Бекн1

Бекн1
Доступные структуры
PDB	Поиск ортолога: K7ER46 PDBE K7ER46 RCSB
showСписок кодов идентификаторов PDB
	2P1L, 2PON, 3DVU, 4DDP, 4MI8
Идентификаторы
Псевдонимы	BECN1 , ATG6, VPS30, Beclin1, Beclin 1
Внешние идентификаторы	Омим : 604378 ; MGI : 1891828 ; Гомологен : 2794 ; Genecards : becn1 ; OMA : becn1 - ортологи
showМестоположение гена ( человек )
Chr.	Chromosome 17 (human)
End	42,833,350 bp
showМестоположение гена ( мышь )
Chr.	Chromosome 11 (mouse)
End	101,193,112 bp
showРНК -паттерн экспрессии
	Top expressed in
	rectum; ; epithelium of colon; ; monocyte; ; Achilles tendon; ; gastric mucosa; ; Skeletal muscle tissue of rectus abdominis; ; gastrocnemius muscle; ; olfactory zone of nasal mucosa; ; muscle layer of sigmoid colon; ; stromal cell of endometrium;
	Top expressed in
	medullary collecting duct; ; Paneth cell; ; blood; ; endothelial cell of lymphatic vessel; ; retinal pigment epithelium; ; endocardial cushion; ; aortic valve; ; ascending aorta; ; hair follicle; ; ciliary body;
	More reference expression data
	; ;
	More reference expression data
showДжин Онтология
Molecular function	phosphatidylinositol 3-kinase binding; protein binding; GTPase binding; ubiquitin protein ligase binding; protein kinase binding; protein homodimerization activity;
Cellular component	endosome membrane; cytoplasm; mitochondrial membranes; trans-Golgi network; Golgi apparatus; cytosol; nucleus; autophagosome; phagophore assembly site; membrane; dendrite; endoplasmic reticulum; phosphatidylinositol 3-kinase complex, class III; endoplasmic reticulum membrane; phosphatidylinositol 3-kinase complex, class III, type II; cytoplasmic vesicle; endosome; extrinsic component of membrane; phosphatidylinositol 3-kinase complex, class III, type I; phagocytic vesicle; mitochondrion; protein-containing complex;
Biological process	negative regulation of cell population proliferation; response to hypoxia; cellular response to aluminum ion; response to vitamin E; lysosome organization; cell cycle; positive regulation of phosphatidylinositol 3-kinase signaling; cellular response to glucose starvation; cellular defense response; cytokinesis; cellular response to epidermal growth factor stimulus; cell division; receptor catabolic process; autophagy of nucleus; cellular response to nitrogen starvation; viral process; late endosome to vacuole transport; apoptotic process; cytoplasm to vacuole transport by the Cvt pathway; endocytosis; engulfment of apoptotic cell; positive regulation of attachment of mitotic spindle microtubules to kinetochore; amyloid-beta metabolic process; neuron development; defense response to virus; response to other organism; mitotic metaphase plate congression; regulation of catalytic activity; negative regulation of reactive oxygen species metabolic process; regulation of cytokinesis; negative regulation of apoptotic process; negative regulation of cell death; autophagosome assembly; macroautophagy; human ageing; response to iron(II) ion; response to lead ion; protein deubiquitination; response to nutrient levels; cellular response to amino acid starvation; cellular response to hydrogen peroxide; cellular response to copper ion; negative regulation of lysosome organization; positive regulation of autophagosome assembly; autophagy of mitochondrion; mitophagy; autophagy; positive regulation of autophagy; response to mitochondrial depolarisation; early endosome to late endosome transport; negative regulation of autophagy; positive regulation of cardiac muscle hypertrophy; negative regulation of autophagosome assembly; positive regulation of intrinsic apoptotic signaling pathway;
	Sources:Amigo / QuickGO
hideOrthologs
	8678
	56208
	ENSG00000126581
	ENSMUSG00000035086
	Q14457
	O88597
	NM_001313998; NM_001313999; NM_001314000; NM_003766
	NM_019584; NM_001359819; NM_001359820; NM_001359821
	NP_001300927; NP_001300928; NP_001300929; NP_003757
	NP_062530; NP_001346748; NP_001346749; NP_001346750
	Wikidata
View/Edit Human	View/Edit Mouse

Беклин-1 -это белок , который у людей кодируется BECN1 геном . ^{[ 5 ]}^{[ 6 ]} Beclin-1 является ортологом млекопитающего гена 6 (ATG6), связанного с дрожжами, и BEC-1 в C. elegans нематоде . ^{[ 7 ]} Этот белок взаимодействует с BCL-2 или PI3K классом III, играя критическую роль в регуляции как аутофагии , так и клеточной гибели .

