DTL (gene)

DTL
Identifiers
Aliases	DTL, CDT2, DCAF2, L2RAMP, denticleless E3 ubiquitin protein ligase homolog
External IDs	OMIM: 610617; MGI: 1924093; HomoloGene: 32313; GeneCards: DTL; OMA:DTL - orthologs
showGene location (Human)
Chr.	Chromosome 1 (human)
End	212,107,400 bp
showGene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	191,307,656 bp
showRNA expression pattern
	Top expressed in
	secondary oocyte; ; trabecular bone; ; embryo; ; testicle; ; ventricular zone; ; bone marrow; ; ganglionic eminence; ; gonad; ; bone marrow cells; ; sperm;
	Top expressed in
	mandibular prominence; ; maxillary prominence; ; zygote; ; secondary oocyte; ; ureter; ; lumbar spinal ganglion; ; primitive streak; ; primary oocyte; ; hand; ; fetal liver hematopoietic progenitor cell;
	More reference expression data
	n/a
showGene ontology
Molecular function	ubiquitin-protein transferase activity; protein binding;
Cellular component	centrosome; nuclear membrane; membrane; chromosome; microtubule organizing center; nucleolus; Cul4A-RING E3 ubiquitin ligase complex; Cul4B-RING E3 ubiquitin ligase complex; cytoskeleton; nucleus; nucleoplasm; cytoplasm; cytosol; Cul4-RING E3 ubiquitin ligase complex;
Biological process	ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein monoubiquitination; regulation of cell cycle; DNA replication; protein ubiquitination; response to UV; translesion synthesis; post-translational protein modification; cellular response to DNA damage stimulus; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of protein catabolic process; mitotic G2 DNA damage checkpoint signaling; rhythmic process;
	Sources:Amigo / QuickGO
hideOrthologs
	51514
	76843
	ENSG00000143476
	ENSMUSG00000037474
	Q9NZJ0
	Q3TLR7
	NM_001286229; NM_001286230; NM_016448
	NM_029766; NM_001305233
	NP_001273158; NP_001273159; NP_057532
	NP_001292162; NP_084042
	Wikidata
View/Edit Human	View/Edit Mouse

Denticleless protein homolog is a protein that in humans is encoded by the DTL gene.^[5]^[6]

Interactions

DTL (gene) has been shown to interact with P21.^[7]

References

^ Jump up to: ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143476 – Ensembl, May 2017
^ Jump up to: ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037474 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cheung WM, Chu AH, Chu PW, Ip NY (May 2001). "Cloning and expression of a novel nuclear matrix-associated protein that is regulated during the retinoic acid-induced neuronal differentiation". J Biol Chem. 276 (20): 17083–91. doi:10.1074/jbc.M010802200. PMID 11278750.
^ "Entrez Gene: DTL denticleless homolog (Drosophila)".
^ Abbas T, Sivaprasad U, Terai K, Amador V, Pagano M, Dutta A (Sep 2008). "PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex". Genes Dev. 22 (18): 2496–506. doi:10.1101/gad.1676108. PMC 2546691. PMID 18794347.

Banks D, Wu M, Higa LA, Gavrilova N, Quan J, Ye T, Kobayashi R, Sun H, Zhang H (2007). "L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes". Cell Cycle. 5 (15): 1719–29. doi:10.4161/cc.5.15.3150. PMID 16861890.
Higa LA, Banks D, Wu M, Kobayashi R, Sun H, Zhang H (2007). «L2DTL/CDT2 взаимодействует с комплексом CUL4/DDB1 и PCNA и регулирует протеолиз CDT1 в ответ на повреждение ДНК» . Клеточный цикл . 5 (15): 1675–80. doi : 10.4161/cc.5.15.3149 . PMID 16861906 .
Jin J, Arias EE, Chen J, Harper JW, Walter JC (2006). «Семейство разнообразных белков CUL4-DDB1, включающих CDT2, который необходим для разрушения фазы фактора репликации CDT1» . Мол Клетка . 23 (5): 709–21. doi : 10.1016/j.molcel.2006.08.010 . PMID 16949367 .
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). «Основанный на вероятности подход для высокопроизводительного анализа фосфорилирования белка и локализации сайта». НАТ Биотехнол . 24 (10): 1285–92. doi : 10.1038/nbt1240 . PMID 16964243 . S2CID 14294292 .
Higa La, Wu M, Ye T, Kobayashi R, Sun H, Zhang H (2006). «Убиквитиновая лигаза CUL4-DDB1 взаимодействует с множественными белками Re40 Repeat и регулирует метилирование гистонов». НАТ Клеточная биол . 8 (11): 1277–83. doi : 10.1038/ncb1490 . HDL : 10397/34293 . PMID 17041588 . S2CID 22180568 .
Сансам К.Л., Шепард Дж.Л., Лай К., Янари А., Даниэльан П.С., Амстердам А., Хопкинс Н., Лис Дж.А. (2006). «DTL/CDT2 необходим как для регуляции CDT1, так и для ранней контрольной точки G2/M» . Гены Дев . 20 (22): 3117–29. doi : 10.1101/gad.1482106 . PMC 1635147 . PMID 17085480 .
Pan HW, Chou Hy, Liu SH, Peng Sy, Liu CL, HSU HC (2007). «Роль L2DTL, регулируемого клеточным циклом ядерного и центросом белка при агрессивной гепатоцеллюлярной карциноме» (PDF) . Клеточный цикл . 5 (22): 2676–87. doi : 10.4161/cc.5.22.3500 . PMID 17106265 .

Эта статья о гене о хромосоме человека 1 является заглушкой . Вы можете помочь Википедии, расширив ее .

[refGRCh38Ensembl-1] Jump up to: ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143476 – Ensembl, May 2017

[refGRCm38Ensembl-2] Jump up to: ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037474 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11278750-5] Cheung WM, Chu AH, Chu PW, Ip NY (May 2001). "Cloning and expression of a novel nuclear matrix-associated protein that is regulated during the retinoic acid-induced neuronal differentiation". J Biol Chem. 276 (20): 17083–91. doi:10.1074/jbc.M010802200. PMID 11278750.

[entrez-6] "Entrez Gene: DTL denticleless homolog (Drosophila)".

[pmid18794347-7] Abbas T, Sivaprasad U, Terai K, Amador V, Pagano M, Dutta A (Sep 2008). "PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex". Genes Dev. 22 (18): 2496–506. doi:10.1101/gad.1676108. PMC 2546691. PMID 18794347.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

Interactions

References

Further reading