Ренин -рецептор

ATP6AP2
Доступные структуры
PDB	Поиск ортолога: PDBE RCSB
showСписок кодов идентификаторов PDB
	3LBS, 3LC8
Идентификаторы
Псевдонимы	ATP6AP2 , APT6M8-9, ATP6IP2, ATP6M8-9, ELDF10, M8-9, MRXE, MRXSH, MSTP009, PRR, RENR, XMRE, XPDS, HT028, ATPASE H+ Transporting Assocsty Brotein 2, CDG2R
Внешние идентификаторы	Омим : 300556 ; MGI : 1917745 ; Гомологен : 38097 ; GeneCards : ATP6AP2 ; OMA : ATP6AP2 - ортологи
showМестоположение гена ( человек )
Chr.	X chromosome (human)
End	40,606,848 bp
showМестоположение гена ( мышь )
Chr.	X chromosome (mouse)
End	12,483,288 bp
showРНК -паттерн экспрессии
	Top expressed in
	visceral pleura; ; tibia; ; germinal epithelium; ; parietal pleura; ; epithelium of nasopharynx; ; retinal pigment epithelium; ; mucosa of paranasal sinus; ; orbitofrontal cortex; ; lateral nuclear group of thalamus; ; renal medulla;
	Top expressed in
	Epithelium of choroid plexus; ; Paneth cell; ; ciliary body; ; iris; ; retinal pigment epithelium; ; conjunctival fornix; ; substantia nigra; ; medial dorsal nucleus; ; medial geniculate nucleus; ; aortic valve;
	More reference expression data
	; ;
	More reference expression data
showДжин Онтология
Molecular function	protein binding; enzyme binding; signaling receptor activity;
Cellular component	integral component of membrane; plasma membrane; extracellular exosome; membrane; external side of plasma membrane; neuron projection; cell body; tertiary granule membrane; ficolin-1-rich granule membrane; extracellular space; apical plasma membrane;
Biological process	positive regulation of transforming growth factor beta1 production; rostrocaudal neural tube patterning; head morphogenesis; regulation of MAPK cascade; eye pigmentation; angiotensin maturation; positive regulation of Wnt signaling pathway; neutrophil degranulation;
	Sources:Amigo / QuickGO
hideОртологи
	10159
	70495
	ENSG00000182220
	ENSMUSG00000031007
	O75787
	Q9CYN9
	NM_005765
	NM_027439
	NP_005756
	NP_081715
	Wikidata
View/Edit Human	View/Edit Mouse

Рецептор ренина, также известный как АТФаза H (+)-транспортирующий лизосомный вспомогательный белок 2 или рецептор проренана , является белком , который у людей кодируется ATP6AP2 геном . ^{[ 5 ]}^{[ 6 ]}^{[ 7 ]}

Функция

Ренин -рецептор связывает ренин и прозенин . Связывание ренина с этим рецептором индуцирует превращение ангиотензиногена в ангиотензин i . ^{[ 8 ]}

This protein is associated with proton-translocating ATPases which have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. This protein has been found associated with the transmembrane sector of the V-type ATPases.^[7]

References

^ Jump up to: ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182220 – Ensembl, May 2017
^ Jump up to: ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031007 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ludwig J, Kerscher S, Brandt U, Pfeiffer K, Getlawi F, Apps DK, Schagger H (Jun 1998). "Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules". J Biol Chem. 273 (18): 10939–47. doi:10.1074/jbc.273.18.10939. PMID 9556572.
^ Demirci FY, White NJ, Rigatti BW, Lewis KF, Gorin MB (Oct 2001). "Identification, genomic structure, and screening of the vacuolar proton-ATPase membrane sector-associated protein M8-9 gene within the COD1 critical region (Xp11.4)". Mol Vis. 7: 234–9. PMID 11590366.
^ Jump up to: ^a ^b "Entrez Gene: ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2".
^ Nguyen G, Delarue F, Burcklé C, Bouzhir L, Giller T, Sraer JD (June 2002). "Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin". J. Clin. Invest. 109 (11): 1417–27. doi:10.1172/JCI14276. PMC 150992. PMID 12045255.

Внешние ссылки

ATP6AP2 Местоположение человеческого гена в браузере генома UCSC .
ATP6AP2 Человеческий ген детали в браузере генома UCSC .

Эта статья о гене человека на хромосоме и/или связанного с ним белка является заглушкой . Вы можете помочь Википедии, расширив ее .

[refGRCh38Ensembl-1] Jump up to: ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182220 – Ensembl, May 2017

[refGRCm38Ensembl-2] Jump up to: ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031007 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9556572-5] Ludwig J, Kerscher S, Brandt U, Pfeiffer K, Getlawi F, Apps DK, Schagger H (Jun 1998). "Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules". J Biol Chem. 273 (18): 10939–47. doi:10.1074/jbc.273.18.10939. PMID 9556572.

[pmid11590366-6] Demirci FY, White NJ, Rigatti BW, Lewis KF, Gorin MB (Oct 2001). "Identification, genomic structure, and screening of the vacuolar proton-ATPase membrane sector-associated protein M8-9 gene within the COD1 critical region (Xp11.4)". Mol Vis. 7: 234–9. PMID 11590366.

[entrez-7] Jump up to: ^a ^b "Entrez Gene: ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2".

[pmid12045255-8] Nguyen G, Delarue F, Burcklé C, Bouzhir L, Giller T, Sraer JD (June 2002). "Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin". J. Clin. Invest. 109 (11): 1417–27. doi:10.1172/JCI14276. PMC 150992. PMID 12045255.

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Функция

References

Further reading

Внешние ссылки