PCP4

PCP4
Identifiers
Aliases	PCP4, PEP-19, Purkinje cell protein 4
External IDs	OMIM: 601629; MGI: 97509; HomoloGene: 4519; GeneCards: PCP4; OMA:PCP4 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	39,929,397 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	96,326,993 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; external globus pallidus; ; middle frontal gyrus; ; Epithelium of choroid plexus; ; putamen; ; caudate nucleus; ; nucleus accumbens; ; seminal vesicula; ; retinal pigment epithelium; ; internal globus pallidus;
	Top expressed in
	striatum of neuraxis; ; olfactory bulb; ; cerebellum; ; layer of retina; ; neural layer of retina; ; cerebellar cortex; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; urinary bladder; ; primary visual cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; calcium ion binding; calmodulin binding;
Cellular component	cytosol; nucleus; protein-containing complex;
Biological process	positive regulation of neuron differentiation; calmodulin dependent kinase signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5121
	18546
	ENSG00000183036
	ENSMUSG00000090223
	P48539
	P63054
	NM_006198
	NM_008791
	NP_006189
	NP_032817
	Wikidata
View/Edit Human	View/Edit Mouse

Purkinje cell protein 4 is a protein that in humans is encoded by the PCP4 gene.^[5]^[6]^[7] Also known as PEP-19, PCP4 is a 7.6 kDa protein with an IQ-motif that binds to calmodulin (CaM).^[8] PCP4 is abundant in Purkinje cells of the cerebellum, and plays an important role in synaptic plasticity.^[8]^[9]

Function

PCP4 knockout mice have been reported to exhibit impaired locomotor learning and markedly altered synaptic plasticity in cerebellar Purkinje neurons.^[8] PCP4 accelerates both the association and dissociation of calcium (Ca²⁺) with calmodulin (CaM), which is postulated to influence the activity of CaM-dependent enzymes, especially CaM kinase II (CaMK-II).^[8]^[10]^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183036 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000090223 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chen H, Bouras C, Antonarakis SE (Jan 1997). "Cloning of the cDNA for a human homolog of the rat PEP-19 gene and mapping to chromosome 21q22.2-q22.3". Hum Genet. 98 (6): 672–7. doi:10.1007/s004390050282. PMID 8931698. S2CID 19837689.
^ Cabin DE, Gardiner K, Reeves RH (Dec 1996). "Molecular genetic characterization and comparative mapping of the human PCP4 gene". Somat Cell Mol Genet. 22 (3): 167–75. doi:10.1007/BF02369907. PMID 8914602. S2CID 41800640.
^ "Entrez Gene: PCP4 Purkinje cell protein 4".
^ ^a ^b ^c ^d Wei P, Blundon JA, Rong Y, Zakharenko SS, Morgan JI (2011). "Impaired locomotor learning and altered cerebellar synaptic plasticity in pep-19/PCP4-null mice". Mol. Cell. Biol. 31 (14): 2838–44. doi:10.1128/MCB.05208-11. PMC 3133400. PMID 21576365.
^ Sangameswaran L, Hempstead J, Morgan JI (1989). "Molecular cloning of a neuron-specific transcript and its regulation during normal and aberrant cerebellar development". Proc. Natl. Acad. Sci. U.S.A. 86 (14): 5651–5. Bibcode:1989PNAS...86.5651S. doi:10.1073/pnas.86.14.5651. PMC 297682. PMID 2748608.
^ Putkey JA, Kleerekoper Q, Gaertner TR, Waxham MN (2004). "A new role for IQ motif proteins in regulating calmodulin function". J. Biol. Chem. 278 (50): 49667–70. doi:10.1074/jbc.C300372200. PMID 14551202.
^ Kleerekoper QK, Putkey JA (2009). "PEP-19, an intrinsically disordered regulator of calmodulin signaling". J. Biol. Chem. 284 (12): 7455–64. doi:10.1074/jbc.M808067200. PMC 2658041. PMID 19106096.

Function

References

Further reading