CLPTM1L

CLPTM1L
Идентификаторы
Псевдонимы	CLPTM1L , CRR9, CLPTM1, CLPTM1
Внешние идентификаторы	Омим : 612585 ; MGI : 2442892 ; Гомологен : 12767 ; GeneCards : CLPTM1L ; OMA : CLPTM1L - ортологи
showМестоположение гена ( человек )
Chr.	Chromosome 5 (human)
End	1,345,099 bp
showМестоположение гена ( мышь )
Chr.	Chromosome 13 (mouse)
End	73,768,724 bp
showРНК -паттерн экспрессии
	Top expressed in
	mucosa of ileum; ; right lobe of thyroid gland; ; body of pancreas; ; left lobe of thyroid gland; ; oocyte; ; upper lobe of left lung; ; gonad; ; secondary oocyte; ; right lobe of liver; ; body of stomach;
	Top expressed in
	lacrimal gland; ; salivary gland; ; submandibular gland; ; seminal vesicula; ; parotid gland; ; calvaria; ; vestibular membrane of cochlear duct; ; stroma of bone marrow; ; crypt of lieberkuhn of small intestine; ; medullary collecting duct;
	More reference expression data
	n/a
hideОртологи
	81037
	218335
	ENSG00000049656 ; ENSG00000274811
	Ensmusg000021610
	Q96KA5
	Q8BXA5
	NM_030782
	NM_146047
	NP_110409
	NP_666159
	Wikidata
View/Edit Human	View/Edit Mouse

Трансмембранное белок 1-подобного белка с губ и неба (CLPTM1-подобный белок), также известный как белок, связанный с устойчивостью к цисплатину , представляет собой белок , который у людей кодируется CLPTM1L геном . ^{[ 5 ]}^{[ 6 ]} CRR9P связан с цисплатином вызванным апоптозом, . ^{[ 6 ]} CLPTM1L, который находится в локусе восприимчивости к раку на хромосоме 5 (5P15.33), обычно чрезмерно экспрессируется в опухолях легких и обеспечивает устойчивость к апоптозу, вызванному генотоксичными агентами, в связи с повышением регуляции анти- Апоптотический белок, BCL-XL. ^{[ 7 ]} Было показано, что ингибирование CLPTM1L ингибирует онкогенную трансформацию и онкогенез, вызванный онкогеном KRAS, частично через сигнальную ось выживания PI3K/AKT. ^{[ 8 ]}

Смотрите также

Расщепленная губа и неба трансмембранное белок 1

References

^ Jump up to: ^a ^b ^c ENSG00000274811 GRCh38: Ensembl release 89: ENSG00000049656, ENSG00000274811 – Ensembl, May 2017
^ Jump up to: ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021610 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CLPTM1-like".
^ Jump up to: ^a ^b Yamamoto K, Okamoto A, Isonishi S, Ochiai K, Ohtake Y (Feb 2001). "A novel gene, CRR9, which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosis". Biochem Biophys Res Commun. 280 (4): 1148–54. doi:10.1006/bbrc.2001.4250. PMID 11162647.
^ James MA, Wen W, Wang Y, Byers LA, Heymach JV, Coombes KR, Girard L, Minna J, You M (2012). "Functional Characterization of CLPTM1L as a Lung". PLOS ONE. 7 (6): 63116. doi:10.1371/journal.pone.0036116. PMC 3366984. PMID 22675468.
^ James MA, Vikis HG, Tate E, Rymaszewski AL, et al. (2014). "CRR9/CLPTM1L regulates cell survival signaling and is required for Ras transformation and lung tumorigenesis". Cancer Res. 74 (4): 1116–27. doi:10.1158/0008-5472.CAN-13-1617. PMC 6005686. PMID 24366883.

External links

Human CLPTM1L genome location and CLPTM1L gene details page in the UCSC Genome Browser.

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Эта статья о гене о хромосоме человека 5 является заглушкой . Вы можете помочь Википедии, расширив ее .

[refGRCh38Ensembl-1] Jump up to: ^a ^b ^c ENSG00000274811 GRCh38: Ensembl release 89: ENSG00000049656, ENSG00000274811 – Ensembl, May 2017

[refGRCm38Ensembl-2] Jump up to: ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021610 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CLPTM1-like".

[Yamamoto-2001-6] Jump up to: ^a ^b Yamamoto K, Okamoto A, Isonishi S, Ochiai K, Ohtake Y (Feb 2001). "A novel gene, CRR9, which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosis". Biochem Biophys Res Commun. 280 (4): 1148–54. doi:10.1006/bbrc.2001.4250. PMID 11162647.

[7] James MA, Wen W, Wang Y, Byers LA, Heymach JV, Coombes KR, Girard L, Minna J, You M (2012). "Functional Characterization of CLPTM1L as a Lung". PLOS ONE. 7 (6): 63116. doi:10.1371/journal.pone.0036116. PMC 3366984. PMID 22675468.

[8] James MA, Vikis HG, Tate E, Rymaszewski AL, et al. (2014). "CRR9/CLPTM1L regulates cell survival signaling and is required for Ras transformation and lung tumorigenesis". Cancer Res. 74 (4): 1116–27. doi:10.1158/0008-5472.CAN-13-1617. PMC 6005686. PMID 24366883.

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Смотрите также

References

External links

Further reading