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Creative Biolabs

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Creative Biolabs, Inc.
Company typeCorporation
IndustryBiotechnology
Founded2005
Headquarters45-1 Ramsey Road, Shirley, New York 11967,
US
ProductsPremade antibody, peptide libraries
ServicesAntibody discovery services, antibody engineering services, bio-manufacturing
Websitewww.creative-biolabs.com/aboutus.html

Creative Biolabs, Inc. is a life-science company which produces and supplies biotech products and services for early drug discovery and development, including various phage display libraries[1] such as pre-made libraries,[2] phage display services,[3][4] antibody sequencing,[5] and antibody humanization.[6] Customers include pharmaceutical companies, academic institutions, government agencies, clinical research organizations and biotechnology companies.

History

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Creative Biolabs Inc. was founded in 2005 by a group of scientists researching on the treatment and prevention of intractable diseases like cancer. The company has distributors in Australia, New Zealand, Japan and other countries in Europe, Asia, and America. Its headquarter is in Shirley, New York.[7] In June 2017, Creative Biolabs set up its first scholarship program.[8]

Services

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Fab construction[9] is a complex technique as Fab fragments contain both variable domains and constant regions. The same heavy and light variable chains used for scFv construction can be used in the construction of Fab.

Construction of pre-made phage display libraries. Pre-made phage display library[10] is a laboratory technique for the study of protein–protein, protein–peptide, and protein–DNA interactions that uses bacteriophages (viruses that infect bacteria) to connect proteins with the genetic information that encodes them.

Sequencing services[11] such as Database Assisted Shotgun Sequencing (DASS) technology

Analysis of microarray hybridization data[12]

Yeast two-hybrid screen[13]

Products

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Monoclonal antibodies such as mouse anti-human Duox2 monoclonal antibody S-40[14]

Immunoglobulin Y (IgY) such as Anti-ADP3 chicken IgY[15]

Antibody libraries such as HuSdLTM phage display human single domain antibody library[16]

Response to COVID-19

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Creative Biolabs offers SARS-CoV-2 S antibodies that come from common hosts like human, mouse, and rabbit, and apply to various lab tests, like ELISA, FC, ICC/IF, etc. Apart from S protein antibodies, Creative Biolabs also provides a comprehensive list of anti-SARS-CoV-2 antibodies to assist with the research and development of drug and vaccine candidates, including but not limited to antibodies targeting genes like N, S1/S2, and ORF7a.[17]

Creative Biolabs Scholarship Program

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Since the first scholarship program in 2017, Creative Biolabs has released scholarship every year. The scholarship award of $1,000 is given to one student of freshman, undergraduate, graduate or Ph.D. level majoring in science-related fields such as Biology, Biochemistry, Chemistry and Molecular Biology.[18]

