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Antimicrobial stewardship

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Antimicrobial stewardship (AMS) refers to coordinated efforts to promote the optimal use of antimicrobial agents, including drug choice, dosing, route, and duration of administration.[1]

Every time an antimicrobial agent is used, it applies selection pressure to microbial populations which can result in disruption to the normal microbiome (dysbiosis) as well as resistance to that agent, and even cross-resistance to other agents. Resistance can then spread to other microbes and to other host organisms. Antimicrobial agents can also have direct toxic effects on people and animals, including damage to kidneys, endocrine glands, liver, teeth and bones. Antimicrobial therapy is justified when the benefits outweigh these risks.

Contrary to popular belief, AMS does not aim to reduce the overall volume or frequency of antimicrobial use, although that often happens to occur with successful AMS interventions. The aims of AMS are to:

  • reduce/eliminate any unnecessary applications of antimicrobials, e.g. giving antibacterial drugs for viral infections, giving two antimicrobials when one would be sufficient
  • ensure that human and animal patients who need antimicrobials receive the optimal drug for them, at the correct time, at an effective dose, via the correct route, for the minimum effective duration
  • minimise environmental contamination with antimicrobial agents

While the primary driver for AMS is to preserve the effectiveness of the antimicrobial drugs we have, by slowing the development of antimicrobial resistance, it also has other important outcomes, including improving patient safety and reducing healthcare costs.

AMS interventions were first implemented in human hospitals, but are now increasingly common in every setting where antimicrobials are used, including primary care, aged care, dental care and veterinary medicine. Although AMS interventions often focus on prescribers, the general public also has an important role to play in AMS, in ensuring they always use and dispose of antimicrobials wisely.

AMS is a key focus of the World Health Organization and the World Organization for Animal Health.

In the U.S., within the context of physicians' prescribing freedom (choice of prescription drugs), AMS had largely been voluntary self-regulation in the form of policies and appeals to adhere to a prescribing self-discipline until 2017, when the Joint Commission prescribed that hospitals should have an Antimicrobial Stewardship team, which was expanded to the outpatient setting in 2020.

As of 2019, California and Missouri had made AMS programs mandatory by law.[2][3]

Definition and goals

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The 2007 definition by the Society for Healthcare Epidemiology of America (SHEA) defines AMS as a "set of coordinated strategies to improve the use of antimicrobial medications with the goal to

Decreasing the overuse of antimicrobials is expected to serve the following goals:

History

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Antimicrobial misuse was recognized as early as the 1940s, when Alexander Fleming remarked on penicillin's decreasing efficacy, because of its overuse.[5]

In 1966, the first systematic assessment of antibiotic use in the Winnipeg, Manitoba, Canada general hospital was published: Medical records were reviewed during two non-consecutive four-month periods (medicine, psychiatry, urology, gynecology and surgery, orthopedics, neurosurgery, ear, nose and throat, and ophthalmology). Information was coded on punched cards using 78 columns.[6] Others in 1968 estimated that 50% of antimicrobial use was either unnecessary or inappropriate.[7] This figure is likely the lower end of the estimate, and continues to be referenced as of 2015.[8]

In the 1970s the first clinical pharmacy services were established in North American hospitals. The first formal evaluation of antibiotic use in children regarding antibiotic choice, dose and necessity of treatment was undertaken at The Children's Hospital of Winnipeg. Researchers observed errors in therapy in 30% of medical orders and 63% of surgical orders.[9] The most frequent error was unnecessary treatment found in 13% of medical and 45% of surgical orders. The authors stated "Many find it difficult to accept that there are standards against which therapy may be judged."

In the 1980s the antibiotic class of cephalosporins was introduced, further increasing bacterial resistance. During this decade infection control programs began to be established in hospitals, which systematically recorded and investigated hospital-acquired infections. Evidence-based treatment guidelines and regulation of antibiotic use surfaced. Australian researchers published the first medical guideline outcomes research.[citation needed]

The term AMS was coined in 1996 by two internists at Emory University School of Medicine, John McGowan and Dale Gerding, a specialist on C. difficile. They suggested "...large-scale, well-controlled trials of antimicrobial use regulation employing sophisticated epidemiologic methods, molecular biological organism typing, and precise resistance mechanism analysis [...] to determine the best methods to prevent and control this problem [antimicrobial resistance] and ensure our optimal antimicrobial use stewardship" and that "...the long-term effects of antimicrobial selection, dosage, and duration of treatment on resistance development should be a part of every antimicrobial treatment decision."[10]

