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Haplogroup M (mtDNA)

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This article is about the human mtDNA haplogroup. For the human Y-DNA haplogroup, see Haplogroup M-P256.

Haplogroup M
Possible time of originca. 55,000-65,000 years ago[1] or 50,000-65,000 years ago[2]
Possible place of originSouth Asia,[3][4][5][6][7][8] Southwest Asia,[2][1] Southeast Asia,[9][10] or East Africa[11][12]
AncestorL3
DescendantsM1, M2, M3, M4'45, M5, M6, M7, M8, M9, M10'42, M12'G, M13, M14, M15, M21, M27, M28, M29'Q, M31'32, M33, M34, M35, M36, M39, M40, M41, M44, M46, M47'50, M48, M49, M51, D
Defining mutations263, 489, 10400, 14783, 15043[13]

Haplogroup M is a human mitochondrial DNA (mtDNA) haplogroup. An enormous haplogroup spanning all the continents, the macro-haplogroup M, like its sibling the macro-haplogroup N, is a descendant of the haplogroup L3.

All mtDNA haplogroups considered native outside of Africa are descendants of either haplogroup M or its sibling haplogroup N.[14] Haplogroup M is relatively young, having a younger most recent common ancestor date than some subclades of haplogroup N such as haplogroup R.[15]

Origins

[edit]

There is a debate concerning the geographical origins of Haplogroup M and its sibling haplogroup N. Both lineages are thought to have been the main surviving lineages involved in the out of Africa migration (or migrations) because all indigenous lineages found outside Africa belong to haplogroup M or haplogroup N. Scientists are unsure whether the mutations that define haplogroups M and N occurred in Africa before the exit from Africa or in Asia after the exit from Africa. Determining the origins of haplogroup M is further complicated by an early back-migration (from Asia to Africa) of bearers of M1.[5]

Its date of origin in absolute terms is only known with great uncertainty, as reconstruction has yielded different (but overlapping) ranges for the age of M in South Asia and East Asia. The same authors give an estimate for t of L3 as 71.6+15.0
−14.5 kya,[16] later (2011) narrowed to the somewhat younger 65±5 kya.[1] Thus, haplogroup M would have emerged around 10,000 or at most 20,000 years after L3, around or somewhat after the recent out-of-Africa migration event.

Haplogroup M1

[edit]

Much discussion concerning the origins of haplogroup M has been related to its subclade haplogroup M1, which is the only variant of macro-haplogroup M found in Africa.[14] Two possibilities were being considered as potential explanations for the presence of M1 in Africa:

  1. M was present in the ancient population which later gave rise to both M1 in Africa, and M more generally found in Eurasia.[17]
  2. The presence of M1 in Africa is the result of a back-migration from Asia which occurred sometime after the Out of Africa migration.[5]

Haplogroup M23

[edit]

In 2009, two independent publications reported a rare, deep-rooted subclade of haplogroup M, referred to as M23, that is present in Madagascar.[18][19]

The origin of M23 is still not clearly understood, a west Eurasian origin had been suggested before. Haplogroup M23 is ancient and found throughout Madagascar. It is suggested to be an Asian component with significant African component. M23 was found only in one individual in Dubai[20]

Asian origin hypothesis

[edit]

According to this theory, anatomically modern humans carrying ancestral haplogroup L3 lineages were involved in the Out of Africa migration from East Africa into Asia. Somewhere in Asia, the ancestral L3 lineages gave rise to haplogroups M and N. The ancestral L3 lineages were then lost by genetic drift as they are infrequent outside Africa. The hypothesis that Asia is the origin of macrohaplogroup M is supported by the following:

  1. The highest frequencies worldwide of macrohaplogroup M are observed in Asia, specifically in the Indian subcontinent, China, Japan and Korea where frequencies range from 60 to 80%. The total frequency of M subclades is even higher in some populations of Siberia or the Americas, but these small populations tend to exhibit strong genetic drift effects, and often their geographical neighbors exhibit very different frequencies.[3][21][22]
  2. Deep time depth >50,000 years of western, central, southern and eastern Indian haplogroups M2, M38, M54, M58, M33, M6, M61, M62 and the distribution of macrohaplogroup M, do not rule out the possibility of macrohaplogroup M arising in Indian population.[23]
  3. With the exception of the African specific M1, India has several M lineages that emerged directly from the root of haplogroup M.[3][22]
  4. Only two subclades of haplogroup M, M1 and M23, are found in Africa, whereas numerous subclades are found outside Africa[3][5] (with some discussion possible only about sub-clade M1, concerning which see below).
  5. Specifically concerning M1
  • Haplogroup M1 has a restricted geographic distribution in Africa, being found mainly in North Africans and East Africa at low or moderate frequencies. If M had originated in Africa around, or before, the Out of Africa migration, it would be expected to have a more widespread distribution [22]
  • According to Gonzalez et al. 2007, M1 appears to have expanded relatively recently. In this study M1 had a younger coalescence age than the Asian-exclusive M lineages.[5]
  • The geographic distribution of M1 in Africa is predominantly North African/supra-equatorial[5] and is largely confined to Afro-Asiatic speakers,[24] which is inconsistent with the Sub-Saharan distribution of sub-clades of haplogroups L3 and L2 that have similar time depths.[14]
  • One of the basal lineages of M1 lineages has been found in Northwest Africa and in the Near East but is absent in East Africa.[5]
  • M1 is not restricted to Africa. It is relatively common in the Mediterranean, peaking in Iberia. M1 also enjoys a well-established presence in the Middle East, from the South of the Arabian Peninsula to Anatolia and from the Levant to Iran. In addition, M1 haplotypes have occasionally been observed in the Caucasus and the Trans Caucasus, and without any accompanying L lineages.[5][14] M1 has also been detected in Central Asia, seemingly reaching as far as Tibet.[5]
  • The fact that the M1 sub-clade of macrohaplogroup M has a coalescence age which overlaps with that of haplogroup U6 (a Eurasian haplogroup whose presence in Africa is due to a back-migration from West Asia) and the distribution of U6 in Africa is also restricted to the same North African and Horn African populations as M1 supports the scenario that M1 and U6 were part of the same population expansion from Asia to Africa.[24]
  • The timing of the proposed migration of M1 and U6-carrying peoples from West Asia to Africa (between 40,000 to 45,000 ybp) is also supported by the fact that it coincides with changes in climatic conditions that reduced the desert areas of North Africa, thereby rendering the region more accessible to entry from the Levant. This climatic change also temporally overlaps with the peopling of Europe by populations bearing haplogroup U5, the European sister clade of haplogroup U6.[24]

African origin hypothesis

[edit]

According to this theory, haplogroups M and N arose from L3 in an East African population ancestral to eurasians that had been isolated from other African populations before the OOA event. Members of this population were involved in the out Africa migration and may have only carried M and N lineages. With the possible exception of haplogroup M1, all other M and N clades in Africa were lost due to admixture with other African populations and genetic drift.[8][17]

The African origin of Haplogroup M is supported by the following arguments and evidence.

  1. L3, the parent clade of haplogroup M, is found throughout Africa, but is rare outside Africa.[17] According to Toomas Kivisild (2003), "the lack of L3 lineages other than M and N in India and among non-African mitochondria in general suggests that the earliest migration(s) of modern humans already carried these two mtDNA ancestors, via a departure route over the Horn of Africa."[8]
  2. Specifically concerning at least M1a:
This study provides evidence that M1, or its ancestor, had an Asiatic origin. The earliest M1 expansion into Africa occurred in northwestern instead of northeastern areas; this early spread reached the Iberian Peninsula even affecting the Basques. The majority of the M1a lineages found outside and inside Africa had a more recent eastern Africa origin. Both western and eastern M1 lineages participated in the Neolithic colonization of the Sahara. The striking parallelism between subclade ages and geographic distribution of M1 and its North African U6 counterpart strongly reinforces this scenario. Finally, a relevant fraction of M1a lineages present today in the European Continent and nearby islands possibly had a Jewish instead of the commonly proposed Amazigh maternal ascendance.[5]

Dispersal

[edit]
Hypothesized map of human migration based on mitochondrial DNA

A number of studies have proposed that the ancestors of modern haplogroup M dispersed from Africa through the southern route across the Horn of Africa along the coastal regions of Asia onwards to New Guinea and Australia. These studies suggested that the migrations of haplogroups M and N occurred separately with haplogroup N heading northwards from East Africa to the Levant. However, the results of numerous recent studies indicate that there was only one migration out of Africa and that haplogroups M and N were part of the same migration. This is based on the analysis of a number of relict populations along the proposed beachcombing route from Africa to Australia, all of which possessed both haplogroups N and M.[4][25]

A 2008 study by Abu-Amero et al., suggests that the Arabian Peninsula may have been the main route out of Africa. However, as the region lacks of autochthonous clades of haplogroups M and N the authors suggest that the area has been a more recent receptor of human migrations than an ancient demographic expansion center along the southern coastal route as proposed under the single migration Out-of-Africa scenario of the African origin hypothesis.[6]

Distribution

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M is the most common mtDNA haplogroup in Asia,[26] super-haplogroup M is distributed all over Asia, where it represents 60% of all maternal lineages.[27]

All Andamanese belong to Haplogroup M.[28] It peaks in the Malaysian aboriginal Negrito tribes at almost 100% but with mtDNA M21a representing Semang; 84% in Mendriq people, Batek people 48%, (almost all belong to the specific Malaysian Negrito haplogroup M21a, this subclade also found in the Orang Asli 21%, Thais 7.8% and Malay 4.6%)[29][30][31] It also peaks very high in Japan and Tibet, where it represents on average about 70% of the maternal lineages (160/216 = 74% Tibet,[32] 205/282 = 73% Tōkai,[33] 231/326 = 71% Okinawa,[33] 148/211 = 70% Japanese,[21] 50/72 = 69% Tibet,[32] 150/217 = 69% Hokkaidō,[34] 24/35 = 69% Zhongdian Tibetan, 175/256 = 68% northern Kyūshū,[33] 38/56 = 68% Qinghai Tibetan, 16/24 = 67% Diqing Tibetan, 66/100 = 66% Miyazaki, 33/51 = 65% Ainu, 214/336 = 64% Tōhoku,[33] 75/118 = 64% Tokyo (JPT)[35]) and is ubiquitous in India[3][14] and South Korea,[33][36][37][38][39] where it has approximately 60% frequency. Among Chinese people both inside and outside of China, haplogroup M accounts for approximately 50% of all mtDNA on average, but the frequency varies from approximately 40% in Hans from Hunan and Fujian in southern China to approximately 60% in Shenyang, Liaoning in northeastern China.[32][33][35][37]

Haplogroup M accounts for approximately 42% of all mtDNA in Filipinos, among whom it is represented mainly by M7c3c and E.[40] In Vietnam, haplogroup M has been found in 37% (52/139) to 48% (20/42) of samples of Vietnamese and in 32% (54/168) of a sample of Chams from Bình Thuận Province.[37][41] Haplogroup M accounts for 43% (92/214) of all mtDNA in a sample of Laotians, with its subclade M7 (M7b, M7c, and M7e) alone accounting for a full third of all haplogroup M, or 14.5% (31/214) of the total sample.[42]

In Oceania, A 2008 study found Haplogroup M in 42% (60/144) of a pool of samples from nine language groups in the Admiralty Islands of Papua New Guinea.[43] M has been found in 35% (17/48) of a sample of Papua New Guinea highlanders from the Bundi area and in 28% (9/32) of a sample of Aboriginal Australians from Kalumburu in northwestern Australia.[44] In a study published in 2015, Haplogroup M was found in 21% (18/86) of a sample of Fijians, but it was not observed in a sample of 21 Rotumans.[45]

Haplogroup M is also relatively common in Northeast Africa, occurring especially among Somalis, Libyans and Oromos at frequencies over 20%.[46][47] Toward the northwest, the lineage is found at comparable frequencies among the Tuareg in Mali and Burkina Faso; particularly the M1a2 subclade (18.42%).[48]

Among the descendant lineages of haplogroup M are C, D, E, G, Q, and Z. Z and G are found in North Eurasian populations, C and D exists among North Eurasian and Native American populations, E is observed in Southeast Asian populations, and Q is common among Melanesian populations. The lineages M2, M3, M4, M5, M6, M18 and M25 are exclusive to South Asia, with M2 reported to be the oldest lineage on the Indian sub-continent with an age estimation of 60,000—75,000 years, and with M5 reported to be the most prevalent in historically Turco-Persian enclaves.[3][49][50]

In 2013, four ancient specimens dated to around 2,500 BC-500 AD, which were excavated from the Tell Ashara (Terqa) and Tell Masaikh (Kar-Assurnasirpal) archaeological sites in the Euphrates Valley, were found to belong to mtDNA haplotypes associated with the M4b1, M49 and/or M61 haplogroups. Since these clades are not found among the current inhabitants of the area, they are believed to have been brought at a more remote period from east of Mesopotamia; possibly by either merchants or the founders of the ancient Terqa population.[51]

In 2016, three Late Pleistocene European hunter-gatherers were also found to carry M lineages. Two of the specimens were from the Goyet archaeological site in Belgium and were dated to 34,000 and 35,000 years ago, respectively. The other ancient individual hailed from the La Rochette site in France, and was dated to 28,000 years ago.[52]

Ancient DNA analysis of Iberomaurusian skeletal remains at the Taforalt site in Morocco, which have been dated to between 15,100 and 13,900 ybp, observed the M1b subclade in one of the fossils (1/7; ~14%).[53] Ancient individuals belonging to the Late Iron Age settlement of Çemialo Sırtı in Batman, southeast Turkey were found to carry haplogroup M; specifically the M1a1 subclade (1/12; ~8.3%). Haplogroup M was also detected in ancient specimens from Southeast Anatolia (0.4%).[54] Additionally, M1 has been observed among ancient Egyptian mummies excavated at the Abusir el-Meleq archaeological site in Middle Egypt, which date from the Pre-Ptolemaic/late New Kingdom and Roman periods.[55] Fossils at the Early Neolithic site of Ifri n'Amr or Moussa in Morocco, which have been dated to around 5,000 BCE, have also been found to carry the M1b subclade. These ancient individuals bore an autochthonous Maghrebi genomic component that peaks among modern Berbers, indicating that they were ancestral to populations in the area.[56] The ancient Egyptian aristocrats Nakht-Ankh and Khnum-Nakht were also found to belong to the M1a1 subclade. The half-brothers lived during the 12th Dynasty, with their tomb located at the Deir Rifeh cemetery in Middle Egypt.[57]

