Jannie Borst

Jannie G. Keyser-Borst is a Dutch cancer immunologist. She became Professor at Leiden University on 16 January 2019 ^[1] At the Leiden University Medical Center she currently runs a research group investigating the regulation of the T cell response ^[2]

Education and career

In 1980 she received her Master's degree in biology with chemistry at Leiden University. For the main part of her PhD she worked at the Dana–Farber Cancer Institute, Harvard Medical School in Boston, supervised by Prof. Dr. Cox P Terhorst. During this time she unraveled the structure of the CD3/T cell complex. After graduation she worked with Immunologists Dr Jan E de Vries and Dr Hergen Spits in the Netherlands. She obtained her Ph.D. degree from Leiden University in 1985. In 1987, she received a 5-year personal fellowship from The Netherlands Organization for Scientific Research.

In 1992, she became staff scientist at the Netherlands Cancer Institute and was named the head of the Division of Immunology in 2002.^[3] In 1999, she was appointed professor in Experimental Oncology at the University of Amsterdam.

Awards

She received the Van Loghem career award from the Dutch Society of Immunology in 2009.^[4]

In 2012, she was elected EMBO member.

In 2018 she received the Delphine Parrott award for inspiring female scientists^[5] by Megan MacLeod during the West of Scotland Immunology Group showcase at the University of Glasgow

Important work

The structure of the human T cel receptor/CD3 complex.^[6]^[7]^[8]
The Gamma delta T cell^[9] and the development of the first Antibody to detect these cells in humans.^[10]
The identification of TNF receptor CD27 and CD70 ligand as important costimulatory system on T cells ^[11]^[12]^[13]

References

^ LUMC. "Prof. Jannie Borst benoemd tot hoogleraar Immunologie in Leiden | LUMC". www.lumc.nl (in Dutch). Retrieved 2019-09-02.
^ LUMC. "Jannie Borst | LUMC". www.lumc.nl (in Dutch). Retrieved 2019-09-02.
^ "Borst, Jannie". Antoni van Leeuwenhoek. Retrieved 2019-09-02.
^ "Van Loghem Laureate Jannie Borst: A fascination for the complexity of life". Retrieved 2019-09-02.
^ "West of Scotland Immunology Group Showcase 2018 | British Society for Immunology". www.immunology.org. Retrieved 2019-09-02.
^ Krangel, M. S.; Bierer, B. E.; Devlin, P.; Clabby, M.; Strominger, J. L.; McLean, J.; Brenner, M. B. (1987-06-01). "T3 glycoprotein is functional although structurally distinct on human T-cell receptor gamma T lymphocytes". Proceedings of the National Academy of Sciences. 84 (11): 3817–3821. Bibcode:1987PNAS...84.3817K. doi:10.1073/pnas.84.11.3817. ISSN 0027-8424. PMC 304967. PMID 3108880.
^ van den Elsen, Peter; Shepley, Beth-Ann; Borst, Jannie; Coligan, John E.; Markham, Alexander F.; Orkin, Stuart; Terhorst, Cox (November 1984). "Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex". Nature. 312 (5993): 413–418. Bibcode:1984Natur.312..413V. doi:10.1038/312413a0. ISSN 0028-0836. PMID 6095101. S2CID 4347265.
^ Jacobs, Heinz; Vandeputte, Dmitri; Tolkamp, Louis; De Vries, Evert; Borst, Jannie; Berns, Anton (April 1994). "CD3 components at the surface of pro-T cells can mediate pre-T cell developmentin vivo". European Journal of Immunology. 24 (4): 934–939. doi:10.1002/eji.1830240423. ISSN 0014-2980. PMID 8149963. S2CID 35576840.
^ Haks, Mariëlle C.; Krimpenfort, Paul; Borst, Jannie; Kruisbeek, Ada M. (1998-04-01). "The CD3γ chain is essential for development of both the TCRαβ and TCRγδ lineages". The EMBO Journal. 17 (7): 1871–1882. doi:10.1093/emboj/17.7.1871. ISSN 0261-4189. PMC 1170534. PMID 9524111.
^ Spits, H.; Borst, J.; Tax, W.; Capel, P. J.; Terhorst, C.; de Vries, J. E. (September 1985). "Characteristics of a monoclonal antibody (WT-31) that recognizes a common epitope on the human T cell receptor for antigen". Journal of Immunology. 135 (3): 1922–1928. doi:10.4049/jimmunol.135.3.1922. ISSN 0022-1767. PMID 2410507. S2CID 20471579.
^ Borst, Jannie; Hendriks, Jenny; Xiao, Yanling (June 2005). "CD27 and CD70 in T cell and B cell activation". Current Opinion in Immunology. 17 (3): 275–281. doi:10.1016/j.coi.2005.04.004. ISSN 0952-7915. PMID 15886117.
^ Church, J. A. (2004-08-01). "Lethal T Cell Immunodeficiency Induced by Chronic Costimulation via CD27-CD70 Interactions". Pediatrics. 114 (2): 552–553. doi:10.1542/peds.114.2.s1.552-b. ISSN 0031-4005. S2CID 57539011.
^ Arens, Ramon; Tesselaar, Kiki; Baars, Paul A; van Schijndel, Gijs M. W; Hendriks, Jenny; Pals, Steven T; Krimpenfort, Paul; Borst, Jannie; van Oers, Marinus H. J (2001-11-01). "Constitutive CD27/CD70 Interaction Induces Expansion of Effector-Type T Cells and Results in IFNγ-Mediated B Cell Depletion". Immunity. 15 (5): 801–812. doi:10.1016/S1074-7613(01)00236-9. ISSN 1074-7613. PMID 11728341.

