Xiao Wang

Xiao Wang
Alma mater	Peking University, University of Chicago
Scientific career
Fields	Chemistry
Institutions	Massachusetts Institute of Technology
Academic advisors	Chuan He
Website	www.wangxiaolab.org

Xiao Wang is a Thomas D. and Virginia W. Cabot Professor at MIT in the Department of Chemistry. She is the first Core Member of the Broad Institute with an academic appointment in the Department of Chemistry at MIT. Her work focuses on designing and producing new tools and methods for analyzing the brain.

Education and career

Wang studied at Peking University and received her B.S. in chemistry and molecular engineering in 2010. At Peking University she studied with Professor Jian Pei working on fluorescent organic materials. In 2015 she received her Ph.D. from the University of Chicago where she worked with Chuan He on elucidating the cellular functions of RNA modifications. While at the University of Chicago, Wang was awarded the Chinese Government Award for Outstanding Self-Financed Students Abroad and the Elizabeth R. Norton Prize for Excellence in Research in Chemistry. She was a postdoctoral fellow of the Life Sciences Foundation at Stanford University. She worked with Karl Deisseroth at Stanford and "developed comprehensive methods for analyzing RNA in intact tissues that merge sequencing with imaging, in order to reveal the locations of various cell types in the brain and to find out how these cells are connected."

Wang became an assistant professor at MIT in 2019 and the Wang Lab at MIT opened on August 1, 2019. In 2020 she was awarded a Searle Scholars Program grant.

Selected publications

1. J Liu*, Y Kim*, C E Richardson*, A Tom*, C Ramakrishnan, F Birey, T Katsumata, S Chen, C Wang, X Wang, L M Joubert, Y Jiang, H Wang, L E Fenno, J B H Tok, S P Pașca, K Shen, Z Bao#, K Deisseroth#. Genetically targeted chemical assembly of functional materials in living cells, tissues, and animals. Science 2020, 367(6484), pp. 1372-1376.
2. Y Liu*, J Liu*, S Chen, T Lei, Y Kim, S Niu, H Wang, X Wang, A M Foudeh, J B-H Tok, Z Bao#. Soft and elastic hydrogel-based microelectronics for localized low-voltage neuromodulation. Nature Biomedical Engineering 2019, 3, 58–68.
3. X Wang*, W E Allen*, M Wright, E Sylwestrak, N Samusik, S Vesuna, K Evans, C Liu, C Ramakrishnan, J Liu, G P Nolan#, F-A Bava#, K Deisseroth#. Three-dimensional intact-tissue-sequencing of single-cell transcriptional states. Science 2018, eaat5691.
4. I A Roundtree, G-Z Luo, Z Zhang, X Wang, T Zhou, Y Cui, J Sha, X Huang, L Guerrero, P Xie, E He, B Shen#, C He#. YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs. elife 2017,6, e31311
5. H Shi*, X Wang*, Z Lu, B S Zhao, H Ma, P J Hsu, C He#. YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA. Cell Research 2017, 27, 315.
6. B S Zhao*, X Wang*, A V Beadell*, Z Lu, H Shi, A Kuuspalu, R K Ho#, C He#. m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition. Nature 2017, 542, 475.
7. X Wang*, B S Zhao*, I A Roundtree, Z Lu, D Han, H Ma, X Weng, K Chen, H Shi, C He#. N6-methyladenosine modulates messenger RNA translation efficiency. Cell 2015, 161, 1388.