In 1997, SHEA and the Infectious Diseases Society of America published guidelines to prevent antimicrobial resistance arguing that "…appropriate antimicrobial stewardship, that includes optimal selection, dose, and duration of treatment, as well as control of antibiotic use, will prevent or slow the emergence of resistance among microorganisms."[11]

Ten years later, in 2007, bacterial, antiviral and antifungal resistance had risen to such a degree that the CDC rang the alarm [citation needed]. The same year, IDSA and SHEA published guidelines for developing an AMS program.[12] Also in 2007, the first pediatric publication used the term AMS.[13]

A survey of pediatric infectious disease consultants in 2008 by the Emerging Infectious Disease Network revealed that only 45 (33%) respondents had an AMS program (ASP), mostly from before 2000, and another 25 (18%) planned an ASP (data unpublished).

In 2012, the SHEA, IDSA and PIDS published a joint policy statement on AMS.[14]

The CDC's NHSN has been monitoring antimicrobial use and resistance in hospitals that volunteer to provide data.[15]

On September 18, 2014, President Barack Obama issued an Executive Order 13676, "Combating Antibiotic-Resistant Bacteria.' This Executive Order charged a Task Force to develop a 5-Year action plan that included steps to reduce the emergence and spread of antibiotic-resistant bacteria and ensure continued availability of effective therapies for infections. Improved AMS is one of the charges of this Executive Order. The Presidential Advisory Council on Combating Antibiotic-Resistant Bacteria (PACCARB) was formed in response to this Executive Order.[16][17]

In 2014, the CDC recommended, that all US hospitals have an antibiotic stewardship program (ASP).[18]

On January 1, 2017 Joint Commission regulations went into effect detailing that hospitals should have an AMS team consisting of infection preventionist(s), pharmacist(s), and a practitioner to write protocols and develop projects focused on the appropriate use of antibiotics.[19] Effective January 1, 2020, the Joint Commission antimicrobial stewardship requirements were expanded to outpatient health care organizations as well.[20] In 2018, a survey of AMS programs in the US showed each 0.50 increase in pharmacist and physician full-time equivalent support predicted a roughly 1.5-fold increase in the programs effectiveness.[21] but in a 2019 survey 45% of responding physicians reported that their institution provided no support for their ASP services.[22]

Locations

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AMS is needed wherever antimicrobials are prescribed in human medicine, namely in acute care hospitals, outpatient clinics, and long-term care institutions, including hospice.[citation needed]

Guidelines for prudent or judicious use in veterinary medicine have been developed by the Canadian Veterinary Medicine Association in 2008.[23] A particular problem is that veterinarians are both prescribers and dispensers. As of 2012, regulators and the Federation of Veterinarians of Europe had been discussing the separation of these activities.[24]

Participants

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Antimicrobial stewardship focuses on prescribers, be it physician, physician assistant, nurse practitioner, on the prescription and the microorganism, if any. At a hospital, AMS can be organized in the form of an AMS committee that meets monthly. The day-to-day work is done by a core group, usually an infectious disease physician, who may or may not serve in hospital epidemiology and infection control, or/ and an infectious diseases or antimicrobial certified pharmacist, ideally but rarely aided by an information technologist.[25] In most cases, both the infectious diseases physician and the infectious diseases pharmacist co-chair the AMS committee and both serve as the directors and champions of the AMS program and committee. The entire committee may include physician representatives, who are top antimicrobial prescribers such as physicians in intensive care medicine, Hematology -Oncology, cystic fibrosis clinicians or hospitalists, a microbiologist, a quality improvement (QI) specialist, and a representative from hospital administration. Six infectious diseases organizations, SHEA, Infectious Diseases Society of America, MAD-ID, National Foundation for Infectious Diseases PIDS, and Society of Infectious Disease Pharmacists, published joint guidance for the knowledge and skills required for antimicrobial stewardship leaders.[26]

For an AMS program to be established the institution has to recognize its value. In the US it has become customary to present a business plan to the executive officers of the hospital administration.

AMS program components

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In the US, the CDC recommends essential components of AMS programs (ASP) for acute care hospitals, small and critical access hospitals, resource-limited facilities, long-term care facilities, and outpatient facilities.[27]

As of 2014, thirteen internet-based institutional ASP resources in US academic medical centers had been published.[28] An ASP has the following tasks, in line with quality improvement theory:

Baseline assessment

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Parts of the baseline assessment are to:

  • Measure baseline antimicrobial use, dosing, duration, costs and use patterns.
  • Study type of microbial isolates, susceptibilities, and trends thereof
  • Identify clinician indication for prescriptions.

