TSC22D3

TSC22D3
Идентификаторы
Псевдонимы	TSC22D3 , DIP, DSIPI, GILZ, TSC-22R, HDIP, TSC22 Доменной член 3 Член 3
Внешние идентификаторы	Омим : 300506 ; MGI : 1196284 ; Гомологен : 104035 ; GeneCards : TSC22D3 ; OMA : TSC22D3 - ортологи
showМестоположение гена ( человек )
Chr.	X chromosome (human)
End	107,777,342 bp
showМестоположение гена ( мышь )
Chr.	X chromosome (mouse)
End	139,501,408 bp
showРНК -паттерн экспрессии
	Top expressed in
	right lung; ; gastric mucosa; ; popliteal artery; ; tibial arteries; ; tibial nerve; ; left coronary artery; ; blood; ; left uterine tube; ; Achilles tendon; ; olfactory bulb;
	Top expressed in
	muscle of thigh; ; belly cord; ; medial head of gastrocnemius muscle; ; right lung lobe; ; stroma of bone marrow; ; left lung lobe; ; temporal muscle; ; triceps brachii muscle; ; ankle; ; sternocleidomastoid muscle;
	More reference expression data
	; ;
	More reference expression data
showGene ontology
Molecular function	MRF binding; protein binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytosol; cytoplasm; nucleus;
Biological process	response to osmotic stress; ion transmembrane transport; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; negative regulation of skeletal muscle tissue development; negative regulation of activation-induced cell death of T cells; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
hideOrthologs
	1831
	14605
	ENSG00000157514
	ENSMUSG00000031431
	Q99576
	Q9Z2S7
	NM_001015881; NM_004089; NM_198057; NM_001318468; NM_001318470
	NM_001077364; NM_010286
	NP_001015881; NP_001305397; NP_001305399; NP_004080; NP_932174
	NP_001070832; NP_034416
	Wikidata
View/Edit Human	View/Edit Mouse

Белок 3 -й семейства доменов TSC22 - это белок , который у людей кодируется TSC22D3 геном . ^{[ 5 ]}^{[ 6 ]}

Функция

Белок, кодируемый этим геном, имеет значительную идентичность последовательности с мышиной TSC-22 и Drosophila SH, которые являются белками лейциновой молнии, которые функционируют как регуляторы транскрипции. Гильц показывает вездесущую экспрессию в тканях, включая тимус, селезенку, легкие, жир, печень, почки, сердце и скелетные мышцы. ^{[ 7 ]}^{[ 8 ]} Экспрессия этого гена стимулируется глюкокортикоидами и интерлейкином 10, и, по-видимому, играет ключевую роль в противовоспалительных и иммуносупрессивных эффектах этого стероида и хемокина. Варианты транскрипта, кодирующие различные изоформы, были идентифицированы для этого гена. ^{[ 6 ]}

Взаимодействия

TSC22D3 has been shown to interact with C-Raf,^[9] NFKB2^[10] and NFKB1.^[10]

