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Jeffrey Leiden

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Jeffrey Leiden
Born
Glencoe, Illinois
NationalityAmerican
Alma materUniversity of Chicago
Occupation(s)Executive Chairman, Vertex Pharmaceuticals
Organizations
Board member of
Awards
WebsiteJeffrey Leiden

Jeffrey Leiden is an American physician, scientist and businessman who is the executive chairman of Vertex Pharmaceuticals, a biotechnology company based in Boston, Massachusetts.[1] He was initially appointed to the board of directors of the company in 2009 and was CEO and president from February 2012 to March 2020.[2][3]

Early life

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Leiden grew up in Glencoe, a suburb north of Chicago. His mother was a primary school teacher, and his father was a clinical psychologist with a PhD in psychology. He has one sister. His grandparents on his mother’s side were Russian immigrants. At ten years old he learned to scuba dive, and by eleven he was a certified scuba instructor.[4]

Education

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Leiden attended a progressive public school in Glencoe, IL called North School which had a special self-paced learning program. In elementary school Leiden skipped second grade and started the University of Chicago after his junior year at New Trier East High School, at the age of 15.[4]

He received his bachelor's degree in biological sciences at age 18, a Ph.D. in virology at age 21 and his M.D. at age 23 from the University of Chicago, where he later became Chief of Cardiology.[5][4] He was elected to several honors societies, including Phi Beta Kappa and Alpha Omega Alpha.[6] Between 1982 and 1987, Leiden was a clinical fellow in cardiology at the Brigham and Women’s Hospital,the Harvard Medical School and a postdoctoral fellow in medicine at the Dana–Farber Cancer Institute.[7]

Career

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In 1987, Leiden was appointed assistant professor of medicine and assistant investigator in the Howard Hughes Medical Institute at the University of Michigan in Ann Arbor.[8]

In 1992, Leiden moved to the University of Chicago as the Rawson Professor of Medicine and Pathology and chief of the Division of Cardiology.[9]

In 1996, Leiden, along with Elizabeth and Gary Nabel founded Cardiogene, a gene therapy company, which was subsequently acquired by Boston Scientific.[10]

In 1999, Leiden was appointed the Elkin Blout Professor of Biological Sciences at the Harvard School of Public Health and Professor of medicine at the Harvard Medical School.[7]

Leiden moved to Abbott Labs in June 2000, as senior vice president and chief scientific officer. Later that year, he was promoted to president and chief operating officer and oversaw all aspects of the company’s global pharmaceutical business, where he led the development and launch of Kaletra and Humira.[11][12]

In 2006, Leiden joined Clarus Ventures as a managing director.[13] At Clarus, Leiden founded and chaired the boards of Lycera Corporation and Variation Biotechnologies, and served as chairman of the board of TyRx, Inc., which was subsequently acquired by Medtronic (NYSE: MDT).[14]

Vertex

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Leiden served as chairman, president and chief executive officer of Vertex from 2012 to 2020. Under his leadership, Vertex developed and launched Kalydeco, Orkambi, Symdeko and Trikafta – the first medicines to treat the underlying cause of cystic fibrosis.[15] The FDA approved Trikafta on October 21, 2019.[16]

In 2015 Leiden established a collaboration between Vertex and CRISPR Therapeutics that led to the discovery and development of Casgevy, (exagamglogene autotemcel; formerly known as CTX001),[17] the first gene editing treatment to show curative potential for two human genetic diseases, sickle cell disease and beta thalassemia.[18][19][20] Casgevy was approved for use in the UK (November 2023), the United States (January 2024) and Europe, (February 2024.)[21]

In 2015 Vertex shareholders voted to recommend reducing Leiden's compensation from its 2014 estimated figure of US$48.5 million. By 2017 his earnings totaled approximately US$17.3 million.[22] Also under his leadership, Vertex acquired Semma Therapeutics for $950 million in 2019. The company developed stem cell-derived therapies including the experimental cell therapy for Type 1 diabetes known as VX-880.[23][24]