In hospitals and clinics using electronic medical records, information technology resources are crucial to focusing on these questions. As of 2015, commercial computer surveillance software programs for microbiology and antimicrobial administrations appear to outnumber "homegrown" institutional programs, and include, but are not limited to TREAT Steward, TheraDoc, Sentri7, and Vigilanz.[29]

Goals of desirable antimicrobial use

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For the desired antimicrobial use, goals need to be formulated:

  • Define "appropriate", rational antimicrobial use for the institution, individual patient units, and define empiric treatment versus culture-directed antimicrobial treatment.[citation needed]
  • Establish treatment guidelines for clinical syndromes. These can be disseminated in the form of memos, in-services or grand rounds and may be most effective in the form of decision-making tools at the point of ordering the prescription.[citation needed]

Interventions on antimicrobial prescribing

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The actual interventions on antimicrobial prescribing consist of numerous elements [30]

Provide feedback, continuing education

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  • Survey prescriber knowledge about antibiotics, antifungal or antiviral drugs.
  • Provide targeted education about particular antibiotics, or one specific antimicrobial at a time, as well as empiric treatment for syndromes versus culture directed treatment.
  • Assist in making duration more visible to prescribers. Some institutions use automatic stop orders.
  • Decreasing diagnostic uncertainty by appropriate testing, including rapid diagnostic methods. The most effective strategy to decrease diagnostic uncertainty would be to align the focus with other safety projects, and QI measures (e.g. blood management, adverse effects etc.).

Biomerieux has published case studies of countries that introduced AMS.[31]

Interventions

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The day-to-day work of the core AMS members is to screen patients' medical records in a prospective audit for some of the following questions, in order of importance:

  • Appropriate antimicrobial choice based on susceptibility, avoiding redundance ?
  • Appropriate dose (mg/kg dosing in children)?
  • Appropriate dosing interval according to age, weight and renal function or drug-drug interaction?
  • Appropriate deescalation of antimicrobials after culture results are final?
  • Appropriate administration route and feasibility of drug conversion from intravenous to by mouth (PO)?

If the answer is no, the team needs to effectively communicate a recommendation, which may be in person or in the medical record.

Further tasks are:

  • Automatic review of the medical record after 72h empiric use, culture results, other laboratory data
  • Advise on appropriate duration of antimicrobial therapy
  • Annual report to administration, calculation of cost savings if any.

Outcomes to measure

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In 2010, two pediatric infectious disease physicians suggested to look at the following variables to judge the outcome of AMS interventions:[32]

  • Annual pharmacy acquisition costs
  • Antibiotic days/1,000 patient days
  • Identifying "drug-bug mismatches"
  • IV to oral conversion
  • Optimal dosing
  • Stopping redundant therapy
  • Reducing adverse events
  • Overall compliance with ASP recommendations

When examining the relationship between an outcome and an intervention, the epidemiological method of time series analysis is preferred, because it accounts for the dependence between time points.[citation needed] A review of 825 studies evaluating any AMS intervention in a community or hospital setting revealed a low overall quality of antimicrobial stewardship studies, most not reporting clinical and microbiological outcome data.[33] A 2014 global stewardship survey identified barriers to the initiation, development and implementation of stewardship programmes internationally.[34]

In 2021, a systematic review was conducted to explore antimicrobial stewardship implementation before and during the COVID-19 pandemic in acute care settings (Elshenawy et al., 2023). It investigates AMS interventions before and during the pandemic, aiming to explore the most common antimicrobial stewardship interventions and outcome measures over the previous 20 years, including the COVID-19 pandemic. The review emphasises the importance of selecting effective strategies to combat antimicrobial resistance. Recommendations include establishing multidisciplinary stewardship teams, prioritizing core strategies initially, and tailoring interventions to local resources. Prospective audits with feedback, antimicrobial guidelines, and measures, such as Procalcitonin-guided prescribing, show promise during the pandemic or crisis. Standardizing measures such as DDD and DOT is crucial for outcome comparison. The integration of Computerized Decision Support Systems is advocated for sustained AMS implementation and preparedness for future crises.[35]

Controversies

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At this time the optimal metrics to benchmark antimicrobial use are still controversial:

