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Reston virus

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Reston ebolavirus
An artificially colored transmission electron micrograph of the Reston virus
Virus classification Edit this classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Negarnaviricota
Class: Monjiviricetes
Order: Mononegavirales
Family: Filoviridae
Genus: Ebolavirus
Species:
Reston ebolavirus
Synonyms

Reston virus (RESTV)

Reston virus (RESTV) is one of six known viruses within the genus Ebolavirus. Reston virus causes Ebola virus disease in non-human primates; unlike the other five ebolaviruses, it is not known to cause disease in humans, but has caused asymptomatic infections.[1][2][3] Reston virus was first described in 1990 as a new "strain" of Ebola virus (EBOV).[4] It is the single member of the species Reston ebolavirus, which is included into the genus Ebolavirus, family Filoviridae, order Mononegavirales.[5] Reston virus is named after Reston, Virginia, US, where the virus was first discovered.

RESTV was discovered in crab-eating macaques from Hazleton Laboratories (now Labcorp Drug Development) in 1989. This attracted significant media attention due to Reston's location in the Washington metropolitan area and the lethality of a closely related Ebola virus. Despite its status as a level-4 organism, Reston virus is non-pathogenic to humans, though hazardous to monkeys;[6][7] the perception of its lethality was compounded by the monkey's coinfection with Simian hemorrhagic fever virus (SHFV).[8] Despite ongoing research, the determinants for lack of human pathogenicity are yet to be discovered.[9]

Nomenclature

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Reston virus was first introduced as a new "strain" of Ebola virus in 1990.[4] In 2000, it received the designation Reston Ebola virus[10][11] and in 2002, the name was changed to Reston ebolavirus.[12][13] Previous abbreviations for the virus were EBOV-R (for Ebola virus Reston) and most recently REBOV (for Reston Ebola virus or Reston ebolavirus). The virus received its current designation in 2010, when it was renamed Reston virus (RESTV).[5]

A virus of the species Reston ebolavirus is a Reston virus (RESTV) if it has the properties of Reston ebolaviruses and if its genome diverges from that of the prototype Reston virus. For example, there exists Reston virus variant Pennsylvania (RESTV/Pen), differing by less than 10% at the nucleotide level.[5]

History

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Discovery

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While investigating an outbreak of Simian hemorrhagic fever (SHFV) in November 1989, an electron microscopist from USAMRIID named Thomas W. Geisbert discovered filoviruses similar in appearance to Ebola virus in tissue samples taken from a crab-eating macaque imported from the Philippines to Hazleton Laboratories in Reston, Virginia. The filovirus was further isolated by Dr. Peter Jahrling, and over the period of three months over a third of the monkeys died—at a rate of two or three a day.[14]

Blood samples were taken from 178 animal handlers during the incident.[15] Of them, six eventually seroconverted, testing positive using ELISA. They remained, however, asymptomatic. In January 1990, an animal handler at Hazelton cut himself while performing a necropsy on the liver of an infected Cynomolgus. Under the direction of the Centers for Disease Control and Prevention (CDC), the animal handler was placed under surveillance for the duration of the incubation period. When the animal handler failed to become ill, it was concluded that the virus had a low pathogenicity in humans.[16]

Investigation

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Crab-eating macaques, imported from the Philippines, were found to be carrying the filovirus.

Following the discovery of a filovirus in crab-eating macaques, an investigation tracing the infection was conducted by the CDC. The monkeys were imported from the Philippines, which had no previous record of SHFV or ebolavirus infections. It was suspected that the monkeys contracted both diseases while in transit aboard KLM Airlines before reaching Reston. Shipments were tracked to New York City, Texas, and Mexico City, none of which produced cases of infection.[17]

By January 1990, Hazelton Laboratories recovered from its previous losses and began importing monkeys again from the same establishment in Manila that had provided the original animals. The imported monkeys became infected and were euthanized.[15] In early February the CDC received reports of the disease in Alice, Texas. In March, the Division of Quarantine at the CDC secured a temporary ban on the importation of monkeys into the United States from anywhere in the world.[18]

Following the announcement of the filovirus disease outbreak in Reston, Virginia, a serosurvey was conducted to assess the prevalence of the infection. Of the several hundred serums received by the CDC, approximately ten percent showed some reaction to ebolavirus antigen—though usually at low levels. Counterintuitively, the majority of the monkeys found positive were from Indonesia.[19]

In May 1990, an investigation led by Susan Fisher-Hoch, Steve Ostroff, and Jerry Jennings was sent to Indonesia. During the investigation, it was hypothesized that there could be a cross infection since monkeys suspected of illness were typically placed in gang cages containing up to twenty to thirty other monkeys suspected of illness. Upon arrival they were told that most of the monkeys were imported from the island of Sumatra. The investigation team found no trace of the virus in either case.[20]

