-Dr16
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Основной комплекс гистосовместимости, класс II, DR16
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| Гаплотипы группы | Перетащите*01: DRB1*1601 Перетащите*01: DRB1*1602 |
| Структура (см. HLA-DR ) | |
| Идентификаторы | Альфа *0101
|
| Символ (ы) | HLA-DRA [ Постоянная мертвая ссылка ] |
| Ebi-hla | Носить*0101 |
| Идентификаторы | Бета 1 *1601 *1602 *1604
|
| Symbol(s) | HLA-DRB1[permanent dead link] |
| EBI-HLA | DRB1*1601 |
| EBI-HLA | DRB1*1602 |
| EBI-HLA | DRB1*1604 |
| Shared data | |
| Locus | chr.6 6p21.31 |
HLA -DR16 (DR16) представляет собой серотип HLA - DR , который распознает генные продукты DRB1 *1601, *1602 и *1604. DR16 находится в Средиземноморье на скромных частотах. DR16 является частью более старой HLA-DR2 серотипов , которая также содержит аналогичные антигены HLA-DR15 .
Аллели
[ редактировать ]| DRB1* | DR16 | DR2 | DR15 | Образец |
| аллель | % | % | % | размер (n) |
| 1601 | 41 | 29 | 19 | 703 |
| 1602 | 47 | 30 | 16 | 239 |
| 1604 | > 50 | 1 |
Болезни ассоциации
[ редактировать ]DR16 связан с кардиомиопатией Чаги , [ 2 ] ревматическая болезнь сердца , [ 3 ] коронарная артерия Этазия , [ 4 ] и хроническая дискоидная волчанка эритематозус. [ 5 ]
DRB1*1601 связан с туберкулеза риском [ 6 ]
DRB1*1602: Juvenile rheumatoid arthritis,[7] rheumatic heart disease,[3] Takayasu arteritis Archived 2007-08-07 at the Wayback Machine,[8] systemic sclerosis (SSc) & anti-DNA topoisomerase I (anti-topo I) antibody,[9][10] melioidosis (Burkholderia pseudomallei infection)[11]
Extended linkage
[edit]DRB1*1601:DQA1*0102:DQB1*0502 haplotype is associated with tubeculousis risk [6]
Genetic Linkage
[edit]DR16 Haplotypes
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| Serotypes | DRA | DRB1 | DRB5 |
|---|---|---|---|
| DR16(2)-DR51 | *0101 | *1601 | *0101 |
| *0101 | *1602 | *0101 | |
| *0101 | *1604 | *0101 | |
| DQA1 | DQB1 | DRB1 | |
| DR16(2)-DQ5 (5.2, 1) | *0102 | *0502 | *1601 |
| HLA-A | HLA-B | DRB1 | |
| A2-B51(5)-DR16(2) | *0201 | *5101 | *1601 |
HLA-DR16 is genetically linked to HLA-DR51 and HLA-DQ5 serotypes.
References
[edit]- ^ derived from IMGT/HLA
- ^ Cruz-Robles D, Reyes P, Monteón-Padilla V, Ortiz-Muñiz A, Vargas-Alarcón G (2004). "MHC class I and class II genes in Mexican patients with Chagas disease". Hum Immunol. 65 (1): 60–5. doi:10.1016/j.humimm.2003.10.008. PMID 14700597.
- ^ Jump up to: a b c Hernández-Pacheco G, Aguilar-García J, Flores-Domínguez C, Rodríguez-Pérez J, Pérez-Hernández N, Alvarez-Leon E, Reyes P, Vargas-Alarcón G (2003). "MHC class II alleles in Mexican patients with rheumatic heart disease". Int J Cardiol. 92 (1): 49–54. doi:10.1016/S0167-5273(03)00040-8. PMID 14602216.
- ^ Akdemir R, Ozhan H, Gunduz H, Erbilen E, Yazici M, Duran S, Orkunoglu F, Albayrak S, Imirzalioglu N, Uyan C (2004). "HLA-DR B1 and DQ B1 polymorphisms in patients with coronary artery ectasia". Acta Cardiol. 59 (5): 499–502. doi:10.2143/AC.59.5.2005222. PMID 15529553. S2CID 25040717.
