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Marta Zlatic

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Marta Zlatic
Born (1977-02-24) 24 February 1977 (age 47)
Zagreb, Croatia
Alma materUniversity of Cambridge (BA, PhD)
SpouseAlbert Cardona
Awards
Scientific career
Fields
Institutions
ThesisEstablishment of connectivity in the embryonic central nervous system of Drosophila. (2004)
Websitewww2.mrc-lmb.cam.ac.uk/group-leaders/t-to-z/marta-zlatic/ Edit this at Wikidata

Marta Zlatic (born 24 February 1977)[4] is a Croatian neuroscientist who is group leader at the MRC Laboratory of Molecular Biology in Cambridge, UK.[3][5] Her research investigates how neural circuits generate behaviour.[1]

Early life and education

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Zlatic is from Zagreb, Croatia.[6][7] She has said that growing up she had excellent Latin and Greek teachers.[8] She was awarded a full scholarship to study the Natural Sciences Tripos at Trinity College, Cambridge. During her summer holidays from Cambridge, Zlatic studied linguistics and Russian at the University of Zagreb. Alongside her studies, Zlatic was involved with the Cambridge theatre scene, taking part in Greek tragedies and Shakespeare's plays.[6] As an undergraduate student Zlatic attended the lectures of Mike Bate, where he discussed the neural circuits of fruit flies. She enjoyed the lectures so much that she applied for a postgraduate degree.[6] During her doctoral research Zlatic looked at the development of neurons in Drosophila.[9][6] As the nervous system starts to form, neurons start to produce axons and dendrites.[6] Zlatic showed that sensory neurons, which allow for sight, sound, pain and touch, look for particular locations in the nervous system using positional cues.

Research and career

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After earning her doctorate, Zlatic was awarded a postdoctoral fellowship at the University of Cambridge which allowed her to travel internationally and study the assembly of neural circuits.[8] In 2009 Zlatic started her independent career at the Janelia Research Campus.[7][10] At Janelia she learnt about the genetic tools used to manipulate the types of neurons in Drosophila.[8] Zlatic has dedicated her career to the study of the nervous system, in particular the positional cue known as the slit protein which controls how sensory neuron axons start and stop growing. She showed that slit proteins control branching along the mediolateral axis but not the dorsoventral axis, indicating that there are positional cues in three-dimensions.[citation needed]

Zlatic is interested the complex functions of the human brain, including language and communication. She studies these phenomena in the Drosophila larva (maggot).[6] She made use of electron microscopy to map the entire Drosophila connectome,[11] and studies the strengths of the connections between neurons that are structurally connected.[12] By investigating the connectivity of these neurons it is hoped that these particular patterns could be associated with the formation of memories.

Awards and honours

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Publications

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Her publications[3] include:

  • Labeling of active neural circuits in vivo with designed calcium integrators[15]
  • A multilevel multimodal circuit enhances action selection in Drosophila[16]
  • The complete connectome of a learning and memory centre in an insect brain[17]

Personal life

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Zlatic is fluent in several languages, including Croatian, English, German, French, Russian, Spanish, Italian, Ancient Greek, and Latin.[6] Alongside her enthusiasm for languages and neuroscience, Zlatic is an actress.[6] She is married to neuroscientist Albert Cardona [Wikidata].[8]

References

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  1. ^ a b "Francis Crick Medal and Lecture". royalsociety.org. Royal Society. Retrieved 2020-08-05.
  2. ^ a b "Find people in the EMBO Communities". people.embo.org.
  3. ^ a b c Marta Zlatic publications indexed by Google Scholar Edit this at Wikidata
  4. ^ Curriculum Vitae (2018)
  5. ^ Marta Zlatic publications from Europe PubMed Central
  6. ^ a b c d e f g h "Marta Zlatic | Janelia Research Campus". janelia.org. Retrieved 2020-08-05.
  7. ^ a b c "MARTA ZLATIC – FKNE". Retrieved 2020-08-05.
  8. ^ a b c d Gewin, Virginia (2014). "Turning point: Marta Zlatic". Nature. 509 (7499): 251. doi:10.1038/nj7499-251a. ISSN 1476-4687.
  9. ^ Zlatic, Marta (2004). Establishment of connectivity in the embryonic central nervous system of Drosophila. cam.ac.uk (PhD thesis). University of Cambridge. OCLC 890159518. EThOS uk.bl.ethos.615935.
  10. ^ "Marta Zlatic". hhmi.org. Howard Hughes Medical Institute. Retrieved 2020-08-05.
  11. ^ Winding, Michael; Pedigo, Benjamin D.; Barnes, Christopher L.; Patsolic, Heather G.; Park, Youngser; Kazimiers, Tom; Fushiki, Akira; Andrade, Ingrid V.; Khandelwal, Avinash; Valdes-Aleman, Javier; Li, Feng; Randel, Nadine; Barsotti, Elizabeth; Correia, Ana; Fetter, Richard D.; Hartenstein, Volker; Priebe, Carey E.; Vogelstein, Joshua T.; Cardona, Albert; Zlatic, Marta (2023-03-10). "The connectome of an insect brain". Science. 379 (6636): –9330. doi:10.1126/science.add9330. PMC 7614541. S2CID 254070919. Retrieved 2023-03-10.
  12. ^ Smith,Nature, Kerri. "How to Map the Circuits That Define Us". scientificamerican.com. Scientific American. Retrieved 2020-08-06.
  13. ^ Anon (2020). "Royal Society announces 2020 winners of prestigious medals and awards". royalsociety.org. London: Royal Society. Retrieved 2020-08-05.
  14. ^ Administrator (2017-03-13). "Dr Marta Zlatic is awarded the Eric Kandel Young Neuroscientist Prize 2017". zoo.cam.ac.uk. Retrieved 2020-08-05.
  15. ^ Fosque, Benjamin F.; Sun, Yi; Dana, Hod; Yang, Chao-Tsung; Ohyama, Tomoko; Tadross, Michael R.; Patel, Ronak; Zlatic, Marta; Kim, Douglas S.; Ahrens, Misha B.; Jayaraman, Vivek (2015). "Labeling of active neural circuits in vivo with designed calcium integrators". Science. 347 (6223): 755–760. doi:10.1126/science.1260922. ISSN 0036-8075. PMID 25678659. S2CID 206562601.
  16. ^ Ohyama, Tomoko; Schneider-Mizell, Casey M.; Fetter, Richard D.; Aleman, Javier Valdes; Franconville, Romain; Rivera-Alba, Marta; Mensh, Brett D.; Branson, Kristin M.; Simpson, Julie H.; Truman, James W.; Cardona, Albert (2015). "A multilevel multimodal circuit enhances action selection in Drosophila". Nature. 520 (7549): 633–639. doi:10.1038/nature14297. ISSN 1476-4687. PMID 25896325. S2CID 4464547. Closed access icon
  17. ^ Eichler, Katharina; Li, Feng; Litwin-Kumar, Ashok; Park, Youngser; Andrade, Ingrid; Schneider-Mizell, Casey M.; Saumweber, Timo; Huser, Annina; Eschbach, Claire; Gerber, Bertram; Fetter, Richard D. (2017). "The complete connectome of a learning and memory centre in an insect brain". Nature. 548 (7666): 175–182. doi:10.1038/nature23455. ISSN 1476-4687. PMC 5806122. PMID 28796202.
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