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Francisco Balzarotti

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Francisco Balzarotti
Born1983
Buanos Aires, Argentina
Alma materUniversity of Buenos Aires (Diploma, PhD)
Known forMINFLUX, super-resolution microscopy, Single Molecule Tracking, Light Microscopy
Scientific career
Fieldsphysics, electronics, optics, microscopy
Institutions
Websitewww.balzarotti-lab.org

Francisco Balzarotti (born in 1983 in Buenos Aires, Argentina) is an Argentinian scientist known for his work in super-resolution microscopy, particularly MINFLUX. He is a Group Leader at the Research Institute of Molecular Pathology (IMP) in Vienna, Austria.[1]

Education

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From 2002 to 2007, Balzarotti studied electrical engineering at the University of Buenos Aires in Buenos Aires, Argentina. In 2012, he earned his Ph.D. in Electrical Engineering, working on research topics such as nanophotonics, optical nanolithography, superlenses, and plasmonics.[2][3]

Career and research

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For his postgraduate work, Balzarotti relocated to Germany to work as a postdoctoral researcher in the Department of NanoBiophotonics[4] at the Max Planck Institute for Biophysical Chemistry, led by Nobel Laureate Stefan W. Hell.

In Göttingen, Balzarotti played a central role in developing the super-resolution microscopy method MINFLUX[5][6] which was named Breakthrough of the Year in 2017 by Physics World.[7] The method was even described as the Holy Grail in Light Microscopy.[8]

MINFLUX combines elements of information theory with the single-emitter nature of PALM/STORM and the beam geometries typically used in STED. During Balzarotti's time in Göttingen, they were able to show that with MINFLUX, a given localization precision can be obtained by using much fewer photons than in conventional centroid-localization techniques such as PALM/STORM. Hence, MINFLUX attains nanometer-scale resolution more quickly and with fewer emitted photons than previously possible. Subsequent work increased the application space of the technology even further.[9][10][11]

Since 2020, Balzarotti has been a Group Leader at the Research Institute of Molecular Pathology (IMP) in Vienna, Austria, supported by the European Research Council. At the IMP, he set up the Advanced Microscopy and Biophysics group.[12][13][14]

Balzarotti's group focuses on the development of novel optical methods and instrumentation for the observation of biological phenomena with the highest fidelity. His interdisciplinary group combines expertise in physics, engineering, mathematics, and biology.

Balzarotti is a well-known microscopist and an established member of the advanced microscopy community. Hence, he is frequently invited as a keynote speaker at key conferences in the field.[15][16]

Balzarotti's group in collaboration with Mark Bates, organized the Single Molecule Localization Symposium 2023, which was hosted at IMP in Vienna.[17]

Awards and honours

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References

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  1. ^ "Francisco Balzarotti's lab at the IMP". Retrieved 2023-07-19.
  2. ^ https://www.linkedin.com/in/francisco-balzarotti/
  3. ^ "Francisco Balzarotti | Light-based microscopy | Research Institute of Molecular Pathology (IMP)".
  4. ^ "Stefan Hell".
  5. ^ "Researchers achieve ultimate resolution limit in fluorescence microscopy".
  6. ^ Balzarotti, Francisco; Eilers, Yvan; Gwosch, Klaus C.; Gynnå, Arvid H.; Westphal, Volker; Stefani, Fernando D.; Elf, Johan; Hell, Stefan W. (2017). "Nanometer resolution imaging and tracking of fluorescent molecules with minimal photon fluxes". Science. 355 (6325): 606–612. arXiv:1611.03401. Bibcode:2017Sci...355..606B. doi:10.1126/science.aak9913. hdl:11858/00-001M-0000-002C-2D9A-4. PMID 28008086. S2CID 5418707.
  7. ^ "First multimessenger observation of a neutron-star merger is Physics World 2017 Breakthrough of the Year". 11 December 2017.
  8. ^ "Researchers achieve ultimate resolution limit in fluorescence microscopy".
  9. ^ Eilers, Yvan; Ta, Haisen; Gwosch, Klaus C.; Balzarotti, Francisco; Hell, Stefan W. (2018). "MINFLUX monitors rapid molecular jumps with superior spatiotemporal resolution". Proceedings of the National Academy of Sciences. 115 (24): 6117–6122. doi:10.1073/pnas.1801672115. PMC 6004438. PMID 29844182.
  10. ^ Pape, Jasmin K.; Stephan, Till; Balzarotti, Francisco; Büchner, Rebecca; Lange, Felix; Riedel, Dietmar; Jakobs, Stefan; Hell, Stefan W. (2020). "Multicolor 3D MINFLUX nanoscopy of mitochondrial MICOS proteins". Proceedings of the National Academy of Sciences. 117 (34): 20607–20614. Bibcode:2020PNAS..11720607P. doi:10.1073/pnas.2009364117. PMC 7456099. PMID 32788360.
  11. ^ Gwosch, Klaus C.; Pape, Jasmin K.; Balzarotti, Francisco; Hoess, Philipp; Ellenberg, Jan; Ries, Jonas; Hell, Stefan W. (2020). "MINFLUX nanoscopy delivers 3D multicolor nanometer resolution in cells". Nature Methods. 17 (2): 217–224. doi:10.1038/s41592-019-0688-0. PMID 31932776. S2CID 256840140.
  12. ^ "Francisco Balzarotti | Light-based microscopy | Research Institute of Molecular Pathology (IMP)".
  13. ^ https://www.balzarotti-lab.org/
  14. ^ "Francisco Balzarotti | Research at a molecular biology institute when you are not a biologist". YouTube.
  15. ^ "Seeing is Believing: Imaging the Molecular Processes of Life – Course and Conference Office".
  16. ^ "Program".
  17. ^ https://smlms.org/
  18. ^ "ERC Starting Grants 2019 – List of Principal Investigators" (PDF). Retrieved 2023-07-19.
  19. ^ "High-throughput 4D imaging for nanoscale cellular studies". Retrieved 2023-07-19.
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