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Ray Iles

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Professor Ray Isles working in his laboratory.
Iles working in his laboratory

Ray Kruse Iles is a biomedical scientist who was head of the Williamson Laboratory for Molecular Oncology at St Bartholomew's Hospital in London.[1]

Career

[edit]

Iles has a particular interest in the interface between rational processing, emotional motivation and endocrinology.[2]

He co-founded the ELK-Health Foundation, with psychotherapist Tadhg Ó Séaghdha, in 2004. The ELK-Foundation Health (named after Iles's father, Eric Leonard Kruse) is now the National Institutes for Stress, Anxiety and Depression (NISAD), centred in Lund, Sweden. It still uses the ELK-Health name in its programmes and clinics, which support people needing to change habits that harm their physical and emotional health.

Iles's interest in women's and reproduction health led him, in 2011, to become the founding director of the biomarker diagnostic company MAPSciences.[3]

Iles is the inventor of new diagnostic technology, six clinical screening tests for pregnancy disorders and Downs Syndrome/prenatal diagnosis,[4][5][6][7][8][9] haemoglobinopathies, thalassemia,[10] and diabetes,[11] and two cancer-related patents.[12][13]

His academic career, after leaving St Bartholomew's, included being Professor of Biomedical Science at Middlesex University heading a Biomedical Science Research Facility, which incorporated molecular pathology, bio-modelling/bioinformatics and environmental health,[14][15] and then Anglia Ruskin University.[16]

Formerly a regular contributor to Kumar and Clark's Clinical Medicine,[17] Iles left academia to concentrate on the two organisations that he co-founded, NISAD and MapSciences.

In 2012, with Suzanne Docherty, he published the textbook Biomedical Science: Essential Laboratory Medicine.[5]

NISAD has supported several research projects of Iles and his students in bioanalysis,[18] cancer research,[19][20] fertility[21] and prenatal care and child development.[22][23][24]

In 2019 Iles became founding dean at Abu Dhabi University’s College of Health Sciences. In July 2020 he became Visiting Professor at the Laboratory of Viral Zoonotics, University of Cambridge.[25]

Personal life

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As a boy Iles attended Mellow Lane Comprehensive School in Hayes, Middlesex.[26]

His cousin is the UK Olympic fencer Richard Kruse, which was the subject of the BBC Radio programme Tracing your Roots.[25]

