CDCA8

CDCA8
Доступные структуры
PDB	Поиск ортолога: PDBE RCSB
showСписок кодов идентификаторов PDB
	2KDD, 2QFA, 2RAW, 2RAX
Идентификаторы
Псевдонимы	CDCA8 , BOR, Borealin, Dasrab, MESRGP, Цикл деления клеток связан 8
Внешние идентификаторы	Омим : 609977 ; MGI : 1196274 ; Гомологен : 23075 ; GeneCards : CDCA8 ; OMA : CDCA8 - ортологи
showGene location (Human)
Chr.	Chromosome 1 (human)
End	37,709,719 bp
showGene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	124,833,104 bp
showRNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; ventricular zone; ; gonad; ; embryo; ; ganglionic eminence; ; right testis; ; left testis; ; mucosa of transverse colon; ; testicle;
	Top expressed in
	Paneth cell; ; renal corpuscle; ; condyle; ; primitive streak; ; fossa; ; primary oocyte; ; ureter; ; medullary collecting duct; ; zygote; ; endocardial cushion;
	More reference expression data
	More reference expression data
showGene ontology
Molecular function	protein binding;
Cellular component	intercellular bridge; nucleolus; nucleoplasm; cytoplasm; spindle; chromosome; cytosol; nucleus; chromosome, centromeric region; chromocenter; midbody; chromosome passenger complex; spindle midzone; cytoskeleton; protein-containing complex;
Biological process	chromosome organization; cell cycle; cell division; mitotic metaphase plate congression; mitotic sister chromatid segregation;
	Sources:Amigo / QuickGO
hideOrthologs
	55143
	52276
	ENSG00000134690
	ENSMUSG00000028873
	Q53HL2
	Q8BHX3
	NM_018101; NM_001256875
	NM_026560
	NP_001243804; NP_060571
	NP_080836
	Wikidata
View/Edit Human	View/Edit Mouse

Бореалин - это белок , который у людей кодируется CDCA8 геном . ^{[ 5 ]}^{[ 6 ]}^{[ 7 ]}

Функция

CDCA8 является компонентом хромосомного пассажирского комплекса, необходимого для стабильности биполярного митотического шпинделя. ^{[ 7 ]}^{[ 8 ]}

Взаимодействия

Было показано, что CDCA8 взаимодействует с Incenp , ^{[ 8 ]} Выживший ^{[ 6 ]}^{[ 8 ]} и Aurora B -киназа . ^{[ 6 ]}^{[ 8 ]}

Ссылки

^ Jump up to: ^а ^{беременный} ^в GRCH38: Ensembl Release 89: ENSG00000134690 - Ensembl , май 2017 г.
^ Jump up to: ^а ^{беременный} ^в GRCM38: Ensembl Release 89: Ensmusg00000028873 - Ensembl , май 2017 г.
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Walker MG (May 2001). "Drug target discovery by gene expression analysis: cell cycle genes". Current Cancer Drug Targets. 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893.
^ Jump up to: ^a ^b ^c Sampath SC, Ohi R, Leismann O, Salic A, Pozniakovski A, Funabiki H (Jul 2004). "The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly". Cell. 118 (2): 187–202. doi:10.1016/j.cell.2004.06.026. PMID 15260989.
^ Jump up to: ^a ^b "Entrez Gene: CDCA8 cell division cycle associated 8".
^ Jump up to: ^a ^b ^c ^d Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, Nigg EA, Gerloff DL, Earnshaw WC (Jul 2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle". The Journal of Cell Biology. 166 (2): 179–91. doi:10.1083/jcb.200404001. PMC 2172304. PMID 15249581.

External links

Human CDCA8 genome location and CDCA8 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] Jump up to: ^а ^{беременный} ^в GRCH38: Ensembl Release 89: ENSG00000134690 - Ensembl , май 2017 г.

[refGRCm38Ensembl-2] Jump up to: ^а ^{беременный} ^в GRCM38: Ensembl Release 89: Ensmusg00000028873 - Ensembl , май 2017 г.

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12188893-5] Walker MG (May 2001). "Drug target discovery by gene expression analysis: cell cycle genes". Current Cancer Drug Targets. 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893.

[Sampath_2004-6] Jump up to: ^a ^b ^c Sampath SC, Ohi R, Leismann O, Salic A, Pozniakovski A, Funabiki H (Jul 2004). "The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly". Cell. 118 (2): 187–202. doi:10.1016/j.cell.2004.06.026. PMID 15260989.

[entrez-7] Jump up to: ^a ^b "Entrez Gene: CDCA8 cell division cycle associated 8".

[Gassman_2004-8] Jump up to: ^a ^b ^c ^d Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, Nigg EA, Gerloff DL, Earnshaw WC (Jul 2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle". The Journal of Cell Biology. 166 (2): 179–91. doi:10.1083/jcb.200404001. PMC 2172304. PMID 15249581.

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Функция

Взаимодействия

Ссылки

Further reading

External links