RDBP

НЕЛЬФЕ
Available structures PDB Ortholog search: PDBe RCSB showList of PDB id codes 1X5P, 2BZ2, 2JX2
Identifiers
Aliases	NELFE, D6S45, NELF-E, RD, RDBP, RDP, negative elongation factor complex member E
External IDs	OMIM: 154040; MGI: 102744; HomoloGene: 134736; GeneCards: NELFE; OMA:NELFE - orthologs
showGene location (Human) Chr. Chromosome 6 (human) Band 6p21.33 Start 31,952,087 bp End 31,959,038 bp
showGene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 B1|17 18.4 cM Start 35,069,367 bp End 35,075,348 bp
showRNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis right uterine tube olfactory zone of nasal mucosa pituitary gland anterior pituitary C1 segment left adrenal cortex ventricular zone right adrenal gland Top expressed in seminiferous tubule internal carotid artery spermatid external carotid artery spermatocyte ventricular zone hair follicle maxillary prominence mandibular prominence epiblast More reference expression data BioGPS More reference expression data
showGene ontology Molecular function nucleic acid binding protein binding chromatin binding RNA binding Cellular component nucleus nucleoplasm NELF complex plasma membrane nuclear body Biological process negative regulation of transcription elongation from RNA polymerase II promoter positive regulation of ERK1 and ERK2 cascade positive regulation of viral transcription transcription by RNA polymerase II regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of histone H3-K4 methylation negative regulation of transcription by RNA polymerase II negative regulation of mRNA polyadenylation transcription elongation from RNA polymerase II promoter transcription, DNA-templated Sources:Amigo / QuickGO
hideOrthologs Species Human Mouse Entrez 7936 27632 Ensembl showENSG00000229363 ENSG00000206357 ENSG00000231044 ENSG00000204356 ENSG00000206268 ENSG00000233801 ENSMUSG00000024369 UniProt P18615 P19426 RefSeq (mRNA) NM_002904 NM_001045863 NM_001045864 NM_138580 RefSeq (protein) NP_002895 NP_001039328 NP_001039329 NP_613046 Location (UCSC) Chr 6: 31.95 – 31.96 Mb Chr 17: 35.07 – 35.08 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Фактор отрицательного удлинения E - это белок , который у людей кодируется RDBP геном .

Функция

Белок, кодируемый этим геном, является частью комплекса, называемого отрицательным фактором удлинения (NELF) , который подавляет удлинение транскрипта РНК -полимеразы II . Этот белок имеет сходство с ядерными РНК-связывающими белками; Однако не было продемонстрировано, что этот белок связывает РНК. Белок содержит тракт чередующихся основных и кислых остатков, в основном аргинина (R) и аспартациновой кислоты (D). Ген локализуется в основной области гистосовместимости ( MHC Class III ) на хромосоме 6.

Взаимодействия

Было показано, что RDBP взаимодействует :

• Кофактор BRCA1 ,
• TH1L, and
• WHSC2.

Further reading

• Yu CY (1999). "Molecular genetics of the human MHC complement gene cluster". Experimental and Clinical Immunogenetics. 15 (4): 213–30. doi:10.1159/000019075. PMID 10072631. S2CID 25061446.
• Stevens M, De Clercq E, Balzarini J (Sep 2006). "The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention". Medicinal Research Reviews. 26 (5): 595–625. doi:10.1002/med.20081. PMC 7168390. PMID 16838299.
• Surowy CS, Hoganson G, Gosink J, Strunk K, Spritz RA (Jun 1990). "The human RD protein is closely related to nuclear RNA-binding proteins and has been highly conserved". Gene. 90 (2): 299–302. doi:10.1016/0378-1119(90)90194-V. PMID 2119325.
• Speiser PW, White PC (Dec 1989). "Structure of the human RD gene: a highly conserved gene in the class III region of the major histocompatibility complex". DNA. 8 (10): 745–51. doi:10.1089/dna.1989.8.745. PMID 2612324.
• Lévi-Strauss M, Carroll MC, Steinmetz M, Meo T (Apr 1988). "A previously undetected MHC gene with an unusual periodic structure". Science. 240 (4849): 201–4. Bibcode:1988Sci...240..201L. doi:10.1126/science.3353717. PMID 3353717.
• Cheng J, Macon KJ, Volanakis JE (Sep 1993). "cDNA cloning and characterization of the protein encoded by RD, a gene located in the class III region of the human major histocompatibility complex". The Biochemical Journal. 294 (2): 589–93. doi:10.1042/bj2940589. PMC 1134496. PMID 8373374.
• Lee SG, Song K (Jun 1997). "Genomic organization of the human DDX13 gene located between RD and RP1 in the class III MHC complex". Molecules and Cells. 7 (3): 414–8. doi:10.1016/S1016-8478(23)13314-0. PMID 9264031.
• Büssow K, Cahill D, Nietfeld W, Bancroft D, Scherzinger E, Lehrach H, Walter G (Nov 1998). "A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library". Nucleic Acids Research. 26 (21): 5007–8. doi:10.1093/nar/26.21.5007. PMC 147919. PMID 9776767.
• Yang Z, Shen L, Dangel AW, Wu LC, Yu CY (Nov 1998). "Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA". Genomics. 53 (3): 338–47. doi:10.1006/geno.1998.5499. PMID 9799600.
• Yamaguchi Y, Takagi T, Wada T, Yano K, Furuya A, Sugimoto S, Hasegawa J, Handa H (Apr 1999). "NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation". Cell. 97 (1): 41–51. doi:10.1016/S0092-8674(00)80713-8. PMID 10199401. S2CID 16855257.
• Ping YH, Rana TM (Apr 2001). "DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation". The Journal of Biological Chemistry. 276 (16): 12951–8. doi:10.1074/jbc.M006130200. PMID 11112772.
• Yamaguchi Y, Inukai N, Narita T, Wada T, Handa H (May 2002). "Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA". Molecular and Cellular Biology. 22 (9): 2918–27. doi:10.1128/MCB.22.9.2918-2927.2002. PMC 133766. PMID 11940650.
• Narita T, Yamaguchi Y, Yano K, Sugimoto S, Chanarat S, Wada T, Kim DK, Hasegawa J, Omori M, Inukai N, Endoh M, Yamada T, Handa H (Mar 2003). "Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex". Molecular and Cellular Biology. 23 (6): 1863–73. doi:10.1128/MCB.23.6.1863-1873.2003. PMC 149481. PMID 12612062.
• Xie T, Rowen L, Aguado B, Ahearn ME, Madan A, Qin S, Campbell RD, Hood L (Dec 2003). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Research. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
• Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (август 2004 г.). «Крупномасштабная характеристика ядерных фосфопротеинов клеток HeLa» . Труды Национальной академии наук Соединенных Штатов Америки . 101 (33): 12130–5. Bibcode : 2004pnas..10112130B . doi : 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935 .
• Aiyar SE, Sun JL, Blair AL, Moskaluk CA, Lu YZ, Ye QN, Yamaguchi Y, Mukherjee A, Ren DM, Handa H, Li R (сентябрь 2004 г.). «Затухание альфа-опосредованной эстрогенной рецепторной транскрипции посредством стимулированного эстрогеном рекрутирования негативного фактора удлинения» . Гены и развитие . 18 (17): 2134–46. doi : 10.1101/gad.1214104 . PMC   515291 . PMID   15342491 .

Внешние ссылки

• ФАКТРИБОК НЕЛЬФЕ