Following the investigation in Indonesia, an experiment was conducted in the level-4 lab at the CDC campus in DeKalb County, Georgia with thirty-two monkeys: sixteen green monkeys (Cercopithecus aethiops) and sixteen crab-eating macaques. Half of the sixteen green monkeys and crab-eating macaques were infected with Reston virus and the other half with Ebola virus. Ebola virus infection was lethal to nearly all monkeys. However, most of the monkeys infected with Reston virus recovered in a month. The surviving monkeys were kept for two years to detect any trace of the virus - none was found. However, the monkeys continued to possess a high level of antibody.[8]

Post-Reston

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Following the test at the CDC campus in DeKalb County, two of the monkeys who had survived Reston virus infection were infected with a very large dose of the Ebola virus in an effort to produce an Ebola vaccine. One of the two monkeys remained resistant; the second died.[8]

The physical building in which the outbreak occurred was demolished on 30 May 1995 and a daycare center was constructed in its place.[21] Modern spatial computer simulation indicates that the pathogen could have reached both major airports (Dulles International Airport and Ronald Reagan Washington National Airport) in less than 45 minutes assuming direct transmission paths.[22]

Outbreaks and cases

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See also: List of Ebola outbreaks
  • 1989 –1990 Philippines – High mortality among crab-eating macaques in a primate facility responsible for exporting animals in the United States.[23] Three workers in the facility developed antibodies but did not get sick.[24]
  • 1989 Reston, Virginia, United States – RESTV was introduced into quarantine facilities in Virginia and Pennsylvania by monkeys imported from the Philippines.[14]
  • 1989–1990 – RESTV was introduced into quarantine facilities in Texas by monkeys imported from the Philippines. Four humans developed antibodies but did not get sick.[9][25]
  • 1996 Alice, Texas, United States – An outbreak occurred at the Texas Primate Center that imported monkeys from the Philippines.[26]
  • 2008 Manila, Philippines – On 11 December 2008, pigs from farms slightly north of Manila, Philippines tested positive for the virus. The CDC and the World Health Organization are investigating.[27] On 23 January 2009, Philippine health officials announced that a hog farm worker had been infected with the virus. Although the man was asymptomatic and the source of the infection is uncertain, this could represent the first case of pig-to-human transmission of Reston virus – a fact that could cause concern, as pigs may be able to transmit more deadly diseases to humans. The situation was investigated.[28] Eventually six workers were found to test sero-positive for antibodies to Reston ebolavirus. None developed any noticeable symptoms of illness.[29]
  • 2015 Manila, Philippines – On 6 September the department of health reported an outbreak of the Reston Ebola virus in a research breeding facility under primates. Twenty-five workers were tested for the virus. All of the workers tested negative for the disease.[30]
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References