Subgroups distribution

[edit]

Source:[58]

  • Haplogroup M2 [2] – found in South Asia, with highest concentrations in SE India and Bangladesh;[14] oldest haplogroup M lineage on the Indian sub-continent.[3] Also found with low frequency in southwestern China.[32]
    • M2a'b
      • M2a – India (Madhya Pradesh), Munda; most common in Bangladesh
        • M2a1 – Malpaharia
          • M2a1a – Uyghur, Sindhi, Hill Kolam, Thailand
            • M2a1a1 – Katkari
              • M2a1a1a – Nihal
                • M2a1a1a1 – Katkari
              • M2a1a1b – Nihal
                • M2a1a1b1 – Nihal
            • M2a1a2 – Madia
              • M2a1a2a – Madia
                • M2a1a2a1 – Kamar
                  • M2a1a2a1a – Kamar
            • M2a1a3 – Mathakur
              • M2a1a3a – Kathakur, Mathakur
                • M2a1a3a1 – Kathakur
              • M2a1a3b – Kathakur
          • M2a1b – Dungri Bhil
          • M2a1c – Andh
      • M2b – Paudi Bhuiya; most common in SE India
        • M2b1 – Korku
          • M2b1a – Korku, Munda
          • M2b1b – Malpaharia
        • M2b2 – Hill Kolam, Jenu Kuruba
        • M2b3 – Betta Kurumba
          • M2b3a – Betta Kurumba
        • M2b4 – Korku
      • M2c – Myanmar, Thailand/Laos
  • Haplogroup M3 – Uyghur, Myanmar, New Delhi (Hindu), Paniya [3] – found mainly in South Asia, with highest concentrations in west and NW India[14]
    • M3a
    • M3b – Kamar of Chhattisgarh
    • M3c – Madia, Myanmar
      • M3c1
        • M3c1a – Jammu and Kashmir, Nepal (Terai Hindu, Tharu), Andhra Pradesh (tribal)
        • M3c1b – Hill Kolam
          • M3c1b1 – Saudi Arabia
            • M3c1b1a – Jenu Kuruba
            • M3c1b1b – Jenu Kuruba
      • M3c2 – Pakistan (Brahui), Jammu and Kashmir, Andh, Thailand
    • M3d – Nepal (Kathmandu), India, Italy (Salerno)
      • M3d1 – New Delhi (Hindu)
        • M3d1a – Nepal (Kathmandu), Cambodia (Lao), United Kingdom
          • M3d1a1 – Tibet (Sherpa)
  • M4'30
    • Haplogroup M4 [4] – found mainly in South Asia but some sequences in Eastern Saudi Arabia
      • Haplogroup M4a – found in Gujarat, India[22]
      • Haplogroup M4b – found among ancient specimens in the Euphrates valley
    • Haplogroup M65
      • Haplogroup M65a – found in India, Pakistan (Balochi, Sindhi), Sarikoli in Taxkorgan, Xinjiang, China,[50] Pamiri in Gorno-Badakhshan, Tajikistan,[50] Ladakh, Myanmar, China
      • Haplogroup M65b – found in India[50] and in Pakistan (Balochi)
    • Haplogroup M30 – mainly in India; also found in Nepal, Pakistan, Central Asia (Kyrgyz, Wakhi, and Sarikoli in Taxkorgan, Xinjiang, China and Tajiks in Dushanbe, Tajikistan[50]), the Middle East, and North Africa.
    • Haplogroup M37
      • Haplogroup M37a – found in Gujarat, India[22]
  • Haplogroup M5 [5] – found in South Asia
    • Haplogroup M5a – found in India (Jammu and Kashmir, Madhya Pradesh, Kathakur,[67] Gadaba[22]), Thailand (Mon in Ratchaburi Province and Lopburi Province[58]), Israel, Kyrgyz in Taxkorgan[50]
      • M5a1
        • M5a1a – India (incl. Jammu and Kashmir)
        • M5a1b – India (Jammu and Kashmir, Dongri Bhil, Nihal, Andh), Pakistan (Burusho), Russia,[68] Spain (Romani), USA (Georgia), USA (California)
      • M5a2 – India
        • M5a2a – Pakistan (Balochi), India (Nihal), Thailand (Tai Yuan in Uttaradit Province[58])
          • M5a2a1 – India (Hindus in New Delhi), Pakistan (Sindhi)
            • M5a2a1a – Saudi Arabia, Iran (Persian),[49] Kazakh, Pakistan (Balochi), India (Dongri Bhil, Korku, Lachungpa), Myanmar
          • M5a2a2 – India (Kamar of Chhattisgarh), Yemen
          • M5a2a3 – India (Pauri Bhuiya, Munda)
          • M5a2a4 – Iran (Persians),[49] Pakistan (Brahui, Makrani, Balochi)
      • M5a3
        • M5a3a – India (Kamar of Chhattisgarh[67])
        • M5a3b – India (Dongri Bhil,[67] Kathodi[67])
      • M5a4 – India (Kathodi,[67] Korku[67])
      • M5a5 – India (Dongri Bhil,[67] Andh[67]), Yemen
    • Haplogroup M5b – found in India and Thailand (Khon Mueang in Chiang Mai Province[58])
      • Haplogroup M5b2b1a – found in Tibet, Ladakh, Nepal
    • Haplogroup M5c – found in India, Thailand (Mon in Lopburi Province and Nakhon Ratchasima Province[58]), Tibet, Nepal
  • Haplogroup M6 [6] – found mainly in South Asia, with highest concentrations in mid-eastern India and Kashmir[14]
    • Haplogroup M6b – found in Kerala, India[22]
    • Haplogroup M61 – found among ancient specimens in the Euphrates valley
  • Haplogroup M7 [7] – found in East Asia and Southeast Asia, especially in Japan, southern China, Vietnam,[70] Laos,[42] and Thailand;[58] also found with low frequency in Central Asia and Siberia
    • Haplogroup M7a
      • Haplogroup M7a* – Japan
      • Haplogroup M7a1
        • Haplogroup M7a1* – Japan, Jiangsu, Shandong
        • Haplogroup M7a1a
          • Haplogroup M7a1a* – Japan, Korea, Beijing, Hebei, Henan, Sichuan, Shanghai, Shandong
          • Haplogroup M7a1a1
            • Haplogroup M7a1a1* – Japan, Korea, Jiangsu, Shandong, Liaoning, Henan
            • Haplogroup M7a1a1a – Japan
          • Haplogroup M7a1a2
            • Haplogroup M7a1a2* – Japan, Jiangsu
            • Haplogroup M7a1a2a – Japan
          • Haplogroup M7a1a3 – Japan
          • Haplogroup M7a1a4
            • Haplogroup M7a1a4* – Japan, Zhejiang
            • Haplogroup M7a1a4a – Japan
          • Haplogroup M7a1a5
            • Haplogroup M7a1a5* – Japan
            • Haplogroup M7a1a5a – Japan, Korea, Tianjin
          • Haplogroup M7a1a6
            • Haplogroup M7a1a6* – Japan, Philippines, Jiangsu, Shanxi, Shandong
            • Haplogroup M7a1a6a – Japan
          • Haplogroup M7a1a7
            • Haplogroup M7a1a7* – Japan, Korea
            • Haplogroup M7a1a7a – Uyghur
          • Haplogroup M7a1a8 – Japan, Jiangsu
          • Haplogroup M7a1a9 – Japan, Korea, Tianjin
          • Haplogroup M7a1a10 – Japan
        • Haplogroup M7a1b
          • Haplogroup M7a1b1
            • Haplogroup M7a1b1* – Japan, China (Minnan Han)
            • Haplogroup M7a1b1a – Japan
          • Haplogroup M7a1b2 – Japan
      • Haplogroup M7a2
        • Haplogroup M7a2* – Japan
        • Haplogroup M7a2a – Japan, Ulchi,[71] Yakut[72]
          • Haplogroup M7a2a1 – Japan
          • Haplogroup M7a2a2
            • Haplogroup M7a2a2* – Japan
            • Haplogroup M7a2a2a
              • Haplogroup M7a2a2a* – Japan (Gunma)
              • Haplogroup M7a2a2a1 – Japan (Aichi)
          • Haplogroup M7a2a3
          • Haplogroup M7a2a4 – Japan
    • Haplogroup M7b'c
      • Haplogroup M7b
        • Haplogroup M7b1a
          • Haplogroup M7b1a1 – Thailand, Laos, Vietnam, Cambodia, Myanmar, Indonesia, China, Karakalpak, Kyrgyz, Mongush, Khamnigan
            • Haplogroup M7b1a1a – Thailand, Uyghur, Korea
              • Haplogroup M7b1a1a1 – Japan, Korea, China, Tajikistan, Thailand, Laos
                • Haplogroup M7b1a1a1a – Japan
                • Haplogroup M7b1a1a1b – Japan, Korea, China, Russia, Kyrgyzstan
                • Haplogroup M7b1a1a1c – Japan
                • Haplogroup M7b1a1a1d – Japan
              • Haplogroup M7b1a1a2 – Thailand, Vietnam, Malaysia, China
              • Haplogroup M7b1a1a3 – Thailand, Laos, Vietnam, China
            • Haplogroup M7b1a1b – Thailand, Laos, Vietnam, China (Hunan, Uyghur, Kyrgyz from Artux[50]), England
            • Haplogroup M7b1a1c – Han Chinese, Uyghurs, Kyrgyz
            • Haplogroup M7b1a1d – Thailand, Laos, Tatar (Buinsk)
            • Haplogroup M7b1a1e – Thailand
              • Haplogroup M7b1a1e1 – Thailand, Vietnam, China
              • Haplogroup M7b1a1e2 – China
            • Haplogroup M7b1a1f – Thailand, Malaysia, Indonesia, Vietnam, China
            • Haplogroup M7b1a1g – Thailand
            • Haplogroup M7b1a1h – Thailand, Chinese (Han from Lanzhou,[74] etc.), Vietnam, Korea, Japan
            • Haplogroup M7b1a1i – Taiwan (Amis), Philippines, Malaysia
          • Haplogroup M7b1a2
            • Haplogroup M7b1a2a – China (Uyghurs, Kyrgyzes in Taxkorgan, Han, Mongol in Inner Mongolia)
              • Haplogroup M7b1a2a1 – Taiwan Aboriginal peoples, Philippines, Indonesia, Malaysia
                • Haplogroup M7b1a2a1a – Atayal, Saisiyat
                • Haplogroup M7b1a2a1b – Atayal
                  • Haplogroup M7b1a2a1b1 – Atayal, Saisiyat
        • Haplogroup M7b1b – Khamnigan, China, Kyrgyz
      • Haplogroup M7c
        • Haplogroup M7c1 – China, Vietnam, Malaysia, Mongolia, Sarikoli, Kazakhstan
          • Haplogroup M7c1a – China, Korea, Japan, Vietnam, Thailand, Indonesia
            • Haplogroup M7c1a1
              • Haplogroup M7c1a1a – China, Mongolia
              • Haplogroup M7c1a1b – Azeri
            • Haplogroup M7c1a2 – China
              • Haplogroup M7c1a2a – She, Uyghur
                • Haplogroup M7c1a2a1 – Japan, Korea, Uyghur
            • Haplogroup M7c1a3 – China, Japan, Vietnam
              • Haplogroup M7c1a3a – Korea
            • Haplogroup M7c1a4
              • Haplogroup M7c1a4a – China
              • Haplogroup M7c1a4b – China
            • Haplogroup M7c1a5 – Japan, Korea
          • Haplogroup M7c1b – Chinese
            • Haplogroup M7c1b1 – Buryats
            • Haplogroup M7c1b2
              • Haplogroup M7c1b2a – Khamnigan, Korea
              • Haplogroup M7c1b2b – China, Thailand, Laos, Malaysia
          • Haplogroup M7c1c – China, Thailand/Laos
            • Haplogroup M7c1c1 – China
              • Haplogroup M7c1c1a – China
                • Haplogroup M7c1c1a1 – Philippines
            • Haplogroup M7c1c2 – Thailand, China (Han)
            • Haplogroup M7c1c3 – Taiwan, Thailand, Philippines, Indonesia, Brunei, Malaysia, Kiribati, Nauru, Saudi Arabia, Madagascar
        • Haplogroup M7c2 – Taiwan, Hainan, Thailand/Laos
          • Haplogroup M7c2a – Thailand/Laos, China (incl. Hainan)
          • Haplogroup M7c2b – Thailand, Taiwan (Han), Czech
        • Haplogroup M7c3 – China (incl. Amis)
  • Haplogroup M8 - China,[61] Northern Thailand (Lisu[62][61]), India
  • Haplogroup M9 [14] – found in East Asia and Central Asia, especially in Tibet. In the Nepalese populations, it is prevalent mainly in Sherpa (27.4%), Tharu-CI (19.6%), Tamang (15.5%), Magar (13.5%), and Tharu-CII.[77] Haplogroup M9* has additionally been found in ancient remains from the Red Deer Cave people in present-day Yunnan.[78]
    • Haplogroup M9a'b
      • Haplogroup M9a – Han (Guangdong, Guangxi, Yunnan, Sichuan, Hunan, Taiwan, Anhui, Shaanxi, Shandong, Hebei), Korean (South Korea), Tujia (Hunan), Kinh (Hue), Mongol (Hohhot), Japanese, Lhoba[61] [TMRCA 23,000 (95% CI 18,100 <-> 28,800) ybp[61]]
        • Haplogroup M9a1 – Han (Hunan) [TMRCA 19,500 (95% CI 13,800 <-> 26,700) ybp[61]]
          • Haplogroup M9a1a – Han (Hebei, Henan, Shaanxi, Anhui, Zhejiang, Hunan, Yunnan, Guangdong, Hong Kong, Taiwan), Manchu (Jilin), Korean (South Korea), Hui (Qinghai), Kazakh (Ili), Kyrgyz (Kyrgyzstan), Nepal [TMRCA 16,500 (95% CI 12,800 <-> 20,900) ybp[61]]
            • Haplogroup M9a1a1 – Han (Henan, Shaanxi, Guangdong, Guangxi, Sichuan, Yunnan), Taiwan, Thailand/Laos, Hui (Yuxi), Tibetan (Nyingchi), Uyghur, Japanese (Hokkaido) [TMRCA 13,900 (95% CI 10,800 <-> 17,600) ybp[61]]
              • Haplogroup M9a1a1a – Japanese, Korean (Seoul), Chinese (incl. a Henan Han), Khamnigan (Buryat Republic), Udege, Nivkh, Tibetan (Qinghai)
              • Haplogroup M9a1a1b – Japanese, Korean (South Korea), Mongol (Inner Mongolia), Han (Hunan)
              • Haplogroup M9a1a1c – Han (Gansu, Shaanxi, Henan, Liaoning, Zhejiang, Jiangxi, Hunan, Guangdong, Sichuan, Yunnan), Ainu, Japanese, Korean, Mongol (Hohhot), Uyghur (Ürümqi), Altaian, Tuvinian, Hui (Xinjiang, Kyrgyzstan), Tujia (Hunan), Bai (Yunnan), Yi (Yunnan)
                • Haplogroup M9a1a1c1 – Han (Henan)
                  • Haplogroup M9a1a1c1a – Han (Henan, Anhui, Shandong, Liaoning, Sichuan, Yunnan, Xinjiang, Lanzhou[74]), Korea, Japanese, Mongol (New Barga Left Banner), Tibetan (Liangshan), Hui (Ili)