Criticism of Vertex pricing structures for Orkambi, a groundbreaking cystic fibrosis drug costing in the region of US$135,000 to US$270,000[25] per patient per year depending on the patient's country, has resulted in campaigns by concerned parent groups addressed to Leiden.[26][27] Leiden wrote to the UK Prime Minister Theresa May in 2018, suggesting Vertex might consider reducing investment in the UK as a result of the lack of agreement between Vertex and the UK's National Health Service on the pricing of a five-year access agreement for Vertex drugs.[28]

On October 24, 2019, Vertex reached an agreement with NHS England for all currently licensed Vertex cystic fibrosis medicines,[29][30][31] having previously reached similar agreements with countries including Scotland, Ireland and France.[32][33] On June 20, 2024, the National Institute for Health and Care Excellence, (NICE) said in its final draft guidance that Orkambi, Symkevi, and Kaftrio are recommended for the treatment of Cystic Fibrosis, with Vertex coming to a long-term, extended, reimbursement agreement[34] with the NHS.[35][36][37] This final decision differs from its provisional draft guidance from November 2023 that recommended that the three drugs were above the acceptable range of NHS resources in terms of cost effectiveness, despite positive outcomes for Cystic Fibrosis patients.[38]

While Leiden served as chairman, the market capitalization of Vertex Pharmaceuticals increased from $7.74 billion at the beginning of 2012 to $69.97 billion in April 2020.[39]

On April 1, 2020, Leiden transitioned to the role of executive chairman. He was succeeded by Reshma Kewalramani, who was previously the company's chief medical officer. Leiden currently serves as executive chairman.[40][41][42]

Boards and awards

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He is an elected member of the National Academy of Medicine, the American Academy of Arts and Sciences, the American Society for Clinical Investigation and the Association of American Physicians.[43][44] He currently serves as a lead independent director [45] of the Massachusetts Mutual Life Insurance Company, and was the former vice chairman of Shire Pharmaceuticals and was formerly a director of PathAI, Millennium Pharmaceuticals, Abbott Labs, Quest Diagnostics, and TAP Pharmaceuticals.[7][46] Leiden is also the chairman of Casana, a home health monitoring company.[47] In May 2022 Leiden was appointed as Chairman of the Board of Odyssey Therapeutics, a company developing novel medicines for cancer and auto-immune disease.[48]

Leiden was named a Crain’s Chicago Business 40 Under 40 in 1994; and served as a member of the NHLBI Board of Scientific Counselors between 1994 and 1999.[7][49] In 2000, he was president of the American Society for Clinical Investigation.[50]

In 2017, Ernst and Young named Leiden an Entrepreneur of the Year in Life Sciences.[51] In 2018, the Massachusetts Biotechnology Council awarded Leiden the Henri A. Termeer Innovative Leadership Award; and the Greater Boston Chamber of Commerce named Leiden to the Academy of Distinguished Bostonians.[52][53] Leiden was also named one of Boston Business Journal’s Power 50 for several years, including most recently in 2022.[54][55] In 2018 and 2020, he was named as part of Boston Magazine’s 100 Most Influential People in Boston[56] and was honored as a New Englander of the Year by the New England Council.[57][58] In 2018 he was named “Best Biopharma CEO” by STAT News.[59] In December 2020 Jeffrey Leiden was honored with the Forbes Lifetime Achievement in BioPharma Award at the 2020 Forbes Healthcare Summit.[60]

Leiden also served in 2016 as co-chairman of the Massachusetts’s Governor’s Digital Healthcare Council;[61] is a member of the Governor's Task Force on Artificial Intelligence;[62][63][64] and the Governor’s STEM Advisory Council.[65]

In 2018 he was honored with the "New Englander of the Year Award" by the New England Council.[66][67]

