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Lin Tian

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Lin Tian
OccupationScientific Director
Academic background
Alma materNorthwestern University
Academic work
DisciplineNeuroscience
InstitutionsMax Planck Florida Institute for Neuroscience

Lin Tian is a Chinese-American neuroscientist and biochemist. She is a Scientific Director of the Max Planck Florida Institute for Neuroscience in Jupiter, FL, and was formerly a professor in the Department of Biochemistry and Molecular Medicine at the University of California, Davis.[1] Tian is known for her research in the fields of neuroscience and biochemical engineering. She develops and applies molecular tools to understand brain function and dysfunction at the individual, neuronal level.

Early life and education

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Tian received her Ph.D. in biochemistry, Molecular and Cellular Biology at Northwestern University, where she studied the mechanism of protein processing by the proteasome. Her graduate advisor was Andreas Matouschek.[2]

From 2007 to 2009, Tian was a postdoctoral scholar at the Howard Hughes Medical Institute's (HHMI) Janelia Research Campus, working with Loren Looger and Karel Svoboda.[3] During this time, Tian began her work on the development of tools for enhanced neuronal imaging and cell-specific labeling.[4] She created protein-based tools, including improved GCaMP indicators, for studying and manipulating the brain and other biological samples.[5]

Career and research

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Tian started her lab at UC Davis in 2012 as an assistant professor, later becoming a Professor and Vice Chair.[6][7] In October 2023, she became a Scientific Director at the Max Planck Florida Institute for Neuroscience.[1][8]

Tian is best known for creating a new classes of genetically encoded indicators for detecting neurotransmitters and neuromodulators, such as serotonin and dopamine.[9][10] She and her team use molecular scaffolds and computational modeling to create the biosensors, which can dynamically map neurotransmitter flow in the brain.[11] These tools are distributed through UNC NeuroTools[12] and Addgene.[13] Her work has implications for drug discovery, aiding in the identification of new therapeutic targets.[14]

She also worked with David E. Olson and developed a method to identify the hallucinogenic potential of psychedelic compounds.[15][16] They engineered psychLight5, a “sensor that glows in the presence of a hallucinogenic compound when it interacts with a serotonin receptor."[15] In 2024, her lab released a new series of opioid sensors.[17]

