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Diego Krapf

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Diego Krapf
Born (1973-11-21) 21 November 1973 (age 50)
Rosario, Argentina
NationalityIsraeli-Argentine-American
Alma materHebrew University of Jerusalem
Known for
SpouseSusan Sasson
Scientific career
FieldsBiophysics
InstitutionsColorado State University
Doctoral advisorAmir Sa'ar
Other academic advisors

Diego Krapf (born November 21, 1973) is an Argentine-Israeli-American physicist known for his work on anomalous diffusion and ergodicity breaking. He currently is a professor in the Department of Electrical and Computer Engineering at Colorado State University.

Early life and education

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Diego Krapf was born on November 21, 1973, to Martha Elbert and Luis Krapf. He spent his childhood growing up in Rosario, Argentina, and he attended the Instituto Politécnico Superior.

In 1992, after finishing high school, Krapf immigrated to Israel, where he spent half a year in Kibbutz Gan Shmuel and then moved to Jerusalem. He enrolled in physics at the Hebrew University of Jerusalem.

Krapf holds a BSc in physics (1997), a MSc in applied physics (2000) and a PhD in applied physics (2004) from the Hebrew University of Jerusalem. After finishing his PhD, he completed a postdoc at the Delft University of Technology (2007), doing research in nanoelectrode fabrication and single molecule experiments using nanopores under the supervision of Cees Dekker and Serge Lemay.[1]

Research

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Since 2007, Krapf is a faculty member in Colorado State University, where he currently heads a Biophysics lab that focuses on anomalous diffusion and cellular architecture using a combination of analytical and experimental tools including single particle tracking and super-resolution imaging.[2][3]

In 2011, Krapf and his team at Colorado State University showed that the motion of membrane proteins on the surface of mammalian cells display anomalous diffusion with a non-ergodic underlying physical mechanism.[4] These results represented a breakthrough in the understanding of membrane dynamics because they provide a completely new way of interpreting the motion of membrane proteins.[5][6] In 2017, the Krapf lab discovered that due to complex branching processes the actin cytoskeleton adjacent to the plasma membrane of mammalian cells form an intricate fractal structure. In 2018, an international team led by Krapf involving researchers from the University of Massachusetts and the Instituto de Biología y Medicina Experimental (Argentina) revealed the organization of the actin-based cytoskeleton in the sperm flagellum using three-dimensional super-resolution imaging.[7] It was discovered that in the midpiece of murine sperm, the actin cytoskeleton forms a double-helix that follows the mitochondrial sheath, a type of filamentous actin structure that had not been previously observed.[8]

Awards

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References

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  1. ^ "Cees Dekker Lab – People". Retrieved 27 March 2021.
  2. ^ "How Nature Controls Traffic on the Surface of Cells". Physics central. 9 March 2017. Archived from the original on 2017-03-14. Retrieved 27 March 2021.
  3. ^ "A traffic cop for the cell surface: Researchers illuminate a basic biological process". 27 February 2017. Archived from the original on 2017-02-27. Retrieved 27 March 2021.
  4. ^ Weigel AV, Simon B, Tamkun MM, Krapf D (April 2011). "Ergodic and nonergodic processes coexist in the plasma membrane as observed by single-molecule tracking". Proceedings of the National Academy of Sciences of the United States of America. 108 (16): 6438–43. Bibcode:2011PNAS..108.6438W. doi:10.1073/pnas.1016325108. PMC 3081000. PMID 21464280.
  5. ^ Barkai E, Garini Y, Metzler R (2012-08-01). "Strange kinetics of single molecules in living cells". Physics Today. 65 (8): 29–35. Bibcode:2012PhT....65h..29B. doi:10.1063/PT.3.1677. ISSN 0031-9228.
  6. ^ "Annual Index". Physics Today. 62 (12): 84. 2009. Bibcode:2009PhT....62l..84.. doi:10.1063/1.3273090. ISSN 0031-9228.
  7. ^ Sadegh S, Higgins JL, Mannion PC, Tamkun MM, Krapf D (2017-03-09). "Plasma Membrane is Compartmentalized by a Self-Similar Cortical Actin Meshwork". Physical Review X. 7 (1): 011031. arXiv:1702.03997. Bibcode:2017PhRvX...7a1031S. doi:10.1103/PhysRevX.7.011031. PMC 5500227. PMID 28690919.
  8. ^ Gervasi MG, Xu X, Carbajal-Gonzalez B, Buffone MG, Visconti PE, Krapf D (June 2018). "The actin cytoskeleton of the mouse sperm flagellum is organized in a helical structure". Journal of Cell Science. 131 (11): jcs215897. doi:10.1242/jcs.215897. PMC 6031324. PMID 29739876.
  9. ^ Colorado State University. "2022 College Faculty and Staff Award Recipients".
  10. ^ Colorado State University. "College Faculty and Staff Award Recipients". Archived from the original on 2021-03-26.
  11. ^ "Premio Dr. Bernardo Houssay 2020".
  12. ^ "Celebrate! Colorado State award winners for 2018". CSU Source. 11 April 2018. Archived from the original on 2020-08-14. Retrieved March 30, 2021.
  13. ^ "2021 College Faculty and Staff Award Recipients". CSU Source. 24 March 2021. Archived from the original on 2020-08-05.
  14. ^ "Hebrew University of Jerusalem, Office of the Rector, Rector's prize". Archived from the original on 2021-01-26.
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