Роль в болезнях

Беклин-1 играет важную роль в онкогенезе и нейродегенерации , участвуя в аутофагической запрограммированной гибели клеток . ^{[ 8 ]} Рак яичников с активированной аутофагией имеет менее агрессивное поведение и более реагирует на химиотерапию. ^{[ 9 ]}

Шизофрения связана с низкими уровнями Beclin-1 в гиппокампе страдающих затронутых, что вызывает снижение аутофагии , что, в свою очередь, приводит к повышению гибели нейрональных клеток. ^[10]

Interactions

BECN1 has been shown to interact with:

Modulators

Trehalose: Trehalose reduces p62/Beclin-1 ratio and increases autophagy in the frontal cortex of ICR mice, possibly by increasing Beclin-1.^[14]

References

^ Jump up to: ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000126581 – Ensembl, May 2017
^ Jump up to: ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035086 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jump up to: ^a ^b Liang XH, Kleeman LK, Jiang HH, Gordon G, Goldman JE, Berry G, et al. (November 1998). "Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein". Journal of Virology. 72 (11): 8586–96. doi:10.1128/JVI.72.11.8586-8596.1998. PMC 110269. PMID 9765397.
^ "Entrez Gene: BECN1 beclin 1 (coiled-coil, myosin-like BCL2 interacting protein)".
^ Takacs-Vellai K, Vellai T, Puoti A, Passannante M, Wicky C, Streit A, et al. (August 2005). "Inactivation of the autophagy gene bec-1 triggers apoptotic cell death in C. elegans". Current Biology. 15 (16): 1513–7. Bibcode:2005CBio...15.1513T. doi:10.1016/j.cub.2005.07.035. PMID 16111945. S2CID 7404414.
^ Zhong Y, Wang QJ, Li X, Yan Y, Backer JM, Chait BT, et al. (April 2009). "Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex". Nature Cell Biology. 11 (4): 468–76. doi:10.1038/ncb1854. PMC 2664389. PMID 19270693.
^ Jump up to: ^a ^b Valente G, Morani F, Nicotra G, Fusco N, Peracchio C, Titone R, et al. (2014). "Expression and clinical significance of the autophagy proteins BECLIN 1 and LC3 in ovarian cancer". BioMed Research International. 2014: 462658. doi:10.1155/2014/462658. PMC 4127242. PMID 25136588.
^ Merenlender-Wagner A, Malishkevich A, Shemer Z, Udawela M, Gibbons A, Scarr E, et al. (February 2015). "Autophagy has a key role in the pathophysiology of schizophrenia". Molecular Psychiatry. 20 (1): 126–32. doi:10.1038/mp.2013.174. PMC 4320293. PMID 24365867.*Lay summary in: Whiteman H (January 1, 2014). "New molecular discovery provides clues to cause of schizophrenia". MediLexicon International Ltd.
^ Erlich S, Mizrachy L, Segev O, Lindenboim L, Zmira O, Adi-Harel S, et al. (2007). "Differential interactions between Beclin 1 and Bcl-2 family members". Autophagy. 3 (6): 561–8. doi:10.4161/auto.4713. PMID 17643073.
^ Yue Z, Horton A, Bravin M, DeJager PL, Selimi F, Heintz N (August 2002). "A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice". Neuron. 35 (5): 921–33. doi:10.1016/S0896-6273(02)00861-9. PMID 12372286. S2CID 10534933.
^ Jump up to: ^a ^b Chang C, Young LN, Morris KL, von Bülow S, Schöneberg J, Yamamoto-Imoto H, et al. (2019-01-17). "Bidirectional Control of Autophagy by BECN1 BARA Domain Dynamics". Molecular Cell. 73 (2): 339–353.e6. doi:10.1016/j.molcel.2018.10.035. ISSN 1097-4164. PMC 6450660. PMID 30581147.
^ Kara NZ, Toker L, Agam G, Anderson GW, Belmaker RH, Einat H (September 2013). "Trehalose induced antidepressant-like effects and autophagy enhancement in mice". Psychopharmacology. 229 (2): 367–75. doi:10.1007/s00213-013-3119-4. PMID 23644913. S2CID 17641899.