Awards and honors

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References

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  1. ^ a b "Internationally recognized leader in biosensor development to join Max Planck Florida". EurekAlert!. Retrieved 2024-03-30.
  2. ^ "Lin". groups.molbiosci.northwestern.edu. Retrieved 2024-03-30.
  3. ^ "Neurotree - Lin Tian Family Tree". neurotree.org. Retrieved 2024-03-30.
  4. ^ Tian, Lin; Yang, Yunlei; Wysocki, Laura M.; Arnold, Alma C.; Hu, Amy; Ravichandran, Balaji; Sternson, Scott M.; Looger, Loren L.; Lavis, Luke D. (2012-03-27). "Selective esterase–ester pair for targeting small molecules with cellular specificity". Proceedings of the National Academy of Sciences. 109 (13): 4756–4761. Bibcode:2012PNAS..109.4756T. doi:10.1073/pnas.1111943109. ISSN 0027-8424. PMC 3323987. PMID 22411832.
  5. ^ Tian, Lin; Hires, S. Andrew; Mao, Tianyi; Huber, Daniel; Chiappe, M. Eugenia; Chalasani, Sreekanth H.; Petreanu, Leopoldo; Akerboom, Jasper; McKinney, Sean A.; Schreiter, Eric R.; Bargmann, Cornelia I.; Jayaraman, Vivek; Svoboda, Karel; Looger, Loren L. (2009-11-08). "Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators". Nature Methods. 6 (12): 875–881. doi:10.1038/nmeth.1398. ISSN 1548-7105. PMC 2858873. PMID 19898485.
  6. ^ "Lin Tian, UC Davis". foundry.lbl.gov. Retrieved 2024-03-30.
  7. ^ Lee, Gabriela M. (2021-01-13). "Lin Tian, PhD | Neuroengineering at UC Davis". neuroengineering.ucdavis.edu. Retrieved 2024-03-30.
  8. ^ "Tian Lab – Max Planck Florida Institute for Neuroscience". mpfi.org. Retrieved 2024-03-30.
  9. ^ "Video: Nanosensors shine a light on brain chemistry". Chemical & Engineering News. Retrieved 2024-03-30.
  10. ^ "Optical Probes Allow Ultrafast, High-Resolution Imaging of Dopamine Activity". www.photonics.com. Retrieved 2024-03-30.
  11. ^ Patriarchi, Tommaso; Cho, Jounhong Ryan; Merten, Katharina; Howe, Mark W.; Marley, Aaron; Xiong, Wei-Hong; Folk, Robert W.; Broussard, Gerard Joey; Liang, Ruqiang; Jang, Min Jee; Zhong, Haining; Dombeck, Daniel; von Zastrow, Mark; Nimmerjahn, Axel; Gradinaru, Viviana (2018-06-29). "Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors". Science. 360 (6396). doi:10.1126/science.aat4422. ISSN 0036-8075. PMC 6287765. PMID 29853555.
  12. ^ "Tian Lab AAV Expression Vectors and Stock AAV Preps". Neurotools. Retrieved 2024-03-30.
  13. ^ "Addgene: Lin Tian Lab Materials". www.addgene.org. Retrieved 2024-03-30.
  14. ^ "AI-designed serotonin sensor may help scientists study sleep and mental health". National Institutes of Health (NIH). 2020-12-23. Retrieved 2024-03-30.
  15. ^ a b Grover, Natalie (2021-04-28). "Non-hallucinogenic psychedelics: scientists close in on compound". The Guardian. ISSN 0261-3077. Retrieved 2024-03-30.
  16. ^ Dong, Chunyang; Ly, Calvin; Dunlap, Lee E.; Vargas, Maxemiliano V.; Sun, Junqing; Hwang, In-Wook; Azinfar, Arya; Oh, Won Chan; Wetsel, William C.; Olson, David E.; Tian, Lin (2021-04-28). "Psychedelic-inspired drug discovery using an engineered biosensor". Cell. 184 (10): 2779–2792.e18. doi:10.1016/j.cell.2021.03.043. ISSN 0092-8674. PMC 8122087. PMID 33915107.
  17. ^ Dong, Chunyang; Gowrishankar, Raajaram; Jin, Yihan; He, Xinyi Jenny; Gupta, Achla; Wang, Huikun; Sayar-Atasoy, Nilüfer; Flores, Rodolfo J.; Mahe, Karan; Tjahjono, Nikki; Liang, Ruqiang; Marley, Aaron; Or Mizuno, Grace; Lo, Darren K.; Sun, Qingtao (2024-07-15). "Unlocking opioid neuropeptide dynamics with genetically encoded biosensors". Nature Neuroscience: 1–14. doi:10.1038/s41593-024-01697-1. ISSN 1546-1726.
  18. ^ Fell, Andy (2022-03-07). "UC Davis Wins 2 Awards From the W.M. Keck Foundation". UC Davis. Retrieved 2024-03-30.
  19. ^ Patriarchi, Tommaso; Mohebi, Ali; Sun, Junqing; Marley, Aaron; Liang, Ruqiang; Dong, Chunyang; Puhger, Kyle; Mizuno, Grace Or; Davis, Carolyn M.; Wiltgen, Brian; von Zastrow, Mark; Berke, Joshua D.; Tian, Lin (2020-09-07). "An expanded palette of dopamine sensors for multiplex imaging in vivo". Nature Methods. 17 (11): 1147–1155. doi:10.1038/s41592-020-0936-3. ISSN 1548-7105. PMC 8169200. PMID 32895537.
  20. ^ "Lin Tian". Rita Allen Foundation. 2016-08-09. Retrieved 2024-03-30.
  21. ^ "Project Details". NIH RePORTER. Retrieved 2024-03-30.
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