DCP1B

DCP1B
Identifiers
Aliases	DCP1B, DCP1, hDcp1b, decapping mRNA 1B
External IDs	OMIM: 609843; MGI: 2442404; HomoloGene: 51881; GeneCards: DCP1B; OMA:DCP1B - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	2,004,535 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	119,221,616 bp
RNA expression pattern
	Top expressed in
	muscle layer of sigmoid colon; ; smooth muscle tissue; ; body of uterus; ; gonad; ; myometrium; ; right adrenal gland; ; right adrenal cortex; ; popliteal artery; ; tibial arteries; ; left adrenal gland;
	Top expressed in
	seminiferous tubule; ; superior cervical ganglion; ; spermatocyte; ; spermatid; ; otolith organ; ; utricle; ; Rostral migratory stream; ; genital tubercle; ; spinal ganglia; ; tail of embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	enzyme regulator activity; enzyme activator activity; protein binding; mRNA binding; hydrolase activity;
Cellular component	P-body; membrane; intracellular membrane-bounded organelle; nucleus; cytoplasm; cytosol;
Biological process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; positive regulation of catalytic activity; deadenylation-independent decapping of nuclear-transcribed mRNA; deadenylation-dependent decapping of nuclear-transcribed mRNA; exonucleolytic catabolism of deadenylated mRNA;
	Sources:Amigo / QuickGO
Orthologs
	196513
	319618
	ENSG00000151065; ENSG00000284850
	ENSMUSG00000041477
	Q8IZD4
	B9EIX0
	NM_152640; NM_001319292
	NM_001033379
	NP_001306221; NP_689853
	NP_001028551
	Wikidata
View/Edit Human	View/Edit Mouse

mRNA-decapping enzyme 1B is a protein that in humans is encoded by the DCP1B gene.^[5]^[6]^[7]

DCP1B is a core component of the mRNA decapping complex, a key factor in the regulation of mRNA decay (Lykke-Andersen, 2002).[supplied by OMIM]^[7]

References

^ ^a ^b ^c ENSG00000284850 GRCh38: Ensembl release 89: ENSG00000151065, ENSG00000284850 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041477 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lykke-Andersen J (December 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Molecular and Cellular Biology. 22 (23): 8114–8121. doi:10.1128/MCB.22.23.8114-8121.2002. PMC 134073. PMID 12417715.
^ Cougot N, Babajko S, Séraphin B (April 2004). "Cytoplasmic foci are sites of mRNA decay in human cells". The Journal of Cell Biology. 165 (1): 31–40. doi:10.1083/jcb.200309008. PMC 2172085. PMID 15067023.
^ ^a ^b "Entrez Gene: DCP1B DCP1 decapping enzyme homolog B (S. cerevisiae)".

Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–1292. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, et al. (January 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Lehner B, Sanderson CM (July 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–1323. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000284850 GRCh38: Ensembl release 89: ENSG00000151065, ENSG00000284850 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041477 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12417715-5] Lykke-Andersen J (December 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Molecular and Cellular Biology. 22 (23): 8114–8121. doi:10.1128/MCB.22.23.8114-8121.2002. PMC 134073. PMID 12417715.

[pmid15067023-6] Cougot N, Babajko S, Séraphin B (April 2004). "Cytoplasmic foci are sites of mRNA decay in human cells". The Journal of Cell Biology. 165 (1): 31–40. doi:10.1083/jcb.200309008. PMC 2172085. PMID 15067023.

[entrez-7] "Entrez Gene: DCP1B DCP1 decapping enzyme homolog B (S. cerevisiae)".

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References

Further reading