References

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  1. ^ Cole, Laurence A.; Butler, Stephen A. (17 February 2020). 100 Years of Human Chorionic Gonadotropin: Reviews and New Perspectives. ISBN 9780128200506.
  2. ^ "Ray Kruse Iles | BSc MSc PhD CBiol FRSB FRSC | College of Health Sciences". ResearchGate. Retrieved 2019-09-16.
  3. ^ "MAP Sciences | Team".
  4. ^ US 6025149, Cuckle, Howard S.; GB & GB, Raymond K., "Urinary screening for down syndrome and other aneuploidies", issued February 15, 2000 
  5. ^ a b "Espacenet - Bibliographic data". worldwide.espacenet.com. Retrieved 2019-02-28.
  6. ^ "Espacenet - Bibliographic data". worldwide.espacenet.com. Retrieved 2019-02-28.
  7. ^ "Espacenet - Bibliographic data". worldwide.espacenet.com. Retrieved 2019-02-28.
  8. ^ "Espacenet - Bibliographic data". worldwide.espacenet.com. Retrieved 2019-02-28.
  9. ^ "Espacenet - Bibliographic data". worldwide.espacenet.com. Retrieved 2019-02-28.
  10. ^ "United States Patent Application: 0190069352". appft.uspto.gov. Retrieved 2019-02-28.
  11. ^ US RE47260, Zhao, Qianglin Quintin & Chen, Huaimo, "System and method for point to multipoint inter-domain MPLS traffic engineering path calculation", issued February 26, 2019 
  12. ^ "Espacenet - Bibliographic data". worldwide.espacenet.com. Retrieved 2019-02-28.
  13. ^ "Espacenet - Bibliographic data". worldwide.espacenet.com. Retrieved 2019-02-28.
  14. ^ "Middlesex University Centre for Investigative & Diagnostic Oncology".
  15. ^ Brunswick, Nicola; McDougall, Sine; Davies, Paul de Mornay (10 June 2010). Reading and Dyslexia in Different Orthographies. ISBN 9781135167813.
  16. ^ Iles, Raymond; Docherty, Suzanne (29 November 2011). Biomedical Sciences: Essential Laboratory Medicine. ISBN 9781119962410.
  17. ^ "Espacenet - Bibliographic data". worldwide.espacenet.com. Retrieved 2019-02-28.
  18. ^ Trivedi, Drupad K.; Iles, Ray K. (November 2014). "Do not just do it, do it right: urinary metabolomics -establishing clinically relevant baselines: Choosing correct tools for shotgun urinary metabolomics". Biomedical Chromatography. 28 (11): 1491–1501. doi:10.1002/bmc.3219. PMID 24788800.
  19. ^ Iles, R.K. (January 2007). "Ectopic hCGβ expression by epithelial cancer: Malignant behaviour, metastasis and inhibition of tumor cell apoptosis". Molecular and Cellular Endocrinology. 260–262: 264–270. doi:10.1016/j.mce.2006.02.019. ISSN 0303-7207. PMID 17069968. S2CID 21216536.
  20. ^ Butler, Stephen A.; Staite, Edyta M.; Iles, Ray K. (2003-01-01). "Reduction of Bladder Cancer Cell Growth in Response to hCGβ CTP37 Vaccinated Mouse Serum". Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics. 14 (2): 93–100. doi:10.3727/000000003108748649. ISSN 0965-0407. PMID 14649543.
  21. ^ Butler, Stephen A.; Luttoo, Jameel; Freire, Maísa O. T.; Abban, Thomas K.; Borrelli, Paola T. A.; Iles, Ray K. (September 2013). "Human Chorionic Gonadotropin (hCG) in the Secretome of Cultured Embryos: Hyperglycosylated hCG and hCG-Free Beta Subunit Are Potential Markers for Infertility Management and Treatment". Reproductive Sciences. 20 (9): 1038–1045. doi:10.1177/1933719112472739. ISSN 1933-7191. PMID 23439616. S2CID 25291112.
  22. ^ Trivedi, Drupad K.; Iles, Ray K. (August 2015). "Shotgun metabolomic profiles in maternal urine identify potential mass spectral markers of abnormal fetal biochemistry - dihydrouracil and progesterone in the metabolism of Down syndrome: Maternal urinary metabolomics markers of Down syndrome". Biomedical Chromatography. 29 (8): 1173–1183. doi:10.1002/bmc.3404. PMID 25545476.
  23. ^ Iles, Ray; Cole, Laurence; Butler, Stephen (2014-06-05). "Direct Analysis of hCGβcf Glycosylation in Normal and Aberrant Pregnancy by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry". International Journal of Molecular Sciences. 15 (6): 10067–10082. doi:10.3390/ijms150610067. ISSN 1422-0067. PMC 4100140. PMID 24905406.
  24. ^ Butler, Stephen A.; Abban, Thomas K.A.; Borrelli, Paola T.A.; Luttoo, Jameel M.; Kemp, Bryn; Iles, Ray K. (September 2013). "Single point biochemical measurement algorithm for early diagnosis of ectopic pregnancy". Clinical Biochemistry. 46 (13–14): 1257–1263. doi:10.1016/j.clinbiochem.2013.06.019. PMID 23830901.
  25. ^ a b "Ray Iles". ResearchGate. Retrieved 13 February 2023.
  26. ^ @Schleswigboy (5 July 2020). "Didn't realise that I was from one of the two first ever Comprehensive schools. Streamed b…" (Tweet) – via Twitter.
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