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Peter K. Vogt

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Peter K. Vogt
Born(1932-03-10)March 10, 1932
Broumov, Czechoslovakia
Alma mater
AwardsPaul Ehrlich and Ludwig Darmstaedter Prize (1988)
Scientific career
Institutions

Peter K. Vogt (born March 10, 1932) is an American molecular biologist, virologist and geneticist. His research focuses on retroviruses and viral and cellular oncogenes.

Life

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Peter K. Vogt was born on March 10, 1932 in Broumov, Czechoslovakia.[1]

Education and academic appointments

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Vogt received his undergraduate education in biology at the University of Würzburg and in 1959 was awarded his Ph.D. at the University of Tübingen for work done at the Max Planck Institute for Virology in Tübingen. From 1959 to 1962 he was Damon Runyon Cancer Research Fellow in the laboratory of Harry Rubin at the University of California in Berkeley and started to work on Rous sarcoma virus.[2][3][4] He taught microbiology and molecular biology to medical and graduate students at the University of Colorado in Denver (1962–1967) and the University of Washington in Seattle (1967–1971). In 1971, he joined the University of Southern California as Hastings Professor of Microbiology and in 1980 assumed the chairmanship of the Department of Microbiology at the School of Medicine. Since 1993, he has been a professor at The Scripps Research Institute in La Jolla.[5][6] He served as senior vice president for scientific affairs at Scripps from 2012 to 2015.

Research

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At the beginning of his scientific career, Vogt studied mechanisms of retroviral cell entry and the role of viral surface proteins in determining host range.[7][8][9] He defined related groups of viral surface proteins and their corresponding receptors on the cell surface.[10][11] During his time in Seattle, his focus shifted to the genetics of retroviruses.[12] Together with his associate Kumao Toyoshima, he isolated the first temperature sensitive mutants of a retrovirus and in collaboration with the biochemist Peter Duesberg discovered the first retroviral oncogene, src.[13] His work on mutants of the Rous sarcoma virus enabled Michael Bishop and Harold Varmus to isolate DNA sequences that represent the src oncogene and to demonstrate the cellular origin of oncogenes.[14] In his extensive studies on avian retroviruses, Vogt discovered oncogenes that play important roles in human cancers, e.g. myc (in collaboration with Bister and Duesberg),[15] jun (with Maki and Bos)[16] and p3k (with Chang).[17]

Honors and awards

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Vogt has received numerous awards, including the Irene Vogeler Prize (1976), the Alexander von Humboldt Award (1984), the Ernst Jung Prize for Medicine (1985),[18] the Robert J. and Claire Pasarow Foundation Medical Research Award (1987), the Paul Ehrlich and Ludwig Darmstaedter Prize (1988),[19] the Bristol-Myers Squibb Award (1989),[20] the Charles S. Mott Prize (1991),[21] the Szent-Györgyi Prize for Progress in Cancer Research (2010),[22] the Pezcoller Foundation-AACR International Award for Cancer Research (2013),[23] the IHV Lifetime Achievement Award for Scientific Contributions (2016),[24] and the AICF Prize for Scientific Excellence in Medicine (2017).[25] In 2019 he was awarded the Louisa Gross Horwitz Prize.[26]

Vogt holds an honorary doctorate from the University of Würzburg (since 1995) and has been elected to several academies, including the National Academy of Sciences USA,[27] the American Philosophical Society,[28] the American Academy of Microbiology,[29] the German National Academy of Sciences Leopoldina,[30] the National Academy of Medicine,[31] the American Academy of Arts and Sciences[32] and the AACR Academy.

Service

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Vogt has served on several scientific advisory and editorial boards, e.g. the National Foundation for Cancer Research[33] and the Proceedings of the National Academy of Sciences, USA (2000–2019).

Painting

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Vogt is also an avid painter.[34] During his time in Würzburg, he studied with the artist Josef Versl.