                  • Haplogroup M9a1a1c1b – Tibetan (Gansu, Qinghai, Sichuan, Yunnan, Chamdo, Lhasa, Nagqu, Ngari, Nyingchi, Shannan, Shigatse), Monpa (Nyingchi), Dirang Monpa (Arunachal Pradesh), Lachungpa (Sikkim), Tu (Huzhu Tu Autonomous County), Dongxiang (Gansu), Buryat (Inner Mongolia, Buryat Republic), Han (Qinghai), Hui (Qinghai), Nepalese
              • Haplogroup M9a1a1d – Salar (Qinghai), Han (Yanting), Bai (Dali)
            • Haplogroup M9a1a2 – Tharu (Chitwan District, Uttar Pradesh), Tibetan (Nagqu, Yunnan, Qinghai, Shigatse), Lhoba (Nyingchi), Dhimal (West Bengal), Chin (Myanmar), Adi (Assam), Tu (Qinghai), Uyghur (Ürümqi), Mongol (Ili), Han (Hunan, Shanxi, Sichuan, Yunnan, Shandong, Ili), Yi (Yunnan), Bai (Dali), Nepalese [TMRCA 6,153.9 ± 5,443.2 ybp; CI=95%[79]]
          • Haplogroup M9a1b – Tibetan (Nyingchi, Nagqu, Lhasa, Chamdo, Ngari, Shannan, Shigatse, Sichuan, Yunnan, Qinghai, Gansu), Monba (Nyingchi), Lhoba (Shannan), Uzbekistan (Fergana), Dongxiang (Linxia), Naga (Sagaing), Burman (Bago), Chin (Chin State), Han (Hunan, Sichuan, Yunnan, Liaoning), Yi (Shuangbai) [TMRCA 9,416.6 ± 3,984.0 ybp; CI=95%[79]]
            • Haplogroup M9a1b1 – Tibetan, Lhoba, Arunachal Pradesh (Sonowal Kachari, Wanchoo, Gallong), Assam (Adi), Sikkim (Lepcha, Lachung), Qinghai (Salar, Tu), Mongol (Mongolia, Inner Mongolia), Guangxi (Gelao, Palyu), Thailand, Bengal, Pakistan (Karachi), Meghalaya (Khasi, Garo), Bodo (West Bengal), Rabha (West Bengal), Rajbanshi (West Bengal), Indonesia, Han (Shaanxi, Henan, Gansu, Sichuan, Yunnan), Hui (Gansu, Qinghai), Burman (Ayeyarwady, Magway, Sagaing), Rakhine (Rakhine, Magway), Chin (Chin State), Naga (Sagaing), Mech (Jhapa district, Nepal), Nepalese, Mosuo (Yunnan), Yi (Yunnan), She (Guizhou), Hani (Yunnan), Pumi (Yunnan), Bai (Dali), Va (Yunnan) [TMRCA 6,557.4 ± 2,102.4 ybp; CI=95%[79]]
            • Haplogroup M9a1b2 – Tibetan (Diqing), Han (Dujiangyan), Kazakh (Altai Republic), Kalmyk [TMRCA 3,225.9 ± 3,494.4 ybp; CI=95%[79]]
        • Haplogroup M9a4
          • Haplogroup M9a4a – Kinh (Hanoi), Han (Shaanxi, Shandong, Zhejiang, Taiwan, Sichuan, Guangdong), Li (Hainan), Mulam (Guangxi), Jino (Xishuangbanna), Dai (Xishuangbanna), Chiang Mai
          • Haplogroup M9a4b – Kinh (Hanoi), South Korea
        • Haplogroup M9a5 – Han (Hunan, Hong Kong), Thailand, Pubiao (Malipo), Li (Hainan), Mulam (Luocheng), Zhuang (Bama Yao Autonomous County), Kinh (Hanoi)
      • Haplogroup M9b – Han (Luocheng, Dujiangyan, Shaanxi), Cham (Binh Thuan), Mulam (Luocheng), Bouyei (Guizhou), Yi (Hezhang), Bunu (Dahua), Hui (Ili), Thailand (Phuan from Sukhothai Province[58][61])
    • Haplogroup E – a subclade of M9 – found especially in Taiwan (Aboriginal peoples), Maritime Southeast Asia, and the Mariana Islands [TMRCA 23,695.4 ± 6,902.4 ybp; CI=95%[79]]
  • Haplogroup M10 [15] – small clade found in East Asia, Southeast Asia, Bangladesh, Central Asia, Saudi Arabia, southern Siberia, Russia, Belarus, and Poland [TMRCA 23,600 (95% CI 17,100 <-> 31,700) ybp[61]]
    • M10-514C!/A15218G/C16362T!
      • M10-514C!/A15218G/C16362T!* – Poland
      • M10-T3167C/C4140T/T8793C/C12549T/A13152G/T14502C/C15040T/T15071C
        • M10a [TMRCA 16,700 (95% CI 11,800 <-> 22,800) ybp[61]]
          • M10a* – Myanmar
          • M10a1 – China, Thailand, Myanmar, Japan, Shor, Daur [TMRCA 14,400 (95% CI 11,100 <-> 18,400) ybp[61]]
            • M10a1* – Myanmar, Central Thailand (Mon), Japan (Aichi)
            • M10a1-G16129A!!!
              • M10a1-A13105G!/T16362C – Shor, Daur
              • M10a1a
                • M10a1a* – China, Saudi Arabia
                • M10a1a1
                  • M10a1a1a – Mongolia,[80] Korea, Japan, China (Han from Kunming, etc.), Iron Age Black Sea Scythian[81]
                  • M10a1a1b – Altai, Korea, Japan, China
                    • M10a1a1b* – Chinese Uyghur
                    • M10a1a1b1
                      • M10a1a1b1* – Japan, China
                      • M10a1a1b1a – China
                      • M10a1a1b1b – China
                      • M10a1a1b1c – Uyghur, Altai-Kizhi[80]
                    • M10a1a1b2
                      • M10a1a1b2* – Taiwan (Hakka)
                      • M10a1a1b2a – Japan
                • M10a1a2 – Northern Thailand (Khon Mueang from Lamphun Province[58])
                • M10a1a3 – Taiwan
              • M10a1b
              • M10a1c – China
          • M10a2 – Japan (Aichi), Kalmyk, Russian (northwestern Russia)
    • M10b – China (Shui[61]), Vietnam (Cờ Lao)[61]
  • Haplogroup M11 [16] – small clade found especially among the Chinese and also in some Japanese, Koreans, Oroqen, Yi, Tibetans, Tajiks in Dushanbe, Tajikistan,[50] and Bangladeshis[32] [TMRCA 20,987.7 ± 5,740.8 ybp; CI=95%[79]]
    • Haplogroup M11* – Myanmar
    • Haplogroup M11a'b'd
      • Haplogroup M11a'b [TMRCA 16,209.0 ± 4,396.8 ybp; CI=95%[79]]
        • Haplogroup M11a – Korea, Turkey [TMRCA 11,972.3 ± 3,523.2 ybp; CI=95%[79]]
          • Haplogroup M11a-C198T
            • Haplogroup M11a-C198T* – Wancho, Miao (from Fenghuang, Hunan)
            • Haplogroup M11a1 – Gallong, Tibet [TMRCA 8,668.6 ± 4,041.6 ybp; CI=95%[79]]
          • Haplogroup M11a2 – Tibet, Han (Zhanjiang) [TMRCA 8,776.3 ± 3,715.2 ybp; CI=95%[79]]
          • Haplogroup M11a3 – Uyghur, Buryat, Oroqen
        • Haplogroup M11b [TMRCA 12,962.0 ± 4,819.2 ybp; CI=95%[79]]
          • Haplogroup M11b1 – Taiwan (Minnan)
            • Haplogroup M11b1a – Japan
              • Haplogroup M11b1a1 – Japan, Han (Tai'an)
          • Haplogroup M11b2 – Japanese (Hokkaido), China, Altai-Kizhi, Tajik (Dushanbe)
      • Haplogroup M11d – China, Teleut, Kyrgyz, Iran
    • Haplogroup M11c – Japan, Korea
  • Haplogroup M12'G
  • Haplogroup M13'46'61
    • Haplogroup M13 – small clade found among Tibetans in Tibet,[32] Oirat Mongols in Xinjiang,[120] Barghuts in Hulunbuir,[80] Koreans,[115] and Yakuts and Dolgans in central Siberia[72] [TMRCA 43,169.4 ± 4,944.0 ybp; CI=95%[79]]
      • M13a [TMRCA 19,266.4 ± 6,720.0 ybp; CI=95%[79]]
        • M13a1 – China [Uyghurs, Mongol, Tibetan (Chamdo, Nagqu)], India [TMRCA 9,539.2 ± 6,249.6 ybp; CI=95%[79]]
          • M13a1a – Japan
          • M13a1b – China (Tibet, Uyghurs)
            • M13a1b1 – Buryat, Barghut, Yakut (Central), Evenk (Taimyr)
        • M13a2 – Tibet, Thailand [TMRCA 8,726.0 ± 4,828.8 ybp; CI=95%[79]]
      • M13b [TMRCA 31,191.8 ± 6,873.6 ybp; CI=95%[79]]
        • M13b1 – Nepal (Tharu), Northeast India, Thailand, Jahai [TMRCA 22,537.6 ± 7,123.2 ybp; CI=95%[79]]
        • M13b2 – Sherdukpen, Dirang Monpa, Tibet [TMRCA 5,441.4 ± 3,888.0 ybp; CI=95%[79]]
      • M13c – Myanmar, Thailand (Mon in Kanchanaburi Province[58]), China (Lahu)
    • Haplogroup M46 – Myanmar, Moken, Urak Lawoi, Malagasy
    • Haplogroup M61 – Thailand (Phuan in Suphan Buri Province, Phuan in Phichit Province, Phuan in Sukhothai Province, Saek in Nakhon Phanom Province[58]), Myanmar, Vietnam, Borneo
      • Haplogroup M61a – China (Yi, Tibet, Lachungpa)
  • Haplogroup M14 – Australia (Kalumburu), Saudi Arabia, India, Tibet?[32]
  • Haplogroup M15 – Australia (Kalumburu), Tibet?[32]
  • Haplogroup M17 – found in Luzon,[40] Chams,[41][121] Maniq,[121] Mon,[121] Blang,[121] Lawa,[121] Thai,[121] and Laotians[121]
    • Haplogroup M17a – Thailand, Vietnam (Cham)
    • Haplogroup M17c – Vietnam (Cham)
      • Haplogroup M17c1 – Philippines (Abaknon)
        • Haplogroup M17c1a – Indonesia
          • Haplogroup M17c1a1 – Philippines (Abaknon)
            • Haplogroup M17c1a1a – Cambodia (incl. Stieng)
  • Haplogroup M19'53
    • Haplogroup M19 – found in the Batak people of Palawan[122]
    • Haplogroup M53 – India
      • Haplogroup M53b – Kamar of Chhattisgarh
  • Haplogroup M21 [19] – small clade found in SE Asia (Semang, Semelai, Temuan,[121] Jehai,[121] Thailand, Maniq,[121] Mon,[121] Karen,[121] Indonesia), China, and Bangladesh
    • Haplogroup M21a – Batek
    • Haplogroup M21b
      • Haplogroup M21b1 – Cambodia (Lao, Tompoun)
        • Haplogroup M21b1a – Semelai, Philippines (Cuyunon of Palawan Island), Indonesia
      • Haplogroup M21b2 – Moken, Cham, Malaysia, India
  • Haplogroup M22 – Drung (Yunnan)
    • Haplogroup M22a – Vietnam (Kinh, Cham), Temuan
    • Haplogroup M22b – Vietnam (Kinh), China (Han in Meizhou), Cambodia
  • Haplogroup M23'75 – China
    • M23 – found in Madagascar, South Africa, USA, Canada
    • M75 – found in China,[59] USA
  • Haplogroup M24'41 [123]
    • Haplogroup M24
      • Haplogroup M24a – found in Thailand, Cambodia (Khmer), Palawan (Tagbanua),[122] and China
      • Haplogroup M24b – found in Thailand, Cambodia (Jarai), and China
    • Haplogroup M41 – found in South Asia
  • Haplogroup M27 [20] – found in Melanesia
  • Haplogroup M28 [21] – found in Melanesia and in a single Han individual from China[32]
  • Haplogroup M29'Q
    • Haplogroup M29 [22] – found in Melanesia
    • Haplogroup Q [23] – found in Melanesia and Australia (Aboriginal peoples)
  • Haplogroup M31 [24] – found among the Onge, in the Andaman Islands[22]
    • Haplogroup M31a
      • Haplogroup M31a1
        • Haplogroup M31a1a – Andaman Islands
        • Haplogroup M31a1b – Andaman Islands
      • Haplogroup M31a2
        • Haplogroup M31a2a – northern India (Munda, etc.), Myanmar
        • Haplogroup M31a2b – India (Paudibhuiya)
    • Haplogroup M31b'c
      • Haplogroup M31b – northern India, Nepal, Myanmar
      • Haplogroup M31c – Nepal (Tharu)
  • Haplogroup M32'56 – Thailand
    • Haplogroup M32
      • Haplogroup M32a – [25] – found in the Andaman Islands
      • Haplogroup M32c – Madagascar, Saudi Arabia, Thailand/Laos, USA
    • Haplogroup M56 – India (Korku[67])
  • Haplogroup M33 – India
  • Haplogroup M34'57
    • Haplogroup M34 [26] – small clade found in South Asia
      • Haplogroup M34a – found in Karnataka, India[22]
        • Haplogroup M34a1 – India
          • Haplogroup M34a1a – India, Myanmar
        • Haplogroup M34a2 – India (Pauri Bhuiya, Munda)
      • Haplogroup M34b – India (Nihal, etc.)
    • Haplogroup M57 – India (Kathakur)
      • Haplogroup M57a – India (Katkari, Nihal), England, Ireland
      • Haplogroup M57b – India (Kathakur)
        • Haplogroup M57b1 – India (Dongri Bhil)
  • Haplogroup M35 [27] – Nepal (Tharu)
    • Haplogroup M35a – Sarikoli,[50] Armenia, Mesolithic Sri Lanka[66]
      • Haplogroup M35a1 – India (Andh, Dongri Bhil), Mauritius
        • Haplogroup M35a1a – India (Betta Kurumba, Mullukurunan)
      • Haplogroup M35a2 – India (Andh, etc.)
    • Haplogroup M35b – found in Karnataka, Ladakh, Nepal (Tharu), Myanmar, Thailand, Slovakia[127]
      • Haplogroup M35b1'2'3 – India, Germany, USA
        • Haplogroup M35b1 – India (Madia)
        • Haplogroup M35b2 – India (Kathodi, Munda), Russia
        • Haplogroup M35b3 – India (Ladakh)
      • Haplogroup M35b4 – India (Toto), Nepal (Kathmandu)
    • Haplogroup M35c – India (Kathodi, Andh)
  • Haplogroup M39'70 [128]
    • Haplogroup M39 [28] – found in South Asia[22]
    • Haplogroup M70 - Nepal (Sherpas, etc.), Tibet, Vietnam (La Hủ)
  • Haplogroup M40 [29] – found in South Asia[22]
    • Haplogroup M40a – Yemen
      • Haplogroup M40a1
        • Haplogroup M40a1a
        • Haplogroup M40a1b
  • Haplogroup M42'74 [129]
  • Haplogroup M48 [31] – rare clade found in Saudi Arabia
  • Haplogroup M49 – found among ancient specimens in the Euphrates valley
  • Haplogroup M55'77 [131]
    • Haplogroup M55 - Myanmar, Thailand, Malay
    • Haplogroup M77 - Indonesia [132]
  • Haplogroup M62'68 [133]
    • Haplogroup M62
    • Haplogroup M68 [134]
      • Haplogroup M68a1
        • Haplogroup M68a1a - Cambodia, Vietnam
        • Haplogroup M68a1b
      • Haplogroup M68a2
        • Haplogroup M68a2a- Cambodia
        • Haplogroup M68a2b
        • Haplogroup M68a2c
  • Haplogroup M71 - India
  • Haplogroup M73'79 [137]
    • Haplogroup M73 [138]
      • Haplogroup M73a
        • Haplogroup M73a1
          • Haplogroup M73a1a
          • Haplogroup M73a1b - Vietnam
        • Haplogroup M73a2 - Papua New Guinea, East Timor
        • Haplogroup M73a3 - Philippines (Aklan)
      • Haplogroup M73b - Indonesia
        • Haplogroup M73b1 - Vietnam, Cambodia, Indonesia
      • Haplogroup M73c
    • Haplogroup M79 - China [139]
  • Haplogroup M80'D

