Cancer Diagnostic Probe

The Cancer Diagnostic Probe (CDP) is a medical device used in Iran during breast cancer surgery.^[1]^[2] First developed by Nano Hesgar Sazan Salamt Arya, an Iranian company,^[1] CDP has received medical approval in Iran, where it is used in surgical centers.^[2]

Development and application

The Cancer Diagnostic Probe was developed by a team led by Mohammad Abdolahad, a 2019 Mustafa Prize laureate and faculty member of the School of Electrical and Computer Engineering at the University of Tehran, to facilitate the determination of cancerous margins.^[2] Abdolahad stated that the clinical trial for the device lasted 4 years and that up to 500 surgeries had been carried out using the CDP by 2020.^[2] According to Sayyed Ruhollah Miri, the head of the Cancer Institute at the Tehran University of Medical Sciences, the CDP reduces the diagnosis time to 1–2 minutes.^[3]

Mechanism

The CDP device is composed of three main parts: "a disposable sensor; a wireless electrical head probe used by the surgeon; [and] a main control computer system which receives the signals from the head probe".^[2] It electrochemically measures the hypoxia glycolysis metabolism in real-time "in pre-cancerous and cancerous lesions in cavity side margins".^[1] It measures the release of H₂O₂ from cancer or atypical cells by the reverse Warburg effect.^[1]^[4]

Reception

The development of CDP was supported by the Iranian Nano Technology Development Headquarters.^[3] After receiving medical approval, this system has been used in breast cancer surgeries in Iran.^[2] As of 2022^[update], four U.S. patents have been published related to CDP.^[5]

References

^ ^a ^b ^c ^d "Real-time Cancer Diagnostic Probe – Iran Advanced Clinical Training Center". Tehran University of Medical Sciences. Archived from the original on 14 January 2023. Retrieved 10 January 2023.
^ ^a ^b ^c ^d ^e ^f "Mustafa (pbuh) Prize laureate presented his Cancer Diagnostic Probe". Mustafa Prize. Archived from the original on 14 January 2023. Retrieved 10 January 2023.
^ ^a ^b "The visit of a delegate of Indian businessmen and doctors to the achievement of Iranian researchers in the treatment of breast cancer". Iranian nanotechnology newsletter (in Persian). 9 January 2023. Archived from the original on 14 January 2023. Retrieved 12 January 2023.
^ Dabbagh, Najmeh; Abbasvandi, Fereshteh; Miripour, Zohreh Sadat; et al. (2022). "Accuracy of cancer diagnostic probe for intra‐surgical checking of cavity side margins in neoadjuvant breast cancer cases: A human model study". The International Journal of Medical Robotics and Computer Assisted Surgery. 18 (1): e2335. doi:10.1002/rcs.2335. ISSN 1478-5951. PMID 34571582. S2CID 238204138. Archived from the original on 14 January 2023. Retrieved 14 January 2023.
^ Miripour, Zohreh Sadat; Abbasvandi, Fereshteh; Aghaee, Parisa; et al. (2022). "Human study on cancer diagnostic probe (CDP) for real-time excising of breast positive cavity side margins based on tracing hypoxia glycolysis; checking diagnostic accuracy in non-neoadjuvant cases". Cancer Medicine. 11 (7): 1630–1645. doi:10.1002/cam4.4503. ISSN 2045-7634. PMC 8986141. PMID 35224879.

[Tehran_University_of_Medical_Sciences-1] "Real-time Cancer Diagnostic Probe – Iran Advanced Clinical Training Center". Tehran University of Medical Sciences. Archived from the original on 14 January 2023. Retrieved 10 January 2023.

[Mustafa_Prize-2] ^ ^a ^b ^c ^d ^e ^f "Mustafa (pbuh) Prize laureate presented his Cancer Diagnostic Probe". Mustafa Prize. Archived from the original on 14 January 2023. Retrieved 10 January 2023.

[Iranian_nanotechnology_newsletter-2023-3] "The visit of a delegate of Indian businessmen and doctors to the achievement of Iranian researchers in the treatment of breast cancer". Iranian nanotechnology newsletter (in Persian). 9 January 2023. Archived from the original on 14 January 2023. Retrieved 12 January 2023.

[4] Dabbagh, Najmeh; Abbasvandi, Fereshteh; Miripour, Zohreh Sadat; et al. (2022). "Accuracy of cancer diagnostic probe for intra‐surgical checking of cavity side margins in neoadjuvant breast cancer cases: A human model study". The International Journal of Medical Robotics and Computer Assisted Surgery. 18 (1): e2335. doi:10.1002/rcs.2335. ISSN 1478-5951. PMID 34571582. S2CID 238204138. Archived from the original on 14 January 2023. Retrieved 14 January 2023.

[5] Miripour, Zohreh Sadat; Abbasvandi, Fereshteh; Aghaee, Parisa; et al. (2022). "Human study on cancer diagnostic probe (CDP) for real-time excising of breast positive cavity side margins based on tracing hypoxia glycolysis; checking diagnostic accuracy in non-neoadjuvant cases". Cancer Medicine. 11 (7): 1630–1645. doi:10.1002/cam4.4503. ISSN 2045-7634. PMC 8986141. PMID 35224879.

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