  • To measure unit of antimicrobials consumed, one can use 'Days Of Therapy' (DOT) or Defined Daily Dose (DDD). The former is more commonly used in the US, the latter is more commonly used in Europe. The 2016 IDSA/SHEA guidelines recommend the use of DOT.[36]
  • Data source for antimicrobial use: Where available, the electronic Medication Administration Record (eMAR) is the most accurate correlate for doses given, but it may be difficult to analyze, because of hold orders and patient refusal, as opposed to administrative data or pharmacy billing data, which may be easier to obtain.
  • The question of "appropriateness of use" is probably the most controversial. Appropriate use depends on the local antimicrobial resistance profile and therefore has different regional answers. Merely the "amount" of antibiotics used is no straightforward metric for appropriateness.
  • In regard to the most effective AMS intervention, the answer will depend on the size of the institution and the resources available: The system of "prior approval" of antimicrobials by infectious disease or pharmacology consultants has been used first historically. It is very time- and labor-intensive, and prescribers do not like its restrictive character. Increasingly, "post-prescription review" is used.
  • It can be difficult to decide if a clinical syndrome or a particular drug should be targeted for interventions and education.

How to best modify prescriber behavior has been the subject of controversy and research. At issue is how feedback is presented to prescribers, individually, in aggregate, with or without peer comparisons, and whether to reward or punish. As long as the best quality metrics for an AMS program are unknown, a combination of antimicrobial consumption, antimicrobial resistance, and antimicrobial and drug resistant organism related mortality are used.[37]

  • Although education consistently shows improvement in participants' knowledge and attitudes, the results do not always translate to better AMS practice.[38][39]
  • Unintended consequences of antimicrobial stewardship programs may include disagreement of infectious disease specialists with colleagues, jeopardizing provider autonomy and provider efficiency.[22]