Subclades

[edit]

Tree

[edit]

This phylogenetic tree of haplogroup M subclades is based on the paper by Mannis van Oven and Manfred Kayser Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation[13] and subsequent published research.

  • M
    • M1
      • M1a
        • M1a1
          • M1a1a
          • M1a1b
            • M1a1b1
          • M1a1c
          • M1a1d
          • M1a1e
          • M1a1f
        • M1a2
          • M1a2a
          • M1a2b
        • M1a3
          • M1a3a
          • M1a3b
        • M1a4
        • M1a5
      • M1b
        • M1b1
          • M1b1a
        • M1b2
          • M1b2a
    • M2
      • M2a
        • M2a1
        • M2a2
        • M2a3
      • M2b
        • M2b1
        • M2b2
    • M3
      • M3a
    • M4"45
      • M4
        • M4a
        • M4b
          • M4b1
      • M18'38
        • M18
        • M38
      • M30
        • M30a
        • M30b
        • M30c
          • M30c1
            • M30c1a
              • M30c1a1
        • M30d
      • M37
        • M37a
      • M43
      • M45
    • M5
      • M5a
        • M5a1
          • M5a1a
          • M5a1b
        • M5a2
          • M5a2a
    • M6
    • M7
      • M7a
        • M7a1
          • M7a1a
            • M7a1a1
              • M7a1a1a
            • M7a1a2
            • M7a1a3
            • M7a1a4
              • M7a1a4a
            • M7a1a5
            • M7a1a6
            • M7a1a7
          • M7a1b
        • M7a2
          • M7a2a
          • M7a2b
      • M7b'c'd'e
        • M7b'd
          • M7b
            • M7b1'2
              • M7b1
              • M7b2
                • M7b2a
                • M7b2b
                • M7b2c
            • M7b3
              • M7b3a
          • M7d
        • M7c'e
          • M7c
            • M7c1
              • M7c1a
              • M7c1b
                • M7c1b1
            • M7c2
              • M7c2a
            • M7c3
              • M7c3a
              • M7c3b
              • M7c3c
          • M7e
    • M8
      • M8a
        • M8a1
        • M8a2
          • M8a2a
          • M8a2b
      • CZ
    • M9
      • M9a'b'c'd
        • M9a'c'd
          • M9a'd
            • M9a
              • M9a1
              • M9a2
              • M9a3
            • M9d
          • M9c
        • M9b
      • E
    • M10'42
      • M10
        • M10a
          • M10a1
          • M10a2
      • M42
        • M42a
    • M11
      • M11a
      • M11b
    • M12'G
      • M12
        • M12a
      • G
    • M13
      • M13a
        • M13a1
    • M14
    • M15
    • M21
      • M21a'b
        • M21a
        • M21b
      • M21c'd
        • M21c
        • M21d
    • M22
    • M23
    • M25
    • M27
      • M27a
      • M27b
      • M27c
    • M28
      • M28a
      • M28b
    • M29'Q
      • M29
        • M29a
        • M29b
      • Q
    • M31
      • M31a
        • M31a1
          • M31a1a
          • M31a1b
        • M31a2
      • M31b'c
        • M31b
          • M31b1
          • M31b2
        • M31c
    • M32'56
      • M32
        • M32a
        • M32c
      • M56
    • M33
      • M33a
      • M33b
      • M33c
    • M34
      • M34a
    • M35
      • M35a
      • M35b
    • M36
      • M36a
    • M39
      • M39a
    • M40
      • M40a
    • M41
    • M44'52
      • M44
      • M52
    • M46
    • M47'50
      • M47
      • M50
    • M48
    • M49
    • M51
    • M52’58
    • M52
    • D

Notable members

[edit]

See also

[edit]
Wikimedia Commons has media related to Haplogroup M (mtDNA).

Phylogenetic tree of human mitochondrial DNA (mtDNA) haplogroups

  Mitochondrial Eve (L)    
L0 L1–6  
L1 L2   L3     L4 L5 L6
M N  
CZ D E G Q   O A S R   I W X Y
C Z B F R0   pre-JT   P   U
HV JT K
H V J T

