SERPINB6

SERPINB6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1M37
Identifiers
Aliases	SERPINB6, CAP, DFNB91, MSTP057, PI-6, PI6, PTI, SPI3, serpin family B member 6
External IDs	OMIM: 173321; MGI: 103123; HomoloGene: 20956; GeneCards: SERPINB6; OMA:SERPINB6 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	2,972,165 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	34,186,777 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; right uterine tube; ; body of pancreas; ; apex of heart; ; left ovary; ; right auricle; ; right ovary; ; canal of the cervix; ; right adrenal gland;
	Top expressed in
	stroma of bone marrow; ; ankle joint; ; endothelial cell of lymphatic vessel; ; Ileal epithelium; ; submandibular gland; ; esophagus; ; ovary; ; skin of external ear; ; belly cord; ; left colon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; protease binding; serine-type endopeptidase inhibitor activity;
Cellular component	cytoplasm; cytosol; extracellular exosome; nucleus; extracellular space; plasma membrane; secretory granule membrane; tertiary granule membrane; ficolin-1-rich granule membrane; extracellular region; collagen-containing extracellular matrix; serine protease inhibitor complex;
Biological process	negative regulation of peptidase activity; hearing; cellular response to osmotic stress; negative regulation of endopeptidase activity; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	5269
	20719
	ENSG00000124570
	ENSMUSG00000060147
	P35237
	Q60854
NM_001195291; NM_001271822; NM_001271823; NM_001271824; NM_001271825;
	NM_001297699; NM_001297700; NM_004568; NM_001374515; NM_001374516; NM_001374517
	NM_001164117; NM_001164118; NM_001243192; NM_009254
NP_001182220; NP_001258751; NP_001258752; NP_001258753; NP_001258754;
	NP_001284628; NP_001284629; NP_004559; NP_001361444; NP_001361445; NP_001361446
	NP_001157589; NP_001157590; NP_001230121; NP_033280
	Wikidata
View/Edit Human	View/Edit Mouse

Serpin B6 is a protein that in humans is encoded by the SERPINB6 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124570 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000060147 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Coughlin P, Sun J, Cerruti L, Salem HH, Bird P (Nov 1993). "Cloning and molecular characterization of a human intracellular serine proteinase inhibitor". Proc Natl Acad Sci U S A. 90 (20): 9417–21. Bibcode:1993PNAS...90.9417C. doi:10.1073/pnas.90.20.9417. PMC 47579. PMID 8415716.
^ Sun J, Stephens R, Mirza G, Kanai H, Ragoussis J, Bird PI (Feb 1999). "A serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes". Cytogenet Cell Genet. 82 (3–4): 273–7. doi:10.1159/000015118 (inactive 2024-07-26). PMID 9858835. S2CID 23659776.{{cite journal}}: CS1 maint: DOI inactive as of July 2024 (link)
^ "Entrez Gene: SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6".

