CLDN11

CLDN11
Identifiers
Aliases	CLDN11, OSP, OTM, claudin 11, HLD22
External IDs	OMIM: 601326; MGI: 106925; HomoloGene: 4093; GeneCards: CLDN11; OMA:CLDN11 - orthologs
showGene location (Human)
Chr.	Chromosome 3 (human)
End	170,454,733 bp
showGene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	31,218,473 bp
showRNA expression pattern
	Top expressed in
	inferior ganglion of vagus nerve; ; subthalamic nucleus; ; superior vestibular nucleus; ; ventral tegmental area; ; pons; ; external globus pallidus; ; pars reticulata; ; C1 segment; ; trigeminal ganglion; ; Pars compacta;
	Top expressed in
	ventral tegmental area; ; lateral geniculate nucleus; ; globus pallidus; ; stria vascularis; ; deep cerebellar nuclei; ; pontine nuclei; ; pineal gland; ; lateral hypothalamus; ; medial geniculate nucleus; ; lumbar subsegment of spinal cord;
	More reference expression data
	More reference expression data
showGene ontology
Molecular function	structural molecule activity; identical protein binding; protein binding;
Cellular component	integral component of membrane; cell junction; membrane; bicellular tight junction; plasma membrane;
Biological process	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;
	Sources:Amigo / QuickGO
hideOrthologs
	5010
	18417
	ENSG00000013297
	ENSMUSG00000037625
	O75508
	Q60771
	NM_005602; NM_001185056
	NM_008770
	NP_001171985; NP_005593
	NP_032796
	Wikidata
View/Edit Human	View/Edit Mouse

Claudin-11 is a protein that in humans is encoded by the CLDN11 gene.^[5]^[6]^[7] It belongs to the group of claudins and was the first member of the family to be knocked out in mice, thereby demonstrating the central role of claudins for intramembranous strands observed in freeze-fracture images.^[8]

Function

The protein encoded by this gene belongs to the claudin family of tight junction associated proteins and is a major component of central nervous system myelin that is necessary for normal CNS function,^[9] hearing,^[10] and spermatogenesis.^[8] There is growing evidence that the protein determines the permeability between layers of myelin sheaths^[11] and, with its expression highly regulated during development, may play an important role in cellular proliferation and migration. In addition, the protein is a candidate autoantigen in the development of autoimmune demyelinating disease.^[7] Finally, experiments in Cldn11-null mice demonstrate that behavioral phenotypes in open field tests, as well as defects in sound lateralization, accompany changes in neurotransmitter levels in the amygdala/ventral hippocampus and auditory brainstem. This study reveals a molecular mechanism by which changes to myelin membrane properties in the absence of degenerative pathology, could lead to neuropsychiatric disease in humans.^[12]

References

^ Jump up to: ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000013297 – Ensembl, May 2017
^ Jump up to: ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037625 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bronstein JM, Kozak CA, Chen XN, Wu S, Danciger M, Korenberg JR, Farber DB (June 1996). "Chromosomal localization of murine and human oligodendrocyte-specific protein genes". Genomics. 34 (2): 255–7. doi:10.1006/geno.1996.0278. PMID 8661061.
^ Bronstein JM, Popper P, Micevych PE, Farber DB (September 1996). "Isolation and characterization of a novel oligodendrocyte-specific protein". Neurology. 47 (3): 772–8. doi:10.1212/wnl.47.3.772. PMID 8797478. S2CID 20873471.
^ Jump up to: ^a ^b "Entrez Gene: CLDN11 claudin 11 (oligodendrocyte transmembrane protein)".
^ Jump up to: ^a ^b Gow A, Southwood CM, Li JS, Pariali M, Riordan GP, Brodie SE, Danias J, Bronstein JM, Kachar B, Lazzarini RA (December 1999). "CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11 null mice". Cell. 99 (6): 649–59. doi:10.1016/S0092-8674(00)81553-6. PMID 10612400. S2CID 10566754.
^ Devaux J, Gow A (December 2008). "Tight junctions potentiate the insulative properties of small CNS myelinated axons". The Journal of Cell Biology. 183 (5): 909–21. doi:10.1083/jcb.200808034. PMC 2592840. PMID 19047465.
^ Gow A, Davies C, Southwood CM, Frolenkov G, Chrustowski M, Ng L, Yamauchi D, Marcus DC, Kachar B (August 2004). "Deafness in Claudin 11-null mice reveals the critical contribution of basal cell tight junctions to stria vascularis function". The Journal of Neuroscience. 24 (32): 7051–62. doi:10.1523/JNEUROSCI.1640-04.2004. PMC 4615685. PMID 15306639.
^ Denninger AR, Breglio A, Maheras KJ, LeDuc G, Cristiglio V, Demé B, Gow A, Kirschner DA (October 2015). "Claudin-11 Tight Junctions in Myelin Are a Barrier to Diffusion and Lack Strong Adhesive Properties". Biophysical Journal. 109 (7): 1387–97. Bibcode:2015BpJ...109.1387D. doi:10.1016/j.bpj.2015.08.012. PMC 4601091. PMID 26445439.
^ Maheras KJ, Peppi M, Ghoddoussi F, Galloway MP, Perrine SA, Gow A (February 2018). "Absence of Claudin 11 in CNS Myelin Perturbs Behavior and Neurotransmitter Levels in Mice". Scientific Reports. 8 (1): 3798. Bibcode:2018NatSR...8.3798M. doi:10.1038/s41598-018-22047-9. PMC 5830493. PMID 29491447.