References

[edit]
  1. ^ a b c Soares, P.; Alshamali, F.; Pereira, J. B.; Fernandes, V.; Silva, N. M.; Afonso, C.; Costa, M. D.; Musilova, E.; Macaulay, V.; Richards, M. B.; Cerny, V.; Pereira, L. (March 2012). "The Expansion of mtDNA Haplogroup L3 within and out of Africa". Molecular Biology and Evolution. 29 (3): 915–927. doi:10.1093/molbev/msr245. PMID 22096215.
  2. ^ a b Vai S, Sarno S, Lari M, Luiselli D, Manzi G, Gallinaro M, Mataich S, Hübner A, Modi A, Pilli E, Tafuri MA, Caramelli D, di Lernia S (March 2019). "Ancestral mitochondrial N lineage from the Neolithic 'green' Sahara". Sci Rep. 9 (1): 3530. Bibcode:2019NatSR...9.3530V. doi:10.1038/s41598-019-39802-1. PMC 6401177. PMID 30837540.
  3. ^ a b c d e f g h Rajkumar; et al. (2005). "Phylogeny and antiquity of M macrohaplogroup inferred from complete mt DNA sequence of Indian specific lineages". BMC Evolutionary Biology. 5: 26. doi:10.1186/1471-2148-5-26. PMC 1079809. PMID 15804362.
  4. ^ a b Macaulay, Vincent; Hill, Catherine; Achilli, Alessandro; Rengo, Chiara; Clarke, Douglas; Meehan, William; Blackburn, James; Semino, Ornella; Scozzari, Rosaria; Cruciani, Fulvio; Taha, Adi; Shaari, Norazila Kassim; Raja, Joseph Maripa; Ismail, Patimah; Zainuddin, Zafarina; Goodwin, William; Bulbeck, David; Bandelt, Hans-Jürgen; Oppenheimer, Stephen; Torroni, Antonio; Richards, Martin (13 May 2005). "Single, Rapid Coastal Settlement of Asia Revealed by Analysis of Complete Mitochondrial Genomes". Science. 308 (5724): 1034–1036. Bibcode:2005Sci...308.1034M. doi:10.1126/science.1109792. PMID 15890885.
  5. ^ a b c d e f g h i j k Gonzalez; et al. (2007). "Mitochondrial lineage M1 traces an early human backflow to Africa". BMC Genomics. 8: 223. doi:10.1186/1471-2164-8-223. PMC 1945034. PMID 17620140.
  6. ^ a b Abu-Amero, KK; Larruga, JM; Cabrera, VM; González, AM; et al. (2008). "Mitochondrial DNA structure in the Arabian Peninsula". BMC Evolutionary Biology. 8 (1): 45. Bibcode:2008BMCEE...8...45A. doi:10.1186/1471-2148-8-45. PMC 2268671. PMID 18269758.
  7. ^ Kivisild, M; Kivisild, T; Metspalu, E; Parik, J; Hudjashov, G; Kaldma, K; Serk, P; Karmin, M; Behar, DM; Gilbert, M Thomas P; Endicott, Phillip; Mastana, Sarabjit; Papiha, Surinder S; Skorecki, Karl; Torroni, Antonio; Villems, Richard (2004). "Most of the extant mtDNA boundaries in South and Southwest Asia were likely shaped during the initial settlement of Eurasia by anatomically modern humans". BMC Genetics. 5: 26. doi:10.1186/1471-2156-5-26. PMC 516768. PMID 15339343.
  8. ^ a b c Kivisild, T; Rootsi, S; Metspalu, M; Mastana, S; Kaldma, K; Parik, J; Metspalu, E; Adojaan, M; et al. (2003). "The Genetic Heritage of the Earliest Settlers Persists Both in Indian Tribal and Caste Populations". American Journal of Human Genetics. 72 (2): 313–32. doi:10.1086/346068. PMC 379225. PMID 12536373.
  9. ^ Marrero, Patricia; Abu-Amero, Khaled K.; Larruga, Jose M.; Cabrera, Vicente M. (2016). "Carriers of human mitochondrial DNA macrohaplogroup M colonized India from southeastern Asia". BMC Evolutionary Biology. 16 (1): 246. Bibcode:2016BMCEE..16..246M. doi:10.1186/s12862-016-0816-8. PMC 5105315. PMID 27832758.
  10. ^ Quintana-Murci, Lluís; et al. (1999). "Where West Meets East: The Complex mtDNA Landscape of the Southwest and Central Asian Corridor". Am. J. Hum. Genet. 74 (5): 827–45. doi:10.1086/383236. PMC 1181978. PMID 15077202.
  11. ^ Chandrasekar, Adimoolam; Kumar, Satish; Sreenath, Jwalapuram; Sarkar, Bishwa Nath; Urade, Bhaskar Pralhad; Mallick, Sujit; Bandopadhyay, Syam Sundar; Barua, Pinuma; Barik, Subihra Sankar; Basu, Debasish; Kiran, Uttaravalli; Gangopadhyay, Prodyot; Sahani, Ramesh; Prasad, Bhagavatula Venkata Ravi; Gangopadhyay, Shampa; Lakshmi, Gandikota Rama; Ravuri, Rajasekhara Reddy; Padmaja, Koneru; Venugopal, Pulamaghatta N.; Sharma, Madhu Bala; Rao, Vadlamudi Raghavendra (2009). "Updating Phylogeny of Mitochondrial DNA Macrohaplogroup M in India: Dispersal of Modern Human in South Asian Corridor". PLOS ONE. 4 (10): e7447. Bibcode:2009PLoSO...4.7447C. doi:10.1371/journal.pone.0007447. PMC 2757894. PMID 19823670.
  12. ^ Osman, Maha M.; Hassan, Hisham Y.; Elnour, Mohammed A.; Makkan, Heeran; Gebremeskel, Eyoab Iyasu; Gais, Thoyba; Koko, Mahmoud E.; Soodyall, Himla; Ibrahim, Muntaser E. (February 2021). "Mitochondrial HVRI and whole mitogenome sequence variations portray similar scenarios on the genetic structure and ancestry of northeast Africans". Meta Gene. 27: 100837. doi:10.1016/j.mgene.2020.100837.
  13. ^ a b van Oven, M; Kayser, M; et al. (2009). "Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation". Human Mutation. 30 (2): E386–E394. doi:10.1002/humu.20921. PMID 18853457. S2CID 27566749.
  14. ^ a b c d e f g h Metspalu, Mait; Kivisild, Toomas; Metspalu, Ene; Parik, Jüri; Hudjashov, Georgi; Kaldma, Katrin; Serk, Piia; Karmin, Monika; Behar, Doron M; Gilbert, M Thomas P; Endicott, Phillip; Mastana, Sarabjit; Papiha, Surinder S; Skorecki, Karl; Torroni, Antonio; Villems, Richard (2004). "Most of the extant mtDNA boundaries in south and southwest Asia were likely shaped during the initial settlement of Eurasia by anatomically modern humans". BMC Genetics. 5 (1): 26. doi:10.1186/1471-2156-5-26. PMC 516768. PMID 15339343.
  15. ^ Fregel, R; Cabrera, V; Larruga, JM; Abu-Amero, KK; González, AM (2015). "Carriers of Mitochondrial DNA Macrohaplogroup N Lineages Reached Australia around 50,000 Years Ago following a Northern Asian Route". PLOS ONE. 10 (6): e0129839. Bibcode:2015PLoSO..1029839F. doi:10.1371/journal.pone.0129839. PMC 4460043. PMID 26053380.
  16. ^ Soares, Pedro; Ermini, Luca; Thomson, Noel; Mormina, Maru; Rito, Teresa; Röhl, Arne; Salas, Antonio; Oppenheimer, Stephen; Macaulay, Vincent; Richards, Martin B. (June 2009). "Correcting for Purifying Selection: An Improved Human Mitochondrial Molecular Clock". The American Journal of Human Genetics. 84 (6): 740–759. doi:10.1016/j.ajhg.2009.05.001. PMC 2694979. PMID 19500773.
  17. ^ a b c Quintana-Murci, Lluís; Semino, Ornella; Bandelt, Hans-J.; Passarino, Giuseppe; McElreavey, Ken; Santachiara-Benerecetti, A. Silvana (December 1999). "Genetic evidence of an early exit of Homo sapiens sapiens from Africa through eastern Africa". Nature Genetics. 23 (4): 437–441. doi:10.1038/70550. PMID 10581031.
  18. ^ Dubut, V; Cartault, F; Payet, C; Thionville, MD; Murail, P; et al. (2009). "Complete mitochondrial sequences for haplogroups M23 and M46: insights into the Asian ancestry of the Malagasy population". Human Biology. 81 (4): 495–500. doi:10.3378/027.081.0407. PMID 20067372. S2CID 31809306.
  19. ^ Ricaut, FX; Razafindrazaka, H; Cox, MP; Dugoujon, JM; Guitard, E; Sambo, C; Mormina, M; Mirazon-Lahr, M; Ludes, B; Crubézy, Eric; et al. (2009). "A new deep branch of eurasian mtDNA macrohaplogroup M reveals additional complexity regarding the settlement of Madagascar". BMC Genomics. 10: 605. doi:10.1186/1471-2164-10-605. PMC 2808327. PMID 20003445.
  20. ^ Capredon, Mélanie; Brucato, Nicolas; Tonasso, Laure; Choesmel-Cadamuro, Valérie; Ricaut, François-Xavier; Razafindrazaka, Harilanto; Rakotondrabe, Andriamihaja Bakomalala; Ratolojanahary, Mamisoa Adelta; Randriamarolaza, Louis-Paul; Champion, Bernard; Dugoujon, Jean-Michel (22 November 2013). "Tracing Arab-Islamic Inheritance in Madagascar: Study of the Y-chromosome and Mitochondrial DNA in the Antemoro". PLOS ONE. 8 (11): e80932. Bibcode:2013PLoSO...880932C. doi:10.1371/journal.pone.0080932. PMC 3838347. PMID 24278350.
  21. ^ a b Maruyama, Sayaka; Minaguchi, Kiyoshi; Saitou, Naruya (2003). "Sequence polymorphisms of the mitochondrial DNA control region and phylogenetic analysis of mtDNA lineages in the Japanese population". Int J Legal Med. 117 (4): 218–225. doi:10.1007/s00414-003-0379-2. PMID 12845447. S2CID 1224295.
  22. ^ a b c d e f g h i j k l m n Thangaraj, Kumarasamy; Chaubey, Gyaneshwer; Singh, Vijay Kumar; Vanniarajan, Ayyasamy; Thanseem, Ismail; Reddy, Alla G; Singh, Lalji (December 2006). "In situ origin of deep rooting lineages of mitochondrial Macrohaplogroup 'M' in India". BMC Genomics. 7 (1): 151. doi:10.1186/1471-2164-7-151. PMC 1534032. PMID 16776823.
  23. ^ Chandrasekar Adimoolam, Kumar S; Sreenath, J; Sarkar, BN; Urade, BP; et al. (2009). "Updating Phylogeny of Mitochondrial DNA Macrohaplogroup M in India: Dispersal of Modern Human in South Asian Corridor". PLOS ONE. 4 (10): e7447. Bibcode:2009PLoSO...4.7447C. doi:10.1371/journal.pone.0007447. PMC 2757894. PMID 19823670.
  24. ^ a b c Olivieri, Anna; Achilli, Alessandro; Pala, Maria; Battaglia, Vincenza; Fornarino, Simona; Al-Zahery, Nadia; Scozzari, Rosaria; Cruciani, Fulvio; Behar, Doron M.; Dugoujon, Jean-Michel; Coudray, Clotilde; Santachiara-Benerecetti, A. Silvana; Semino, Ornella; Bandelt, Hans-Jürgen; Torroni, Antonio (15 December 2006). "The mtDNA Legacy of the Levantine Early Upper Palaeolithic in Africa". Science. 314 (5806): 1767–1770. Bibcode:2006Sci...314.1767O. doi:10.1126/science.1135566. PMID 17170302.
  25. ^ Hudjashov, G; Kivisild, T; Underhill, PA; Endicott, P; Sanchez, JJ; Lin, AA; Shen, P; Oefner, P; et al. (2007). "Revealing the prehistoric settlement of Australia by Y chromosome and mtDNA analysis". Proceedings of the National Academy of Sciences of the United States of America. 104 (21): 8726–30. Bibcode:2007PNAS..104.8726H. doi:10.1073/pnas.0702928104. PMC 1885570. PMID 17496137.
  26. ^ Ghezzi; et al. (2005). "Mitochondrial DNA haplogroup K is associated with a lower risk of Parkinson's disease in Italians". European Journal of Human Genetics. 13 (6): 748–752. doi:10.1038/sj.ejhg.5201425. hdl:2434/781361. PMID 15827561.
  27. ^ Petraglia, Michael D.; Allchin, Bridget, eds. (2007). The Evolution and History of Human Populations in South Asia. Vertebrate Paleobiology and Paleoanthropology Series. doi:10.1007/1-4020-5562-5. ISBN 978-1-4020-5561-4.[page needed]
  28. ^ Endicott, Phillip; Metspalu, Mait; Stringer, Chris; Macaulay, Vincent; Cooper, Alan; Sanchez, Juan J. (20 December 2006). "Multiplexed SNP Typing of Ancient DNA Clarifies the Origin of Andaman mtDNA Haplogroups amongst South Asian Tribal Populations". PLOS ONE. 1 (1): e81. Bibcode:2006PLoSO...1...81E. doi:10.1371/journal.pone.0000081. PMC 1766372. PMID 17218991.
  29. ^ Harrod, James B (2014). "The 200,000-Year Evolution of Homo sapiens sapiens Language and Myth Families based on the mtDNA Phylotree, Fossil mtDNA and Archaeology: A Thought Experiment". Journal of the Association for the Study of Language in Prehistory (19).
  30. ^ Hill, C.; Soares, P.; Mormina, M.; MacAulay, V.; Clarke, D.; Blumbach, P. B.; Vizuete-Forster, M.; Forster, P.; Bulbeck, D.; Oppenheimer, S.; Richards, M. (2006). "A Mitochondrial Stratigraphy for Island Southeast Asia". American Journal of Human Genetics. 80 (1): 29–43. doi:10.1086/510412. PMC 1876738. PMID 17160892.
  31. ^ Hill, C; Soares, P; Mormina, M; Macaulay, V; Clarke, D; Blumbach, PB; Vizuete-Forster, M; Forster, P; Bulbeck, D; Oppenheimer, S; Richards, M (2007). "A mitochondrial stratigraphy for island southeast Asia". Am. J. Hum. Genet. 80 (1): 29–43. doi:10.1086/510412. PMC 1876738. PMID 17160892.
  32. ^ a b c d e f g h i j k l m n o Ji, Fuyun; Sharpley, Mark S.; Derbeneva, Olga; et al. (2012). "Mitochondrial DNA variant associated with Leber hereditary optic neuropathy and high-altitude Tibetans". PNAS. 109 (19): 7391–7396. Bibcode:2012PNAS..109.7391J. doi:10.1073/pnas.1202484109. PMC 3358837. PMID 22517755.
  33. ^ a b c d e f Umetsu, Kazuo; Tanaka, Masashi; Yuasa, Isao; et al. (2005). "Multiplex amplified product-length polymorphism analysis of 36 mitochondrial single-nucleotide polymorphisms for haplogrouping of East Asian populations". Electrophoresis. 26 (1): 91–98. doi:10.1002/elps.200406129. PMID 15624129. S2CID 44989190.
  34. ^ Asari, Masaru; Umetsu, Kazuo; Adachi, Noboru; et al. (2007). "Utility of haplogroup determination for forensic mtDNA analysis in the Japanese population". Legal Medicine. 9 (5): 237–240. doi:10.1016/j.legalmed.2007.01.007. PMID 17467322.