See also

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References

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  1. ^ "Antimicrobial Stewardship: A competency-based approach". OpenWHO. Archived from the original on 2024-03-27. Retrieved 2024-03-27.
  2. ^ "California Senate Bill No. 1311". Archived from the original on 2020-04-21.
  3. ^ "Missouri Dept. of Health & Senior Services". Archived from the original on August 10, 2020. Retrieved September 19, 2019.
  4. ^ Dellit TH; et al. (1 January 2007). "Guidelines for Developing an Institutional Program to Enhance Antimicrobial Stewardship". SHEA. Archived from the original on 25 May 2014. Retrieved 9 November 2013.
  5. ^ "Fleming, Alexander: The Penicillin Finder Assays its Future". The New York Times. 25 June 1945. p. 21.
  6. ^ Ruedy, J. (1966). "A method of determining patterns of use of antibacterial drugs". Can Med Assoc J. 95 (16): 807–12. PMC 1935763. PMID 5928520.
  7. ^ Reimann; D'Ambola (1968). "Cost of antimicrobial drugs in a hospital". JAMA. 205 (7): 537. doi:10.1001/jama.205.7.537. PMID 5695313.
  8. ^ "What Is Antibiotic Stewardship?". Thermo Fisher. Archived from the original on 30 June 2022. Retrieved 21 June 2022.
  9. ^ Schollenberg, E.; Albritton WL (1980). "Antibiotic misuse in a pediatric teaching hospital". Can Med Assoc J. 122 (1): 49–52. PMC 1801611. PMID 7363195.
  10. ^ McGowan, JE Jr; Gerding, DN (August 1996). "Does antibiotic restriction prevent resistance?". New Horizon. 4 (3): 370–6. PMID 8856755.
  11. ^ Shlaes, D; et al. (April 1997). "Guidelines for the prevention of antimicrobial resistance in hospitals". Infect Control Hosp Epidemiol. 18 (4): 275–91. doi:10.2307/30141215. JSTOR 30141215. PMID 9131374. S2CID 20368182.
  12. ^ Dellit, TH; Owens, RC; McGowan, JE Jr; Gerding, DN; Weinstein, RA; Burke, JP; Huskins, WC; Paterson, DL; Fishman, NO; Carpenter, CF; Brennan, PJ; Billeter, M; Hooton, TM (2007). "Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship". Clin Infect Dis. 44 (2): 159–177. doi:10.1086/510393. PMID 17173212.
  13. ^ Patel, SJ; Larson EL; Kubin CJ; Saiman L (June 2007). "A review of antimicrobial control strategies in hospitalized and ambulatory pediatric populations". Pediatr Infect Dis J. 26 (6): 531–7. doi:10.1097/inf.0b013e3180593170. PMID 17529873. S2CID 11115250.
  14. ^ Society for Healthcare Epidemiology of America; Infectious Diseases Society of America; Pediatric Infectious Diseases Society (April 2012). "Policy statement on antimicrobial stewardship by the Society for Healthcare Epidemiology of America (SHEA), the Infectious Diseases Society of America (IDSA), and the Pediatric Infectious Diseases Society (PIDS)". Infect Control Hosp Epidemiol. 33 (4): 322–7. doi:10.1086/665010. PMID 22418625.
  15. ^ HICPAC (March 2013). "Updates on NHSN Monitoring of Antimicrobial Use and Resistance" (PDF). Retrieved 1 June 2014.
  16. ^ "Executive Order 13676-Combating Antibiotic-Resistant Bacteria". Obama White House Archives. 18 September 2014. Archived from the original on 23 January 2017. Retrieved September 24, 2019.
  17. ^ "PACCARB". CDC. Archived from the original on November 13, 2019. Retrieved September 25, 2019.
  18. ^ Loria A. Pollack, Arjun Srinivasan (2014). "Core Elements of Hospital Antibiotic Stewardship Programs From the Centers for Disease Control and Prevention". Clin Infect Dis. 59 (suppl 3): S97–S100. doi:10.1093/cid/ciu542. PMC 6521960. PMID 25261548.
  19. ^ Joint Commission (July 2016). "New Antimicrobial Stewardship Standard" (PDF). Joint Commission Perspectives. Vol. 36, no. 7. Archived (PDF) from the original on 2016-09-23. Retrieved 2016-09-22.
  20. ^ "Joint Commission Prepublication Standards – New Requirements Addressing Antimicrobial Stewardship". Archived from the original on October 12, 2019. Retrieved September 19, 2019.
  21. ^ Doernberg, Sarah B; Abbo, Lilian M; Burdette, Steven D; Fishman, Neil O; Goodman, Edward L; Kravitz, Gary R; Leggett, James E; Moehring, Rebekah W; Newland, Jason G; Robinson, Philip A; Spivak, Emily S; Tamma, Pranita D; Chambers, Henry F (2018-09-28). "Essential Resources and Strategies for Antibiotic Stewardship Programs in the Acute Care Setting". Clinical Infectious Diseases. 67 (8): 1168–1174. doi:10.1093/cid/ciy255. ISSN 1058-4838. PMID 29590355. Archived from the original on 2022-08-14. Retrieved 2022-09-06.
  22. ^ a b Durkin, Michael J.; Lake, Jason; Polgreen, Philip M.; Beekmann, Susan E.; Hersh, Adam L.; Newland, Jason G. (2022-04-20). "Exploring unintended consequences of adult antimicrobial stewardship programs: An Emerging Infections Network survey". Infection Control & Hospital Epidemiology. 44 (5): 791–793. doi:10.1017/ice.2022.104. ISSN 0899-823X. PMID 35441586. S2CID 248263512.
