Dawn Bowdish

Dawn M. E. Bowdish
Born	(1976-05-21) May 21, 1976 Canada
Alma mater	University of British Columbia, Vancouver University of Oxford, England
Known for	Discovery of immunomodulatory properties of LL-37, MARCO signalling complex recognizing Mycobacterium tuberculosis, age-associated inflammation and its effects on pneumococcal pneumonia susceptibility and aging microbiome driving age-associated inflammation.
Scientific career
Fields	Biology Immunology Aging
Institutions	McMaster University
Academic advisors	Lori Burrows Joe Lam Robert E. W. Hancock Siamon Gordon

Dawn M. E. Bowdish, (born May 21, 1976) is a Canadian immunologist and currently a professor in the Department of Pathology and Molecular Medicine at McMaster University in Ontario, Canada. She is a Tier 2 Canada Research Chair in Aging & Immunity. She is known for several discoveries including the immunomodulatory properties of the antimicrobial peptide LL-37, how MARCO signalling complex recognizes Mycobacterium tuberculosis, age-associated inflammation and its effects on clearing pneumococcal pneumonia and how the aging gut microbiome drives age-associated inflammation.

Career and research

Training

Bowdish was born and raised in Hamilton, Ontario, Canada in 1976. In 1999, she graduated from the University of Guelph with an Honours Bachelor of Science in microbiology. Bowdish was a graduate student and obtained her PhD from the University of British Columbia between 2000 – 2005. There, under the supervision of Robert E. W. Hancock, she discovered the immunomodulatory role of the host defence peptide LL-37. As a Canadian Institute of Health Research Post-Doctoral Fellow, Bowdish worked at the University of Oxford from 2005-2008 under the supervision of Siamon Gordon in the Department of Pathology. It was during this time that she discovered the role of MARCO (macrophage receptor with collagenous structure) in recognizing and eliciting an immune response against trehalose dimycolate, the main immunogenic component in the outer membrane of Mycobacterium tuberculosis

Career

In 2009, she joined the Department of Pathology & Molecular Medicine at McMaster University and was promoted to associate professor in 2014. In 2019, she was promoted to tenure professor in the same department. The Bowdish lab focuses primarily on the effects of aging on the immune system, specifically macrophages. Her lab has been able to elucidate a mechanistic explanation for how aging alters myeloid cells and how these cells increase susceptibility to pneumococcal pneumonia. In 2017, the Bowdish lab demonstrated that age-associated gut microbe dysbiosis in mice increases age-associated inflammation. Bowdish currently holds an h-index score of 38. Bowdish's published works have received much media attention and continue to contribute more information regarding the interplay between the immune system, the gut microbiota, susceptibility to infection and aging.

Personal life

While attending post-secondary studies, Dawn was debating between a degree in Women's studies or Microbiology, but ultimately decided on Microbiology. Bowdish promotes social media use and encourages scientists to use these platforms as networking tools, to enhance interactions with the lay public and to promote diversity and equality in the sciences.

Fellowships and awards

• 2003-2005, Canada Graduate Scholarship awarded by the Canadian Institute of Health Research
• 2005-2008, Post-doctoral Fellowship awarded by the Canadian Institutes of Health Research
• 2006, Cangene Gold Award
• 2006-2008, JMH Junior Research Fellowship awarded by Linacre College at the University of Oxford
• 2010, ASPIRE, Pfizer Young Investigator Award
• 2011, G. Jeanette Thorbecke New Investigator Award, Society of Leukocyte Biology
• 2012, Ontario Lung Association-Pfizer Canada Research Award
• 2014-2019, Canada Research Chair in Aging & Immunity, Tier 2
• 2016-2017, Breathe New Life Award
• 2018-2022, University Scholar
• 2019, McMaster Student's Union (MSU) Community Engagement Award

Editorships

• Editor, Immunity & Ageing Journal, 2019–present

Leadership

• Board of Directors, Ontario Lung Association, June 2015 – 2019
• Vice-chair, 2016 Gordon conference on Acute Respiratory Infections (Galveston, Texas)
• co-Chair, 2018 Gordon conference on Acute Respiratory Infections (Ventura, California)

