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Kathryn Moore

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Kathryn J. Moore
Alma materMcGill University
Known forAtherosclerosis
AwardsNational Institutes of Health R35 Outstanding Investigator Award

Fellow of the National Academy of Sciences

American Heart Association Distinguished Scientist Award
Scientific career
FieldsAtherosclerosis and Inflammation
InstitutionsHarvard Medical School
New York University Langone Medical Center
ThesisRegulation of macrophage function during intracellular infection with Leishmania donovani. (1994)
Doctoral advisorGreg Matlashewski
Websitehttps://kathrynmoorelab.com/

Kathryn J. Moore is a Canadian-born American biomedical scientist and cell biologist. She is the Jean and David Blechman Professor of Cardiology and the founding director of the Cardiovascular Research Center[1] at the New York University Grossman School of Medicine. Moore's research considers the pathogenesis of atherosclerosis, with a focus on the identification of novel therapeutic targets. She was elected Fellow of the National Academy of Sciences in 2021.[2]

Early life and education

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Kathryn Moore was born in Montreal, Quebec, Canada, where she attended McGill University. Moore studied microbiology, receiving her BSc (Distinction) from McGill University in 1989. She remained there for graduate studies, studying mechanisms by which the intracellular pathogen Leishmania donovani subverts macrophage microbicidal functions,[3][4][5] under the Canadian immunologist Greg Matlashewski. Moore was awarded her PhD in parasitology in 1994.[6]

Research and career

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Moore joined the Harvard Medical School faculty as an Instructor in Medicine in 1999 and was promoted to Assistant Professor in 2002. Her early research focused on innate immune mechanisms of chronic inflammation in age-related diseases such as atherosclerosis and Alzheimer’s Disease.[7][8]

In 2009, Moore was recruited to the New York University Langone Medical Center, where she continued to focus on origins of cardiovascular and metabolic diseases, in particular the roles that chronic inflammation and lipid dysregulation play in these processes.[9] She contributed to seminal studies showing that cholesterol crystals in atherosclerotic plaques cause lysosomal damage that activates the NLRP3 inflammasome to promote the maturation and release of interleukin-1b.[8]

Awards and honors

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References

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  1. ^ "Cardiovascular Research Center". NYU Langone Health. Retrieved 2022-11-02.
  2. ^ a b "2021 NAS Election". www.nasonline.org. Retrieved 2021-05-03.
  3. ^ Moore, K. J.; Labrecque, S.; Matlashewski, G. (1993-05-15). "Alteration of Leishmania donovani infection levels by selective impairment of macrophage signal transduction". Journal of Immunology (Baltimore, Md.: 1950). 150 (10): 4457–4465. ISSN 0022-1767. PMID 8482844.
  4. ^ Moore, K. J.; Turco, S. J.; Matlashewski, G. (Jan 1994). "Leishmania donovani infection enhances macrophage viability in the absence of exogenous growth factor". Journal of Leukocyte Biology. 55 (1): 91–98. doi:10.1002/jlb.55.1.91. ISSN 0741-5400. PMID 8283144.
  5. ^ Moore, K. J.; Matlashewski, G. (1994-03-15). "Intracellular infection by Leishmania donovani inhibits macrophage apoptosis". Journal of Immunology (Baltimore, Md.: 1950). 152 (6): 2930–2937. ISSN 0022-1767. PMID 8144893.
  6. ^ "Kathryn J. Moore". National Academy of Sciences Member Directory. Retrieved 5 May 2023.
  7. ^ a b "EMF: New Scholar Award in Aging: Kathryn J. Moore Ph.D." www.ellison-med-fn.org. Retrieved 2022-11-04.
  8. ^ a b "New way discovered to block inflammation". ScienceDaily. Retrieved 2024-07-31.
  9. ^ "Kathryn J. Moore". med.nyu.edu. Retrieved 2024-07-31.
  10. ^ "Claflin Distinguished Scholars Past Recipients". MGH Executive Committee On Research. Retrieved 2022-11-04.
  11. ^ "ATVB Special Recognition Awards". professional.heart.org. Retrieved 2022-11-04.
  12. ^ "Jeffrey M. Hoeg Arteriosclerosis, Thrombosis, and Vascular Biology Award for Basic Science and Clinical Research". professional.heart.org. Retrieved 2022-11-04.
  13. ^ "Professional Heart Daily". professional.heart.org. Retrieved 2023-09-13.
  14. ^ "Highly Cited Researchers". publons.com. Retrieved 2023-09-24.
  15. ^ "Highly Cited Researchers". publons.com. Retrieved 2023-09-24.
  16. ^ "George Lyman Duff Memorial Lecture". professional.heart.org. Retrieved 2023-09-14.
  17. ^ "Highly Cited Researchers". publons.com. Retrieved 2023-09-24.
  18. ^ "Kathryn J. Moore, Ph.D., FAHA, named the American Heart Association's 2021 Distinguished Scientist in Arteriosclerosis, Thrombosis and Vascular Biology". American Heart Association. Retrieved 2023-09-14.
  19. ^ "Gill Foundation Honors Excellence in Cardiovascular Medicine, Research". UKNow. 2022-03-16. Retrieved 2023-09-24.
  20. ^ "Internal Medicine | The Gill Awards | University of Kentucky College of Medicine". medicine.uky.edu. Retrieved 2023-09-24.
  21. ^ "Grand Prix de la Fondation Lefoulon-Delalande 2024". Fondation Lefoulon-Delalande (in French). Retrieved 2024-06-05.
  22. ^ Cortigiano, Cameron (2024-06-18). "Dr. Kathryn Moore awarded for cardiovascular physiology research". www.beckersasc.com. Retrieved 2024-07-29.
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