References

^ Jump up to: ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000157514 – Ensembl, May 2017
^ Jump up to: ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031431 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Vogel P, Mägert HJ, Cieslak A, Adermann K, Forssmann WG (Dec 1996). "hDIP--a potential transcriptional regulator related to murine TSC-22 and Drosophila shortsighted (shs)--is expressed in a large number of human tissues". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1309 (3): 200–4. doi:10.1016/s0167-4781(96)00177-7. PMID 8982256.
^ Jump up to: ^a ^b "Entrez Gene: TSC22D3 TSC22 domain family, member 3".
^ Ayyar, Vivaswath S.; Almon, Richard R.; Jusko, William J.; DuBois, Debra C. (2015-06-01). "Quantitative tissue-specific dynamics of in vivo GILZ mRNA expression and regulation by endogenous and exogenous glucocorticoids". Physiological Reports. 3 (6): e12382. doi:10.14814/phy2.12382. PMC 4510616. PMID 26056061.
^ Cannarile, L.; Zollo, O.; D'Adamio, F.; Ayroldi, E.; Marchetti, C.; Tabilio, A.; Bruscoli, S.; Riccardi, C. (2001-02-01). "Cloning, chromosomal assignment and tissue distribution of human GILZ, a glucocorticoid hormone-induced gene". Cell Death and Differentiation. 8 (2): 201–203. doi:10.1038/sj.cdd.4400798. ISSN 1350-9047. PMID 11313722.
^ Ayroldi E, Zollo O, Macchiarulo A, Di Marco B, Marchetti C, Riccardi C (Nov 2002). "Glucocorticoid-induced leucine zipper inhibits the Raf-extracellular signal-regulated kinase pathway by binding to Raf-1". Molecular and Cellular Biology. 22 (22): 7929–41. doi:10.1128/MCB.22.22.7929-7941.2002. PMC 134721. PMID 12391160.
^ Jump up to: ^a ^b Ayroldi E, Migliorati G, Bruscoli S, Marchetti C, Zollo O, Cannarile L, D'Adamio F, Riccardi C (Aug 2001). "Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB". Blood. 98 (3): 743–53. doi:10.1182/blood.V98.3.743. PMID 11468175.

Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Cannarile L, Zollo O, D'Adamio F, Ayroldi E, Marchetti C, Tabilio A, Bruscoli S, Riccardi C (Feb 2001). "Cloning, chromosomal assignment and tissue distribution of human GILZ, a glucocorticoid hormone-induced gene". Cell Death and Differentiation. 8 (2): 201–3. doi:10.1038/sj.cdd.4400798. PMID 11313722.
Mittelstadt PR, Ashwell JD (Aug 2001). "Inhibition of AP-1 by the glucocorticoid-inducible protein GILZ". The Journal of Biological Chemistry. 276 (31): 29603–10. doi:10.1074/jbc.M101522200. PMID 11397794.
Ayroldi E, Migliorati G, Bruscoli S, Marchetti C, Zollo O, Cannarile L, D'Adamio F, Riccardi C (Aug 2001). "Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB". Blood. 98 (3): 743–53. doi:10.1182/blood.V98.3.743. PMID 11468175.
Ayroldi E, Zollo O, Macchiarulo A, Di Marco B, Marchetti C, Riccardi C (Nov 2002). "Glucocorticoid-induced leucine zipper inhibits the Raf-extracellular signal-regulated kinase pathway by binding to Raf-1". Molecular and Cellular Biology. 22 (22): 7929–41. doi:10.1128/MCB.22.22.7929-7941.2002. PMC 134721. PMID 12391160.
Berrebi D, Bruscoli S, Cohen N, Foussat A, Migliorati G, Bouchet-Delbos L, Maillot MC, Portier A, Couderc J, Galanaud P, Peuchmaur M, Riccardi C, Emilie D (Jan 2003). "Synthesis of glucocorticoid-induced leucine zipper (GILZ) by macrophages: an anti-inflammatory and immunosuppressive mechanism shared by glucocorticoids and IL-10". Blood. 101 (2): 729–38. doi:10.1182/blood-2002-02-0538. PMID 12393603.
Shi X, Shi W, Li Q, Song B, Wan M, Bai S, Cao X (Apr 2003). "A glucocorticoid-induced leucine-zipper protein, GILZ, inhibits adipogenesis of mesenchymal cells". EMBO Reports. 4 (4): 374–80. doi:10.1038/sj.embor.embor805. PMC 1319161. PMID 12671681.
Asselin-Labat ML, David M, Biola-Vidamment A, Lecoeuche D, Zennaro MC, Bertoglio J, Pallardy M (Jul 2004). "GILZ, a new target for the transcription factor FoxO3, protects T lymphocytes from interleukin-2 withdrawal-induced apoptosis". Blood. 104 (1): 215–23. doi:10.1182/blood-2003-12-4295. PMID 15031210.
A, Kerbrat S, Lombès M, Bertoglio J, Palardy M (Jul на молнии » выражение молнии Молекула эндокринология 19 (7): 1752–64. два : 10 1210/ me.2004-0 15705665PMID
Rual JF, Vengate K, Hao T, Hirth-Christ-Christ, Dricot A, Li N, Berriz GF, FD Gibbons, Dress M, Ayvi-gedehossou N, Click N, Simon C, Boxem M, Silthern S, Roenberg J, Голдберг Д.С., Чжан Л.В., Вонг С.Л., Фрэнк, Лик, Альбала JS, Blue J, Fraughton C, LaMoseas E, Sevik S, Bex C, Psychones P, Syrorski RS, Vandenhaut FP, Vidal M (октябрь 2005 г.). «На пути к протеому белково-белок-белковой сетевой белок. Природа . 437 (7062): 1173–8. Bibcode : 2005 Natur . doi : 10.1038/nature04209 . 16189514PMID S2CID 4427026 .
Саундарараджан Р., Чжан Т.Т., Ван Дж., Вандевалле А., Пирс Д (декабрь 2005 г.). «Новая роль для индуцированного глюкокортикоидами белка лейцинового молния в эпителиальном транспорте натриевых каналов» . Журнал биологической химии . 280 (48): 39970–81. doi : 10.1074/jbc.m508658200 . PMID 16216878 .
Hamdi H, Godot V, Maillot MC, Prejean MV, Cohen N, Krzysiek R, Lemoine FM, Zou W, Emilie D (июль 2007). «Индукция антиген-специфических регуляторных Т-лимфоцитов человека дендритными клетками человека, экспрессирующих глюкокортикоид-индуцированную лейциновую молнию» . Кровь . 110 (1): 211–9. doi : 10.1182/blood-2006-10-052506 . PMC 2077304 . PMID 17356131 .

