GJB7

GJB7
Identifiers
Aliases	GJB7, CX25, bA136M9.1, connexin25, gap junction protein beta 7
External IDs	OMIM: 611921; HomoloGene: 89311; GeneCards: GJB7; OMA:GJB7 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	87,329,278 bp
RNA expression pattern
	Top expressed in
	gonad; ; right uterine tube; ; testicle; ; placenta; ; pituitary gland; ; anterior pituitary; ; olfactory zone of nasal mucosa; ; right lung; ; bone marrow; ; mucosa of transverse colon;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	gap junction channel activity;
Cellular component	integral component of membrane; gap junction; cell junction; plasma membrane; connexin complex; membrane;
Biological process	cell communication; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	375519
	n/a
	ENSG00000164411
	n/a
	Q6PEY0
	n/a
	NM_198568
	n/a
	NP_940970
	n/a
	Wikidata
View/Edit Human

Gap junction beta-7 protein (GJB7), also known as connexin-25 (Cx25), is a protein that in humans is encoded by the GJB7 gene.^[3]

Function

Connexins, such as GJB7, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits.^[3]^[4]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164411 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: gap junction protein".
^ Söhl G, Nielsen PA, Eiberger J, Willecke K (2003). "Expression profiles of the novel human connexin genes hCx30.2, hCx40.1, and hCx62 differ from their putative mouse orthologues". Cell Commun. Adhes. 10 (1): 27–36. doi:10.1080/15419060302063. PMID 12881038. S2CID 225894.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164411 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: gap junction protein".

[pmid12881038-4] Söhl G, Nielsen PA, Eiberger J, Willecke K (2003). "Expression profiles of the novel human connexin genes hCx30.2, hCx40.1, and hCx62 differ from their putative mouse orthologues". Cell Commun. Adhes. 10 (1): 27–36. doi:10.1080/15419060302063. PMID 12881038. S2CID 225894.

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