GPR128

ADGRG7
Identifiers
Aliases	ADGRG7, GPR128, adhesion G protein-coupled receptor G7
External IDs	OMIM: 612307; MGI: 2441732; HomoloGene: 13115; GeneCards: ADGRG7; OMA:ADGRG7 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	100,695,479 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	56,616,218 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; duodenum; ; testicle; ; right lobe of liver; ; mucosa of transverse colon; ; gonad; ; rectum; ; gallbladder; ; smooth muscle tissue; ; appendix;
	Top expressed in
	jejunum; ; ileum; ; colon; ; duodenum; ; spermatid; ; uterus; ; yolk sac; ; ovary; ; embryo; ; granulocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; protein binding; transmembrane signaling receptor activity; signal transducer activity;
Cellular component	integral component of membrane; membrane; intracellular anatomical structure; integral component of plasma membrane;
Biological process	G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; signal transduction; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	84873
	239853
	ENSG00000144820
	ENSMUSG00000022755
	Q96K78
	Q8BM96
	NM_001308362; NM_032787
	NM_172825
	NP_001295291; NP_116176
	NP_766413
	Wikidata
View/Edit Human	View/Edit Mouse

G protein-coupled receptor 128 is a protein encoded by the ADGRG7 gene.^[5]^[6]^[7] GPR128 is a member of the adhesion GPCR family.^[8]^[9] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.^[10]

GPR128 is specifically expressed in human liver as well as in mouse bone marrow and intestinal tissues.^[11]

Function

Ni et al. showed that Gpr128 deletion in mice causes reduced body weight and induced intestinal contraction frequency.^[12]

Clinical significance

A 111-kb copy number gain with breakpoints within the TRK-fused gene (a target of translocations in lymphoma and thyroid tumors) and GPR128 has been identified in the genome of patients with atypical myeloproliferative neoplasms.^[13] Notably, the fused gene was also detected in few healthy individuals.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000144820 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022755 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: GPR128 G protein-coupled receptor 128".
^ Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (November 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.
^ Hamann, J; Aust, G; Araç, D; Engel, FB; Formstone, C; Fredriksson, R; Hall, RA; Harty, BL; Kirchhoff, C; Knapp, B; Krishnan, A; Liebscher, I; Lin, HH; Martinelli, DC; Monk, KR; Peeters, MC; Piao, X; Prömel, S; Schöneberg, T; Schwartz, TW; Singer, K; Stacey, M; Ushkaryov, YA; Vallon, M; Wolfrum, U; Wright, MW; Xu, L; Langenhan, T; Schiöth, HB (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–67. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.
^ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.
^ Langenhan, T; Aust, G; Hamann, J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165. S2CID 6958640.
^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.
^ Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–67. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.
^ Ni YY, Chen Y, Lu SY, Sun BY, Wang F, Wu XL, Dang SY, Zhang GH, Zhang HX, Kuang Y, Fei J, Gu MM, Rong WF, Wang ZG (January 2014). "Deletion of Gpr128 results in weight loss and increased intestinal contraction frequency". World Journal of Gastroenterology. 20 (2): 498–508. doi:10.3748/wjg.v20.i2.498. PMC 3923024. PMID 24574718.
^ Chase A, Ernst T, Fiebig A, Collins A, Grand F, Erben P, Reiter A, Schreiber S, Cross NC (January 2010). "TFG, a target of chromosome translocations in lymphoma and soft tissue tumors, fuses to GPR128 in healthy individuals". Haematologica. 95 (1): 20–6. doi:10.3324/haematol.2009.011536. PMC 2805730. PMID 19797732.

External links

Adhesion GPCR consortium

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000144820 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022755 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GPR128 G protein-coupled receptor 128".

[pmid12435584-6] Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (November 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.

[7] Hamann, J; Aust, G; Araç, D; Engel, FB; Formstone, C; Fredriksson, R; Hall, RA; Harty, BL; Kirchhoff, C; Knapp, B; Krishnan, A; Liebscher, I; Lin, HH; Martinelli, DC; Monk, KR; Peeters, MC; Piao, X; Prömel, S; Schöneberg, T; Schwartz, TW; Singer, K; Stacey, M; Ushkaryov, YA; Vallon, M; Wolfrum, U; Wright, MW; Xu, L; Langenhan, T; Schiöth, HB (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–67. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.

[isbn1-4419-7912-3-8] Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.

[9] Langenhan, T; Aust, G; Hamann, J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165. S2CID 6958640.

[pmid22333914-10] Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.

[11] Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–67. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.

[12] Ni YY, Chen Y, Lu SY, Sun BY, Wang F, Wu XL, Dang SY, Zhang GH, Zhang HX, Kuang Y, Fei J, Gu MM, Rong WF, Wang ZG (January 2014). "Deletion of Gpr128 results in weight loss and increased intestinal contraction frequency". World Journal of Gastroenterology. 20 (2): 498–508. doi:10.3748/wjg.v20.i2.498. PMC 3923024. PMID 24574718.

[13] Chase A, Ernst T, Fiebig A, Collins A, Grand F, Erben P, Reiter A, Schreiber S, Cross NC (January 2010). "TFG, a target of chromosome translocations in lymphoma and soft tissue tumors, fuses to GPR128 in healthy individuals". Haematologica. 95 (1): 20–6. doi:10.3324/haematol.2009.011536. PMC 2805730. PMID 19797732.

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