WASL (ген)

Wasl
Доступные структуры
PDB	Поиск ортолога: PDBE RCSB
showСписок кодов идентификаторов PDB
	2FF3, 2LNH, 2VCP, 4CC2, 4CC7
Идентификаторы
Псевдонимы	WASL , N-WASP, NWASP, WASPB, WASL (Gene), синдром Вискотт-Альдрича, такой как оса, как фактор развития зародышеобразования актина
Внешние идентификаторы	Омим : 605056 ; MGI : 1920428 ; Гомологен : 136779 ; Genecards : wasl ; OMA : WASL - Ортологи
showGene location (Human)
Chr.	Chromosome 7 (human)
End	123,749,003 bp
showGene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	24,665,008 bp
showRNA expression pattern
	Top expressed in
	middle temporal gyrus; ; lateral nuclear group of thalamus; ; jejunal mucosa; ; Brodmann area 23; ; skin of thigh; ; mucosa of colon; ; mucosa of sigmoid colon; ; renal medulla; ; trigeminal ganglion; ; postcentral gyrus;
	Top expressed in
	medullary collecting duct; ; Region I of hippocampus proper; ; renal corpuscle; ; ciliary body; ; retinal pigment epithelium; ; conjunctival fornix; ; vestibular membrane of cochlear duct; ; facial motor nucleus; ; Paneth cell; ; Epithelium of choroid plexus;
	More reference expression data
	More reference expression data
showGene ontology
Molecular function	GTPase regulator activity; protein binding; actin binding;
Cellular component	cytoplasm; endocytic vesicle membrane; cytosol; plasma membrane; actin cytoskeleton; actin cap; extracellular exosome; cytoskeleton; nucleus; lamellipodium; cytoplasmic vesicle;
Biological process	negative regulation of membrane tubulation; regulation of transcription, DNA-templated; response to bacterium; Fc-gamma receptor signaling pathway involved in phagocytosis; vesicle organization; actin filament organization; ephrin receptor signaling pathway; regulation of nitric-oxide synthase activity; positive regulation of Arp2/3 complex-mediated actin nucleation; transcription, DNA-templated; regulation of protein localization; cell division; vesicle budding from membrane; positive regulation of clathrin-dependent endocytosis; vesicle transport along actin filament; cell cycle; actin polymerization or depolymerization; spindle localization; negative regulation of lymphocyte migration; positive regulation of filopodium assembly; actin cytoskeleton organization; membrane organization; dendritic spine morphogenesis;
	Sources:Amigo / QuickGO
hideOrthologs
	8976
	73178
	ENSG00000106299
	ENSMUSG00000029684
	O00401
	Q91YD9
	NM_003941
	NM_001167745; NM_028459
	NP_003932
	NP_001161217; NP_082735
	Wikidata
View/Edit Human	View/Edit Mouse

Белок с синдромом нервного Вискотта -Альдрича является белком , который у людей кодируется WASL геном . ^{[ 5 ]}^{[ 6 ]}^{[ 7 ]}

Семейство синдрома Вискотт -Альдрича (было) белков имеет сходную доменную структуру и участвует в трансдукции сигналов от рецепторов на клеточной поверхности в актиновый цитоскелет . Наличие ряда различных мотивов предполагает, что они регулируются рядом различных стимулов и взаимодействуют с несколькими белками . Недавние исследования показали, что эти белки, прямо или косвенно, ассоциируются с небольшой GTPase , CDC42 , известными, регулирующими образование актиновых филаментов и цитоскелетным организующим комплексом, ARP2/3 . Продукт гена WASL - это гомолог, который был белком , однако, в отличие от последнего, он повсеместно экспрессируется и показывает самую высокую экспрессию в нейронных тканях. Было показано, что он связывает CDC42 напрямую и индуцирует образование длинных актиновых микроспанов. ^{[ 7 ]}

According to one study, mouse DAB1 regulates actin cytoskeleton through N-WASP.^[8]