  23. ^ CVMA (2008). "CVMA Prudent Use Guidelines 2008 for beef cattle, dairy cattle, poultry, and swine" (PDF).
  24. ^ "Federation of Veterinarians of Europe (FVE) concerned about separating antimicrobial prescribing and supply". Vet. Rec. 15 (171(24)): 609. December 2012. doi:10.1136/vr.e8348. PMID 23248102. S2CID 39298144.
  25. ^ "Core Elements | Antibiotic Stewardship Program". Thermo Fisher Scientific. Archived from the original on 2022-08-16. Retrieved 2022-08-04.
  26. ^ Cosgrove, SE (1975). "Guidance for the knowledge and skills required for antimicrobial stewardship leaders". Infect Control Hosp Epidemiol. 35 (20): 1444–51. doi:10.1016/0006-2952(75)90415-3. PMID 20.
  27. ^ "CDC-Core Elements of Antibiotic Stewardship". 27 July 2021.
  28. ^ Timothy P. Gauthier; Evan Lantz; Alexander Heyliger; Sarah M. Francis; Laura Smith (2014). "Internet-Based Institutional Antimicrobial Stewardship Program Resources in Leading US Academic Medical Centers". Clinical Infectious Diseases. 58 (3): 445–446. doi:10.1093/cid/cit705. PMID 24170198.
  29. ^ Jason G. Newland; Jeffrey S. Gerber; Scott J. Weissman; Samir S. Shah; Chelsea Turgeon; Erin B. Hedican; Cary Thurm; Matt Hall; Joshua Courter; Thomas V. Brogan; Holly Maples; Brian R. Lee; Adam L. Hersh (March 2014). "Prevalence and Characteristics of Antimicrobial Stewardship Programs at Freestanding Children's Hospitals in the United States". Infection Control and Hospital Epidemiology. 35 (3): 265–271. doi:10.1086/675277. PMID 24521592. S2CID 10924837.
  30. ^ Di Bella, Stefano; Beović, Bojana; Fabbiani, Massimiliano; Valentini, Michael; Luzzati, Roberto (2020-07-10). "Antimicrobial Stewardship: From Bedside to Theory. Thirteen Examples of Old and More Recent Strategies from Everyday Clinical Practice". Antibiotics. 9 (7): 398. doi:10.3390/antibiotics9070398. ISSN 2079-6382. PMC 7399849. PMID 32664288.
  31. ^ Be SMART with Resistance Archived 2015-04-02 at the Wayback Machine, Biomerieux, Intern. Newsletter October 2013, 8 pp
  32. ^ Newland, Jason; Adam Hersh (2010). "Purpose and design of antimicrobial stewardship programs in pediatrics". Pediatr Infect Dis J. 29 (9): 862–863. doi:10.1097/INF.0b013e3181ef2507. PMID 20720473.
  33. ^ Schweitzer, V. A.; van Heijl, I.; van Werkhoven, C. H.; Islam, J.; Hendriks-Spoor, K. D.; Bielicki, J.; Bonten, M. J. M.; Walker, A. S.; Llewelyn, M. J.; Consensus on Antimicrobial Stewardship Evaluations (CASE) study group (May 2019). "The quality of studies evaluating antimicrobial stewardship interventions: a systematic review" (PDF). Clinical Microbiology and Infection. 25 (5): 555–561. doi:10.1016/j.cmi.2018.11.002. ISSN 1469-0691. PMID 30472426. Archived (PDF) from the original on 2020-05-05. Retrieved 2019-12-03.
  34. ^ Howard P. et al., ESCMID Study Group for Antimicrobial Policies (ESGAP) & ISC. Group on Antimicrobial Stewardship ECCMID 2013, Berlin Presentation Nr. 24
  35. ^ Abdelsalam Elshenawy, Rasha (10 February 2023). "Antimicrobial stewardship implementation before and during the COVID-19 pandemic in the acute care settings: a systematic review". PMC Public Health Journal. Retrieved 12 March 2024.
  36. ^ Barlam, Tamar F.; Cosgrove, Sara E.; Abbo, Lilian M.; MacDougall, Conan; Schuetz, Audrey N.; Septimus, Edward J.; Srinivasan, Arjun; Dellit, Timothy H.; Falck-Ytter, Yngve T.; Fishman, Neil O.; Hamilton, Cindy W.; Jenkins, Timothy C.; Lipsett, Pamela A.; Malani, Preeti N.; May, Larissa S. (2016-05-15). "Implementing an Antibiotic Stewardship Program: Guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America". Clinical Infectious Diseases. 62 (10): e51–e77. doi:10.1093/cid/ciw118. ISSN 1537-6591. PMC 5006285. PMID 27080992. Archived from the original on 2023-11-05. Retrieved 2023-10-12.
  37. ^ Morris, Brener S, S (2012). "Use of a structured panel process to define quality metrics for antimicrobial stewardship programs". Infect Control Hosp Epidemiol. 33 (5): 500–6. doi:10.1086/665324. PMID 22476277. S2CID 30685714.
  38. ^ Yeung, Eugene Y. H.; Alexander, Megan (2017). "Use of junior doctor-led peer education to improve antibiotic stewardship". British Journal of Clinical Pharmacology. 83 (12): 2831–2832. doi:10.1111/bcp.13375. ISSN 1365-2125. PMC 5698584. PMID 28799275.
  39. ^ MacDougall, Conan; Schwartz, Brian S.; Kim, Lisa; Nanamori, Mari; Shekarchian, Sharmin; Chin-Hong, Peter V. (2017-01-01). "An Interprofessional Curriculum on Antimicrobial Stewardship Improves Knowledge and Attitudes Toward Appropriate Antimicrobial Use and Collaboration". Open Forum Infectious Diseases. 4 (1): ofw225. doi:10.1093/ofid/ofw225. PMC 5414113. PMID 28480231.
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