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David Reich (geneticist)

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This article is about the geneticist. For the anesthesiologist/hospital president, see David L. Reich.
David Reich
Born
David Emil Reich

(1974-07-14) July 14, 1974 (age 50)
Washington, D.C., United States
Alma materHarvard University
St Catherine's College, Oxford
Awards
Scientific career
ThesisGenetic analysis of human evolutionary history with implications for gene mapping (1999)
Doctoral advisorDavid Goldstein[3]

David Emil Reich[4] (born July 14, 1974) is an American geneticist known for his research into the population genetics of ancient humans, including their migrations and the mixing of populations, discovered by analysis of genome-wide patterns of mutations. He is professor in the department of genetics at the Harvard Medical School, and an associate of the Broad Institute. Reich was highlighted as one of Nature's 10 for his contributions to science in 2015.[5] He received the Dan David Prize in 2017, the NAS Award in Molecular Biology, the Wiley Prize, and the Darwin–Wallace Medal in 2019. In 2021 he was awarded the Massry Prize.[6]

Early life

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Reich grew up as part of a Jewish family in Washington, D.C. His parents are novelist Tova Reich (sister of Rabbi Avi Weiss) and Walter Reich, a professor at George Washington University, who served as the first director of the United States Holocaust Memorial Museum.[7][8] David Reich started out as a sociology major as an undergraduate at Harvard College, but later turned his attention to physics and medicine. After graduation, he attended the University of Oxford, originally with the intent of preparing for medical school.[7] He was awarded a PhD in zoology in 1999 for research supervised by David Goldstein. His thesis was titled "Genetic analysis of human evolutionary history with implications for gene mapping".[3]

Academic career

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Reich received a BA in physics from Harvard University and a PhD in zoology from St. Catherine's College in the University of Oxford in 1999.[9] He joined Harvard Medical School in 2003.[7] Reich is currently a geneticist and professor in the department of genetics at Harvard Medical School, and an associate of the Broad Institute, whose research studies compare the modern human genome with those of chimpanzees, Neanderthals, and Denisovans.

Reich's genetics research focuses primarily on finding complex genetic patterns that cause susceptibility to common diseases among large populations, rather than looking for specific genetic markers associated with relatively rare illnesses.

Genetic research

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Split of chimpanzees and humans (2006)

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Main article: Human-chimp MRCA

Reich's research team at Harvard University has produced evidence that, over a span of at least four million years, various parts of the human genome diverged gradually from those of chimpanzees.[10] The split between the human and chimpanzee lineages may have occurred millions of years later than fossilized bones suggest, and the break may not have been as clean as previously thought. The genetic evidence developed by Reich's team suggests that after the two species initially separated, they may have continued interbreeding for several million years. A final genetic split transpired between 6.3 million and 5.4 million years ago.[11]

Indian population (2009)

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Main article: Genetics and archaeogenetics of South Asia
See also: ANI and ASI and Dravidian migrations

Reich's 2009 paper Reconstructing Indian population history[12] was a landmark study in the research on India's genepool and the origins of its population. Reich et al. (2009), in a collaborative effort between the Harvard Medical School and the Indian Centre for Cellular and Molecular Biology (CCMB), examined the entire genomes worth 560,000 single-nucleotide polymorphisms (SNPs), as compared to 420 SNPs in prior work. They also cross-compared them with the genomes of other regions available in the global genome database.[13] Through this study, they were able to discern two genetic groups in the majority of populations in India, which they called "Ancestral North Indians" (ANI) and "Ancestral South Indians" (ASI).[note 1] They found that the ANI genes are close to those of Middle Easterners, Central Asians and Europeans whereas the ASI genes are dissimilar to all other known populations outside India.[note 2][note 3] These two distinct groups, which had split ca. 50,000 years ago, formed the basis for the present population of India.[14]

A follow-up study by Moorjani et al. (2013) revealed that the two groups mixed between 1,900 and 4,200 years ago (2200 BCE–100 CE), after which a shift to endogamy took place and admixture became rare.[note 4] Speaking to Fountain Ink, David Reich stated, "Prior to 4,200 years ago, there were unmixed groups in India. Sometime between 1,900 to 4,200 years ago, profound, pervasive convulsive mixture occurred, affecting every Indo-European and Dravidian group in India without exception." Reich pointed out that their work does not show that a substantial migration occurred during this time.[15]