Select publications

• Bowdish, D. M.; Davidson, D. J.; Speert, D. P.; Hancock, R. E. (2004). "The human cationic peptide LL-37 induces activation of the extracellular signal-regulated kinase and p38 kinase pathways in primary human monocytes". Journal of Immunology. 172 (6): 3758–3765. doi:10.4049/jimmunol.172.6.3758. PMID 15004180.
• Bowdish, D. M.; Davidson, D. J.; Lau, Y. E.; Lee, K.; Scott, M. G.; Hancock, R. E. (2005). "Impact of LL-37 on anti-infective immunity". Journal of Leukocyte Biology. 77 (4): 451–459. doi:10.1189/jlb.0704380. PMID 15569695.
• Bowdish, D. M.; Davidson, D. J.; Hancock, R. E. (2005). "A re-evaluation of the role of host defence peptides in mammalian immunity". Current Protein & Peptide Science. 6 (1): 35–51. doi:10.2174/1389203053027494. PMID 15638767.
• Bowdish, D. M.; Davidson, D. J.; Scott, M. G.; Hancock, R. E. (2005). "Immunomodulatory activities of small host defense peptides". Antimicrobial Agents and Chemotherapy. 49 (5): 1727–1732. doi:10.1128/AAC.49.5.1727-1732.2005. PMC 1087655. PMID 15855488.
• Bowdish, D. M.; Sakamoto, K.; Kim, M. J.; Kroos, M.; Mukhopadhyay, S; Leifer, C. A.; Tryggvason, K.; Gordon, S.; Russell, D. G. (2009). "MARCO, TLR2, and CD14 Are Required for Macrophage Cytokine Responses to Mycobacterial Trehalose Dimycolate and Mycobacterium tuberculosis". PLOS Pathogens. 5 (6): e1000474. doi:10.1371/journal.ppat.1000474. PMC 2688075. PMID 19521507.
• Verschoor, C. P.; Johnstone, J.; Millar, J.; Dorrington, M. G.; Habibagahi, M.; Lelic, A.; Loeb, M.; Bramson, J. L.; Bowdish, D. M. (2013). "Blood CD33(+)HLA-DR(-) myeloid-derived suppressor cells are increased with age and a history of cancer". Journal of Leukocyte Biology. 93 (4): 633–637. doi:10.1189/jlb.0912461. PMC 3701116. PMID 23341539.
• Verschoor, C. P.; Johnstone, J.; Loeb, M.; Bramson, J. L.; Bowdish, D. M. (2014). "Anti-pneumococcal deficits of monocyte-derived macrophages from the advanced-age, frail elderly and related impairments in PI3K-AKT signaling". Human Immunology. 75 (12): 1192–1196. doi:10.1016/j.humimm.2014.10.004. PMID 25446401.
• Verschoor, C. P.; Johnstone, J.; Millar, J.; Parsons, R.; Lelic, A.; Loeb, M.; Bramson, J. L.; Bowdish, D. M. (2014). "Alterations to the Frequency and Function of Peripheral Blood Monocytes and Associations with Chronic Disease in the Advanced-Age, Frail Elderly". PLOS ONE. 9 (8): e104522. Bibcode:2014PLoSO...9j4522V. doi:10.1371/journal.pone.0104522. PMC 4126708. PMID 25105870.
• Verschoor, C. P.; Naidoo, A.; Wallace, J. G.; Johnstone, J.; Loeb, M.; Bramson, J. L.; Bowdish, D. M. (2015). "Circulating muramyl dipeptide is negatively associated with interleukin-10 in the frail elderly". Inflammation. 38 (1): 272–277. doi:10.1007/s10753-014-0030-z. PMID 25278013. S2CID 20051568.
• Puchta, A.; Naidoo, A.; Verschoor, C. P.; Loukov, D.; Thevaranjan, N.; Mandur, T. S.; Nguyen, P.; Jordana, M.; Loeb, M.; Xing, Z.; Kobzik, L.; Larché, M. J.; Bowdish, D. M. (2016). "TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity". PLOS Pathogens. 12 (1): e1005368. doi:10.1371/journal.ppat.1005368. PMC 4713203. PMID 26766566.
• Loukov, D.; Naidoo, A.; Puchta, A.; Marin, J. L.; Bowdish, D. M. (2016). "Tumor necrosis factor drives increased splenic monopoiesis in old mice". Journal of Leukocyte Biology. 100 (1): 121–129. doi:10.1189/jlb.3MA0915-433RR. PMID 27037197.
• Fei, F.; Lee, K. M.; McCarry, B. E.; Bowdish, D. M. (2016). "Age-associated metabolic dysregulation in bone marrow-derived macrophages stimulated with lipopolysaccharide". Scientific Reports. 6: 22637. Bibcode:2016NatSR...622637F. doi:10.1038/srep22637. PMC 4778050. PMID 26940652.
• Thevaranjan, N.; Puchta, A.; Schulz, C.; Naidoo, A.; Szamosi, J. C.; Verschoor, C. P.; Loukov, D.; Schenck, L. P.; Jury, J.; Foley, K. P.; Schertzer, J.D.; Larché, M. J.; Davidson, D. J.; Verdú, E. F.; Surette, M. G.; Bowdish, D. M. E. (2017). "Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction". Cell Host & Microbe. 21 (4): 455–466. doi:10.1016/j.chom.2017.03.002. PMC 5392495. PMID 28407483.

External links

• Bowdish Lab - Macrophage Biology at McMaster University
• Dawn Bowdish publications indexed by Google Scholar