Diseases associated with WASL include Wiskottt-Aldrich Syndrome and Vaccinia.^[9]

Interactions

WASL (gene) has been shown to interact with:

References

^ Jump up to: ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106299 – Ensembl, May 2017
^ Jump up to: ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029684 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jump up to: ^a ^b Miki H, Sasaki T, Takai Y, Takenawa T (Jan 1998). "Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP". Nature. 391 (6662): 93–6. Bibcode:1998Natur.391...93M. doi:10.1038/34208. PMID 9422512. S2CID 4363890.
^ Fukuoka M, Miki H, Takenawa T (Sep 1997). "Identification of N-WASP homologs in human and rat brain". Gene. 196 (1–2): 43–8. doi:10.1016/S0378-1119(97)00184-4. PMID 9322739.
^ Jump up to: ^a ^b "Entrez Gene: WASL Wiskott–Aldrich syndrome-like".
^ Suetsugu S, Tezuka T, Morimura T, Hattori M, Mikoshiba K, Yamamoto T, Takenawa T (Nov 2004). "Regulation of actin cytoskeleton by mDab1 through N-WASP and ubiquitination of mDab1". The Biochemical Journal. 384 (Pt 1): 1–8. doi:10.1042/BJ20041103. PMC 1134082. PMID 15361067.
^ "WASL Gene - GeneCards | WASL Protein | WASL Antibody". www.genecards.org. Retrieved 2018-11-25.
^ Carlier MF, Nioche P, Broutin-L'Hermite I, Boujemaa R, Le Clainche C, Egile C, Garbay C, Ducruix A, Sansonetti P, Pantaloni D (Jul 2000). "GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott–Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex". The Journal of Biological Chemistry. 275 (29): 21946–52. doi:10.1074/jbc.M000687200. PMID 10781580.
^ Mizutani K, Miki H, He H, Maruta H, Takenawa T (Feb 2002). "Essential role of neural Wiskott–Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts". Cancer Research. 62 (3): 669–74. PMID 11830518.
^ Rohatgi R, Nollau P, Ho HY, Kirschner MW, Mayer BJ (Jul 2001). "Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway". The Journal of Biological Chemistry. 276 (28): 26448–52. doi:10.1074/jbc.M103856200. PMID 11340081.
^ Mimuro H, Suzuki T, Suetsugu S, Miki H, Takenawa T, Sasakawa C (Sep 2000). "Profilin is required for sustaining efficient intra- and intercellular spreading of Shigella flexneri". The Journal of Biological Chemistry. 275 (37): 28893–901. doi:10.1074/jbc.M003882200. PMID 10867004.
^ Suetsugu S, Miki H, Takenawa T (Nov 1998). "The essential role of profilin in the assembly of actin for microspike formation". The EMBO Journal. 17 (22): 6516–26. doi:10.1093/emboj/17.22.6516. PMC 1170999. PMID 9822597.
^ Abe T, Kato M, Miki H, Takenawa T, Endo T (Jan 2003). "Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth". Journal of Cell Science. 116 (Pt 1): 155–68. doi:10.1242/jcs.00208. PMID 12456725.