Leiden was ranked 13th on Forbes' list of most innovative leaders for 2019, the highest-ranking leader in the healthcare/biotech sector.[68]

He is trustee of the Boston Symphony Orchestra.[69]

Leiden is a member of the MIT Presidential CEO Advisory Board.[70]

In November 2022 Leiden was named as one of several strategic advisors for the newly launched Life Sciences Private Capital, a private equity division of J.P. Morgan.[71]

He is a director of the Massachusetts Competitive Partnership (MACP) and previously served as chair from January 2020 to December 2022.[72][73]

Philanthropy

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In December 2017, Leiden and his wife Lisa established a professorship in translational medicine at the Brigham and Women’s Hospital and Harvard Medical School.[74] The Leidens are also major donors to the Museum of Fine Arts, Boston, Ariadne Labs and the Bottom Line Foundation.[12][75]

References

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  1. ^ Joe Carlson (December 16, 2011). "Vertex names Leiden incoming CEO". Modern Healthcare.
  2. ^ "Jeffrey Leiden M.D., Ph.D. and Dennis Winger Join Vertex Pharmaceuticals Incorporated's Board of Directors". Biospace. July 8, 2009.
  3. ^ "Jeffrey "Jeff" Leiden Chairman/President/CEO, Vertex Pharmaceuticals Inc". Bloomberg L.P. Retrieved May 12, 2018.
  4. ^ a b c "First Rounders podcast: Jeffrey Leiden". Nature Biotechnology. 36 (3): 224. 2018-03-06. doi:10.1038/nbt.4087. ISSN 1546-1696. PMID 29509728.
  5. ^ Arsenio Oloroso Jr. (September 24, 1994). "Jeffrey M. Leiden Section Chief of Cardiology University of Chicago Medical Center". Crain's Chicago Business.
  6. ^ "Medicine on the Midway – Spring 2019". issuu. Retrieved 2019-07-02.
  7. ^ a b c d "Executive Profile Jeffrey Marc Leiden". Bloomberg L.P. Retrieved May 11, 2018.
  8. ^ Hoffman, Michelle (December 6, 1991). "Putting new muscle into gene therapy". Science. 254 (5037): 1455–1456. Bibcode:1991Sci...254.1455H. doi:10.1126/science.1962203. PMID 1962203.
  9. ^ Emily Mullin. "Jeffrey Leiden—Vertex Pharmaceuticals". FierceBiotech. Retrieved May 10, 2018.
  10. ^ "Ins and Outs of Cardiovascular Gene Therapy; Cardiogene: The Insuide; Eurogene: The Outside". BioCentury. September 29, 1997.
  11. ^ "Harvard cardiologist Jeffrey Leiden elected new chief scientific officer at Abbott Laboratories". Medscape. June 16, 2000.
  12. ^ a b "Jeffrey Leiden, M.D., Ph.D." Vertex Pharmaceuticals. Retrieved May 10, 2018.
  13. ^ "Dr. Jeffrey Leiden Joins Clarus Ventures As Partner". Biospace. November 1, 2006.
  14. ^ "Jeffrey Leiden M.D., Ph.D. and Dennis Winger Join Vertex Pharmaceuticals' Board of Directors". Evaluate. July 7, 2009.
  15. ^ Matthew Herper (August 8, 2017). "For Vertex Pharmaceuticals, Can One Billion-Dollar Breakthrough Beget Another?". Forbes.
  16. ^ Commissioner, Office of the (2019-10-24). "FDA approves new breakthrough therapy for cystic fibrosis". FDA. Retrieved 2019-10-25.
  17. ^ Shapiro, Lindsey (17 May 2024). "Casgevy (exagamglogene autotemcel) for sickle cell disease". Sickle Cell Disease News.
  18. ^ "1st Patients To Get CRISPR Gene-Editing Treatment Continue To Thrive". NPR.org. Retrieved 2021-02-23.
