PFKFB1

PFKFB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1K6M
Identifiers
Aliases	PFKFB1, F6PK, HL2K, PFRX, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
External IDs	OMIM: 311790; MGI: 107816; HomoloGene: 105654; GeneCards: PFKFB1; OMA:PFKFB1 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xp11.21 Start 54,932,961 bp End 54,998,534 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X F3 Start 149,371,225 bp End 149,426,874 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh right lobe of liver gastrocnemius muscle Skeletal muscle tissue of rectus abdominis gonad vastus lateralis muscle muscle of arm biceps brachii testicle triceps brachii muscle Top expressed in muscle of thigh sternocleidomastoid muscle vastus lateralis muscle triceps brachii muscle masseter muscle tibialis anterior muscle temporal muscle digastric muscle gastrocnemius muscle right ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding fructose-6-phosphate binding kinase activity catalytic activity protein binding identical protein binding fructose-2,6-bisphosphate 2-phosphatase activity hydrolase activity ATP binding 6-phosphofructo-2-kinase activity kinase binding Cellular component cytosol 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex Biological process gluconeogenesis response to glucagon glycolytic process phosphorylation fructose metabolic process response to glucocorticoid carbohydrate phosphorylation response to insulin positive regulation of glucokinase activity fructose 2,6-bisphosphate metabolic process animal organ regeneration response to starvation metabolism response to cAMP dephosphorylation negative regulation of glycolytic process positive regulation of glycolytic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5207 18639 Ensembl ENSG00000158571 ENSMUSG00000025271 UniProt P16118 P70266 RefSeq (mRNA) NM_001271804 NM_001271805 NM_002625 NM_008824 NM_001374170 NM_001374171 NM_001374172 NM_001374173 NM_001374175 RefSeq (protein) NP_001258733 NP_001258734 NP_002616 NP_032850 NP_001361099 NP_001361100 NP_001361101 NP_001361102 NP_001361104 Location (UCSC) Chr X: 54.93 – 55 Mb Chr X: 149.37 – 149.43 Mb PubMed search
Wikidata
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6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 is an enzyme that in humans is encoded by the PFKFB1 gene.

This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis.

Further reading

• Lange AJ, Pilkis SJ (1990). "Sequence of human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase". Nucleic Acids Res. 18 (12): 3652. doi:10.1093/nar/18.12.3652. PMC 331036. PMID 2163524.
• Marker AJ, Colosia AD, Tauler A, et al. (1989). "Glucocorticoid regulation of hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene expression". J. Biol. Chem. 264 (12): 7000–4. doi:10.1016/S0021-9258(18)83531-1. PMID 2540168.
• Algaier J, Uyeda K (1988). "Molecular cloning, sequence analysis, and expression of a human liver cDNA coding for fructose-6-P,2-kinase:fructose-2,6-bisphosphatase". Biochem. Biophys. Res. Commun. 153 (1): 328–33. doi:10.1016/S0006-291X(88)81226-9. PMID 2837207.
• Lee YH, Li Y, Uyeda K, Hasemann CA (2003). "Tissue-specific structure/function differentiation of the liver isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase". J. Biol. Chem. 278 (1): 523–30. doi:10.1074/jbc.M209105200. PMID 12379646.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.