prominence internal carotid artery mandibular prominence external carotid artery hand somite More reference expression data BioGPS More reference expression data
Gene ontology Molecular function iron ion binding oxygen binding protein binding heme binding metal ion binding oxygen carrier activity peroxidase activity haptoglobin binding organic acid binding Cellular component hemoglobin complex extracellular exosome haptoglobin-hemoglobin complex Biological process oxygen transport negative regulation of transcription by RNA polymerase II erythrocyte maturation transport hydrogen peroxide catabolic process protein heterooligomerization cellular oxidant detoxification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3050 15126 Ensembl ENSG00000130656 ENSMUSG00000055609 UniProt P02008 P06467 RefSeq (mRNA) NM_005332 NM_010405 RefSeq (protein) NP_005323 NP_034535 Location (UCSC) Chr 16: 0.14 – 0.15 Mb Chr 11: 32.23 – 32.23 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Hemoglobin subunit zeta is a protein that in humans is encoded by the HBZ gene.

Zeta-globin is an alpha-like hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult life. The zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta1 - 3'.

Further reading

• Giardina B, Messana I, Scatena R, Castagnola M (1995). "The multiple functions of hemoglobin". Critical Reviews in Biochemistry and Molecular Biology. 30 (3): 165–96. doi:10.3109/10409239509085142. PMID 7555018.
• Proudfoot NJ, Brownlee GG (September 1976). "3' non-coding region sequences in eukaryotic messenger RNA". Nature. 263 (5574): 211–4. Bibcode:1976Natur.263..211P. doi:10.1038/263211a0. PMID 822353. S2CID 4211839.
• Fougerousse F, Meloni R, Roudaut C, Beckmann JS (March 1992). "Dinucleotide repeat polymorphism at the human hemoglobin alpha-1 pseudo-gene (HBAP1)". Nucleic Acids Research. 20 (5): 1165. doi:10.1093/nar/20.5.1165. PMC 312136. PMID 1549498.
• Hess J, Perez-Stable C, Wu GJ, Weir B, Tinoco I, Shen CK (July 1985). "End-to-end transcription of an Alu family repeat. A new type of polymerase-III-dependent terminator and its evolutionary implication". Journal of Molecular Biology. 184 (1): 7–21. doi:10.1016/0022-2836(85)90039-7. PMID 2411938.
• Marotta CA, Forget BG, Weissman SM, Verma IM, McCaffrey RP, Baltimore D (June 1974). "Nucleotide sequences of human globin messenger RNA". Proceedings of the National Academy of Sciences of the United States of America. 71 (6): 2300–4. Bibcode:1974PNAS...71.2300M. doi:10.1073/pnas.71.6.2300. PMC 388440. PMID 4135409.
• Perez-Stable C, Ayres TM, Shen CK (September 1984). "Distinctive sequence organization and functional programming of an Alu repeat promoter". Proceedings of the National Academy of Sciences of the United States of America. 81 (17): 5291–5. Bibcode:1984PNAS...81.5291P. doi:10.1073/pnas.81.17.5291. PMC 391689. PMID 6089189.
• Clegg JB, Gagnon J (October 1981). "Structure of the zeta chain of human embryonic hemoglobin". Proceedings of the National Academy of Sciences of the United States of America. 78 (10): 6076–80. Bibcode:1981PNAS...78.6076C. doi:10.1073/pnas.78.10.6076. PMC 348980. PMID 6171809.
• Aschauer H, Schäfer W, Sanguansermsri T, Braunitzer G (December 1981). "[Human embryonic haemoglobins. Ac-Ser-Leu-Thr-is the N-terminal sequence of the zeta-chains (author's transl)]". Hoppe-Seyler's Zeitschrift für Physiologische Chemie. 362 (12): 1657–9. PMID 6172357.
• Aschauer H, Sanguansermsri T, Braunitzer G (August 1981). "[Human embryonic haemoglobins. The primary structure of the zeta chains (author's transl)]". Hoppe-Seyler's Zeitschrift für Physiologische Chemie. 362 (8): 1159–62. PMID 6179844.
• Proudfoot NJ, Gil A, Maniatis T (December 1982). "The structure of the human zeta-globin gene and a closely linked, nearly identical pseudogene". Cell. 31 (3 Pt 2): 553–63. doi:10.1016/0092-8674(82)90311-7. PMID 6297773. S2CID 36907055.
• Goodbourn SE, Higgs DR, Clegg JB, Weatherall DJ (August 1983). "Molecular basis of length polymorphism in the human zeta-globin gene complex". Proceedings of the National Academy of Sciences of the United States of America. 80 (16): 5022–6. Bibcode:1983PNAS...80.5022G. doi:10.1073/pnas.80.16.5022. PMC 384180. PMID 6308667.
• Cohen-Solal MM, Authier B, deRiel JK, Murnane MJ, Forget BG (1983). "Cloning and nucleotide sequence analysis of human embryonic zeta-globin cDNA". DNA. 1 (4): 355–63. doi:10.1089/dna.1982.1.355. PMID 6963223.
• Orkin SH, Michelson A (July 1980). "Partial deletion of the alpha-globin structural gene in human alpha-thalassaemia". Nature. 286 (5772): 538–40. Bibcode:1980Natur.286..538O. doi:10.1038/286538a0. PMID 7402334. S2CID 4251647.
• Flint J, Thomas K, Micklem G, Raynham H, Clark K, Doggett NA, King A, Higgs DR (March 1997). "The relationship between chromosome structure and function at a human telomeric region". Nature Genetics. 15 (3): 252–7. doi:10.1038/ng0397-252. PMID 9054936. S2CID 20630444.
• Luo HY, Liang XL, Frye C, Wonio M, Hankins GD, Chui DH, Alter BP (July 1999). "Embryonic hemoglobins are expressed in definitive cells". Blood. 94 (1): 359–61. doi:10.1182/blood.V94.1.359.413a29_359_361. PMID 10381533.
• Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR (February 2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Human Molecular Genetics. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
• Lau ET, Kwok YK, Chui DH, Wong HS, Luo HY, Tang MH (July 2001). "Embryonic and fetal globins are expressed in adult erythroid progenitor cells and in erythroid cell cultures". Prenatal Diagnosis. 21 (7): 529–39. doi:10.1002/pd.81. PMID 11494285. S2CID 11841129.