  19. ^ "Vertex reveals promising data from first CRISPR-treated patients". PMLive. 2019-11-20. Retrieved 2021-02-23.
  20. ^ Smith, Jonathan (2019-06-07). "CRISPR Therapeutics and Vertex Pharmaceuticals Seal Deal Worth up to €890M". Labiotech.eu. Retrieved 2021-02-23.
  21. ^ Barrie R (13 February 2024). "CRISPR gene therapy Casgevy secures approval in Europe". Pharmaceutical Technology.
  22. ^ "BRIEF-Vertex Pharma CEO's FY 2017 Total Compensation $17.3 Mln". Reuters. 2018-04-17. Retrieved 2019-05-29.
  23. ^ Gelman, Max (29 January 2021). "The diabetes 'cure' Vertex acquired in its 2019 Semma buyout? It's headed to the clinic". Endpoints News.
  24. ^ Bell, Jacob (10 March 2021). "Vertex begins human testing for diabetes cell therapy". BiopharmaDive.
  25. ^ Thomas, Katie (2018-06-24). "A Drug Costs $272,000 a Year. Not So Fast, Says New York State". The New York Times. ISSN 0362-4331. Retrieved 2019-02-03.
  26. ^ Boseley S, ed. (2019-02-03). "Cystic fibrosis: the patients facing shorter lives due to drug's expense". The Guardian. ISSN 0261-3077. Retrieved 2019-02-03.
  27. ^ "CF Support Group | Letter to Dr Jeffrey Leiden". CF Support Group. Retrieved 2019-02-03.
  28. ^ "Orkambi: Drugs maker says NHS 'undervalues' patient lives". Sky News. Retrieved 2019-02-03.
  29. ^ "Vertex, NHS England and NICE finally reach agreement for Orkambi". PMLive. 2019-10-24. Retrieved 2019-10-25.
  30. ^ "Vertex and the U.K. reach a deal for cystic fibrosis medicines". STAT. 2019-10-24. Retrieved 2019-10-25.
  31. ^ "Cystic fibrosis drug deadlock 'must end'". 2019-02-04. Retrieved 2019-05-07.
  32. ^ Bruce, Francesca. "Vertex Inks New Cystic Fibrosis Deals In Europe". Pink Sheet. Retrieved 3 April 2022.
  33. ^ "Landmark NHS deal to open up access to life-changing cystic fibrosis drug". NHS. Retrieved 3 April 2022.
  34. ^ Manalac, Tristan (21 June 2024). "Vertex Finally Reaches Pricing Deal With England's NHS for Cystic Fibrosis Drugs". BioSpace.
  35. ^ Furlong, Ashleigh (20 June 2024). "Vertex Reaches Pricing Deal With NHS for Cystic Fibrosis Drugs". Bloomberg.
  36. ^ Silverman, Ed (20 June 2024). "Vertex reaches a new deal with NHS England over its pricey cystic fibrosis treatments". STAT.
  37. ^ Inácio, Patricia (26 June 2024). "3 CFTR modulators guaranteed public reimbursement in England". Cystic Fibrosis News Today.
  38. ^ Lipanovic, David (2023-11-14). "NICE does not recommend three cystic fibrosis drugs in draft guidance". The Pharmaceutical Journal. Retrieved 2024-02-25.
  39. ^ Doler, Kathleen (16 July 2020). "How A Medical Brainiac CEO Turned Brilliance Into Billions".
  40. ^ DeAngelis, Allison (25 July 2019). "Vertex CEO Jeff Leiden to step down". www.bizjournals.com. Retrieved 2019-07-31.
  41. ^ "Vertex's Reshma Kewalramani takes CEO post as longtime vet Jeff Leiden moves to new role". Endpoints News. Retrieved 2020-04-02.
  42. ^ "Vertex Pharmaceuticals Incorporated Form 10-K". Retrieved 3 April 2022.
  43. ^ "Keynote Speakers". Massachusetts Institute of Technology. February 22, 2013.
  44. ^ Pray, Leslie (August 14, 2007). Understanding the Benefits and Risks of Pharmaceuticals. National Academies Press. ISBN 9780309179768.
