KIF14

KIF14
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4OZQ
Identifiers
Aliases	KIF14, MKS12, kinesin family member 14, MCPH20
External IDs	OMIM: 611279; MGI: 1098226; HomoloGene: 8916; GeneCards: KIF14; OMA:KIF14 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q32.1 Start 200,551,497 bp End 200,620,751 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 E4|1 59.8 cM Start 136,394,081 bp End 136,459,249 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte trabecular bone gonad ventricular zone buccal mucosa cell testicle embryo bone marrow thymus ganglionic eminence Top expressed in zygote tail of embryo genital tubercle secondary oocyte spermatocyte ventricular zone spermatid yolk sac blastocyst embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function tubulin binding nucleotide binding protein kinase binding plus-end-directed microtubule motor activity PDZ domain binding microtubule motor activity microtubule binding ATP binding protein binding ATPase activity Cellular component spindle cytoplasm kinesin complex nucleus membrane midbody microtubule plasma membrane spindle midzone cytoskeleton cytosol Flemming body Biological process negative regulation of integrin activation cerebral cortex development negative regulation of apoptotic process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process regulation of neuron apoptotic process hippocampus development regulation of cell growth cell division substrate adhesion-dependent cell spreading regulation of G1/S transition of mitotic cell cycle cell proliferation in forebrain regulation of G2/M transition of mitotic cell cycle cerebellar granular layer structural organization olfactory bulb development microtubule depolymerization proteasome-mediated ubiquitin-dependent protein catabolic process cerebellar Purkinje cell layer structural organization regulation of myelination positive regulation of cell population proliferation regulation of Rap protein signal transduction cerebellar cortex development positive regulation of cytokinesis negative regulation of neuron apoptotic process establishment of protein localization regulation of cell migration mitotic metaphase plate congression regulation of cell maturation microtubule-based movement activation of protein kinase activity regulation of cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9928 381293 Ensembl ENSG00000118193 ENSMUSG00000041498 UniProt Q15058 L0N7N1 RefSeq (mRNA) NM_001305792 NM_014875 NM_001081258 NM_001287179 RefSeq (protein) NP_001292721 NP_055690 NP_001274108 Location (UCSC) Chr 1: 200.55 – 200.62 Mb Chr 1: 136.39 – 136.46 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Kinesin-like protein KIF14 is a protein that in humans is encoded by the KIF14 gene.

Further reading

• Nakagawa T, Tanaka Y, Matsuoka E, et al. (1997). "Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9654–9. Bibcode:1997PNAS...94.9654N. doi:10.1073/pnas.94.18.9654. PMC 23244. PMID 9275178.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Corson TW, Huang A, Tsao MS, Gallie BL (2005). "KIF14 is a candidate oncogene in the 1q minimal region of genomic gain in multiple cancers". Oncogene. 24 (30): 4741–53. doi:10.1038/sj.onc.1208641. PMID 15897902.
• Gruneberg U, Neef R, Li X, et al. (2006). "KIF14 and citron kinase act together to promote efficient cytokinesis". J. Cell Biol. 172 (3): 363–72. doi:10.1083/jcb.200511061. PMC 2063646. PMID 16431929.
• Corson TW, Gallie BL (2006). "KIF14 mRNA expression is a predictor of grade and outcome in breast cancer". Int. J. Cancer. 119 (5): 1088–94. doi:10.1002/ijc.21954. PMID 16570270.
• Carleton M, Mao M, Biery M, et al. (2006). "RNA interference-mediated silencing of mitotic kinesin KIF14 disrupts cell cycle progression and induces cytokinesis failure". Mol. Cell. Biol. 26 (10): 3853–63. doi:10.1128/MCB.26.10.3853-3863.2006. PMC 1488988. PMID 16648480.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Bowles E, Corson TW, Bayani J, et al. (2007). "Profiling genomic copy number changes in retinoblastoma beyond loss of RB1". Genes Chromosomes Cancer. 46 (2): 118–29. doi:10.1002/gcc.20383. PMID 17099872. S2CID 22499766.
• Vasilescu J, Zweitzig DR, Denis NJ, et al. (2007). "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells". J. Proteome Res. 6 (1): 298–305. CiteSeerX 10.1.1.401.4220. doi:10.1021/pr060438j. PMID 17203973.
• Corson TW, Zhu CQ, Lau SK, et al. (2007). "KIF14 messenger RNA expression is independently prognostic for outcome in lung cancer". Clin. Cancer Res. 13 (11): 3229–34. doi:10.1158/1078-0432.CCR-07-0393. PMID 17545527.
• Madhavan J, Coral K, Mallikarjuna K, et al. (2007). "High expression of KIF14 in retinoblastoma: association with older age at diagnosis". Invest. Ophthalmol. Vis. Sci. 48 (11): 4901–6. doi:10.1167/iovs.07-0063. PMID 17962437.