[refGRCh38Ensembl-1] Jump up to: ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000157514 – Ensembl, May 2017

[refGRCm38Ensembl-2] Jump up to: ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031431 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8982256-5] Vogel P, Mägert HJ, Cieslak A, Adermann K, Forssmann WG (Dec 1996). "hDIP--a potential transcriptional regulator related to murine TSC-22 and Drosophila shortsighted (shs)--is expressed in a large number of human tissues". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1309 (3): 200–4. doi:10.1016/s0167-4781(96)00177-7. PMID 8982256.

[entrez-6] Jump up to: ^a ^b "Entrez Gene: TSC22D3 TSC22 domain family, member 3".

[7] Ayyar, Vivaswath S.; Almon, Richard R.; Jusko, William J.; DuBois, Debra C. (2015-06-01). "Quantitative tissue-specific dynamics of in vivo GILZ mRNA expression and regulation by endogenous and exogenous glucocorticoids". Physiological Reports. 3 (6): e12382. doi:10.14814/phy2.12382. PMC 4510616. PMID 26056061.

[8] Cannarile, L.; Zollo, O.; D'Adamio, F.; Ayroldi, E.; Marchetti, C.; Tabilio, A.; Bruscoli, S.; Riccardi, C. (2001-02-01). "Cloning, chromosomal assignment and tissue distribution of human GILZ, a glucocorticoid hormone-induced gene". Cell Death and Differentiation. 8 (2): 201–203. doi:10.1038/sj.cdd.4400798. ISSN 1350-9047. PMID 11313722.

[pmid12391160-9] Ayroldi E, Zollo O, Macchiarulo A, Di Marco B, Marchetti C, Riccardi C (Nov 2002). "Glucocorticoid-induced leucine zipper inhibits the Raf-extracellular signal-regulated kinase pathway by binding to Raf-1". Molecular and Cellular Biology. 22 (22): 7929–41. doi:10.1128/MCB.22.22.7929-7941.2002. PMC 134721. PMID 12391160.

[pmid11468175-10] Jump up to: ^a ^b Ayroldi E, Migliorati G, Bruscoli S, Marchetti C, Zollo O, Cannarile L, D'Adamio F, Riccardi C (Aug 2001). "Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB". Blood. 98 (3): 743–53. doi:10.1182/blood.V98.3.743. PMID 11468175.

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Функция

Взаимодействия

References

Further reading