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Marsha Moses

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Marsha A. Moses
Born
Boston
Alma materStonehill College
Boston University
Scientific career
InstitutionsHarvard Medical School
Children's Hospital Medical Center
ThesisControl of the low Km cAMP phosphodiesterase by an endogenous modulator in the prostate and heart of adult and aged rats (1986)

Marsha A. Moses is an American physician who is the Julia Dyckman Andrus Professor at Harvard Medical School and the Director of the Vascular Biology Program at Boston Children's Hospital. Her research considers the biochemical mechanisms that are responsible for tumor growth and progression. She is a Fellow of the American Institute for Medical and Biological Engineering, the American Academy of Arts and Sciences and the American Association for the Advancement of Science.

Early life and education

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Moses was born in Boston. She was an undergraduate student at Stonehill College, graduating in 1975.[1] Moses earned a doctorate at Boston University. Her research considered control of the phosphodiesterase by an endogenous modulator in the prostate.[2]

Research and career

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Moses studies the mechanisms that underpin angiogenesis during tumor progression. Angiogenesis describes the process by which tumors recruit their own blood vessels. In the absence of angiogenesis, tumors remain dormant, but can become active and grow if they are influenced by certain genes. Moses has investigated what regulates these cancer-promoting genes, and the molecular-level differences between dormant and active tumors.[3] She focused on triple-negative breast cancer, cells of which release extracellular vesicles that cross the blood–brain barrier and promote brain metastases.[3][4] Moses demonstrated that obesity could cause tumors that were previously dormant to restart angiogenesis.[5][6] She has shown that a tumor-specific CRISPR gene editing system could be used to stop the growth of triple-negative breast cancer.[7][8]

Moses has developed multiple tools for theranostics; apparatus capable of both diagnostics and therapeutics. She has identified several inhibitors of tumor formation that function at the transcriptional and translational level.[citation needed]

Moses created initiatives focused on proteomics and biomarker discovery at Boston Children's Hospital.[9] Her urinary proteomics initiative realized sensitive, specific, non-invasive tests for cancer.[citation needed] She developed a human sample repository to uncover non-invasive biomarkers for human cancers.[10]

Awards and honors

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Selected publications

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  • M. S. O'Reilly; L. Holmgren; Y. Shing; et al. (21 October 1994). "Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma". Cell. 79 (2): 315–28. doi:10.1016/0092-8674(94)90200-3. ISSN 0092-8674. PMID 7525077. Wikidata Q29615947.
  • Marsha A. Moses; Judith Sudhalter; Robert Langer (1 June 1990). "Identification of an Inhibitor of Neovascularization from Cartilage". Science. 248 (4961): 1408–1410. Bibcode:1990Sci...248.1408M. doi:10.1126/SCIENCE.1694043. ISSN 0036-8075. PMID 1694043. Wikidata Q44052793.
  • Roopali Roy; Jiang Yang; Marsha A Moses (8 September 2009). "Matrix metalloproteinases as novel biomarkers and potential therapeutic targets in human cancer". Journal of Clinical Oncology. 27 (31): 5287–5297. doi:10.1200/JCO.2009.23.5556. ISSN 0732-183X. PMC 2773480. PMID 19738110. Wikidata Q37412311.

References

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  1. ^ "Board of Trustees". Stonehill College. Retrieved 2023-04-21.
  2. ^ "Control of the low Km cAMP phosphodiesterase by an endogenous modulator in the prostate and heart of adult and aged rats | WorldCat.org". www.worldcat.org. Retrieved 2023-04-21.
  3. ^ a b "Marsha A. Moses | Researcher". Breast Cancer Research Foundation. 2014-06-23. Retrieved 2023-04-21.
  4. ^ "Sneaky Spread". hms.harvard.edu. Retrieved 2023-04-21.
  5. ^ Fliesler, Nancy (2022-11-22). "Obesity is raising cancer risk. Why?". Boston Children's Answers. Retrieved 2023-04-21.
  6. ^ Roy, Roopali; Yang, Jiang; Shimura, Takaya; Merritt, Lauren; Alluin, Justine; Man, Emily; Daisy, Cassandra; Aldakhlallah, Rama; Dillon, Deborah; Pories, Susan; Chodosh, Lewis A.; Moses, Marsha A. (2022-10-11). "Escape from breast tumor dormancy: The convergence of obesity and menopause". Proceedings of the National Academy of Sciences. 119 (41): e2204758119. doi:10.1073/pnas.2204758119. ISSN 0027-8424. PMC 9564105. PMID 36191215.
  7. ^ "Breast cancer progression may be halted with CRISPR gene editing". Drug Target Review. Retrieved 2023-04-21.
  8. ^ Ktori, Sophia (2019-08-27). "CRISPR Genome Editing Holds Back Triple-Negative Breast Cancer in Mice". GEN – Genetic Engineering and Biotechnology News. Retrieved 2023-04-21.
  9. ^ "Mining the human urinary proteome biomarker discovery for human cancer and its metastases". www.hilarispublisher.com. Retrieved 2023-04-21.
  10. ^ a b "Pincus Medalist Marsha Moses delivers annual scientific lecture at UMass Medical School". UMass Chan Medical School. 2020-12-11. Retrieved 2023-04-21.
  11. ^ "Children's Hospital Boston's Dr. Marsha Moses Elected to the Prestigious Institute of Medicine". PRWeb. Retrieved 2023-04-21.
  12. ^ "2013 NAI Fellows Commemorative Book by National Academy of Inventors – Issuu". issuu.com. Retrieved 2023-04-21.
  13. ^ "Marsha A. Moses, Ph.D. COF-3096 – AIMBE". Retrieved 2023-04-21.
  14. ^ Writer, Juan Siliezar Harvard Staff (2019-11-26). "9 Harvard researchers named AAAS Fellows". Harvard Gazette. Retrieved 2023-04-21.
  15. ^ "Marsha A. Moses". American Academy of Arts & Sciences. Retrieved 2023-04-21.
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