  45. ^ "Corporate Governance". MassMutual. 2024.
  46. ^ "STEM Council Co-Chairs". Massachusetts Department of Higher Education. Retrieved May 20, 2018.
  47. ^ Jennings, Katie. "This Smart Toilet Seat Might Save Your Life One Day". Forbes. Retrieved 2021-02-11.
  48. ^ "Odyssey Therapeutics:News". odysseytx.com/news. 24 May 2022.
  49. ^ "40 Under 40 historical archive". Crain's Chicago Business. July 9, 2014.
  50. ^ "The American Society for Clinical Investigation". Retrieved 2019-07-15.
  51. ^ "EY Announces Winners for the Entrepreneur Of The Year® 2017 New England Award". Ernst & Young. June 28, 2017.
  52. ^ "MassBio to Honor Dr. Jeffrey Leiden with Henri A. Termeer Innovative Leadership Award". MassBio. March 6, 2018.
  53. ^ "With $500m initiative, Baker is a biotech holdout no longer". Boston Globe. June 21, 2017.
  54. ^ "Meet the 2022 Boston Business Journal Power 50 Movement Makers". Boston Business Journal. 16 November 2022.
  55. ^ "Meet the 2018 Boston Business Journal Power 50". Boston Business Journal. October 9, 2018.
  56. ^ "Power List: The 100 Most Influential Bostonians". Boston Magazine. 28 April 2020. Retrieved 2020-05-05.
  57. ^ "2018 New Englanders of the Year Announced". The New England Council. Retrieved November 18, 2018.
  58. ^ "The 100 Most Influential People in Boston". Boston Magazine. April 24, 2018.
  59. ^ "Leiden victorious in best biopharma CEO tally; Alles tops worst list". STAT. 2018-12-18. Retrieved 2019-07-02.
  60. ^ "A Tribute to Jeffrey Leiden: Forbes Lifetime Achievement in BioPharma Award | 2020 Forbes Healthcare Summit". Forbes. Retrieved 2020-12-15.
  61. ^ Wood, Colin (22 November 2016). "Massachusetts announces Digital Healthcare Council". Statescoop.
  62. ^ Solis, Steven (14 February 2024). "Massachusetts taps tech leaders, Boston officials for AI task force". Axios.
  63. ^ "Massachusetts Establishes Task Force to Scale AI Adoption in the State". cdo magazine. 7 March 2024.
  64. ^ "Governor Healey Signs Executive Order Establishing Artificial Intelligence (AI) Strategic Task Force". Mass.gov. 14 February 2024.
  65. ^ "Healey-Driscoll Administration Announces 2024 STEM Summit". Mass.gov. 22 April 2024.
  66. ^ "The New England Council Annual Dinner 2018". Conventures. 2018.
  67. ^ "New England Council hosts annual New Englander of the Year awards". Bill Bret Boston. 13 October 2018.
  68. ^ "America's Most Innovative Leaders". Forbes. Retrieved 2019-09-10.
  69. ^ "Boston Symphony Orchestra concert program, Subscription Series, Season 139 (2019–2020), Week 6, page 5". collections.bso.org. Retrieved 2020-05-05.
  70. ^ "Jeffrey Leiden, M.D., Ph.D." Vertex.
  71. ^ Bayer, Max (3 November 2022). "J.P. Morgan's new life sciences private equity arm will be hottest ticket at firm's upcoming conference". Fierce Biotech.
  72. ^ "MACP". masscompetes.org.
  73. ^ "Jeffrey Leiden, MD, PhD". Vrtx.com.
  74. ^ "Bench to Bedside". Harvard Medical School. November 1, 2017.
  75. ^ "The Future is Now: New Investments". Museum of Fine Arts, Boston. Retrieved May 24, 2018.
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