Внешние ссылки

человека и геном BECN1 Местоположение генома BECN1 и страница гена в браузере UCSC Genome .
Обзор всей структурной информации, доступной в PDB для Uniprot : Q14457 (Beclin-1) в PDBE-KB .

[refGRCh38Ensembl-1] Jump up to: ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000126581 – Ensembl, May 2017

[refGRCm38Ensembl-2] Jump up to: ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035086 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9765397-5] Jump up to: ^a ^b Liang XH, Kleeman LK, Jiang HH, Gordon G, Goldman JE, Berry G, et al. (November 1998). "Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein". Journal of Virology. 72 (11): 8586–96. doi:10.1128/JVI.72.11.8586-8596.1998. PMC 110269. PMID 9765397.

[entrez-6] "Entrez Gene: BECN1 beclin 1 (coiled-coil, myosin-like BCL2 interacting protein)".

[pmid16111945-7] Takacs-Vellai K, Vellai T, Puoti A, Passannante M, Wicky C, Streit A, et al. (August 2005). "Inactivation of the autophagy gene bec-1 triggers apoptotic cell death in C. elegans". Current Biology. 15 (16): 1513–7. Bibcode:2005CBio...15.1513T. doi:10.1016/j.cub.2005.07.035. PMID 16111945. S2CID 7404414.

[pmid19270693-8] Zhong Y, Wang QJ, Li X, Yan Y, Backer JM, Chait BT, et al. (April 2009). "Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex". Nature Cell Biology. 11 (4): 468–76. doi:10.1038/ncb1854. PMC 2664389. PMID 19270693.

[Valente_2014-9] Jump up to: ^a ^b Valente G, Morani F, Nicotra G, Fusco N, Peracchio C, Titone R, et al. (2014). "Expression and clinical significance of the autophagy proteins BECLIN 1 and LC3 in ovarian cancer". BioMed Research International. 2014: 462658. doi:10.1155/2014/462658. PMC 4127242. PMID 25136588.

[pmid24365867-10] Merenlender-Wagner A, Malishkevich A, Shemer Z, Udawela M, Gibbons A, Scarr E, et al. (February 2015). "Autophagy has a key role in the pathophysiology of schizophrenia". Molecular Psychiatry. 20 (1): 126–32. doi:10.1038/mp.2013.174. PMC 4320293. PMID 24365867.*Lay summary in: Whiteman H (January 1, 2014). "New molecular discovery provides clues to cause of schizophrenia". MediLexicon International Ltd.

[pmid17643073-11] Erlich S, Mizrachy L, Segev O, Lindenboim L, Zmira O, Adi-Harel S, et al. (2007). "Differential interactions between Beclin 1 and Bcl-2 family members". Autophagy. 3 (6): 561–8. doi:10.4161/auto.4713. PMID 17643073.

[pmid12372286-12] Yue Z, Horton A, Bravin M, DeJager PL, Selimi F, Heintz N (August 2002). "A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice". Neuron. 35 (5): 921–33. doi:10.1016/S0896-6273(02)00861-9. PMID 12372286. S2CID 10534933.

[:0-13] Jump up to: ^a ^b Chang C, Young LN, Morris KL, von Bülow S, Schöneberg J, Yamamoto-Imoto H, et al. (2019-01-17). "Bidirectional Control of Autophagy by BECN1 BARA Domain Dynamics". Molecular Cell. 73 (2): 339–353.e6. doi:10.1016/j.molcel.2018.10.035. ISSN 1097-4164. PMC 6450660. PMID 30581147.

[14] Kara NZ, Toker L, Agam G, Anderson GW, Belmaker RH, Einat H (September 2013). "Trehalose induced antidepressant-like effects and autophagy enhancement in mice". Psychopharmacology. 229 (2): 367–75. doi:10.1007/s00213-013-3119-4. PMID 23644913. S2CID 17641899.

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Роль в болезнях

Interactions

Modulators

References

Further reading

Внешние ссылки