Neuropeptide B

NPB
Identifiers
Aliases	NPB, L7, PPL7, PPneuropeptide B
External IDs	OMIM: 607996; MGI: 2387153; HomoloGene: 102151; GeneCards: NPB; OMA:NPB - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	81,902,905 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	120,499,919 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; testicle; ; hypothalamus; ; substantia nigra; ; nucleus accumbens; ; amygdala; ; stromal cell of endometrium; ; Brodmann area 9; ; putamen; ; anterior cingulate cortex;
	Top expressed in
	stomach; ; embryo; ; testicle; ; morula; ; embryo; ; right kidney; ; spermatid; ; placenta; ; urinary bladder; ; cerebellar cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; G protein-coupled receptor binding;
Cellular component	extracellular region;
Biological process	neuropeptide signaling pathway; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	256933
	208990
	ENSG00000183979
	ENSMUSG00000044034
	Q8NG41
	Q8K4P1
	NM_148896
	NM_153288; NM_001347616; NM_001347617
	NP_683694
	NP_001334545; NP_001334546; NP_695020
	Wikidata
View/Edit Human	View/Edit Mouse

Neuropeptide B is a short biologically active peptide whose precursor in humans is encoded by the NBP gene. Neuropeptide B acts via two G protein-coupled receptors, neuropeptide B/W receptors, called NPBW1 and NPBW2 encoded by the genes NPBWR1 and NPBWR2, respectively. Neuropeptide B is thought to be associated with the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway.^[5]^[6] It is expressed throughout the CNS with high levels in the substantia nigra, hypothalamus, hippocampus, and spinal cord.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183979 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044034 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Singh G, Davenport AP (Aug 2006). "Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system". British Journal of Pharmacology. 148 (8): 1033–41. doi:10.1038/sj.bjp.0706825. PMC 1752024. PMID 16847439.
^ Hondo M, Ishii M, Sakurai T (2008). "The NPB/NPW Neuropeptide System and Its Role in Regulating Energy Homeostasis, Pain, and Emotion". Orphan G Protein-Coupled Receptors and Novel Neuropeptides. Results and Problems in Cell Differentiation. Vol. 46. pp. 239–56. doi:10.1007/400_2007_056. ISBN 978-3-540-78350-3. PMID 18204824.

External links

Uniprot: Neuropeptide B precursor

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183979 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044034 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Singh G, Davenport AP (Aug 2006). "Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system". British Journal of Pharmacology. 148 (8): 1033–41. doi:10.1038/sj.bjp.0706825. PMC 1752024. PMID 16847439.

[6] Hondo M, Ishii M, Sakurai T (2008). "The NPB/NPW Neuropeptide System and Its Role in Regulating Energy Homeostasis, Pain, and Emotion". Orphan G Protein-Coupled Receptors and Novel Neuropeptides. Results and Problems in Cell Differentiation. Vol. 46. pp. 239–56. doi:10.1007/400_2007_056. ISBN 978-3-540-78350-3. PMID 18204824.

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)