  35. ^ a b c Zheng, H-X; Yan, S; Qin, Z-D; Wang, Y; Tan, J-Z; et al. (2011). "Major Population Expansion of East Asians Began before Neolithic Time: Evidence of mtDNA Genomes". PLOS ONE. 6 (10): e25835. Bibcode:2011PLoSO...625835Z. doi:10.1371/journal.pone.0025835. PMC 3188578. PMID 21998705.
  36. ^ Kim, W; Yoo, T-K; Shin, D-J; Rho, H-W; Jin, H-J; et al. (2008). "Mitochondrial DNA Haplogroup Analysis Reveals no Association between the Common Genetic Lineages and Prostate Cancer in the Korean Population". PLOS ONE. 3 (5): e2211. Bibcode:2008PLoSO...3.2211K. doi:10.1371/journal.pone.0002211. PMC 2376063. PMID 18493608.
  37. ^ a b c Jin, H-J; Tyler-Smith, C; Kim, W (2009). "The Peopling of Korea Revealed by Analyses of Mitochondrial DNA and Y-Chromosomal Markers". PLOS ONE. 4 (1): e4210. Bibcode:2009PLoSO...4.4210J. doi:10.1371/journal.pone.0004210. PMC 2615218. PMID 19148289.
  38. ^ a b c d e f g h i j k Derenko, Miroslava; Malyarchuk, Boris; Grzybowski, Tomasz; et al. (2007). "Phylogeographic Analysis of Mitochondrial DNA in Northern Asian Populations". Am. J. Hum. Genet. 81 (5): 1025–1041. doi:10.1086/522933. PMC 2265662. PMID 17924343.
  39. ^ Beom Hong, Seung; Cheol Kim, Ki; Kim, Wook (2014). "Mitochondrial DNA haplogroups and homogeneity in the Korean population". Genes & Genomics. 36 (5): 583–590. doi:10.1007/s13258-014-0194-9. S2CID 16827252.
  40. ^ a b c Tabbada, Kristina A.; Trejaut, Jean; Loo, Jun-Hun; et al. (January 2010). "Philippine Mitochondrial DNA Diversity: A Populated Viaduct between Taiwan and Indonesia?". Mol. Biol. Evol. 27 (1): 21–31. doi:10.1093/molbev/msp215. PMID 19755666.
  41. ^ a b Peng, Min-Sheng; Ho Quang, Huy; Pham Dang, Khoa; et al. (2010). "Tracing the Austronesian Footprint in Mainland Southeast Asia: A Perspective from Mitochondrial DNA". Mol. Biol. Evol. 27 (10): 2417–2430. doi:10.1093/molbev/msq131. PMID 20513740.
  42. ^ a b Bodner, Martin; Zimmermann, Bettina; Röck, Alexander; et al. (2011). "Southeast Asian diversity: first insights into the complex mtDNA structure of Laos". BMC Evolutionary Biology. 11 (1): 49. Bibcode:2011BMCEE..11...49B. doi:10.1186/1471-2148-11-49. PMC 3050724. PMID 21333001.
  43. ^ Kayser, Manfred; Choi, Ying; van Oven, Mannis; et al. (July 2008). "", (2008) "The Impact of the Austronesian Expansion: Evidence from mtDNA and Y Chromosome Diversity in the Admiralty Islands of Melanesia". Molecular Biology and Evolution. 25 (7): 1362–1374. doi:10.1093/molbev/msn078. PMID 18390477.
  44. ^ Hudjashov, Georgi; Kivisild, Toomas; Underhill, Peter A.; et al. (2007). "Revealing the prehistoric settlement of Australia by Y chromosome and mtDNA analysis". PNAS. 104 (21): 8726–8730. Bibcode:2007PNAS..104.8726H. doi:10.1073/pnas.0702928104. PMC 1885570. PMID 17496137.
  45. ^ Shipley, G. P.; Taylor, D. A.; Tyagi, A.; Tiwari, G.; Redd, A. (2015). "Genetic structure among Fijian island populations". Journal of Human Genetics. 60 (2): 69–75. doi:10.1038/jhg.2014.105. PMID 25566758. S2CID 26321736.
  46. ^ Non, Amy (2010). Analyses of genetic data within an interdisciplinary framework to investigate recent human evolutionary history and complex disease (Thesis). OCLC 705932464.[page needed]
  47. ^ Holden, Anne D; Forster, Peter (April 2005). MtDNA variation in North, East, and Central African populations gives clues to a possible back-migration from the Middle East. Seventy-Fourth Annual Meeting of the American Association of Physical Anthropologists.
  48. ^ Luísa Pereira; Viktor Černý; María Cerezo; Nuno M Silva; Martin Hájek; Alžběta Vašíková; Martina Kujanová; Radim Brdička; Antonio Salas (17 March 2010). "Linking the sub-Saharan and West Eurasian gene pools: maternal and paternal heritage of the Tuareg nomads from the African Sahel". European Journal of Human Genetics. 18 (8): 915–923. doi:10.1038/ejhg.2010.21. PMC 2987384. PMID 20234393.
  49. ^ a b c d e Derenko, M; Malyarchuk, B; Bahmanimehr, A; Denisova, G; Perkova, M; et al. (2013). "Complete Mitochondrial DNA Diversity in Iranians". PLOS ONE. 8 (11): e80673. Bibcode:2013PLoSO...880673D. doi:10.1371/journal.pone.0080673. PMC 3828245. PMID 24244704.
  50. ^ a b c d e f g h i j k l m n o p q r s t u v Peng, Min-Sheng; Xu, Weifang; Song, Jiao-Jiao; Chen, Xing; Sulaiman, Xierzhatijiang; Cai, Liuhong; Liu, He-Qun; Wu, Shi-Fang; Gao, Yun; Abdulloevich, Najmudinov Tojiddin; Afanasevna, Manilova Elena; Ibrohimovich, Khudoidodov Behruz; Chen, Xi; Yang, Wei-Kang; Wu, Miao; Li, Gui-Mei; Yang, Xing-Yan; Rakha, Allah; Yao, Yong-Gang; Upur, Halmurat; Zhang, Ya-Ping (January 2018). "Mitochondrial genomes uncover the maternal history of the Pamir populations". European Journal of Human Genetics. 26 (1): 124–136. doi:10.1038/s41431-017-0028-8. PMC 5839027. PMID 29187735.
  51. ^ Witas HW, Tomczyk J, Jędrychowska-Dańska K, Chaubey G, Płoszaj T (2013). "mtDNA from the Early Bronze Age to the Roman Period Suggests a Genetic Link between the Indian Subcontinent and Mesopotamian Cradle of Civilization". PLOS ONE. 8 (9): e73682. Bibcode:2013PLoSO...873682W. doi:10.1371/journal.pone.0073682. PMC 3770703. PMID 24040024.
  52. ^ Cosimo Posth; Gabriel Renaud; Alissa Mittnik; Dorothée G. Drucker; Hélène Rougier; Christophe Cupillard; Frédérique Valentin; Corinne Thevenet; Anja Furtwängler; Christoph Wißing; Michael Francken; Maria Malina; Michael Bolus; Martina Lari; Elena Gigli; Giulia Capecchi; Isabelle Crevecoeur; Cédric Beauval; Damien Flas; Mietje Germonpré; Johannes van der Plicht; Richard Cottiaux; Bernard Gély; Annamaria Ronchitelli; Kurt Wehrberger; Dan Grigorescu; Jiří Svoboda; Patrick Semal; David Caramelli; Hervé Bocherens; Katerina Harvati; Nicholas J. Conard; Wolfgang Haak; Adam Powell (21 March 2016). "Pleistocene Mitochondrial Genomes Suggest a Single Major Dispersal of Non-Africans and a Late Glacial Population Turnover in Europe". Current Biology. 26 (6): 827–833. Bibcode:2016CBio...26..827P. doi:10.1016/j.cub.2016.01.037. hdl:2440/114930. PMID 26853362. S2CID 140098861.
  53. ^ van de Loosdrecht, Marieke; Bouzouggar, Abdeljalil; Humphrey, Louise; Posth, Cosimo; Barton, Nick; Aximu-Petri, Ayinuer; Nickel, Birgit; Nagel, Sarah; Talbi, El Hassan; El Hajraoui, Mohammed Abdeljalil; Amzazi, Saaïd; Hublin, Jean-Jacques; Pääbo, Svante; Schiffels, Stephan; Meyer, Matthias; Haak, Wolfgang; Jeong, Choongwon; Krause, Johannes (4 May 2018). "Pleistocene North African genomes link Near Eastern and sub-Saharan African human populations". Science. 360 (6388): 548–552. Bibcode:2018Sci...360..548V. doi:10.1126/science.aar8380. PMID 29545507.
  54. ^ Reyhan Yaka. "Archaeogenetics of Late Iron Age Çemialo Sırtı, Batman: Investigating maternal genetic continuity in North Mesopotamia since the Neolithic". bioRxiv 10.1101/172890.
  55. ^ Schuenemann, Verena J.; et al. (2017). "Ancient Egyptian mummy genomes suggest an increase of Sub-Saharan African ancestry in post-Roman periods". Nature Communications. 8: 15694. Bibcode:2017NatCo...815694S. doi:10.1038/ncomms15694. PMC 5459999. PMID 28556824.
  56. ^ Fregel; et al. (2018). "Ancient genomes from North Africa evidence prehistoric migrations to the Maghreb from both the Levant and Europe". bioRxiv 10.1101/191569.
  57. ^ Drosou, Konstantina; Price, Campbell; Brown, Terence A. (February 2018). "The kinship of two 12th Dynasty mummies revealed by ancient DNA sequencing". Journal of Archaeological Science: Reports. 17: 793–797. Bibcode:2018JArSR..17..793D. doi:10.1016/j.jasrep.2017.12.025.
  58. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac Kutanan, Wibhu; Kampuansai, Jatupol; Srikummool, Metawee; Kangwanpong, Daoroong; Ghirotto, Silvia; Brunelli, Andrea; Stoneking, Mark (January 2017). "Complete mitochondrial genomes of Thai and Lao populations indicate an ancient origin of Austroasiatic groups and demic diffusion in the spread of Tai–Kadai languages". Human Genetics. 136 (1): 85–98. doi:10.1007/s00439-016-1742-y. PMC 5214972. PMID 27837350.
  59. ^ a b c d Kong, Q.-P.; Sun, C.; Wang, H.-W.; Zhao, M.; Wang, W.-Z.; Zhong, L.; Hao, X.-D.; Pan, H.; Wang, S.-Y.; Cheng, Y.-T.; Zhu, C.-L.; Wu, S.-F.; Liu, L.-N.; Jin, J.-Q.; Yao, Y.-G.; Zhang, Y.-P. (January 2011). "Large-Scale mtDNA Screening Reveals a Surprising Matrilineal Complexity in East Asia and Its Implications to the Peopling of the Region". Molecular Biology and Evolution. 28 (1): 513–522. doi:10.1093/molbev/msq219. PMID 20713468.
  60. ^ Jinam, Timothy A.; Hong, Lih-Chun; Phipps, Maude E.; Stoneking, Mark; Ameen, Mahmood; Edo, Juli; Hugo; SNP Consortium, Pan-Asian; Saitou, Naruya (2012). "Evolutionary History of Continental Southeast Asians: 'Early Train' Hypothesis Based on Genetic Analysis of Mitochondrial and Autosomal DNA Data". Mol. Biol. Evol. 29 (11): 3513–3527. doi:10.1093/molbev/mss169. PMID 22729749.
  61. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as at au av aw ax ay az ba bb bc bd be bf bg bh bi bj bk bl bm bn bo bp bq br bs bt bu bv bw bx by bz ca cb cc cd ce cf cg ch ci cj ck cl cm cn co cp cq cr cs ct cu cv cw cx cy cz da db dc dd de df dg dh di dj dk dl dm dn do dp dq dr ds dt du dv dw dx dy dz ea eb ec ed YFull MTree 1.01.14609 as of 21 August 2019
  62. ^ a b c d e f g h i j k l m n Kutanan, Wibhu; Shoocongdej, Rasmi; Srikummool, Metawee; Hübner, Alexander; Suttipai, Thanatip; Srithawong, Suparat; Kampuansai, Jatupol; Stoneking, Mark (November 2020). "Cultural variation impacts paternal and maternal genetic lineages of the Hmong-Mien and Sino-Tibetan groups from Thailand". European Journal of Human Genetics. 28 (11): 1563–1579. doi:10.1038/s41431-020-0693-x. PMC 7576213. PMID 32690935.
  63. ^ Hartmann, Anne; Thieme, Marian; Nanduri, Lahiri K.; Stempfl, Thomas; Moehle, Christoph; Kivisild, Toomas; Oefner, Peter J. (January 2009). "Validation of microarray-based resequencing of 93 worldwide mitochondrial genomes". Human Mutation. 30 (1): 115–122. doi:10.1002/humu.20816. PMID 18623076.
  64. ^ a b c d e f g h Lippold, S; Xu, H; Ko, A; Li, M; Renaud, G; Butthof, A; Schröder, R; Stoneking, M (2014). "Human paternal and maternal demographic histories: insights from high-resolution Y chromosome and mtDNA sequences". Investig Genet. 5: 13. bioRxiv 10.1101/001792. doi:10.1186/2041-2223-5-13. PMC 4174254. PMID 25254093.
  65. ^ a b c d e Fornarino, Simona; Pala, Maria; Battaglia, Vincenza; et al. (2009). "Mitochondrial and Y-chromosome diversity of the Tharus (Nepal): a reservoir of genetic variation". BMC Evolutionary Biology. 9 (1): 154. Bibcode:2009BMCEE...9..154F. doi:10.1186/1471-2148-9-154. PMC 2720951. PMID 19573232.
  66. ^ a b Fernando, A. S.; Wanninayaka, A.; Dewage, D.; Karunanayake, E. H.; Rai, N.; Somadeva, R.; Tennekoon, K. H.; Ranasinghe, R. (February 2023). "The mitochondrial genomes of two Pre-historic Hunter Gatherers in Sri Lanka". Journal of Human Genetics. 68 (2): 103–105. doi:10.1038/s10038-022-01099-w. PMID 36450887.
  67. ^ a b c d e f g h i j k l m n o p q r s Chandrasekar, A; Kumar, S; Sreenath, J; Sarkar, BN; Urade, BP; et al. (2009). "Updating Phylogeny of Mitochondrial DNA Macrohaplogroup M in India: Dispersal of Modern Human in South Asian Corridor". PLOS ONE. 4 (10): e7447. Bibcode:2009PLoSO...4.7447C. doi:10.1371/journal.pone.0007447. PMC 2757894. PMID 19823670.
  68. ^ Malyarchuk, B. A.; Perkova, M. A.; Derenko, M. V.; Vanecek, T.; Lazur, J.; Gomolcak, P. (2008). "Mitochondrial DNA Variability in Slovaks, with Application to the Roma Origin". Annals of Human Genetics. 72 (2): 228–240. doi:10.1111/j.1469-1809.2007.00410.x. PMID 18205894. S2CID 205598108.
  69. ^ Kutanan,W., Kampuansai,J., Brunelli,A., Ghirotto,S., Pittayaporn,P., Ruangchai,S., Schroder,R., Macholdt,E., Srikummool,M., Kangwanpong,D., Hubner,A., Arias,L. and Stoneking,M., "New insights from Thailand into the maternal genetic history of Mainland Southeast Asia." Eur. J. Hum. Genet. (2018).
  70. ^ Peng; et al. (2011). "Tracing the legacy of the early Hainan Islanders - a perspective from mitochondrial DNA". BMC Evolutionary Biology. 11 (1): 46. Bibcode:2011BMCEE..11...46P. doi:10.1186/1471-2148-11-46. PMC 3048540. PMID 21324107.
