Spondin 1

SPON1
Available structures PDB Ortholog search: PDBe RCSB showList of PDB id codes 2ZOT, 2ZOU, 3COO, 3Q13
Identifiers
Aliases	SPON1, VSGP/F-spondin, f-spondin, Spondin 1
External IDs	OMIM: 604989; MGI: 2385287; HomoloGene: 4453; GeneCards: SPON1; OMA:SPON1 - orthologs
showGene location (Human) Chr. Chromosome 11 (human) Band 11p15.2 Start 13,962,723 bp End 14,268,133 bp
showGene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 F1 Start 113,365,235 bp End 113,642,605 bp
showRNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gallbladder mucosa of sigmoid colon pericardium lower lobe of lung cardia mucosa of urinary bladder external globus pallidus right lung visceral pleura parietal pleura Top expressed in epithelium of lens iris ciliary body external carotid artery cervix internal carotid artery retinal pigment epithelium atrium decidua suprachiasmatic nucleus More reference expression data BioGPS More reference expression data
showGene ontology Molecular function protein binding metal ion binding extracellular matrix structural constituent LBD domain binding Cellular component extracellular matrix extracellular region endoplasmic reticulum lumen extracellular space collagen-containing extracellular matrix Biological process cell adhesion protein O-linked fucosylation positive regulation of protein processing positive regulation of protein binding negative regulation of amyloid-beta formation positive regulation of amyloid precursor protein catabolic process Sources:Amigo / QuickGO
hideOrthologs Species Human Mouse Entrez 10418 233744 Ensembl ENSG00000262655 ENSMUSG00000038156 UniProt Q9HCB6 Q8VCC9 RefSeq (mRNA) NM_006108 NM_145584 RefSeq (protein) NP_006099 NP_663559 Location (UCSC) Chr 11: 13.96 – 14.27 Mb Chr 7: 113.37 – 113.64 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Spondin-1 (also known as F-spondin) is a protein that in humans is encoded by the SPON1 gene. It is secreted by cells of the floor plate and may be involved in axon guidance The protein contains 807 amino acids and is structurally composed of six thrombospondin domains, one reelin domain, and one spondin domain.

Further reading

• Nakajima D, Okazaki N, Yamakawa H (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Klar A, Baldassare M, Jessell TM (1992). "F-spondin: a gene expressed at high levels in the floor plate encodes a secreted protein that promotes neural cell adhesion and neurite extension". Cell. 69 (1): 95–110. doi:10.1016/0092-8674(92)90121-R. PMID 1555244. S2CID 14880785.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Miyamoto K, Morishita Y, Yamazaki M (2001). "Isolation and characterization of vascular smooth muscle cell growth promoting factor from bovine ovarian follicular fluid and its cDNA cloning from bovine and human ovary". Arch. Biochem. Biophys. 390 (1): 93–100. doi:10.1006/abbi.2001.2367. PMID 11368520.
• Gonzalez de Peredo A, Klein D, Macek B (2002). "C-mannosylation and o-fucosylation of thrombospondin type 1 repeats". Mol. Cell. Proteomics. 1 (1): 11–8. doi:10.1074/mcp.M100011-MCP200. PMID 12096136.
• Strausberg RL, Feingold EA, Grouse LH (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ho A, Südhof TC (2004). "Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2548–53. Bibcode:2004PNAS..101.2548H. doi:10.1073/pnas.0308655100. PMC 356987. PMID 14983046.
• Gerhard DS, Wagner L, Feingold EA (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Pyle-Chenault RA, Stolk JA, Molesh DA (2005). "VSGP/F-spondin: a new ovarian cancer marker". Tumour Biol. 26 (5): 245–57. doi:10.1159/000087379. PMID 16103746. S2CID 13409234.
• Otsuki T, Ota T, Nishikawa T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Kitagawa M, Kudo Y, Iizuka S (2006). "Effect of F-spondin on cementoblastic differentiation of human periodontal ligament cells" (PDF). Biochem. Biophys. Res. Commun. 349 (3): 1050–6. doi:10.1016/j.bbrc.2006.08.142. PMID 16965763.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9HCB6 (Spondin-1) at the PDBe-KB.