- ^ López-Tello A, Rodríguez-Carreón AA, Jurado F, et al. (2007). "Association of HLA-DRB1*16 with chronic discoid lupus erythematosus in Mexican mestizo patients". Clin. Exp. Dermatol. 32 (4): 435–8. doi:10.1111/j.1365-2230.2007.02391.x. PMID 17376212. S2CID 19569740.
- ^ Jump up to: a b Dubaniewicz A, Moszkowska G, Szczerkowska Z (2005). "Frequency of DRB1-DQB1 two-locus haplotypes in tuberculosis: preliminary report". Tuberculosis (Edinb). 85 (4): 259–67. doi:10.1016/j.tube.2004.12.003. PMID 15958261.
- ^ Garavito G, Yunis E, Egea E, Ramirez L, Malagón C, Iglesias A, De La Cruz O, Uribe O, Navarro E, Martinez P, Jaraquemada D (2004). "HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos". Hum Immunol. 65 (4): 359–65. doi:10.1016/j.humimm.2004.01.016. PMID 15120191.
- ^ Salazar M, Varela A, Ramirez L, Uribe O, Vasquez G, Egea E, Yunis E, Iglesias-Gamarra A (2000). "Association of HLA-DRB1*1602 and DRB1*1001 with in Colombian mestizos as markers of Amerindian ancestry". Int J Cardiol. 75 (Suppl 1): S113–6. doi:10.1016/s0167-5273(00)00181-9. PMID 10980348.
- ^ Kuwana M, Kaburaki J, Arnett F, Howard R, Medsger T, Wright T (1999). "Influence of ethnic background on clinical and serologic features in patients with systemic sclerosis and anti-DNA topoisomerase I antibody". Arthritis Rheum. 42 (3): 465–74. doi:10.1002/1529-0131(199904)42:3<465::AID-ANR11>3.0.CO;2-Y. PMID 10088769.
- ^ Jump up to: a b Tan F, Stivers D, Arnett F, Chakraborty R, Howard R, Reveille J (1999). "HLA haplotypes and microsatellite polymorphisms in and around the major histocompatibility complex region in a Native American population with a high prevalence of scleroderma (systemic sclerosis)". Tissue Antigens. 53 (1): 74–80. doi:10.1034/j.1399-0039.1999.530108.x. PMID 10082433.
- ^ Dharakul T, Vejbaesya S, Chaowagul W, Luangtrakool P, Stephens H, Songsivilai S (1998). "HLA-DR and -DQ associations with melioidosis". Hum Immunol. 59 (9): 580–6. doi:10.1016/S0198-8859(98)00052-4. PMID 9757914.
- ^ Wongsurawat T, Nakkuntod J, Charoenwongse P, Snabboon T, Sridama V, Hirankarn N (2006). "The association between HLA class II haplotype with Graves' disease in Thai population". Tissue Antigens. 67 (1): 79–83. doi:10.1111/j.1399-0039.2005.00498.x. PMID 16451208.
- ^ Park M, Park Y, Song E, Park H, Kim T, Park D, Park K, Cho B (2005). "Association of HLA-DR and -DQ genes with Graves disease in Koreans". Hum Immunol. 66 (6): 741–7. doi:10.1016/j.humimm.2005.03.001. PMID 15993720.
- ^ Cervantes J, Lema C, Valentina Hurtado L, Andrade R, Hurtado Gomez L, Torrico L, Zegarra L, Quiroga G, Asturizaga D, Dulon A, Prada R, Panoso W, Yashiki S, Fujiyoshi T, Sonoda S (2003). "HLA-DRB1*1602 allele is positively associated with HPV cervical infection in Bolivian Andean women". Hum Immunol. 64 (9): 890–5. doi:10.1016/S0198-8859(03)00163-0. PMID 12941545.
- ^ Arnett F, Howard R, Tan F, Moulds J, Bias W, Durban E, Cameron H, Paxton G, Hodge T, Weathers P, Reveille J (1996). "Increased prevalence of systemic sclerosis in a Native American tribe in Oklahoma. Association with an Amerindian HLA haplotype". Arthritis Rheum. 39 (8): 1362–70. doi:10.1002/art.1780390814. PMID 8702445.