HCN3

HCN3
Identifiers
Aliases	HCN3, hyperpolarization activated cyclic nucleotide gated potassium channel 3
External IDs	OMIM: 609973; MGI: 1298211; HomoloGene: 22453; GeneCards: HCN3; OMA:HCN3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q22 Start 155,277,463 bp End 155,289,848 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 F1 Start 89,053,381 bp End 89,067,503 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum testicle ganglionic eminence mucosa of transverse colon ventricular zone pituitary gland anterior pituitary hypothalamus superior frontal gyrus right frontal lobe Top expressed in neural layer of retina perirhinal cortex entorhinal cortex pineal gland barrel cortex CA3 field spinal ganglia glossopharyngeal ganglion olfactory bulb choroid plexus of fourth ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding potassium channel activity cAMP binding sodium channel activity voltage-gated ion channel activity ion channel activity voltage-gated potassium channel activity voltage-gated sodium channel activity protein binding Cellular component integral component of membrane membrane plasma membrane synapse neuronal cell body axon dendrite cone cell pedicle integral component of plasma membrane Biological process sodium ion transmembrane transport sodium ion transport cellular response to dopamine regulation of membrane potential regulation of ion transmembrane transport ion transport potassium ion transport response to cisplatin transmembrane transport potassium ion transmembrane transport cellular response to cAMP Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57657 15168 Ensembl ENSG00000143630 ENSG00000263324 ENSMUSG00000028051 UniProt Q9P1Z3 O88705 RefSeq (mRNA) NM_020897 NM_008227 RefSeq (protein) NP_065948 NP_032253 Location (UCSC) Chr 1: 155.28 – 155.29 Mb Chr 3: 89.05 – 89.07 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 is a protein that in humans is encoded by the HCN3 gene.

See also

• Cyclic nucleotide-gated ion channel

Further reading

• Santoro B, Grant SG, Bartsch D, Kandel ER (1998). "Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14815–20. Bibcode:1997PNAS...9414815S. doi:10.1073/pnas.94.26.14815. PMC 25120. PMID 9405696.
• Ludwig A, Zong X, Jeglitsch M, et al. (1998). "A family of hyperpolarization-activated mammalian cation channels". Nature. 393 (6685): 587–91. Bibcode:1998Natur.393..587L. doi:10.1038/31255. PMID 9634236. S2CID 4429453.
• Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Much B, Wahl-Schott C, Zong X, et al. (2003). "Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels". J. Biol. Chem. 278 (44): 43781–6. doi:10.1074/jbc.M306958200. PMID 12928435.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Stieber J, Stöckl G, Herrmann S, et al. (2005). "Functional expression of the human HCN3 channel". J. Biol. Chem. 280 (41): 34635–43. doi:10.1074/jbc.M502508200. PMID 16043489.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

External links

• HCN3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.