References

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  1. ^ American Men and Women of Science, Thomson Gale
  2. ^ Vogt, PK; Rubin H (1961). "Localization of infectious virus and viral antigen in chick fibroblasts during successive stages of infection with Rous sarcoma virus". Virology. 13 (4): 528–44. doi:10.1016/0042-6822(61)90284-7. PMID 13781861.
  3. ^ Rubin, H; Vogt PK (1962). "An avian leukosis virus associated with stocks of Rous sarcoma virus". Virology. 17: 184–94. doi:10.1016/0042-6822(62)90096-x. PMID 14494905.
  4. ^ Vogt, PK; Rubin H (1962). "The cytology of Rous sarcoma virus infection". Cold Spring Harb Symp Quant Biol. 27: 395–405. doi:10.1101/sqb.1962.027.001.037. PMID 13997686.
  5. ^ "TSRI Faculty website".
  6. ^ "TSRI press release".
  7. ^ Ishizaki, R; Vogt PK. (1966). "Immunological relationships among envelope antigens of avian tumor viruses". Virology. 30 (3): 375–87. doi:10.1016/0042-6822(66)90116-4. PMID 4288417.
  8. ^ Vogt, PK; Ishizaki R (1966). Burdette, WJ (ed.). "Criteria for the classification of avian tumor viruses". Viruses Inducing Cancer. Salt Lake City: University of Utah Press: 71–90. {{cite journal}}: Cite journal requires |journal= (help)
  9. ^ Vogt, PK; Ishizaki R (1966). "Patterns of viral interference in the avian leukosis and sarcoma complex". Virology. 30 (3): 368–74. doi:10.1016/0042-6822(66)90115-2. PMID 4288416.
  10. ^ Vogt, PK (1963). "The Cell Surface in Tumor Virus Infection". Cancer Res. 23: 1519–27. PMID 14072691.
  11. ^ Vogt, PK; Luykx N (1963). "Observations on the surface of cells infected with Rous sarcoma virus". Virology. 20: 75–87. doi:10.1016/0042-6822(63)90142-9. PMID 13997684.
  12. ^ Toyoshima, K; Vogt PK (1969). "Temperature sensitive mutants of an avian sarcoma virus". Virology. 39 (4): 930–1. doi:10.1016/0042-6822(69)90030-0. PMID 4311641.
  13. ^ Duesberg, PH; Vogt PK (1970). "Differences between the ribonucleic acids of transforming and nontransforming avian tumor viruses". Proc Natl Acad Sci U S A. 67 (4): 1673–80. Bibcode:1970PNAS...67.1673D. doi:10.1073/pnas.67.4.1673. PMC 283411. PMID 4321342.
  14. ^ "The Nobel Prize in Physiology or Medicine 1989". NobelPrize.org.
  15. ^ Duesberg, PH; Bister K; Vogt PK (1977). "The RNA of avian acute leukemia virus MC29". Proc Natl Acad Sci U S A. 74 (10): 4320–4. Bibcode:1977PNAS...74.4320D. doi:10.1073/pnas.74.10.4320. PMC 431932. PMID 200913.
  16. ^ Maki, Y; Bos TJ; Davis C; Starbuck M; Vogt PK (1987). "Avian sarcoma virus 17 carries the jun oncogene". Proc Natl Acad Sci U S A. 84 (9): 2848–52. Bibcode:1987PNAS...84.2848M. doi:10.1073/pnas.84.9.2848. PMC 304757. PMID 3033666.
  17. ^ Chang, HW; Aoki M; Fruman D; Auger KR; Bellacosa A; Tsichlis PN; Cantley LC; Roberts TM; Vogt PK (1997). "Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase". Science. 276 (5320): 1848–50. doi:10.1126/science.276.5320.1848. PMID 9188528.
  18. ^ "Jung Prize Laureates".
  19. ^ "Paul Ehrlich and Ludwig Darmstaedter Prize Laureates".
  20. ^ "Cancer Research Cover June 15, 1989" (PDF).
  21. ^ Vogt, Peter K. (1992). "A transcription factor becomes oncogenic". Cancer. 69 (10): 2610–2614. doi:10.1002/1097-0142(19920515)69:10<2610::AID-CNCR2820691035>3.0.CO;2-J. PMID 1568185.
  22. ^ "2010 Prize: Peter K. Vogt, Ph.D." 28 March 2017.
  23. ^ "Pezcoller-AACR International Award for Extraordinary Achievement in Cancer Research". Archived from the original on 2018-02-08. Retrieved 2018-02-07.
  24. ^ "About the Meeting: IHV Meeting". somvweb.som.umaryland.edu.
  25. ^ "Scientific Prize". AMERICAN-ITALIAN CANCER FOUNDATION.
  26. ^ "The Louisa Gross Horwitz Prize". Columbia University Irving Medical Center. June 14, 2018.
  27. ^ "Peter K. Vogt". nasonline.org.
  28. ^ "APS Member History". amphilsoc.org.
  29. ^ "American Academy of Microbiology".
  30. ^ "Leopoldina Member directory".
  31. ^ "Directory".
  32. ^ "Peter K. Vogt". American Academy of Arts & Sciences. 9 October 2023.
  33. ^ "Our Team – National Foundation for Cancer Research". Retrieved 2018-03-31.
  34. ^ "Gallery website".
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