Antiglucocorticoid
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Class of pharmaceutical drugs
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| Antiglucocorticoid | |
|---|---|
| Drug class | |
 Mifepristone, an antiglucocorticoid that is used in the treatment of Cushing's syndrome. | |
| Class identifiers | |
| Synonyms | Glucocorticoid antagonist; Cortisol antagonist; Anticorticosteroid |
| Use | Cushing's syndrome, others |
| Biological target | Glucocorticoid receptor |
| Chemical class | Steroids |
| Legal status | |
| In Wikidata | |
An antiglucocorticoid is a drug which reduces glucocorticoid activity in the body. They include direct glucocorticoid receptor antagonists such as mifepristone and synthesis inhibitors such as metyrapone, ketoconazole, and aminoglutethimide. They are used to treat Cushing's syndrome.
Antiglucocorticoids could be effective antidepressants for a subset of specific mood disorders, but their use is limited by side effects.[1]
See also
[edit]References
[edit]- ^ Gallagher P, Malik N, Newham J, Young AH, Ferrier IN, Mackin P (2008). MacKin P (ed.). "Antiglucocorticoid treatments for mood disorders". Cochrane Database of Systematic Reviews (1): CD005168. doi:10.1002/14651858.CD005168.pub2. PMID 18254070. (Retracted, see doi:10.1002/14651858.CD005168.pub3, PMID 26098594. If this is an intentional citation to a retracted paper, please replace
{{retracted|...}}with{{retracted|...|intentional=yes}}.)
| Glucocorticoids | |
|---|---|
| Antiglucocorticoids |
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| Synthesis modifiers | |
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