Metspalu et al. (2011), representing a collaboration between the Estonian Biocenter and CCMB, confirmed that the Indian populations are characterized by two major ancestry components. One of them is spread at comparable frequency and haplotype diversity in populations of South and West Asia and the Caucasus. The second component is more restricted to South Asia and accounts for more than 50% of the ancestry in Indian populations. Haplotype diversity associated with these South Asian ancestry components is significantly higher than that of the components dominating the West Eurasian ancestry palette.[16]

Human genetic map (2011)

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Reich was a co-leader, along with statistician Simon Myers, of a team of genetics researchers from Harvard University and the University of Oxford that made the most complete human genetic map then known in July 2011.[17]

Interbreeding of Neanderthals and humans (2010–2012)

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Main article: Neanderthal admixture

Reich's research team significantly contributed to the discovery that Neanderthals and Denisovans interbred with modern human populations as they dispersed from Africa into Eurasia 70,000–30,000 years ago.[18]

Genetic markers for prostate cancer

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Reich's lab received media attention following its discovery of a genetic marker which is linked to an increased likelihood of developing prostate cancer.[19] Reich has also argued that the higher incidence of prostate cancer among African Americans, compared to European Americans, appears to be largely genetic in origin.[20]

Indo-European origins

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Reich has suggested that the Indo-European languages may have originated south of the Caucausus, in present day Iran or Armenia:

"Ancient DNA available from this time in Anatolia shows no evidence of steppe ancestry similar to that in the Yamnaya (although the evidence here is circumstantial as no ancient DNA from the Hittites themselves has yet been published). This suggests to me that the most likely location of the population that first spoke an Indo-European language was south of the Caucasus Mountains, perhaps in present-day Iran or Armenia, because ancient DNA from people who lived there matches what we would expect for a source population both for the Yamnaya and for ancient Anatolians. If this scenario is right the population sent one branch up into the steppe – mixing with steppe hunter-gatherers in a one-to-one ratio to become the Yamnaya as described earlier – and another to Anatolia to found the ancestors of people there who spoke languages such as Hittite."[20]

Software tools

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Reich has developed ADMIXTOOLS 2, an R software package primarily used for analyzing admixture, in collaboration with Nick Patterson.[21]

Books

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Notes

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  1. ^ Reich (2009) excluded the Austro-Asiatic and Tibeto-Burman speakers from their analysis in order to avoid interference.
  2. ^ Reich (2009): "We analyze 25 diverse groups to provide strong evidence for two ancient populations, genetically divergent, that are ancestral to most Indians today. One, the "Ancestral North Indians" (ANI), is genetically close to Middle Easterners, Central Asians, and Europeans, while the other, the "Ancestral South Indians" (ASI), is as distinct from ANI and East Asians as they are from each other."
  3. ^ Moorjani et al. (2013): "Most Indian groups descend from a mixture of two genetically divergent populations: Ancestral North Indians (ANI) related to Central Asians, Middle Easterners, Caucasians, and Europeans; and Ancestral South Indians (ASI) not closely related to groups outside the subcontinent."
  4. ^ Moorjani et al. (2013): "We report genome-wide data from 73 groups from the Indian subcontinent and analyze linkage disequilibrium to estimate ANI-ASI mixture dates ranging from about 1,900 to 4,200 years ago. In a subset of groups, 100% of the mixture is consistent with having occurred during this period. These results show that India experienced a demographic transformation several thousand years ago, from a region in which major population mixture was common to one in which mixture even between closely related groups became rare because of a shift to endogamy."

