KCNC2

KCNC2
Identifiers
Aliases	KCNC2, KV3.2, potassium voltage-gated channel subfamily C member 2
External IDs	OMIM: 176256; MGI: 96668; HomoloGene: 71199; GeneCards: KCNC2; OMA:KCNC2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	75,209,839 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	112,302,929 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; Brodmann area 9; ; cingulate gyrus; ; anterior cingulate cortex; ; right frontal lobe; ; testicle; ; hypothalamus; ; amygdala; ; pituitary gland; ; hippocampus proper;
	Top expressed in
	lateral geniculate nucleus; ; medial geniculate nucleus; ; medial dorsal nucleus; ; inferior colliculus; ; globus pallidus; ; superior colliculus; ; subiculum; ; primary motor cortex; ; piriform cortex; ; medial vestibular nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	potassium channel activity; transmembrane transporter binding; voltage-gated ion channel activity; ion channel activity; voltage-gated potassium channel activity; delayed rectifier potassium channel activity; voltage-gated ion channel activity involved in regulation of presynaptic membrane potential;
Cellular component	integral component of membrane; vesicle; perikaryon; postsynaptic membrane; cell projection; membrane; voltage-gated potassium channel complex; plasma membrane; synapse; integral component of plasma membrane; intracellular anatomical structure; neuronal cell body membrane; axon; cell junction; terminal bouton; neuronal cell body; dendrite; basolateral plasma membrane; apical plasma membrane; axolemma; neuron projection; presynaptic membrane; dendrite membrane;
Biological process	response to organic cyclic compound; protein heterooligomerization; regulation of insulin secretion; response to nerve growth factor; regulation of ion transmembrane transport; cellular response to toxic substance; response to magnesium ion; ion transport; globus pallidus development; nitric oxide-cGMP-mediated signaling pathway; potassium ion transport; ion transmembrane transport; transmembrane transport; response to amine; positive regulation of potassium ion transmembrane transport; cellular response to nitric oxide; response to light intensity; response to ethanol; protein homooligomerization; response to toxic substance; cellular response to ammonium ion; potassium ion transmembrane transport; positive regulation of voltage-gated potassium channel activity; regulation of presynaptic membrane potential;
	Sources:Amigo / QuickGO
Orthologs
	3747
	268345
	ENSG00000166006
	ENSMUSG00000035681
	Q96PR1
	Q14B80
NM_001260497; NM_001260498; NM_001260499; NM_139136; NM_139137;
	NM_153748
	NM_001025581; NM_001359752; NM_001359753; NM_001379643; NM_001379644
NP_001247426; NP_001247427; NP_001247428; NP_631874; NP_631875;
	NP_715624
	NP_001020752; NP_001346681; NP_001346682; NP_001366572; NP_001366573
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium voltage-gated channel subfamily C member 2 is a protein that in humans is encoded by the KCNC2 gene.^[5]^[6] The protein encoded by this gene is a voltage-gated potassium channel subunit (Kv3.2).^[7]

Expression pattern

K_v3.1 and K_v3.2 channels are prominently expressed in neurons that fire at high frequency. K_v3.2 channels are prominently expressed in brain (fast-spiking GABAergic interneurons of the neocortex, hippocampus, and caudate nucleus; terminal fields of thalamocortical projections), and in retinal ganglion cells.^[8]^[9]^[7]

Physiological role

K_v3.1/K_v3.2 conductance is necessary and kinetically optimized for high-frequency action potential generation.^[9]^[10] Sometimes in heteromeric complexes with K_v3.1; important for the high-frequency firing of fast spiking GABAergic interneurons and retinal ganglion cells; and GABA release via regulation of action potential duration in presynaptic terminals.^[7]^[8]

Pharmacological properties

K_v3.2 currents in heterologous systems are highly sensitive to external tetraethylammonium (TEA) or 4-aminopyridine (4-AP) (IC₅₀ values are 0.1 mM for both of the drugs).^[7]^[9] This can be useful in identifying native channels.^[9]