External links

Human CLDN11 genome location and CLDN11 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] Jump up to: ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000013297 – Ensembl, May 2017

[refGRCm38Ensembl-2] Jump up to: ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037625 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8661061-5] Bronstein JM, Kozak CA, Chen XN, Wu S, Danciger M, Korenberg JR, Farber DB (June 1996). "Chromosomal localization of murine and human oligodendrocyte-specific protein genes". Genomics. 34 (2): 255–7. doi:10.1006/geno.1996.0278. PMID 8661061.

[pmid8797478-6] Bronstein JM, Popper P, Micevych PE, Farber DB (September 1996). "Isolation and characterization of a novel oligodendrocyte-specific protein". Neurology. 47 (3): 772–8. doi:10.1212/wnl.47.3.772. PMID 8797478. S2CID 20873471.

[entrez-7] Jump up to: ^a ^b "Entrez Gene: CLDN11 claudin 11 (oligodendrocyte transmembrane protein)".

[Gow_1999-8] Jump up to: ^a ^b Gow A, Southwood CM, Li JS, Pariali M, Riordan GP, Brodie SE, Danias J, Bronstein JM, Kachar B, Lazzarini RA (December 1999). "CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11 null mice". Cell. 99 (6): 649–59. doi:10.1016/S0092-8674(00)81553-6. PMID 10612400. S2CID 10566754.

[9] Devaux J, Gow A (December 2008). "Tight junctions potentiate the insulative properties of small CNS myelinated axons". The Journal of Cell Biology. 183 (5): 909–21. doi:10.1083/jcb.200808034. PMC 2592840. PMID 19047465.

[Gow_2004-10] Gow A, Davies C, Southwood CM, Frolenkov G, Chrustowski M, Ng L, Yamauchi D, Marcus DC, Kachar B (August 2004). "Deafness in Claudin 11-null mice reveals the critical contribution of basal cell tight junctions to stria vascularis function". The Journal of Neuroscience. 24 (32): 7051–62. doi:10.1523/JNEUROSCI.1640-04.2004. PMC 4615685. PMID 15306639.

[11] Denninger AR, Breglio A, Maheras KJ, LeDuc G, Cristiglio V, Demé B, Gow A, Kirschner DA (October 2015). "Claudin-11 Tight Junctions in Myelin Are a Barrier to Diffusion and Lack Strong Adhesive Properties". Biophysical Journal. 109 (7): 1387–97. Bibcode:2015BpJ...109.1387D. doi:10.1016/j.bpj.2015.08.012. PMC 4601091. PMID 26445439.

[12] Maheras KJ, Peppi M, Ghoddoussi F, Galloway MP, Perrine SA, Gow A (February 2018). "Absence of Claudin 11 in CNS Myelin Perturbs Behavior and Neurotransmitter Levels in Mice". Scientific Reports. 8 (1): 3798. Bibcode:2018NatSR...8.3798M. doi:10.1038/s41598-018-22047-9. PMC 5830493. PMID 29491447.

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Function

References

Further reading

External links