  71. ^ Sukernik, Rem I.; Volodko, Natalia V.; Mazunin, Ilya O.; Eltsov, Nikolai P.; Dryomov, Stanislav V.; Starikovskaya, Elena B. (2012). "Mitochondrial Genome Diversity in the Tubalar, Even, and Ulchi: Contribution to Prehistory of Native Siberians and Their Affinities to Native Americans". American Journal of Physical Anthropology. 148 (1): 123–138. doi:10.1002/ajpa.22050. PMID 22487888.
  72. ^ a b c Fedorova, Sardana A; Reidla, Maere; Metspalu, Ene; et al. (2013). "Autosomal and uniparental portraits of the native populations of Sakha (Yakutia): implications for the peopling of Northeast Eurasia". BMC Evolutionary Biology. 13 (1): 127. Bibcode:2013BMCEE..13..127F. doi:10.1186/1471-2148-13-127. PMC 3695835. PMID 23782551.
  73. ^ a b c d e f g h i j k l m n o p q Duggan, AT; Whitten, M; Wiebe, V; Crawford, M; Butthof, A; et al. (2013). "Investigating the Prehistory of Tungusic Peoples of Siberia and the Amur-Ussuri Region with Complete mtDNA Genome Sequences and Y-chromosomal Markers". PLOS ONE. 8 (12): e83570. Bibcode:2013PLoSO...883570D. doi:10.1371/journal.pone.0083570. PMC 3861515. PMID 24349531.
  74. ^ a b c d Yao, Hongbin; Wang, Mengge; Zou, Xing; Li, Yingxiang; Yang, Xiaomin; Li, Ailin; Yeh, Hui-Yuan; Wang, Peixin; Wang, Zheng; Bai, Jingya; Guo, Jianxin; Chen, Jinwen; Ding, Xiao; Zhang, Yan; Lin, Baoquan; Wang, Chuan-Chao; He, Guanglin (May 2021). "New insights into the fine-scale history of western–eastern admixture of the northwestern Chinese population in the Hexi Corridor via genome-wide genetic legacy". Molecular Genetics and Genomics. 296 (3): 631–651. doi:10.1007/s00438-021-01767-0. PMID 33650010.
  75. ^ a b Tanaka, Masashi; Cabrera, Vicente M.; González, Ana M.; et al. (October 2004). "Mitochondrial Genome Variation in Eastern Asia and the Peopling of Japan". Genome Res. 14 (10): 1832–1850. doi:10.1101/gr.2286304. PMC 524407. PMID 15466285.
  76. ^ Chen, Jing; He, Guanglin; Ren, Zheng; Wang, Qiyan; Liu, Yubo; Zhang, Hongling; Yang, Meiqing; Zhang, Han; Ji, Jingyan; Zhao, Jing; Guo, Jianxin; Chen, Jinwen; Zhu, Kongyang; Yang, Xiaomin; Wang, Rui; Ma, Hao; Tao, Le; Liu, Yilan; Shen, Qu; Yang, Wenjiao; Wang, Chuan-Chao; Huang, Jiang (17 February 2022). "Fine-Scale Population Admixture Landscape of Tai–Kadai-Speaking Maonan in Southwest China Inferred From Genome-Wide SNP Data". Frontiers in Genetics. 13. doi:10.3389/fgene.2022.815285. PMC 8891617. PMID 35251126.
  77. ^ Basnet, Rajdip; Rai, Niraj; Tamang, Rakesh; Awasthi, Nagendra Prasad; Pradhan, Isha; Parajuli, Pawan; Kashyap, Deepak; Reddy, Alla Govardhan; Chaubey, Gyaneshwer; Das Manandhar, Krishna; Shrestha, Tilak Ram; Thangaraj, Kumarasamy (15 October 2022). "The matrilineal ancestry of Nepali populations". Human Genetics. 142 (2): 167–180. doi:10.1007/s00439-022-02488-z. PMID 36242641. S2CID 252904281.
  78. ^ Zhang, Xiaoming; Ji, Xueping; Li, Chunmei; Yang, Tingyu; Huang, Jiahui; Zhao, Yinhui; Wu, Yun; Ma, Shiwu; Pang, Yuhong; Huang, Yanyi; He, Yaoxi (July 2022). "A Late Pleistocene human genome from Southwest China". Current Biology. 32 (14): 3095–3109.e5. Bibcode:2022CBio...32E3095Z. doi:10.1016/j.cub.2022.06.016. PMID 35839766. S2CID 250502011.
  79. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak Behar et al., 2012b[full citation needed]
  80. ^ a b c Derenko, M; Malyarchuk, B; Denisova, G; Perkova, M; Rogalla, U; et al. (2012). "Complete Mitochondrial DNA Analysis of Eastern Eurasian Haplogroups Rarely Found in Populations of Northern Asia and Eastern Europe". PLOS ONE. 7 (2): e32179. Bibcode:2012PLoSO...732179D. doi:10.1371/journal.pone.0032179. PMC 3283723. PMID 22363811.
  81. ^ Juras, A.; Krzewinska, M.; Nikitin, A.G.; Ehler, E.; Chylenski, M.; Lukasik, S.; Krenz-Niedbala, M.; Sinika, V.; Piontek, J.; Ivanova, S.; Dabert, M.; Gotherstrom, A. (2017). "Diverse origin of mitochondrial lineages in Iron Age Black Sea Scythians". Sci Rep. 7: 43950. Bibcode:2017NatSR...743950J. doi:10.1038/srep43950. PMC 5339713. PMID 28266657.
  82. ^ a b c Ko, Albert Min-Shan; Chen, Chung-Yu; Fu, Qiaomei; Delfin, Frederick; Li, Mingkun; Chiu, Hung-Lin; Stoneking, Mark; Ko, Ying-Chin (2014). "Early Austronesians: into and out of Taiwan". The American Journal of Human Genetics. 94 (3): 426–436. doi:10.1016/j.ajhg.2014.02.003. PMC 3951936. PMID 24607387.
  83. ^ Lee, Hwan Young; Yoo, Ji-Eun; Park, Myung Jin; Chung, Ukhee; Kim, Chong-Youl; Shin, Kyoung-Jin (November 2006). "East Asian mtDNA haplogroup determination in Koreans: Haplogroup-level coding region SNP analysis and subhaplogroup-level control region sequence analysis". Electrophoresis. 27 (22): 4408–4418. doi:10.1002/elps.200600151. PMID 17058303.
  84. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag MtDNA Haplotree at Family Tree DNA
  85. ^ a b c Yu, Dandan; Jia, Xiaoyun; Zhang, A-Mei; Li, Shiqiang; Zou, Yang; Zhang, Qingjiong; Yao, Yong-Gang (18 October 2010). "Mitochondrial DNA Sequence Variation and Haplogroup Distribution in Chinese Patients with LHON and m.14484T>C". PLOS ONE. 5 (10): e13426. Bibcode:2010PLoSO...513426Y. doi:10.1371/journal.pone.0013426. PMC 2956641. PMID 20976138.
  86. ^ Ji, Yanli; Zhang, A-Mei; Jia, Xiaoyun; Zhang, Ya-Ping; Xiao, Xueshan; Li, Shiqiang; Guo, Xiangming; Bandelt, Hans-Jürgen; Zhang, Qingjiong; Yao, Yong-Gang (December 2008). "Mitochondrial DNA Haplogroups M7b1′2 and M8a Affect Clinical Expression of Leber Hereditary Optic Neuropathy in Chinese Families with the m.11778G→A Mutation". The American Journal of Human Genetics. 83 (6): 760–768. doi:10.1016/j.ajhg.2008.11.002. PMC 2668067. PMID 19026397.
  87. ^ a b c d e f g h Zhao, Dan; Ding, Yingying; Lin, Haijiang; Chen, Xiaoxiao; Shen, Weiwei; Gao, Meiyang; Wei, Qian; Zhou, Sujuan; Liu, Xing; He, Na (June 2019). "Mitochondrial Haplogroups N9 and G Are Associated with Metabolic Syndrome Among Human Immunodeficiency Virus-Infected Patients in China". AIDS Research and Human Retroviruses. 35 (6): 536–543. doi:10.1089/aid.2018.0151. PMID 30950284.
  88. ^ Lu, Dongsheng; Lou, Haiyi; Yuan, Kai; Wang, Xiaoji; Wang, Yuchen; Zhang, Chao; Lu, Yan; Yang, Xiong; Deng, Lian; Zhou, Ying; Feng, Qidi; Hu, Ya; Ding, Qiliang; Yang, Yajun; Li, Shilin; Jin, Li; Guan, Yaqun; Su, Bing; Kang, Longli; Xu, Shuhua (September 2016). "Ancestral Origins and Genetic History of Tibetan Highlanders". The American Journal of Human Genetics. 99 (3): 580–594. doi:10.1016/j.ajhg.2016.07.002. PMC 5011065. PMID 27569548.
  89. ^ a b c d e f g h i Kang, Longli; Zheng, Hong-Xiang; Zhang, Menghan; Yan, Shi; Li, Lei; Liu, Lijun; Liu, Kai; Hu, Kang; Chen, Feng; Ma, Lifeng; Qin, Zhendong; Wang, Yi; Wang, Xiaofeng; Jin, Li (8 August 2016). "MtDNA analysis reveals enriched pathogenic mutations in Tibetan highlanders". Scientific Reports. 6 (1): 31083. Bibcode:2016NatSR...631083K. doi:10.1038/srep31083. PMC 4976311. PMID 27498855.
  90. ^ a b c d Summerer, Monika; Horst, Jürgen; Erhart, Gertraud; Weißensteiner, Hansi; Schönherr, Sebastian; Pacher, Dominic; Forer, Lukas; Horst, David; Manhart, Angelika; Horst, Basil; Sanguansermsri, Torpong; Kloss-Brandstätter, Anita (December 2014). "Large-scale mitochondrial DNA analysis in Southeast Asia reveals evolutionary effects of cultural isolation in the multi-ethnic population of Myanmar". BMC Evolutionary Biology. 14 (1): 17. Bibcode:2014BMCEE..14...17S. doi:10.1186/1471-2148-14-17. PMC 3913319. PMID 24467713.
  91. ^ Ingman, Max; Gyllensten, Ulf (October 2007). "Rate variation between mitochondrial domains and adaptive evolution in humans". Human Molecular Genetics. 16 (19): 2281–2287. doi:10.1093/hmg/ddm180. PMID 17617636.
  92. ^ a b c d e f g h i j k l Pankratov, Vasili; Litvinov, Sergei; Kassian, Alexei; Shulhin, Dzmitry; Tchebotarev, Lieve; Yunusbayev, Bayazit; Möls, Märt; Sahakyan, Hovhannes; Yepiskoposyan, Levon; Rootsi, Siiri; Metspalu, Ene; Golubenko, Maria; Ekomasova, Natalia; Akhatova, Farida; Khusnutdinova, Elza; Heyer, Evelyne; Endicott, Phillip; Derenko, Miroslava; Malyarchuk, Boris; Metspalu, Mait; Davydenko, Oleg; Villems, Richard; Kushniarevich, Alena (25 July 2016). "East Eurasian ancestry in the middle of Europe: genetic footprints of Steppe nomads in the genomes of Belarusian Lipka Tatars". Scientific Reports. 6 (1): 30197. Bibcode:2016NatSR...630197P. doi:10.1038/srep30197. PMC 4958967. PMID 27453128.
  93. ^ Just, Rebecca S.; Scheible, Melissa K.; Fast, Spence A.; Sturk-Andreaggi, Kimberly; Röck, Alexander W.; Bush, Jocelyn M.; Higginbotham, Jennifer L.; Peck, Michelle A.; Ring, Joseph D.; Huber, Gabriela E.; Xavier, Catarina; Strobl, Christina; Lyons, Elizabeth A.; Diegoli, Toni M.; Bodner, Martin; Fendt, Liane; Kralj, Petra; Nagl, Simone; Niederwieser, Daniela; Zimmermann, Bettina; Parson, Walther; Irwin, Jodi A. (January 2015). "Full mtGenome reference data: Development and characterization of 588 forensic-quality haplotypes representing three U.S. populations". Forensic Science International: Genetics. 14: 141–155. doi:10.1016/j.fsigen.2014.09.021. PMID 25450785.
  94. ^ a b c d e f g h i j k l m n Kutanan, Wibhu; Kampuansai, Jatupol; Brunelli, Andrea; Ghirotto, Silvia; Pittayaporn, Pittayawat; Ruangchai, Sukhum; Schröder, Roland; Macholdt, Enrico; Srikummool, Metawee; Kangwanpong, Daoroong; Hübner, Alexander; Arias, Leonardo; Stoneking, Mark (June 2018). "New insights from Thailand into the maternal genetic history of Mainland Southeast Asia". European Journal of Human Genetics. 26 (6): 898–911. doi:10.1038/s41431-018-0113-7. PMC 5974021. PMID 29483671.
  95. ^ a b Kong, Qing-Peng; Yao, Yong-Gang; Sun, Chang; Bandelt, Hans-Jürgen; Zhu, Chun-Ling; Zhang, Ya-Ping (September 2003). "Phylogeny of East Asian Mitochondrial DNA Lineages Inferred from Complete Sequences". The American Journal of Human Genetics. 73 (3): 671–676. doi:10.1086/377718. PMC 1180693. PMID 12870132.
  96. ^ a b c Duong, Nguyen Thuy; Macholdt, Enrico; Ton, Nguyen Dang; Arias, Leonardo; Schröder, Roland; Van Phong, Nguyen; Thi Bich Thuy, Vo; Ha, Nguyen Hai; Thi Thu Hue, Huynh; Thi Xuan, Nguyen; Thi Phuong Oanh, Kim; Hien, Le Thi Thu; Hoang, Nguyen Huy; Pakendorf, Brigitte; Stoneking, Mark; Van Hai, Nong (3 August 2018). "Complete human mtDNA genome sequences from Vietnam and the phylogeography of Mainland Southeast Asia". Scientific Reports. 8 (1): 11651. Bibcode:2018NatSR...811651D. doi:10.1038/s41598-018-29989-0. PMC 6076260. PMID 30076323.
  97. ^ Zou, Yang; Jia, Xiaoyun; Zhang, A-Mei; Wang, Wen-Zhi; Li, Shiqiang; Guo, Xiangming; Kong, Qing-Peng; Zhang, Qingjiong; Yao, Yong-Gang (August 2010). "The MT-ND1 and MT-ND5 genes are mutational hotspots for Chinese families with clinical features of LHON but lacking the three primary mutations". Biochemical and Biophysical Research Communications. 399 (2): 179–185. doi:10.1016/j.bbrc.2010.07.051. PMID 20643099.
  98. ^ a b c d e f g h Jiang, Chunhua; Cui, Jianhua; Liu, Fuyu; Gao, Liang; Luo, Yongjun; Li, Peng; Guan, Libin; Gao, Yuqi (30 January 2014). "Mitochondrial DNA 10609T Promotes Hypoxia-Induced Increase of Intracellular ROS and Is a Risk Factor of High Altitude Polycythemia". PLOS ONE. 9 (1): e87775. Bibcode:2014PLoSO...987775J. doi:10.1371/journal.pone.0087775. PMC 3907523. PMID 24498190.
  99. ^ Kong, Q.-P.; Sun, C.; Wang, H.-W.; Zhao, M.; Wang, W.-Z.; Zhong, L.; Hao, X.-D.; Pan, H.; Wang, S.-Y.; Cheng, Y.-T.; Zhu, C.-L.; Wu, S.-F.; Liu, L.-N.; Jin, J.-Q.; Yao, Y.-G.; Zhang, Y.-P. (January 2011). "Large-Scale mtDNA Screening Reveals a Surprising Matrilineal Complexity in East Asia and Its Implications to the Peopling of the Region". Molecular Biology and Evolution. 28 (1): 513–522. doi:10.1093/molbev/msq219. PMID 20713468.
  100. ^ a b c d Liu, Jia; Wang, Li-Dong; Sun, Yan-Bo; Li, En-Min; Xu, Li-Yan; Zhang, Ya-Ping; Yao, Yong-Gang; Kong, Qing-Peng (April 2012). "Deciphering the Signature of Selective Constraints on Cancerous Mitochondrial Genome". Molecular Biology and Evolution. 29 (4): 1255–1261. doi:10.1093/molbev/msr290. PMID 22130971.