Sun J, Coughlin P, Salem HH, Bird P (1995). "Production and characterization of recombinant human proteinase inhibitor 6 expressed in Pichia pastoris". Biochim. Biophys. Acta. 1252 (1): 28–34. doi:10.1016/0167-4838(95)00108-7. PMID 7548163.
Coughlin P, Nicholl J, Sun J, et al. (1995). "Chromosomal mapping of the human proteinase inhibitor 6 (PI6) gene to 6p25 by fluorescence in situ hybridization". Genomics. 26 (2): 431–3. doi:10.1016/0888-7543(95)80240-M. PMID 7601482.
Morgenstern KA, Sprecher C, Holth L, et al. (1994). "Complementary DNA cloning and kinetic characterization of a novel intracellular serine proteinase inhibitor: mechanism of action with trypsin and factor Xa as model proteinases". Biochemistry. 33 (11): 3432–41. doi:10.1021/bi00177a037. PMID 8136380.
Morgenstern KA, Henzel WJ, Baker JB, et al. (1993). "Isolation and characterization of an intracellular serine proteinase inhibitor from a monkey kidney epithelial cell line". J. Biol. Chem. 268 (29): 21560–8. doi:10.1016/S0021-9258(20)80578-X. PMID 8408007.
Coughlin PB, Tetaz T, Salem HH (1993). "Identification and purification of a novel serine proteinase inhibitor". J. Biol. Chem. 268 (13): 9541–7. doi:10.1016/S0021-9258(18)98385-7. PMID 8486644.
Riewald M, Morgenstern KA, Schleef RR (1996). "Identification and characterization of the cytoplasmic antiproteinase (CAP) in human platelets. Evidence for the interaction of CAP with endogenous platelet proteins". J. Biol. Chem. 271 (12): 7160–7. doi:10.1074/jbc.271.12.7160. PMID 8636153.
Riewald M, Schleef RR (1996). "Human cytoplasmic antiproteinase neutralizes rapidly and efficiently chymotrypsin and trypsin-like proteases utilizing distinct reactive site residues". J. Biol. Chem. 271 (24): 14526–32. doi:10.1074/jbc.271.24.14526. PMID 8662739.
Scott FL, Paddle-Ledinek JE, Cerruti L, et al. (1999). "Proteinase inhibitor 6 (PI-6) expression in human skin: induction of PI-6 and a PI-6/proteinase complex during keratinocyte differentiation". Exp. Cell Res. 245 (2): 263–71. doi:10.1006/excr.1998.4241. PMID 9851866.
Mikolajczyk SD, Millar LS, Marker KM, et al. (1999). "Identification of a novel complex between human kallikrein 2 and protease inhibitor-6 in prostate cancer tissue". Cancer Res. 59 (16): 3927–30. PMID 10463585.
Saedi MS, Zhu Z, Marker K, et al. (2002). "Human kallikrein 2 (hK2), but not prostate-specific antigen (PSA), rapidly complexes with protease inhibitor 6 (PI-6) released from prostate carcinoma cells". Int. J. Cancer. 94 (4): 558–63. doi:10.1002/ijc.1501. PMID 11745444. S2CID 2826757.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 171–84. PMID 12107413.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Strik MC, Wolbink A, Wouters D, et al. (2004). "Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers". Blood. 103 (7): 2710–7. doi:10.1182/blood-2003-08-2981. PMID 14670919.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Charron Y, Madani R, Nef S, et al. (2006). "Expression of serpinb6 serpins in germ and somatic cells of mouse gonads". Mol. Reprod. Dev. 73 (1): 9–19. doi:10.1002/mrd.20385. PMID 16175637. S2CID 42438203.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links

The MEROPS online database for peptidases and their inhibitors: I04.011
SERPINB6+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124570 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000060147 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8415716-5] Coughlin P, Sun J, Cerruti L, Salem HH, Bird P (Nov 1993). "Cloning and molecular characterization of a human intracellular serine proteinase inhibitor". Proc Natl Acad Sci U S A. 90 (20): 9417–21. Bibcode:1993PNAS...90.9417C. doi:10.1073/pnas.90.20.9417. PMC 47579. PMID 8415716.

[pmid9858835-6] Sun J, Stephens R, Mirza G, Kanai H, Ragoussis J, Bird PI (Feb 1999). "A serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes". Cytogenet Cell Genet. 82 (3–4): 273–7. doi:10.1159/000015118 (inactive 2024-07-26). PMID 9858835. S2CID 23659776.{{cite journal}}: CS1 maint: DOI inactive as of July 2024 (link)

[entrez-7] "Entrez Gene: SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6".

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[6]

[7]

v t e Serpins
inhibitory	Alpha 1-antichymotrypsin Alpha 1-antitrypsin Alpha 2-antiplasmin Antithrombin C1-inhibitor Heparin cofactor II Protein C inhibitor Plasminogen activator inhibitor-1 Plasminogen activator inhibitor-2 Protein Z-related protease inhibitor SERPINA1 SERPINA2 SERPINA3 SERPINA4 SERPINA5 SERPINA9 SERPINA14 SERPINB1 SERPINB2 SERPINB3 SERPINB4 SERPINB5 SERPINB6 SERPINB7 SERPINB8 SERPINB9 SERPINB10 SERPINB13 SERPINC1 SERPIND1 SERPINE1 SERPINE2 SERPINE2 SERPINF1 SERPING1 SERPINH1 SERPINI1 SERPINI2
Cross class inhibitory	MENT SCCA-1 CrmA
noninhibitory	Heat shock protein 47 Maspin Ovalbumin Transcortin Thyroxine-binding globulin Angiotensinogen PEDF
see also disorders of globin and globulin proteins

SERPINB6

See also

References

Further reading

External links