Transcript variants

There are four transcript variants of K_v3.2 gene: K_v3.2a, K_v3.2b, K_v3.2c, K_v3.2d. K_v3.2 isoforms differ only in their C-terminal sequence.^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166006 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035681 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Haas M, Ward DC, Lee J, Roses AD, Clarke V, D'Eustachio P, Lau D, Vega-Saenz de Miera E, Rudy B (Mar 1994). "Localization of Shaw-related K+ channel genes on mouse and human chromosomes". Mamm Genome. 4 (12): 711–5. doi:10.1007/BF00357794. PMID 8111118. S2CID 24121259.
^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
^ ^a ^b ^c ^d Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X (December 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol. Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
^ ^a ^b Kolodin YO (2008-04-27). "Ionic conductances underlying excitability in tonically firing retinal ganglion cells of adult rat". Retrieved 2008-10-20.
^ ^a ^b ^c ^d Rudy B, McBain CJ (September 2001). "K_v3 channels: voltage-gated K⁺ channels designed for high-frequency repetitive firing". Trends in Neurosciences. 24 (9): 517–26. doi:10.1016/S0166-2236(00)01892-0. PMID 11506885. S2CID 36100588.
^ Lien CC, Jonas P (March 2003). "K_v3 potassium conductance is necessary and kinetically optimized for high-frequency action potential generation in hippocampal interneurons". Journal of Neuroscience. 23 (6): 2058–68. doi:10.1523/JNEUROSCI.23-06-02058.2003. PMC 6742035. PMID 12657664.
^ Rudy B, Chow A, Lau D, Amarillo Y, Ozaita A, Saganich M, Moreno H, Nadal MS, Hernandez-Pineda R, Hernandez-Cruz A, Erisir A, Leonard C, Vega-Saenz de Miera E (April 1999). "Contributions of K_v3 channels to neuronal excitability". Annals of the New York Academy of Sciences. 868 (1 MOLECULAR AND): 304–43. Bibcode:1999NYASA.868..304R. doi:10.1111/j.1749-6632.1999.tb11295.x. PMID 10414303. S2CID 25289187.

External links

Kv3.2+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
KCNC2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166006 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035681 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8111118-5] Haas M, Ward DC, Lee J, Roses AD, Clarke V, D'Eustachio P, Lau D, Vega-Saenz de Miera E, Rudy B (Mar 1994). "Localization of Shaw-related K+ channel genes on mouse and human chromosomes". Mamm Genome. 4 (12): 711–5. doi:10.1007/BF00357794. PMID 8111118. S2CID 24121259.

[pmid16382104-6] Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

[Gutman-7] Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X (December 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol. Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

[y-8] Kolodin YO (2008-04-27). "Ionic conductances underlying excitability in tonically firing retinal ganglion cells of adult rat". Retrieved 2008-10-20.

[Rudy1-9] Rudy B, McBain CJ (September 2001). "K_v3 channels: voltage-gated K⁺ channels designed for high-frequency repetitive firing". Trends in Neurosciences. 24 (9): 517–26. doi:10.1016/S0166-2236(00)01892-0. PMID 11506885. S2CID 36100588.

[Lien-10] Lien CC, Jonas P (March 2003). "K_v3 potassium conductance is necessary and kinetically optimized for high-frequency action potential generation in hippocampal interneurons". Journal of Neuroscience. 23 (6): 2058–68. doi:10.1523/JNEUROSCI.23-06-02058.2003. PMC 6742035. PMID 12657664.

[Rudy2-11] Rudy B, Chow A, Lau D, Amarillo Y, Ozaita A, Saganich M, Moreno H, Nadal MS, Hernandez-Pineda R, Hernandez-Cruz A, Erisir A, Leonard C, Vega-Saenz de Miera E (April 1999). "Contributions of K_v3 channels to neuronal excitability". Annals of the New York Academy of Sciences. 868 (1 MOLECULAR AND): 304–43. Bibcode:1999NYASA.868..304R. doi:10.1111/j.1749-6632.1999.tb11295.x. PMID 10414303. S2CID 25289187.

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