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  2. ^ "About Ebola Virus Disease". CDC. Retrieved 18 October 2014.
  3. ^ "Years of Ebola Virus Disease Outbreaks | 2014-2016 Outbreak West Africa | History | Ebola (Ebola Virus Disease) | CDC". 2018-11-09.
  4. ^ a b Geisbert, T. W.; Jahrling, P. B. (1990). "Use of immunoelectron microscopy to show Ebola virus during the 1989 United States epizootic". Journal of Clinical Pathology. 43 (10): 813–816. doi:10.1136/jcp.43.10.813. PMC 502829. PMID 2229429.
  5. ^ a b c Kuhn, Jens H.; Becker, Stephan; Ebihara, Hideki; Geisbert, Thomas W.; Johnson, Karl M.; Kawaoka, Yoshihiro; Lipkin, W. Ian; Negredo, Ana I; et al. (2010). "Proposal for a revised taxonomy of the family Filoviridae: Classification, names of taxa and viruses, and virus abbreviations". Archives of Virology. 155 (12): 2083–103. doi:10.1007/s00705-010-0814-x. PMC 3074192. PMID 21046175.
  6. ^ Special Pathogens Branch CDC (2008-01-14). "Known Cases and Outbreaks of Ebola Hemorrhagic Fever". Centers for Disease Control and Prevention. Archived from the original on 2008-08-29. Retrieved 2008-08-02.
  7. ^ McCormick & Fisher-Hoch 1999, p. 300
  8. ^ a b c McCormick & Fisher-Hoch 1999, pp. 307–309
  9. ^ a b Cantoni, Diego (December 28, 2016). "Risks Posed by Reston, the Forgotten Ebolavirus". mSphere. 1 (6). doi:10.1128/mSphere.00322-16. PMC 5196033. PMID 28066813.
  10. ^ Netesov, S. V.; Feldmann, H.; Jahrling, P. B.; Klenk, H. D.; Sanchez, A. (2000). "Family Filoviridae". In van Regenmortel, M. H. V.; Fauquet, C. M.; Bishop, D. H. L.; Carstens, E. B.; Estes, M. K.; Lemon, S. M.; Maniloff, J.; Mayo, M. A.; McGeoch, D. J.; Pringle, C. R.; Wickner, R. B. (eds.). Virus Taxonomy—Seventh Report of the International Committee on Taxonomy of Viruses. San Diego, USA: Academic Press. pp. 539–48. ISBN 978-0-12-370200-5.
  11. ^ Pringle, C. R. (1998). "Virus taxonomy-San Diego 1998". Archives of Virology. 143 (7): 1449–59. doi:10.1007/s007050050389. PMID 9742051. S2CID 13229117.
  12. ^ Feldmann, H.; Geisbert, T. W.; Jahrling, P. B.; Klenk, H.-D.; Netesov, S. V.; Peters, C. J.; Sanchez, A.; Swanepoel, R.; Volchkov, V. E. (2005). "Family Filoviridae". In Fauquet, C. M.; Mayo, M. A.; Maniloff, J.; Desselberger, U.; Ball, L. A. (eds.). Virus Taxonomy—Eighth Report of the International Committee on Taxonomy of Viruses. San Diego, USA: Elsevier/Academic Press. pp. 645–653. ISBN 978-0-12-370200-5.
  13. ^ Mayo, M. A. (2002). "ICTV at the Paris ICV: results of the plenary session and the binomial ballot". Archives of Virology. 147 (11): 2254–60. doi:10.1007/s007050200052. S2CID 43887711.
  14. ^ a b McCormick & Fisher-Hoch 1999, pp. 277–279
  15. ^ a b Waterman, Tara (1999). "Ebola Reston Outbreak Stanford Honors Thesis". Stanford University. Retrieved 2008-08-02.
  16. ^ McCormick & Fisher-Hoch 1999, pp. 298–299
  17. ^ McCormick & Fisher-Hoch 1999, pp. 286–289
  18. ^ McCormick & Fisher-Hoch 1999, pp. 294–295
  19. ^ McCormick & Fisher-Hoch 1999, pp. 302–303
  20. ^ McCormick & Fisher-Hoch 1999, pp. 304–305
  21. ^ "Isaac Newton Metro KinderCare | Daycare, Preschool & Early Education in Reston, VA | KinderCare".
  22. ^ von Csefalvay, Chris (2023), "Spatial dynamics of epidemics", Computational Modeling of Infectious Disease, Elsevier, pp. 257–303, doi:10.1016/b978-0-32-395389-4.00017-7, ISBN 978-0-323-95389-4, retrieved 2023-03-05
  23. ^ Hayes, C. G.; Burans, J. P.; Ksiazek, T. G.; Del Rosario, R. A.; Miranda, M. E.; Manaloto, C. R.; Barrientos, A. B.; Robles, C. G.; Dayrit, M. M.; Peters, C. J. (1992). "Outbreak of fatal illness among captive macaques in the Philippines caused by an Ebola-related filovirus". The American Journal of Tropical Medicine and Hygiene. 46 (6): 664–671. doi:10.4269/ajtmh.1992.46.664. PMID 1621890.
  24. ^ Miranda, M. E.; White, M. E.; Dayrit, M. M.; Hayes, C. G.; Ksiazek, T. G.; Burans, J. P. (1991). "Seroepidemiological study of filovirus related to Ebola in the Philippines". Lancet. 337 (8738): 425–426. doi:10.1016/0140-6736(91)91199-5. PMID 1671441. S2CID 28273498.
  25. ^ CDC (6 April 1990). "Update: filovirus infection in animal handlers". MMWR Morb Mortal Wkly Rep. 39 (13): 221. PMID 2107388. Retrieved 4 August 2021.
  26. ^ Lianne Hart (23 April 1996). "MEDICINE : Texas Ebola Scare Is Over, but Coast Isn't Completely Clear". Los Angeles Times.
  27. ^ Gale, Jason (2008-12-11). "Pig Ebola May Lead Scientists to 'Elusive Reservoir' of Virus". New York City: Bloomberg L.P. Retrieved 2008-12-22.
  28. ^ McNeil Jr, Donald G. (2009-01-24). "Pig-to-Human Ebola Case Suspected in Philippines". The New York Times. Retrieved 2009-01-26.
  29. ^ Barrette, R. W.; Metwally, S. A.; Rowland, J. M.; Xu, L.; Zaki, S. R.; Nichol, S. T.; Rollin, P. E.; Towner, J. S.; Shieh, W.-J.; Batten, B.; Sealy, T. K.; Carrillo, C.; Moran, K. E.; Bracht, A. J.; Mayr, G. A.; Sirios-Cruz, M.; Catbagan, D. P.; Lautner, E. A.; Ksiazek, T. G.; White, W. R.; McIntosh, M. T. (2009). "Discovery of Swine as a Host for the Reston ebolavirus". Science. 325 (5937): 204–206. Bibcode:2009Sci...325..204B. doi:10.1126/science.1172705. ISSN 0036-8075. PMID 19590002.
  30. ^ "Philippine monkeys infected with Ebola not lethal to humans". News 24. 23 April 1996. Retrieved 6 September 2014.
  31. ^ (1) Preston, Richard (1995). The Hot Zone, A Terrifying True Story. Anchor Books. ISBN 978-0-385-47956-1. OCLC 32052009. At Google Books.
    (2) "Best Sellers: June 4, 1995". The New York Times Book Review. New York. 1995-06-04. Retrieved 2014-09-10.
    (3) "About The Hot Zone". Random House. Retrieved 2014-09-10.

Bibliography

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