[1] LUMC. "Prof. Jannie Borst benoemd tot hoogleraar Immunologie in Leiden | LUMC". www.lumc.nl (in Dutch). Retrieved 2019-09-02.

[2] LUMC. "Jannie Borst | LUMC". www.lumc.nl (in Dutch). Retrieved 2019-09-02.

[3] "Borst, Jannie". Antoni van Leeuwenhoek. Retrieved 2019-09-02.

[4] "Van Loghem Laureate Jannie Borst: A fascination for the complexity of life". Retrieved 2019-09-02.

[5] "West of Scotland Immunology Group Showcase 2018 | British Society for Immunology". www.immunology.org. Retrieved 2019-09-02.

[6] Krangel, M. S.; Bierer, B. E.; Devlin, P.; Clabby, M.; Strominger, J. L.; McLean, J.; Brenner, M. B. (1987-06-01). "T3 glycoprotein is functional although structurally distinct on human T-cell receptor gamma T lymphocytes". Proceedings of the National Academy of Sciences. 84 (11): 3817–3821. Bibcode:1987PNAS...84.3817K. doi:10.1073/pnas.84.11.3817. ISSN 0027-8424. PMC 304967. PMID 3108880.

[7] van den Elsen, Peter; Shepley, Beth-Ann; Borst, Jannie; Coligan, John E.; Markham, Alexander F.; Orkin, Stuart; Terhorst, Cox (November 1984). "Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex". Nature. 312 (5993): 413–418. Bibcode:1984Natur.312..413V. doi:10.1038/312413a0. ISSN 0028-0836. PMID 6095101. S2CID 4347265.

[8] Jacobs, Heinz; Vandeputte, Dmitri; Tolkamp, Louis; De Vries, Evert; Borst, Jannie; Berns, Anton (April 1994). "CD3 components at the surface of pro-T cells can mediate pre-T cell developmentin vivo". European Journal of Immunology. 24 (4): 934–939. doi:10.1002/eji.1830240423. ISSN 0014-2980. PMID 8149963. S2CID 35576840.

[9] Haks, Mariëlle C.; Krimpenfort, Paul; Borst, Jannie; Kruisbeek, Ada M. (1998-04-01). "The CD3γ chain is essential for development of both the TCRαβ and TCRγδ lineages". The EMBO Journal. 17 (7): 1871–1882. doi:10.1093/emboj/17.7.1871. ISSN 0261-4189. PMC 1170534. PMID 9524111.

[10] Spits, H.; Borst, J.; Tax, W.; Capel, P. J.; Terhorst, C.; de Vries, J. E. (September 1985). "Characteristics of a monoclonal antibody (WT-31) that recognizes a common epitope on the human T cell receptor for antigen". Journal of Immunology. 135 (3): 1922–1928. doi:10.4049/jimmunol.135.3.1922. ISSN 0022-1767. PMID 2410507. S2CID 20471579.

[11] Borst, Jannie; Hendriks, Jenny; Xiao, Yanling (June 2005). "CD27 and CD70 in T cell and B cell activation". Current Opinion in Immunology. 17 (3): 275–281. doi:10.1016/j.coi.2005.04.004. ISSN 0952-7915. PMID 15886117.

[12] Church, J. A. (2004-08-01). "Lethal T Cell Immunodeficiency Induced by Chronic Costimulation via CD27-CD70 Interactions". Pediatrics. 114 (2): 552–553. doi:10.1542/peds.114.2.s1.552-b. ISSN 0031-4005. S2CID 57539011.

[13] Arens, Ramon; Tesselaar, Kiki; Baars, Paul A; van Schijndel, Gijs M. W; Hendriks, Jenny; Pals, Steven T; Krimpenfort, Paul; Borst, Jannie; van Oers, Marinus H. J (2001-11-01). "Constitutive CD27/CD70 Interaction Induces Expansion of Effector-Type T Cells and Results in IFNγ-Mediated B Cell Depletion". Immunity. 15 (5): 801–812. doi:10.1016/S1074-7613(01)00236-9. ISSN 1074-7613. PMID 11728341.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]