Ramesh N, Antón IM, Martínez-Quiles N, Geha RS (Jan 1999). "Waltzing with WASP". Trends in Cell Biology. 9 (1): 15–9. doi:10.1016/S0962-8924(98)01411-1. PMID 10087612.
Carlier MF, Ducruix A, Pantaloni D (Sep 1999). "Signalling to actin: the Cdc42-N-WASP-Arp2/3 connection". Chemistry & Biology. 6 (9): R235–40. doi:10.1016/S1074-5521(99)80107-0. PMID 10467124.
Suzuki T, Miki H, Takenawa T, Sasakawa C (May 1998). "Neural Wiskott–Aldrich syndrome protein is implicated in the actin-based motility of Shigella flexneri". The EMBO Journal. 17 (10): 2767–76. doi:10.1093/emboj/17.10.2767. PMC 1170617. PMID 9582270.
Suetsugu S, Miki H, Takenawa T (Nov 1998). "The essential role of profilin in the assembly of actin for microspike formation". The EMBO Journal. 17 (22): 6516–26. doi:10.1093/emboj/17.22.6516. PMC 1170999. PMID 9822597.
Qualmann B, Roos J, DiGregorio PJ, Kelly RB (Feb 1999). "Syndapin I, a synaptic dynamin-binding protein that associates with the neural Wiskott–Aldrich syndrome protein". Molecular Biology of the Cell. 10 (2): 501–13. doi:10.1091/mbc.10.2.501. PMC 25183. PMID 9950691.
Suetsugu S, Miki H, Takenawa T (Jun 1999). "Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex". Biochemical and Biophysical Research Communications. 260 (1): 296–302. doi:10.1006/bbrc.1999.0894. PMID 10381382.
Egile C, Loisel TP, Laurent V, Li R, Pantaloni D, Sansonetti PJ, Carlier MF (Sep 1999). "Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin-based motility". The Journal of Cell Biology. 146 (6): 1319–32. doi:10.1083/jcb.146.6.1319. PMC 2156126. PMID 10491394.
Higgs HN, Blanchoin L, Pollard TD (Nov 1999). "Influence of the C terminus of Wiskott–Aldrich syndrome protein (WASp) and the Arp2/3 complex on actin polymerization". Biochemistry. 38 (46): 15212–22. doi:10.1021/bi991843. PMID 10563804.
Qualmann B, Kelly RB (Mar 2000). "Syndapin isoforms participate in receptor-mediated endocytosis and actin organization". The Journal of Cell Biology. 148 (5): 1047–62. doi:10.1083/jcb.148.5.1047. PMC 2174535. PMID 10704453.
Kim AS, Kakalis LT, Abdul-Manan N, Liu GA, Rosen MK (Mar 2000). "Autoinhibition and activation mechanisms of the Wiskott–Aldrich syndrome protein". Nature. 404 (6774): 151–8. Bibcode:2000Natur.404..151K. doi:10.1038/35004513. PMID 10724160. S2CID 4416185.
Carlier MF, Nioche P, Broutin-L'Hermite I, Boujemaa R, Le Clainche C, Egile C, Garbay C, Ducruix A, Sansonetti P, Pantaloni D (Jul 2000). "GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott–Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex". The Journal of Biological Chemistry. 275 (29): 21946–52. doi:10.1074/jbc.M000687200. PMID 10781580.
Mimuro H, Suzuki T, Suetsugu S, Miki H, Takewawa T, Sasakawa C (сентябрь 2000). «Профилин необходим для поддержания эффективного внутри- и межклеточного распространения Shigella flexneri» . Журнал биологической химии . 275 (37): 28893–901. doi : 10.1074/jbc.m003882200 . PMID 10867004 .
Prehoda Ke, Scott Ja, Mullins Rd, Lim WA (октябрь 2000). «Интеграция нескольких сигналов посредством кооперативной регуляции комплекса N-WASP-ARP2/3». Наука . 290 (5492): 801–6. Bibcode : 2000sci ... 290..801p . doi : 10.1126/science.290.5492.801 . PMID 11052943 .
Modregger J, Ritter B, Witter B, Paulsson M, Plomann M (Dec 2000). «Все три изоформы Pacsin связываются с эндоцитарными белками и ингибируют эндоцитоз». Журнал сотовой науки . 113 (24): 4511–21. doi : 10.1242/jcs.113.24.4511 . PMID 11082044 .
Маршанд Дж. Б., Кайзер Д.А., Поллард Т.Д., Хиггс Х.Н. (январь 2001 г.). «Взаимодействие белков WASP/SCAR с комплексом ARP2/3 позвоночных». Природная клеточная биология . 3 (1): 76–82. doi : 10.1038/35050590 . PMID 11146629 . S2CID 30437883 .
Fukuoka M, Suetsugu S, Miki H, Fukami K, Endo T, Taskawa T (февраль 2001 г.). «Новый белок, связывающий белок, связывающий синдром, связывающий нейрот Вискотт-Альдрич (N-WASP), пожелает, индуцирует активацию комплекса ARP2/3 независимо от CDC42» . Журнал клеточной биологии . 152 (3): 471–82. doi : 10.1083/jcb.152.3.471 . PMC 2196001 . PMID 11157975 .

