Tetraspanin 9

TSPAN9
Identifiers
Aliases	TSPAN9, NET-5, NET5, PP1057, tetraspanin 9
External IDs	OMIM: 613137; MGI: 1924558; HomoloGene: 4860; GeneCards: TSPAN9; OMA:TSPAN9 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	3,286,564 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	128,120,557 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; right auricle; ; left ventricle; ; right lung; ; right lobe of liver; ; stromal cell of endometrium; ; vena cava; ; gallbladder;
	Top expressed in
	gastrula; ; yolk sac; ; cerebellar cortex; ; endothelial cell of lymphatic vessel; ; decidua; ; internal carotid artery; ; lip; ; right lung; ; iris; ; external carotid artery;
	More reference expression data
	n/a
Gene ontology
Molecular function	molecular function;
Cellular component	integral component of membrane; plasma membrane; tetraspanin-enriched microdomain; integral component of plasma membrane; membrane; focal adhesion;
Biological process	cell surface receptor signaling pathway; biological process;
	Sources:Amigo / QuickGO
Orthologs
	10867
	109246
	ENSG00000011105
	ENSMUSG00000030352
	O75954
	Q8BJU2
	NM_001168320; NM_006675
NM_175414; NM_001356301; NM_001379133; NM_001379134; NM_001379135;
	NM_001379136
	NP_001161792; NP_006666
NP_780623; NP_001343230; NP_001366062; NP_001366063; NP_001366064;
	NP_001366065
	Wikidata
View/Edit Human	View/Edit Mouse

Tetraspanin 9 is a protein that in humans is encoded by the TSPAN9 gene. ^[5]

Function

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternatively spliced transcripts encoding the same protein have been identified. [provided by RefSeq, Nov 2009].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000011105 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030352 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Tetraspanin 9". Retrieved 2017-11-30.

Protty MB, Watkins NA, Colombo D, Thomas SG, Heath VL, Herbert JM, Bicknell R, Senis YA, Ashman LK, Berditchevski F, Ouwehand WH, Watson SP, Tomlinson MG (2009). "Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains". Biochem. J. 417 (1): 391–400. doi:10.1042/BJ20081126. PMC 2652832. PMID 18795891.
Kotha J, Zhang C, Longhurst CM, Lu Y, Jacobs J, Cheng Y, Jennings LK (2009). "Functional relevance of tetraspanin CD9 in vascular smooth muscle cell injury phenotypes: a novel target for the prevention of neointimal hyperplasia". Atherosclerosis. 203 (2): 377–86. doi:10.1016/j.atherosclerosis.2008.07.036. PMID 18799160.
Chapuis J, Hot D, Hansmannel F, Kerdraon O, Ferreira S, Hubans C, Maurage CA, Huot L, Bensemain F, Laumet G, Ayral AM, Fievet N, Hauw JJ, DeKosky ST, Lemoine Y, Iwatsubo T, Wavrant-Devrièze F, Dartigues JF, Tzourio C, Buée L, Pasquier F, Berr C, Mann D, Lendon C, Alpérovitch A, Kamboh MI, Amouyel P, Lambert JC (2009). "Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease". Mol. Psychiatry. 14 (11): 1004–16. doi:10.1038/mp.2009.10. PMC 2860783. PMID 19204726.
Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y (2010). "Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals". Am. J. Hypertens. 23 (1): 70–7. doi:10.1038/ajh.2009.190. PMID 19851296.
Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y (2010). "Association of genetic variants with hemorrhagic stroke in Japanese individuals". Int. J. Mol. Med. 25 (4): 649–56. doi:10.3892/ijmm_00000388. PMID 20198315.
Stiles KM, Kielian M (2016). "Role of TSPAN9 in Alphavirus Entry and Early Endosomes". J. Virol. 90 (9): 4289–97. doi:10.1128/JVI.00018-16. PMC 4836341. PMID 26865714.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000011105 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030352 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Tetraspanin 9". Retrieved 2017-11-30.

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Function

References

Further reading