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Protein-coding gene in the species Homo sapiens
TUBA1B Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E4H , 4TV8 , 3RYI , 3JAR , 4TUY , 4TV9 , 4YJ2 , 3RYH , 3JAK , 3JAS , 4F61 , 3UT5 , 4O4J , 4YJ3 , 4EB6 , 4WBN , 3JAW , 4O2A , 3RYF , 3JAL , 4O4H , 4LNU , 3J8Y , 4IIJ , 4O4I , 3RYC , 4O4L , 4O2B , 4I50 , 3JAT , 4HNA , 4F6R , 3J8X , 5CA0 , 5ITZ , 5JQG , 5IJ0 , 5FNV , 5IJ9
Identifiers Aliases TUBA1B External IDs OMIM : 602530 ; MGI : 107804 ; HomoloGene : 134527 ; GeneCards : TUBA1B ; OMA :TUBA1B - orthologs Wikidata
Tubulin alpha-1B chain is a protein that in humans is encoded by the TUBA1B gene .[5] [6] [7]
TUBA1B has been shown to interact with PIK3R1 .[8] [9]
^ a b c GRCh38: Ensembl release 89: ENSG00000123416 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023004 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Banerjee A (Jun 2002). "Increased levels of tyrosinated alpha-, beta(III)-, and beta(IV)-tubulin isotypes in paclitaxel-resistant MCF-7 breast cancer cells". Biochem Biophys Res Commun . 293 (1): 598–601. doi :10.1016/S0006-291X(02)00269-3 . PMID 12054644 . ^ Cowan NJ, Dobner PR, Fuchs EV, Cleveland DW (Jan 1984). "Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions" . Mol Cell Biol . 3 (10): 1738–45. doi :10.1128/mcb.3.10.1738 . PMC 370035 PMID 6646120 . ^ "Entrez Gene: TUBA1B tubulin, alpha 1b" .^ Kapeller, R; Toker A; Cantley L C; Carpenter C L (Oct 1995). "Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin" . J. Biol. Chem . 270 (43). UNITED STATES: 25985–91. doi :10.1074/jbc.270.43.25985 ISSN 0021-9258 . PMID 7592789 . ^ "Anti-alpha Tubulin antibody [GT114] (GTX628802) | GeneTex" .
Venter JC (1993). "Identification of new human receptor and transporter genes by high throughput cDNA (EST) sequencing". J. Pharm. Pharmacol . 45. Suppl 1: 355–60. PMID 8098743 . Lopez-Fanarraga M, Avila J, Guasch A, et al. (2002). "Review: postchaperonin tubulin folding cofactors and their role in microtubule dynamics". J. Struct. Biol . 135 (2): 219–29. doi :10.1006/jsbi.2001.4386 . PMID 11580271 . Kapeller R, Toker A, Cantley LC, Carpenter CL (1995). "Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin" . J. Biol. Chem . 270 (43): 25985–91. doi :10.1074/jbc.270.43.25985 PMID 7592789 . Alexandrova N, Niklinski J, Bliskovsky V, et al. (1995). "The N-terminal domain of c-Myc associates with alpha-tubulin and microtubules in vivo and in vitro" . Mol. Cell. Biol . 15 (9): 5188–95. doi :10.1128/mcb.15.9.5188 . PMC 230766 PMID 7651436 . Szasz J, Yaffe MB, Sternlicht H (1993). "Site-directed mutagenesis of alpha-tubulin. Reductive methylation studies of the Lys 394 region" . Biophys. J . 64 (3): 792–802. Bibcode :1993BpJ....64..792S . doi :10.1016/S0006-3495(93)81440-1 . PMC 1262393 PMID 8097117 . Baumann MH, Wisniewski T, Levy E, et al. (1996). "C-terminal fragments of alpha- and beta-tubulin form amyloid fibrils in vitro and associate with amyloid deposits of familial cerebral amyloid angiopathy, British type" . Biochem. Biophys. Res. Commun . 219 (1): 238–42. doi :10.1006/bbrc.1996.0211 PMID 8619814 . Gress TM, Müller-Pillasch F, Geng M, et al. (1996). "A pancreatic cancer-specific expression profile". Oncogene . 13 (8): 1819–30. PMID 8895530 . Crépieux P, Kwon H, Leclerc N, et al. (1997). "I kappaB alpha physically interacts with a cytoskeleton-associated protein through its signal response domain" . Mol. Cell. Biol . 17 (12): 7375–85. doi :10.1128/mcb.17.12.7375 . PMC 232593 PMID 9372968 . Herreros L, Rodríguez-Fernandez JL, Brown MC, et al. (2000). "Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton" . J. Biol. Chem . 275 (34): 26436–40. doi :10.1074/jbc.M003970200 hdl :10261/135387 PMID 10840040 . Watts NR, Sackett DL, Ward RD, et al. (2000). "HIV-1 rev depolymerizes microtubules to form stable bilayered rings" . J. Cell Biol . 150 (2): 349–60. doi :10.1083/jcb.150.2.349 . PMC 2180222 PMID 10908577 . Takeoka A, Shimizu M, Horio T (2001). "Identification of an alpha-tubulin mutant of fission yeast from gamma-tubulin-interacting protein screening: genetic evidence for alpha-/gamma-tubulin interaction". J. Cell Sci . 113. Pt 24 (24): 4557–62. doi :10.1242/jcs.113.24.4557 . PMID 11082048 . Germani A, Bruzzoni-Giovanelli H, Fellous A, et al. (2001). "SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis" . Oncogene . 19 (52): 5997–6006. doi :10.1038/sj.onc.1204002 PMID 11146551 . Yokota S, Yanagi H, Yura T, Kubota H (2001). "Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle". Eur. J. Biochem . 268 (17): 4664–73. doi :10.1046/j.1432-1327.2001.02393.x . PMID 11532003 . Rommelaere H, De Neve M, Neirynck K, et al. (2001). "Prefoldin recognition motifs in the nonhomologous proteins of the actin and tubulin families" . J. Biol. Chem . 276 (44): 41023–8. doi :10.1074/jbc.M106591200 PMID 11535601 . Klein C, Kramer EM, Cardine AM, et al. (2002). "Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau" . J. Neurosci . 22 (3): 698–707. doi :10.1523/JNEUROSCI.22-03-00698.2002 . PMC 6758498 PMID 11826099 . Saugstad JA, Yang S, Pohl J, et al. (2002). "Interaction between metabotropic glutamate receptor 7 and alpha tubulin" . J. Neurochem . 80 (6): 980–8. doi :10.1046/j.0022-3042.2002.00778.x . PMC 2925652 PMID 11953448 .
PDB gallery
1ffx : TUBULIN:STATHMIN-LIKE DOMAIN COMPLEX
1ia0 : KIF1A HEAD-MICROTUBULE COMPLEX STRUCTURE IN ATP-FORM
1jff : Refined structure of alpha-beta tubulin from zinc-induced sheets stabilized with taxol
1sa0 : TUBULIN-COLCHICINE: STATHMIN-LIKE DOMAIN COMPLEX
1sa1 : Tubulin-podophyllotoxin: stathmin-like domain complex
1tub : TUBULIN ALPHA-BETA DIMER, ELECTRON DIFFRACTION
1tvk : The binding mode of epothilone A on a,b-tubulin by electron crystallography
1z2b : Tubulin-colchicine-vinblastine: stathmin-like domain complex
2hxf : KIF1A head-microtubule complex structure in amppnp-form
2hxh : KIF1A head-microtubule complex structure in adp-form