References

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  1. ^ "365 days: Nature's 10". Nature. 528 (7583): 459–467. 2015. Bibcode:2015Natur.528..459.. doi:10.1038/528459a. ISSN 0028-0836. PMID 26701036.
  2. ^ https://www.york.ac.uk/archaeology/news-and-events/news/external/news2022/antiquity-prize-win/
  3. ^ a b Reich, David Emile (1999). Genetic analysis of human evolutionary history with implications for gene mapping. ox.ac.uk (DPhil thesis). University of Oxford. OCLC 863264589. EThOS uk.bl.ethos.580823. Free access icon
  4. ^ "David Reich | Genetics". genetics.hms.harvard.edu. Retrieved 2018-01-08.
  5. ^ "Nature's 10". Nature. 528 (7583): 459–467. December 2015. Bibcode:2015Natur.528..459.. doi:10.1038/528459a. PMID 26701036. S2CID 4450003.
  6. ^ Massry Prize 2021
  7. ^ a b c Zimmer, Carl (2018-03-20). "David Reich Unearths Human History Etched in Bone". The New York Times. Retrieved 2018-03-20.
  8. ^ Rincon, Paul (11 April 2018). "How ancient DNA is transforming our view of the past". BBC. Retrieved 11 April 2018.
  9. ^ Emile., Reich, David (1999). Genetic analysis of human evolutionary history with implications for gene mapping (Thesis). University of Oxford.{{cite thesis}}: CS1 maint: multiple names: authors list (link)
  10. ^ ScienceNews.org – 'Hybrid-Driven Evolution: Genomes show complexity of human-chimp split: Not only did the evolutionary parting of human from chimpanzee ancestors occur more recently than had been indicated by previous data, but it also played out over an extended period during which forerunners of people and chimps interbred', Bruce Bower, Science News (May 20, 2006)
  11. ^ Patterson, N.; Richter, D. J.; Gnerre, S.; Lander, E. S.; Reich, D. (2006). "Genetic evidence for complex speciation of humans and chimpanzees". Nature. 441 (7097): 1103–1108. Bibcode:2006Natur.441.1103P. doi:10.1038/nature04789. PMID 16710306. S2CID 2325560.
  12. ^ Reich 2009.
  13. ^ Chakravarti, Aravinda (24 September 2009). "Tracing India's invisible lthreads" (PDF). Nature (News & Views). Archived from the original (PDF) on 3 September 2015. Retrieved 16 March 2016.
  14. ^ Dolgin, Elie (September 23, 2009). "Indian ancestry revealed". Nature. doi:10.1038/news.2009.935 – via www.nature.com.
  15. ^ Srinath Perur, The origins of Indians. What our genes are telling us., Fountain Ink
  16. ^ Metspalu et al. 2011.
  17. ^ David Cameron (July 20, 2011). "Detail distinguishes map of African-American genomics". Harvard Gazette. Retrieved July 22, 2011.
  18. ^ Reich, D.; Green, R.E.; Kircher, M.; Krause, J.; Patterson, N.; Durand, E.Y.; et al. (2010). "Genetic history of an archaic hominin group from Denisova Cave in Siberia". Nature. 468 (7327): 1053–1060. Bibcode:2010Natur.468.1053R. doi:10.1038/nature09710. PMC 4306417. PMID 21179161. Reich, D.; Patterson, N.; Kircher, M.; Delfin, F.; Nandineni, M.R.; Pugach, I.; et al. (2011). "Denisova Admixture and the First Modern Human Dispersals into Southeast Asia and Oceania". The American Journal of Human Genetics. 89 (4): 516–528. doi:10.1016/j.ajhg.2011.09.005. PMC 3188841. PMID 21944045. Sankararaman, S.; Patterson, N.; Li, H.; Pääbo, S.; Reich, D; Akey, J.M. (2012). "The Date of Interbreeding between Neandertals and Modern Humans". PLOS Genetics. 8 (10): e1002947. arXiv:1208.2238. doi:10.1371/journal.pgen.1002947. PMC 3464203. PMID 23055938. Carl Zimmer, "Interbreeding with Neanderthals", Discover, March 2013, pp. 38–44.
  19. ^ https://reich.hms.harvard.edu/sites/reich.hms.harvard.edu/files/inline-files/2007_NG_Haiman_colorectal_and_prostate.pdf [bare URL PDF]
  20. ^ a b Who We Are and How We Got Here: Ancient DNA and the New Science of the Human Past. By David Reich. New York: Pantheon, 2018.
  21. ^ "Inferring demographic history from genetic data". uqrmaie1.github.io. Retrieved 2022-05-18.

Sources

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