Эта статья о гене о хромосоме человека 7 является заглушкой . Вы можете помочь Википедии, расширив ее .

[refGRCh38Ensembl-1] Jump up to: ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106299 – Ensembl, May 2017

[refGRCm38Ensembl-2] Jump up to: ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029684 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9422512-5] Jump up to: ^a ^b Miki H, Sasaki T, Takai Y, Takenawa T (Jan 1998). "Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP". Nature. 391 (6662): 93–6. Bibcode:1998Natur.391...93M. doi:10.1038/34208. PMID 9422512. S2CID 4363890.

[pmid9322739-6] Fukuoka M, Miki H, Takenawa T (Sep 1997). "Identification of N-WASP homologs in human and rat brain". Gene. 196 (1–2): 43–8. doi:10.1016/S0378-1119(97)00184-4. PMID 9322739.

[entrez-7] Jump up to: ^a ^b "Entrez Gene: WASL Wiskott–Aldrich syndrome-like".

[pmid15361067-8] Suetsugu S, Tezuka T, Morimura T, Hattori M, Mikoshiba K, Yamamoto T, Takenawa T (Nov 2004). "Regulation of actin cytoskeleton by mDab1 through N-WASP and ubiquitination of mDab1". The Biochemical Journal. 384 (Pt 1): 1–8. doi:10.1042/BJ20041103. PMC 1134082. PMID 15361067.

[9] "WASL Gene - GeneCards | WASL Protein | WASL Antibody". www.genecards.org. Retrieved 2018-11-25.

[pmid10781580-10] Carlier MF, Nioche P, Broutin-L'Hermite I, Boujemaa R, Le Clainche C, Egile C, Garbay C, Ducruix A, Sansonetti P, Pantaloni D (Jul 2000). "GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott–Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex". The Journal of Biological Chemistry. 275 (29): 21946–52. doi:10.1074/jbc.M000687200. PMID 10781580.

[pmid11830518-11] Mizutani K, Miki H, He H, Maruta H, Takenawa T (Feb 2002). "Essential role of neural Wiskott–Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts". Cancer Research. 62 (3): 669–74. PMID 11830518.

[pmid11340081-12] Rohatgi R, Nollau P, Ho HY, Kirschner MW, Mayer BJ (Jul 2001). "Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway". The Journal of Biological Chemistry. 276 (28): 26448–52. doi:10.1074/jbc.M103856200. PMID 11340081.

[pmid10867004-13] Mimuro H, Suzuki T, Suetsugu S, Miki H, Takenawa T, Sasakawa C (Sep 2000). "Profilin is required for sustaining efficient intra- and intercellular spreading of Shigella flexneri". The Journal of Biological Chemistry. 275 (37): 28893–901. doi:10.1074/jbc.M003882200. PMID 10867004.

[pmid9822597-14] Suetsugu S, Miki H, Takenawa T (Nov 1998). "The essential role of profilin in the assembly of actin for microspike formation". The EMBO Journal. 17 (22): 6516–26. doi:10.1093/emboj/17.22.6516. PMC 1170999. PMID 9822597.

[pmid12456725-15] Abe T, Kato M, Miki H, Takenawa T, Endo T (Jan 2003). "Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth". Journal of Cell Science. 116 (Pt 1): 155–68. doi:10.1242/jcs.00208. PMID 12456725.

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Interactions

References

Further reading