Оловянный мезопорфирин

Оловянный мезопорфирин

Имена
Имя IUPAC 3- [18- (2-карбоксиэтил) -8,13-диэтил-3,7,12,17-тетраметилпорфирин-21,24-диид-2-ил] пропаноевая кислота; олово (4+); дихлорид
Identifiers
CAS Number	106344-20-1
3D model (JSmol)	Interactive image
DrugBank	DB04912
PubChem CID	15978579
UNII	0KAE1U0G7Q
показывать InChI InChI=1S/C34H38N4O4.2ClH.Sn/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;;/h13-16H,7-12H2,1-6H3,(H4,35,36,37,38,39,40,41,42);2*1H;/q;;;+4/p-4 Key: LLDZJTIZVZFNCM-UHFFFAOYSA-J
показывать SMILES CCC1=C(C2=NC1=CC3=C(C(=C([N-]3)C=C4C(=C(C(=CC5=NC(=C2)C(=C5C)CC)[N-]4)C)CCC(=O)O)CCC(=O)O)C)C.[Cl-].[Cl-].[Sn+4]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Оловянный мезопорфирин (SNMP) , также известный как Stannsoporfin , представляет собой синтетический металлопорфирин , который состоит из группы конкурентных ингибиторов гемоксигеназы , ограничивающего скорость фермента в катаболическом пути гема . Хин -мезопорфирин является одним из наиболее мощных соединений металлопорфирина из всех остальных.

Структура

Как следует из названия, оловянный мезопорфирин, общая структура очень похожа на естественную молекулу гема . Он состоит из кольцевой структурированной молекулы протопорфирина IX , которая имеет олово в качестве центрального атома. Поскольку это синтетическая молекула, две винильные группы как в положениях C2, так и C4 на макроциле порфирина снижаются для формирования этильных групп Это найдено на оловянном мезопорфирине. Молекулярная масса оловянного мезопорфирина составляет 754,3 г/моль.

Mechanism

In the heme catabolic pathway, heme oxygenase catalyzes the breakdown of heme to biliverdin and well as carbon monoxide that is exhaled. Biliverdin is then converted to bilirubin with biliverdin reductase. As high biliverdin levels are usually related to bilirubinemia, tin mesoporphyrin has been found to aid in treatment and prevention of this, primarily in newborn infants. Tin mesoporphyrin competitively inhibits the heme oxygenase enzyme, which prevents the breakdown of heme to biliverdin leading to accumulation of heme and not bilirubin.

Application

The application of stannsoporfin or tin mesoporphyrin is currently still being researched. Clinical studies have outlined its use in the treatment of hyperbilirubinemia infants and also the prevention of neonatal jaundice. It has also been found to reduce edema and hematoma in spontaneous intracerebral hemorrhage(ICH) from patients who suffered traumatic brain injuries.

Treatment in hyperbilirubinemia

In one study, tin mesoporphyrin was administered intramuscularly to a newborn that was only 46 hours old with a low birth weight who had also suffered from severe hyperbilirubinemia. Along with blue light treatment, the newborn showed a steady decrease in its total serum biliverdin within 10 hours after administration.

Prevention of neonatal jaundice

It has also been found that tin mesoporphyrin can aid in the prevention of neonatal jaundice. When administered to pre-discharge newborns who were at risk for neonatal jaundice the results showed a decrease in total biliverdin load, the possibility of postnatal bilirubin progression, as well as the use and duration of phototherapy.

Treatment in spontaneous intracerebral hemorrhage

Tin mesoporphyrin has also been found potentially reduce intracerebral mass in intracerebral hemorrhage cases by decreasing the hematoma and edema volumes.

Concerns of use

Tin is a metal and can potentially be toxic. Consider the application of it in terms of dosage and other contributing factors. If tin mesoporphyin is going to be utilized in medicine, it is important to understand if there are any specific interactions with other medications. Since this compound has not been thoroughly investigated yet, there may be adverse effects of symptoms that can come with its application.