  101. ^ a b c d e f g h i j k l m n o p q r s Derenko, Miroslava; Denisova, Galina; Malyarchuk, Boris; Dambueva, Irina; Bazarov, Boris (January 2018). "Mitogenomic diversity and differentiation of the Buryats". Journal of Human Genetics. 63 (1): 71–81. doi:10.1038/s10038-017-0370-2. PMID 29215085.
  102. ^ a b Malyarchuk, Boris; Litvinov, Andrey; Derenko, Miroslava; Skonieczna, Katarzyna; Grzybowski, Tomasz; Grosheva, Aleksandra; Shneider, Yuri; Rychkov, Sergei; Zhukova, Olga (September 2017). "Mitogenomic diversity in Russians and Poles". Forensic Science International: Genetics. 30: 51–56. doi:10.1016/j.fsigen.2017.06.003. PMID 28633069.
  103. ^ Marchi, Nina; Hegay, Tatyana; Mennecier, Philippe; Georges, Myriam; Laurent, Romain; Whitten, Mark; Endicott, Philipp; Aldashev, Almaz; Dorzhu, Choduraa; Nasyrova, Firuza; Chichlo, Boris; Ségurel, Laure; Heyer, Evelyne (April 2017). "Sex-specific genetic diversity is shaped by cultural factors in Inner Asian human populations". American Journal of Physical Anthropology. 162 (4): 627–640. doi:10.1002/ajpa.23151. PMID 28158897.
  104. ^ a b Wang, Hua-Wei; Jia, Xiaoyun; Ji, Yanli; Kong, Qing-Peng; Zhang, Qingjiong; Yao, Yong-Gang; Zhang, Ya-Ping (August 2008). "Strikingly different penetrance of LHON in two Chinese families with primary mutation G11778A is independent of mtDNA haplogroup background and secondary mutation G13708A". Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 643 (1–2): 48–53. Bibcode:2008MRFMM.643...48W. doi:10.1016/j.mrfmmm.2008.06.004. PMID 18619472.
  105. ^ a b Mielnik-Sikorska, Marta; Daca, Patrycja; Malyarchuk, Boris; Derenko, Miroslava; Skonieczna, Katarzyna; Perkova, Maria; Dobosz, Tadeusz; Grzybowski, Tomasz (14 January 2013). "The History of Slavs Inferred from Complete Mitochondrial Genome Sequences". PLOS ONE. 8 (1): e54360. Bibcode:2013PLoSO...854360M. doi:10.1371/journal.pone.0054360. PMC 3544712. PMID 23342138.
  106. ^ Kılınç, Gülşah Merve; Kashuba, Natalija; Yaka, Reyhan; Sümer, Arev Pelin; Yüncü, Eren; Shergin, Dmitrij; Ivanov, Grigorij Leonidovich; Kichigin, Dmitrii; Pestereva, Kjunnej; Volkov, Denis; Mandryka, Pavel; Kharinskii, Artur; Tishkin, Alexey; Ineshin, Evgenij; Kovychev, Evgeniy; Stepanov, Aleksandr; Alekseev, Aanatolij; Fedoseeva, Svetlana Aleksandrovna; Somel, Mehmet; Jakobsson, Mattias; Krzewińska, Maja; Storå, Jan; Götherström, Anders (12 June 2018). "Investigating Holocene human population history in North Asia using ancient mitogenomes". Scientific Reports. 8 (1): 8969. Bibcode:2018NatSR...8.8969K. doi:10.1038/s41598-018-27325-0. PMC 5997703. PMID 29895902.
  107. ^ a b Malyarchuk, B.; Derenko, M.; Denisova, G.; Kravtsova, O. (October 2010). "Mitogenomic Diversity in Tatars from the Volga-Ural Region of Russia". Molecular Biology and Evolution. 27 (10): 2220–2226. doi:10.1093/molbev/msq065. PMID 20457583.
  108. ^ Loo, Jun-Hun; Trejaut, Jean A; Yen, Ju-Chen; Chen, Zong-Sian; Ng, Wai-Mei; Huang, Chin-Yuan; Hsu, Kuang-Nan; Hung, Kuo-Hua; Hsiao, Yachun; Wei, Yau-Huei; Lin, Marie (December 2014). "Mitochondrial DNA association study of type 2 diabetes with or without ischemic stroke in Taiwan". BMC Research Notes. 7 (1): 223. doi:10.1186/1756-0500-7-223. PMC 4108081. PMID 24713204.
  109. ^ a b Dryomov, Stanislav V.; Nazhmidenova, Azhar M.; Starikovskaya, Elena B.; Shalaurova, Sofia A.; Rohland, Nadin; Mallick, Swapan; Bernardos, Rebecca; Derevianko, Anatoly P.; Reich, David; Sukernik, Rem I. (28 January 2021). "Mitochondrial genome diversity on the Central Siberian Plateau with particular reference to the prehistory of northernmost Eurasia". PLOS ONE. 16 (1): e0244228. Bibcode:2021PLoSO..1644228D. doi:10.1371/journal.pone.0244228. PMC 7842996. PMID 33507977.
  110. ^ a b Wang, Cheng-Ye; Li, Hui; Hao, Xiao-Dan; Liu, Jia; Wang, Jia-Xin; Wang, Wen-Zhi; Kong, Qing-Peng; Zhang, Ya-Ping (28 June 2011). "Uncovering the Profile of Somatic mtDNA Mutations in Chinese Colorectal Cancer Patients". PLOS ONE. 6 (6): e21613. Bibcode:2011PLoSO...621613W. doi:10.1371/journal.pone.0021613. PMC 3125228. PMID 21738732.
  111. ^ Zhang, A-Mei; Jia, Xiaoyun; Yao, Yong-Gang; Zhang, Qingjiong (November 2008). "Co-occurrence of A1555G and G11778A in a Chinese family with high penetrance of Leber's hereditary optic neuropathy". Biochemical and Biophysical Research Communications. 376 (1): 221–224. doi:10.1016/j.bbrc.2008.08.128. PMID 18775412.
  112. ^ Jeong, Choongwon; Wang, Ke; Wilkin, Shevan; Taylor, William Timothy Treal; Miller, Bryan K.; Bemmann, Jan H.; Stahl, Raphaela; Chiovelli, Chelsea; Knolle, Florian; Ulziibayar, Sodnom; Khatanbaatar, Dorjpurev; Erdenebaatar, Diimaajav; Erdenebat, Ulambayar; Ochir, Ayudai; Ankhsanaa, Ganbold; Vanchigdash, Chuluunkhuu; Ochir, Battuga; Munkhbayar, Chuluunbat; Tumen, Dashzeveg; Kovalev, Alexey; Kradin, Nikolay; Bazarov, Bilikto A.; Miyagashev, Denis A.; Konovalov, Prokopiy B.; Zhambaltarova, Elena; Miller, Alicia Ventresca; Haak, Wolfgang; Schiffels, Stephan; Krause, Johannes; Boivin, Nicole; Erdene, Myagmar; Hendy, Jessica; Warinner, Christina (November 2020). "A Dynamic 6,000-Year Genetic History of Eurasia's Eastern Steppe". Cell. 183 (4): 890–904.e29. doi:10.1016/j.cell.2020.10.015. PMC 7664836. PMID 33157037.
  113. ^ a b Zhao, Mian; Kong, Qing-Peng; Wang, Hua-Wei; Peng, Min-Sheng; Xie, Xiao-Dong; Wang, Wen-Zhi; Duan, Jian-Guo; Cai, Ming-Cui; Zhao, Shi-Neng; Tu, Yuan-Quan; Wu, Shi-Fang; Yao, Yong-Gang; Bandelt, Hans-Jürgen; Zhang, Ya-Ping (15 December 2009). "Mitochondrial genome evidence reveals successful Late Paleolithic settlement on the Tibetan Plateau". Proceedings of the National Academy of Sciences. 106 (50): 21230–21235. Bibcode:2009PNAS..10621230Z. doi:10.1073/pnas.0907844106. PMC 2795552. PMID 19955425.
  114. ^ Kang, Longli; Zheng, Hong-Xiang; Chen, Feng; Yan, Shi; Liu, Kai; Qin, Zhendong; Liu, Lijun; Zhao, Zhipeng; Li, Lei; Wang, Xiaofeng; He, Yungang; Jin, Li (December 2013). "mtDNA Lineage Expansions in Sherpa Population Suggest Adaptive Evolution in Tibetan Highlands". Molecular Biology and Evolution. 30 (12): 2579–2587. doi:10.1093/molbev/mst147. PMID 24002810.
  115. ^ a b c d Kong, Qing-Peng; Bandelt, Hans-Jürgen; Sun, Chang; et al. (2006). "Updating the East Asian mtDNA phylogeny: a prerequisite for the identification of pathogenic mutations". Human Molecular Genetics. 15 (13): 2076–2086. doi:10.1093/hmg/ddl130. PMID 16714301.
  116. ^ Zhang, Xiaoming; Li, Chunmei; Zhou, Yanan; Huang, Jiahui; Yu, Tengsong; Liu, Xu; Shi, Hong; Liu, Hong; Chia, Stephen; Huang, Shenmin; Guo, Yaozheng; Shoocongdej, Rasmi; Ji, Xueping; Su, Bing (April 2020). "A Matrilineal Genetic Perspective of Hanging Coffin Custom in Southern China and Northern Thailand". iScience. 23 (4): 101032. Bibcode:2020iSci...23j1032Z. doi:10.1016/j.isci.2020.101032. PMC 7163074. PMID 32304863.
  117. ^ Dryomov, Stanislav V.; Starikovskaya, Elena B.; Nazhmidenova, Azhar M.; Morozov, Igor V.; Sukernik, Rem I. (December 2020). "Genetic legacy of cultures indigenous to the Northeast Asian coast in mitochondrial genomes of nearly extinct maritime tribes". BMC Evolutionary Biology. 20 (1): 83. Bibcode:2020BMCEE..20...83D. doi:10.1186/s12862-020-01652-1. PMC 7359603. PMID 32660486.
  118. ^ Wang, Cheng-Ye; Zhao, Zhong-Bao (January 2012). "Somatic mtDNA mutations in lung tissues of pesticide-exposed fruit growers". Toxicology. 291 (1–3): 51–55. Bibcode:2012Toxgy.291...51W. doi:10.1016/j.tox.2011.10.018. PMID 22079233.
  119. ^ Ingman, M.; Kaessmann, H.; Paabo, S.; Gyllensten, U. (2000). "Mitochondrial genome variation and the origin of modern humans". Nature. 408 (6813): 708–713. Bibcode:2000Natur.408..708I. doi:10.1038/35047064. PMID 11130070. S2CID 52850476.
  120. ^ Yao, Yong-Gang; Kong, Qing-Peng; Wang, Cheng-Ye; et al. (2004). "Different Matrilineal Contributions to Genetic Structure of Ethnic Groups in the Silk Road Region in China". Mol. Biol. Evol. 21 (12): 2265–2280. doi:10.1093/molbev/msh238. PMID 15317881.
  121. ^ a b c d e f g h i j k l m n o p Kutanan, Wibhu; Kampuansai, Jatupol; Changmai, Piya; et al. (2018). "Contrasting maternal and paternal genetic variation of hunter-gatherer groups in Thailand". Scientific Reports. 8 (1): 1536. Bibcode:2018NatSR...8.1536K. doi:10.1038/s41598-018-20020-0. PMC 5784115. PMID 29367746.
  122. ^ a b c Scholes, Clarissa; Siddle, Katherine; Ducourneau, Axel; et al. (2011). "Genetic Diversity and Evidence for Population Admixture in Batak Negritos from Palawan". American Journal of Physical Anthropology. 146 (1): 62–72. doi:10.1002/ajpa.21544. PMID 21796613.
  123. ^ "M24'41 MTree".
  124. ^ Brook, Kevin Alan (2022). The Maternal Genetic Lineages of Ashkenazic Jews. Academic Studies Press. p. 81. doi:10.2307/j.ctv33mgbcn. ISBN 978-1-64469-984-3. JSTOR j.ctv33mgbcn. S2CID 254519342.
  125. ^ a b c d e f g h i Jiao-Yang Tian; Hua-Wei Wang; Yu-Chun Li; Wen Zhang; Yong-Gang Yao; Jits van Straten; Martin B. Richards; Qing-Peng Kong (11 February 2015). "A Genetic Contribution from the Far East into Ashkenazi Jews via the Ancient Silk Road". Scientific Reports. 5: 8377. Bibcode:2015NatSR...5E8377T. doi:10.1038/srep08377. PMC 4323646. PMID 25669617.
  126. ^ Brook, Kevin Alan (2022). The Maternal Genetic Lineages of Ashkenazic Jews. Academic Studies Press. p. 80. doi:10.2307/j.ctv33mgbcn. ISBN 978-1-64469-984-3. JSTOR j.ctv33mgbcn. S2CID 254519342.
  127. ^ Malyarchuk, B. A.; Perkova, M. A.; Derenko, M. V.; Vanecek, T.; Lazur, J.; Gomolcak, P. (March 2008). "Mitochondrial DNA Variability in Slovaks, with Application to the Roma Origin". Annals of Human Genetics. 72 (2): 228–240. doi:10.1111/j.1469-1809.2007.00410.x. PMID 18205894.
  128. ^ "M39'70 MTree".
  129. ^ "M42'74 MTree".
  130. ^ Zhang, Xiaoming; Qi, Xuebin; Yang, Zhaohui; Serey, Bun; Sovannary, Tuot; Bunnath, Long; Seang Aun, Hong; Samnom, Ham; Zhang, Hui; Lin, Qiang; van Oven, Mannis; Shi, Hong; Su, Bing (14 October 2013). "Analysis of mitochondrial genome diversity identifies new and ancient maternal lineages in Cambodian aborigines". Nature Communications. 4 (1): 2599. Bibcode:2013NatCo...4.2599Z. doi:10.1038/ncomms3599. PMID 24121720.
  131. ^ "M55'77 MTree".
  132. ^ "M77 MTree".
  133. ^ "M62'68 MTree".
  134. ^ "M68 MTree".
  135. ^ Wang, Tianyi; Wang, Wei; Xie, Guangmao; Li, Zhen; Fan, Xuechun; Yang, Qingping; Wu, Xichao; Cao, Peng; Liu, Yichen; Yang, Ruowei; Liu, Feng; Dai, Qingyan; Feng, Xiaotian; Wu, Xiaohong; Qin, Ling; Li, Fajun; Ping, Wanjing; Zhang, Lizhao; Zhang, Ming; Liu, Yalin; Chen, Xiaoshan; Zhang, Dongju; Zhou, Zhenyu; Wu, Yun; Shafiey, Hassan; Gao, Xing; Curnoe, Darren; Mao, Xiaowei; Bennett, E. Andrew; Ji, Xueping; Yang, Melinda A.; Fu, Qiaomei (July 2021). "Human population history at the crossroads of East and Southeast Asia since 11,000 years ago". Cell. 184 (14): 3829–3841.e21. doi:10.1016/j.cell.2021.05.018. PMID 34171307.
  136. ^ a b Kutanan, Wibhu; Kampuansai, Jatupol; Changmai, Piya; Flegontov, Pavel; Schröder, Roland; Macholdt, Enrico; Hübner, Alexander; Kangwanpong, Daoroong; Stoneking, Mark (24 January 2018). "Contrasting maternal and paternal genetic variation of hunter-gatherer groups in Thailand". Scientific Reports. 8 (1): 1536. Bibcode:2018NatSR...8.1536K. doi:10.1038/s41598-018-20020-0. PMC 5784115. PMID 29367746.
  137. ^ "M73'79 MTree".
  138. ^ "M73 MTree".
  139. ^ "M79 MTree".
  140. ^ Comas, David; Plaza, Stéphanie; Wells, R Spencer; Yuldaseva, Nadira; Lao, Oscar; Calafell, Francesc; Bertranpetit, Jaume (June 2004). "Admixture, migrations, and dispersals in Central Asia: evidence from maternal DNA lineages". European Journal of Human Genetics. 12 (6): 495–504. doi:10.1038/sj.ejhg.5201160. PMID 14872198.
  141. ^ Nadine Epstein (September–October 2012). "The Moment Magazine Great DNA Experiment". Moment Magazine. p. 43. Retrieved 7 March 2024.
  142. ^ Nadine Epstein (September–October 2012). "The Moment Magazine Great DNA Experiment". Moment Magazine. p. 45. Retrieved 7 March 2024.
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