Winter (llama)
Winter (born 2015 or 2016) is a female llama who lives on a research farm near Ghent, Belgium and is notable for her role in award-winning research on the SARS-CoV2 virus.[1]
In 2016 Jason McLellan and Daniel Wrapp chose the nine-month-old Winter as the llama they would inject with stabilized spike proteins from SARS-CoV-1 and MERS-CoV viruses, hoping that she would produce antibodies or the smaller nanobodies to further their aim "to isolate a single antibody that could neutralize all coronaviruses".[1]
Camelids, including llamas, produce nanobodies, which are a form of antibody about half the size of human antibodies and are very stable and so can be easily manipulated.[2][3]
When the genetic sequence of SARS-CoV-2 was released in January 2020, scientists worked quickly to test whether any of the antibodies that they had previously isolated against the original SARS-CoV (taken from Winter) could also bind and neutralize SARS-CoV-2. They discovered that one of these nanobodies, which they had characterized using the Argonne National Laboratory's Advanced Photon Source, might be effective against SARS-CoV-2. This nanobody — called VHH72 — is now under development as a treatment for COVID-19. Jason McLellan and Daniel Wrapp received a 2020 Golden Goose Award for this research.[1][2]
As of 2021[update] Llama Winter lives at LABIOMISTA, the arts and culture park of artist Koen Vanmechelen in Genk, Limburg, Belgium, where people can visit and learn more about her.[4]
References
[edit]- ^ a b c Swenson, Haylie (December 2020). "2020 Golden Goose Award: A Llama Named Winter". American Association for the Advancement of Science. Retrieved 23 March 2023.
- ^ a b Andre Salle's (9 March 2021). "Why the lovable llama might be a secret weapon against COVID-19". Argonne National Laboratory.
- ^ Kramer, Jillian (6 May 2020). "Hoping Llamas Will Become Coronavirus Heroes". The New York Times – via NYTimes.com.
- ^ Vanmecheln, Kurt. "Winter's Kilobytes × we (Wk×W) | LABIOMISTA". www.labiomista.be. Retrieved 18 November 2021.
Further reading
[edit]- "Belgian, U.S. scientists look to llama in search for COVID-19 treatment". Reuters. 5 May 2020.
- Alex Robinson (5 May 2020), "Meet Winter, the Llama Who Might Just Save Us All From COVID-19", Modern Farmer
- "Meet Winter, the 4-year-old llama whose blood might hold a treatment for COVID-19". Canadian Broadcasting Corporation. 11 May 2020.
- "COVID-19 Researchers Study Llama's Special Antibodies". Morning Edition. NPR. 19 May 2020.
- Dan Solomon (2 December 2020), "How a Llama and a University of Texas Lab Led to the Most Promising COVID-19 Treatment Yet – Researchers Daniel Wrapp and Jason McLellan owe a scientific honor they won this week to a Belgian camelid named Winter.", Texas Monthly
- Marissa Parra (18 March 2021). "Llama Nanobodies Are At Center Of COVID-19 Treatment Study At Argonne National Laboratory". Chicago: WBBM-TV – via CBS Local.
- Karin Brulliard; Carolyn Y. Johnson (6 May 2020). "The urgent quest for a coronavirus treatment involves door-to-door blood collection and a llama named Winter". The Washington Post.
- Julie Mazziotta (7 May 2020), "A Llama Named Winter May Hold the Key to a Coronavirus Treatment – New research found that Winter the llama has antibodies that can neutralize the COVID-19 virus", People
This article incorporates public domain material from Why the lovable llama might be a secret weapon against COVID-19. United States Department of Energy.
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