References

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  1. ^ "Creative Biolabs Works with UEC for Commercial Phage Display Technology". PR.com. Retrieved 2017-05-18.
  2. ^ Fukunaga, K; Taki, M (2012). "Practical Tips for Construction of Custom Peptide Libraries and Affinity Selection by Using Commercially Available Phage Display Cloning Systems". J Nucleic Acids. 2012: 295719. doi:10.1155/2012/295719. PMC 3444042. PMID 22991651.
  3. ^ "Creative Biolabs Announced Phage Display Technology For Anti-membrane Protein Antibody Production". BioSpace. Retrieved 2017-05-18.
  4. ^ "Creative Biolabs Announces A Successful Completion Of Virbac's Unique Monoclonal Antibody Discovery Project Through Cooperation With In-Cell-Art". ASK. Retrieved 2017-05-18.
  5. ^ "Creative Biolabs Introduces Innovative Antibody Sequencing Service with DASS Technology for Quicker Testing and Guaranteed Results". PRWeb. Retrieved 2017-05-18.
  6. ^ "Creative Biolabs Updates Its Antibody Humanization Service to Further Accelerate Your Monoclonal Antibody Research". EIN Presswire. 8 August 2015. Retrieved 2017-05-18.
  7. ^ "Company Overview of Creative Biolabs Inc". Bloomberg. Retrieved 2017-05-18.
  8. ^ "Creative Biolabs Scholarship Program". The Company of Biologists. Retrieved 2017-05-18.
  9. ^ Wanczyk, Heather; Barker, Tolga; Rood, Debra; Zapata, Daniel I.; Howell, Amy R.; Richardson, Stewart K.; Zinckgraf, John; Marusov, Gregory P.; Lynes, Michael A. (2013-03-19). "Cloning and Characterization of a Hybridoma Secreting a 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-Specific Monoclonal Antibody and Recombinant F(ab)". Toxins. 5 (3): 568–589. doi:10.3390/toxins5030568. ISSN 2072-6651. PMC 3705279. PMID 23518474.
  10. ^ US 9156906, Franco, Alessandra, "Glycopeptides and methods of making and using them", published Oct 13, 2015 
  11. ^ Hammerberg, Bruce; Eguiluz-Hernandez, Sitka (2017-02-01). "Therapeutic anti-IgE monoclonal antibody single chain variable fragment (scFv) safety and immunomodulatory effects after one time injection in four dogs". Veterinary Dermatology. 28 (1): 52–e13. doi:10.1111/vde.12354. ISSN 1365-3164. PMID 27426720. S2CID 22605797.
  12. ^ Gass, Justin T.; Olive, M. Foster (2008-04-28). "Transcriptional profiling of the rat frontal cortex following administration of the mGlu5 antagonists MPEP and MTEP". European Journal of Pharmacology. 584 (2–3): 253–262. doi:10.1016/j.ejphar.2008.02.032. ISSN 0014-2999. PMC 2386089. PMID 18346726.
  13. ^ Horgan, Conor P.; Hanscom, Sara R.; Kelly, Eoin E.; McCaffrey, Mary W. (2012-02-14). "Tumor Susceptibility Gene 101 (TSG101) Is a Novel Binding-Partner for the Class II Rab11-FIPs". PLOS ONE. 7 (2): e32030. Bibcode:2012PLoSO...732030H. doi:10.1371/journal.pone.0032030. ISSN 1932-6203. PMC 3279423. PMID 22348143.
  14. ^ Wu, Yongzhong; Antony, Smitha; Juhasz, Agnes; Lu, Jiamo; Ge, Yun; Jiang, Guojian; Roy, Krishnendu; Doroshow, James H. (2011-04-08). "Up-regulation and Sustained Activation of Stat1 Are Essential for Interferon-γ (IFN-γ)-induced Dual Oxidase 2 (Duox2) and Dual Oxidase A2 (DuoxA2) Expression in Human Pancreatic Cancer Cell Lines". The Journal of Biological Chemistry. 286 (14): 12245–12256. doi:10.1074/jbc.M110.191031. ISSN 0021-9258. PMC 3069428. PMID 21321110.
  15. ^ Morimoto, Jumpei; Sarkar, Mohosin; Kenrick, Sophia; Kodadek, Thomas (2014-08-20). "Dextran as a Generally Applicable Multivalent Scaffold for Improving Immunoglobulin-Binding Affinities of Peptide and Peptidomimetic Ligands". Bioconjugate Chemistry. 25 (8): 1479–1491. doi:10.1021/bc500226j. ISSN 1043-1802. PMC 4140544. PMID 25073654.
  16. ^ Ma, Lin; Gu, Kai; Zhang, Cheng-hai; Chen, Xue-tao; Jiang, Yi; Melcher, Karsten; Zhang, Juan; Wang, Min; Xu, H Eric (June 2016). "Generation and characterization of a human nanobody against VEGFR-2". Acta Pharmacologica Sinica. 37 (6): 857–864. doi:10.1038/aps.2016.2. ISSN 1671-4083. PMC 4954766. PMID 27108602.
  17. ^ "Creative Biolabs Supplies Resourceful Antibodies for Research Use on the COVID-19". MarketWatch. Retrieved 2020-08-10.
  18. ^ "Creative Biolabs Scholarship Program". scholarships. Retrieved 2020-08-10.
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